[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-reaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-reaction":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,82,105,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100466807","phase-3-propofol-and-etomidate-admixtures-comparisons-trial-peac-trial-100466807",false,"NCT05358535","Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)","PEAC","Inclusion Criteria:\n\n1. Adult patients (age ≥18 years old)\n2. Having endoscopic procedure at CUH with anesthesia\n3. ASA 3 or above\n4. Ejection Fraction test result available\n\nExclusion Criteria:\n\n1. Known allergies or adverse reactions to study drugs or study drug components or preservatives\n2. Patient refusal\n3. Clinician refusal\n4. Documented cognitive impairments precluding subject ability to consent for themselves unless a surrogate documented legally acceptable decision maker consents for patient participation\n5. Prisoner or incarcerated or patients held by law enforcement officials in custody\n6. Pregnancy or patient refusal for pregnancy testing or screening (standard UTSW policy and protocol requires pregnancy testing for appropriate patients prior to anesthesia)","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).",[26,27,28,29,30,31],"Anesthesia","Propofol Adverse Reaction","Etomidate Adverse Reaction","Anesthesia Complication","Anesthesia; Adverse Effect","Anesthesia; Reaction",[33,34,35,36,37,38,39],"anesthesia","anesthesiology","adverse drug reaction","drug side effect","sedation","cardiopulmonary","hemodynamics","RECRUITING","2026-01-16",{"date":43,"type":44},"2026-01-20","ACTUAL",{"date":46,"type":44},"2022-09-19",{"date":48,"type":20},"2027-03",{"name":50,"class":51},"University of Texas Southwestern Medical Center","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":4,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":64,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":52},"100600909","phase-4-individual-cerebral-hemodynamic-oxygenation-relationships---ichor-4-100600909","NCT07103616","Individual Cerebral Hemodynamic Oxygenation Relationships - ICHOR 4","ICHOR","Inclusion Criteria:\n\n* Patients who are scheduled for a clinically indicated MRI at the sponsor institution.\n* Patients who are able to tolerate an MRI.\n* Patients who require clinical anesthesia for their MRI.\n* Patients with conditions not believed to alter oxygen metabolism or blood flow in the brain, including but not limited to patients with orthopedic indications, undescended testicles, hernia repairs, term equivalent age scans.\n* Patients who have no medical conditions that make the use of propofol or dexmedetomidine better for their clinical outcome.\n* Patients between birth and up-to 7 year of age.\n* Patients with conditions known to alter oxygen metabolism or blood flow in the brain, e.g. traumatic brain injury, hypoxic ischemic encephalopathy, tumor.\n\nExclusion Criteria:\n\n* Patients with an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Preterm infants less than 25 weeks postmenstrual age (PMA) at the time of the scan.\n* Patients who are clinically too unstable to extend their MRI by up-to 10 minutes.\n* Patients who do not require clinical anesthesia.\n* Patients at risk for propofol infusion syndrome (known severe metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis, hepatomegaly, renal failure, ECG ST segment elevation, and\u002For cardiac failure)\n* Patient at risk for sensitivity to volatile halogenated anesthetic agents (known congenital Long QT Syndrome or patients taking drugs that can prolong the QT interval),\n* Patients with Perioperative Hyperkalemia (known neuromuscular disease, particularly Duchenne muscular dystrophy)",true,"7 Years",{"count":63,"type":20},130,[65],"PHASE4","The goal of this clinical trial is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: Propofol or Dexmedetomidine. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of Propofol and Dexmedetomidine are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized.\n\n* Change in cerebral blood flow (ml blood\u002F100g\u002Fmin)\n* Change in cerebral metabolic rate of oxygen (ml O2\u002F100g\u002Fmin)\n\nResearchers will compare Propofol (Group A) to Dexmedetomidine (Group B) to see if compare the hemodynamic response to anesthesia.\n\nParticipants will be randomized to receive one of two equally safe anesthetics (Propofol or Dexmedetomidine).",[31,26],[69,70,71,26],"Magnetic Resonance Imaging","Cerebral Blood Flow","Cerebral Metabolism","NOT_YET_RECRUITING","2025-07-29",{"date":75,"type":44},"2025-08-05",{"date":77,"type":20},"2025-09-01",{"date":79,"type":20},"2028-09-01",{"name":81,"class":51},"Children's Hospital Los Angeles",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":58,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":52},"100395956","phase-4-individual-cerebral-hemodynamic-oxygenation-relationships-100395956","NCT04435834","Individual Cerebral Hemodynamic Oxygenation Relationships","Cerebral Hemodynamics- ICHOR II","Inclusion Criteria:\n\n* Patients who are scheduled for a clinically indicated MRI at the sponsor institution.\n* Patients who are able to tolerate an MRI.\n* Patients who require clinical anesthesia for their MRI.\n* Patients with conditions not believed to alter oxygen metabolism or blood flow in the brain, including but not limited to patients with orthopedic indications, undescended testicles, hernia repairs, term equivalent age scans.\n* Patients who have no medical conditions that make the use of propofol or sevoflurane better for their clinical outcome.\n* Patients between birth and up-to 1 year of age.\n* Patients with conditions known to alter oxygen metabolism or blood flow in the brain, e.g. traumatic brain injury, hypoxic ischemic encephalopathy, tumor.\n\nExclusion Criteria:\n\n* Patients with an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Preterm infants less than 25 weeks postmenstrual age (PMA) at the time of the scan.\n* Patients who are clinically too unstable to extend their MRI by up-to 10 minutes.\n* Patients who do not require clinical anesthesia.\n* Patients at risk for propofol infusion syndrome (known severe metabolic acidosis, hyperkalemia, lipemia, rhabdomyolysis, hepatomegaly, renal failure, ECG ST segment elevation, and\u002For cardiac failure)\n* Patients at risk for sevoflurane-based malignant hyperthermia (known ryanodine receptor mutations)\n* Patient at risk for sensitivity to volatile halogenated anesthetic agents (known congenital Long QT Syndrome or patients taking drugs that can prolong the QT interval),\n* Patients with Perioperative Hyperkalemia (known neuromuscular disease, particularly Duchenne muscular dystrophy)","1 Year",{"count":91,"type":20},30,[65],"This is a randomized controlled trial in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: propofol or sevoflurane. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of propofol and sevoflurane are in clinical equipoise will be offered to have the anesthesia they will receive during their MRI randomized. All eligible subjects will be asked to provide informed consent before participating in the study.",[26,31],[69,70,71,26],"2024-08-29",{"date":98,"type":44},"2024-09-03",{"date":100,"type":44},"2020-06-09",{"date":102,"type":20},"2026-09-10",{"name":104,"class":51},"Matthew Borzage",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":60,"sex":16,"minAge":113,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":116,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":134},"100549532","the-effect-of-accompaniment-by-older-adults-on-anesthetic-recovery-100549532","NCT06435247","The Effect of Accompaniment by Older Adults on Anesthetic Recovery","The Effect of Accompaniment by Older Adults on Anaesthetic Recovery","AAR","Inclusion Criteria: Scheduled for elective surgery under balanced anesthesia with a hospital stay not exceeding 48 hours.\n\n* ASA (American society of anesthesiologist) I y II\n* Education level Hight school or higher\n\nExclusion Criteria:\n\n* History of diseasses associated with dementia\n* Emergency surgery.\n* Regional anesthesia or sedation\n* Moderate to severe cognitive impairment\n* History of smoking or drugs\n* Surgerios with risk of major bleeding more or equal 1000ml\n* Hip or long bone surgeries","60 Years",{"count":115,"type":20},240,[117],"NA","Summary:\n\nIn 2022, Mexico estimated a population of 17,958,707 older adults. With increased life expectancy, it is essential to seek strategies that improve the health of this population, as they are more vulnerable compared to other age groups due to functional and cognitive decline, along with an increase in chronic diseases and medication intake. During this stage of life, there is a possibility of requiring surgical treatment, which is the focus of this protocol proposing a maneuver that impacts patients' health without requiring economic costs. The proposal suggests the accompaniment of older adults by a family member during the immediate post-anesthetic period. Hypothesis: Accompaniment of older adults during the immediate postoperative period improves the quality of anesthetic recovery by 60%. This value is based on a study by Shem, where accompanying older adults prior to anesthetic induction resulted in a 61% reduction in anxiety among older adults. Anesthesiologists have expanded their role in perioperative medicine alongside geriatric medicine services for older surgical patients.\n\nAn experimental study will be conducted with two randomly divided groups: one group with accompaniment and one group without accompaniment in the recovery area. Both groups will be assessed using different questionnaires: 1. Pfeiffer Test for cognitive impairment diagnosis, 2. QoR-15 to assess the quality of anesthetic recovery, 3. Beck Anxiety Questionnaire, all of which will be administered 24 hours after surgery. Delirium will also be assessed using NuDESC at 24 hours, day 5, and 30 days after surgery. General data prior to surgery will be recorded, and vital signs such as heart rate, blood pressure, and pain on a verbal scale from 0 to 10 will be monitored during the postoperative period.\n\nStatistical analysis will involve representing baseline characteristics of the population using mean and standard deviation or median and interquartile range, depending on the distribution type. X2 will be used to compare both groups in terms of outcomes. Finally, a multivariate analysis will be conducted using logistic regression to adjust for confounding variables.",[120,31],"Elderly",[122,123,124],"ancianos","añadir la calidad de la recuperación anestésica","añadir acompañamiento","2024-08-24",{"date":127,"type":44},"2024-08-27",{"date":129,"type":44},"2024-07-01",{"date":131,"type":20},"2025-12",{"name":133,"class":51},"American British Cowdray Medical Center",2,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":60,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":143,"targetDuration":89,"studyType":145,"phases":4,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":52},"100506068","registry-of-anesthesia-and-perioperative-medicine-100506068","NCT05869578","Registry of Anesthesia and Perioperative Medicine","Registry of Patients Subjected to the Perioperative Care of the Anesthesia Service of Clinica Alemana of Santiago Chile","RAMP","Inclusion Criteria:\n\n* All individuals\n* Individuals agreeing to participate in the study by signing a consent\n\nExclusion Criteria:\n\n* The subjects who had insufficient data in their files",{"count":144,"type":20},10000,"OBSERVATIONAL","To assess mortality and morbidity associated to anesthesia interventions",[148,149,150,30,29,31],"Perioperative Complication","Perioperative\u002FPostoperative Complications","Anesthesia Morbidity","2023-05-19",{"date":153,"type":44},"2023-05-22",{"date":155,"type":20},"2023-06-01",{"date":157,"type":20},"2045-01-01",{"name":159,"class":51},"Clinica Alemana de Santiago"]