[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anesthesia-regional\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anesthesia-regional":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,73,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637906","optimized-costoclavicular-block-for-elderly-proximal-humeral-fracture-surgery-100637906",false,"NCT07612514","Optimized Costoclavicular Block for Elderly Proximal Humeral Fracture Surgery","Effect of an Optimized Ultrasound-Guided Costoclavicular Brachial Plexus Block Strategy on Anesthetic Efficacy and Diaphragmatic Function in Elderly Patients Undergoing Internal Fixation of Proximal Humeral Fractures: A Multicenter, Prospective, Randomized Controlled Clinical Trial","OptCCB","Inclusion Criteria:\n\n* Signed informed consent\n* Age ≥65 years\n* BMI \\\u003C30\n* American Society of Anesthesiologists (ASA) physical status I to III\n* Unilateral proximal humeral fracture scheduled for open reduction and internal fixation via an anterior surgical approach (including deltopectoral approach and anteromedial deltoid approach)\n\nExclusion Criteria:\n\n* Inability to perform T2 thoracic paravertebral block for any reason\n* Coagulation dysfunction or current use of anticoagulant therapy\n* History of upper extremity nerve injury or phrenic nerve injury\n* Severe polytrauma\n* Preoperative uncontrolled severe respiratory dysfunction (resting SpO2 \\\u003C90% or home oxygen therapy, or FEV1 \\\u003C30% of predicted value)\n* Preoperative uncontrolled asthma, pulmonary infection, pneumothorax, or history of prior lung surgery\n* Preoperative uncontrolled hypertension with admission systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>110 mmHg\n* Preoperative uncontrolled coronary artery disease, valvular heart disease, or arrhythmia\n* Any condition that precludes nerve block performance (e.g., local infection or swelling at the puncture site, inability to change position)\n* Inability to communicate or cooperate with anesthesia administration (e.g., language barrier, intellectual disability, Alzheimer's disease, Parkinson's disease)\n* Allergy to ropivacaine or any other contraindication to nerve block","ALL","65 Years",{"count":20,"type":21},356,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Proximal humeral fractures are common in elderly patients and often require surgical fixation (open reduction and internal fixation). Traditional regional anesthesia techniques, such as the interscalene brachial plexus block, may provide incomplete pain relief in the medial upper arm area and carry a high risk of hemidiaphragmatic paralysis, which can lead to breathing difficulties.\n\nObjective: This study aims to evaluate whether an optimized nerve block strategy-ultrasound-guided costoclavicular brachial plexus block combined with superficial cervical plexus block and T2 thoracic paravertebral block-improves anesthetic success and reduces diaphragm dysfunction compared to the traditional interscalene approach in elderly patients undergoing proximal humeral fracture surgery.\n\nStudy Design: This is a multicenter, prospective, randomized, controlled, double-blind (participants and outcome assessors), superiority clinical trial.\n\nPopulation: A total of 356 elderly patients (aged ≥65 years) with unilateral proximal humeral fractures scheduled for open reduction and internal fixation via an anterior surgical approach will be enrolled from three centers in Shanghai, China.\n\nIntervention: Participants will be randomly assigned in a 1:1 ratio to one of two groups:\n\n* Experimental Group (Optimized Strategy): Receives ultrasound-guided costoclavicular brachial plexus block + superficial cervical plexus block + T2 thoracic paravertebral block (0.375% ropivacaine 20 mL for brachial plexus, 0.25% ropivacaine 10 mL for each of the other blocks).\n* Control Group (Traditional Strategy): Receives ultrasound-guided interscalene brachial plexus block + superficial cervical plexus block + T2 thoracic paravertebral block (same drug regimen).\n\nAll nerve blocks will be performed under ultrasound guidance by a single anesthesiologist. Patients and outcome assessors will be blinded to group assignment; the performing anesthesiologist cannot be blinded due to the distinct anatomical approaches.\n\nMain Outcomes:\n\n* Primary Outcome: Nerve block success rate, defined as no pain or only mild pain requiring no rescue analgesics (e.g., intravenous opioids, conversion to general anesthesia, or local infiltration) during surgery.\n* Key Secondary Outcomes: Rate of hemidiaphragmatic paralysis (assessed by ultrasound M-mode); rate of conversion to general anesthesia; postoperative pain (NRS, 0-10) at 24 hours; perioperative stress biomarkers (cortisol, ACTH, IL-6, HMGB-1, CRP, galectin-3); and postoperative shoulder function recovery.\n\nSafety Monitoring: Adverse events, including unplanned conversion to general anesthesia, respiratory depression, pneumothorax, and severe hemidiaphragmatic paralysis, will be recorded and managed according to predefined protocols. An independent Data Monitoring Committee will review safety data and conduct interim analyses for futility.\n\nStudy Duration: The study is expected to take approximately 24 months from first patient enrollment to final follow-up completion.\n\nEthical Approval: This study has been approved by the Ethics Committee of Shanghai Tongren Hospital. Approvals from the ethics committees of the other participating centers (Shanghai Sixth People's Hospital and Shanghai Xuhui Central Hospital) will be obtained before study initiation at those sites.",[27,28,29],"Proximal Humeral Fracture","Anesthesia, Regional","Diaphragmatic Paralysis",[27,31,32,33,29,34],"Elderly","Costoclavicular Block","Interscalene Block","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-05-21",{"date":38,"type":39},"2026-05-28","ACTUAL",{"date":41,"type":21},"2026-10-01",{"date":43,"type":21},"2029-09-30",{"name":45,"class":46},"Shanghai Tong Ren Hospital","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100385667","fab-block-vs-placebo-for-hip-arthroplasty-patients-100385667","NCT04301687","FAB Block vs. Placebo for Hip Arthroplasty Patients","The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroplasty: A Randomized-Controlled Trial Secondary IDs:","Inclusion Criteria:\n\n* ASA I-III patients\n* Ages 18-60yrs\n* BMI ≤ 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Preexisting neurological deficits or peripheral neuropathy in the distribution of femoral, obturator, or lateral cutaneous nerves\n* Local infection\n* Contra-indication to regional anesthesia e.g. bleeding diathesis, coagulopathy\n* Chronic pain disorders\n* History of use of over 30mg oxycodone or equivalent per day\n* Contraindication to a component of multi-modal analgesia\n* Allergy to local anesthetics\n* History of significant psychiatric conditions that may affect patient assessment\n* Pregnancy\n* Inability to provide informed consent\n* Patient refusal of FAB\n* Revision arthroscopy surgeries","18 Years","85 Years",{"count":58,"type":21},95,[24],"Hip arthroplasty surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory obturator nerve branches to the hip joint with a single injection, theoretically blocking most of the innervation relevant to hip arthroscopy while sparing the main femoral nerve branches to the quadriceps muscles. The investigators aim to demonstrate the analgesic benefits of FAB. The investigators hypothesize that FAB will reduce opioid consumption and improve postoperative quality of recovery in patients having hip arthroplasty. This is a randomized, controlled, double-blind study and half the patients will be randomized to receive the femoral articular branch block and the other half of patients will be randomized to receive a placebo block. A comparison of pain will be made between both groups.",[62,28,63],"Hip Arthroplasty","Femoral Articular Branch Block","2026-04-21",{"date":66,"type":39},"2026-04-27",{"date":68,"type":21},"2026-12",{"date":70,"type":21},"2028-12",{"name":72,"class":46},"Women's College Hospital",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100620651","bifes-vs-ipack-in-postoperative-knee-arthroplasty-analgesia-100620651","NCT07360392","BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia","Comparison of Postoperative Analgesic Effects of Two Different Anesthesia Techniques in Knee Arthroplasty: Nerve Blocks Named BiFeS and iPACK","Inclusion Criteria:\n\n* Scheduled for unilateral total knee arthroplasty\n* Classified as ASA physical status I-III\n\nExclusion Criteria:\n\n* Scheduled for revision arthroplasty or bilateral surgery\n* Allergy to local anesthetics or contraindication to regional blocks\n* Neurological disorders, peripheral neuropathy, or conditions affecting lower extremity muscle strength\n* Coagulopathy or receiving anticoagulant therapy\n* History of severe liver, kidney, or heart failure\n* Chronic opioid use or history of substance abuse\n* Patients experiencing intraoperative complications (e.g., excessive bleeding)\n* Cases in which adequate sensory blockade is not achieved after the block","80 Years",{"count":82,"type":21},88,[24],"The Biceps Femoris Short Head (BiFeS) block is a new fascial plane block technique targeting the sensory innervation of the posterolateral capsule of the knee while preserving motor function. The aim of this study is to evaluate the postoperative analgesic efficacy of the BiFeS block combined with the adductor canal block (ACB) in patients undergoing total knee arthroplasty, compared to ACB + iPACK block. The study is planned as a prospective, randomized, double-blind, parallel two-group trial. Patients will be randomized in a 1:1 ratio to receive ACB + iPACK (Group A) or ACB + BiFeS (Group B). Postoperative pain scores (VAS), opioid consumption, early mobilization, and quality of recovery (QoR-15) outcomes will be compared.",[86,87,28],"Arthroplasty, Replacement, Knee","Pain, Postoperative",[89,90,91,92,93],"Pain Management","Knee Arthroplasty","BiFes","iPACK","Nerve Block","RECRUITING","2026-04-20",{"date":97,"type":39},"2026-04-22",{"date":95,"type":39},{"date":100,"type":21},"2027-06-01",{"name":102,"class":46},"Amasya University",1,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":80,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":120,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":103},"100623447","the-effects-of-transversalis-fascia-plane-block-on-opioid-consumption-in-patients-undergoing-hand-assisted-laparoscopic-donor-nephrectomy-a-randomized-controlled-prospective-study-100623447","NCT07396753","The Effects of Transversalis Fascia Plane Block on Opioid Consumption in Patients Undergoing Hand-Assisted Laparoscopic Donor Nephrectomy: A Randomized Controlled Prospective Study","Inclusion Criteria:\n\n* Approved by the transplant committee for living kidney donation\n* Scheduled for hand-assisted laparoscopic donor nephrectomy (HALDN)\n* Able to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to any medications used in the study (e.g., local anesthetics, opioids)\n* Chronic opioid use or use of opioid receptor agonists\n* Inability to communicate effectively (e.g., cognitive impairment, language barrier)\n* Chronic organ failure or major organ dysfunction\n* Refusal or inability to provide informed consent\n* Foreign nationality (if follow-up or consent is restricted)\n* American Society of Anesthesiologists (ASA) physical status ≥ III",{"count":111,"type":21},50,[24],"This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive surgery performed in living kidney donors.\n\nAlthough HALDN is less invasive than open surgery, patients often experience significant pain after the operation, mainly due to the surgical incisions in the lower abdomen and trocar entry sites. Poorly controlled pain can delay recovery and increase the need for opioid pain medications, which may cause side effects such as nausea, vomiting, itching, and sedation.\n\nThe transversalis fascia plane block is an ultrasound-guided regional anesthesia technique in which a local anesthetic is injected into a specific tissue plane in the lower abdominal wall. This injection temporarily blocks pain signals from nerves supplying the lower abdomen and groin area. The technique has been shown to reduce pain and opioid use after various lower abdominal surgeries and is considered minimally invasive and safe when performed under ultrasound guidance.\n\nIn this study, patients undergoing HALDN will be randomly assigned to one of two groups. One group will receive standard general anesthesia only, while the other group will receive general anesthesia plus a transversalis fascia plane block using a local anesthetic (bupivacaine). All patients will receive the same standard pain treatment after surgery, including paracetamol and patient-controlled morphine.\n\nThe main goal of the study is to compare the amount of opioid pain medication used during the first 24 hours after surgery between the two groups. Secondary outcomes include pain scores measured using the Numeric Rating Scale (NRS), the frequency of opioid-related side effects, and patient satisfaction with pain control.\n\nThe results of this study may help determine whether adding the transversalis fascia plane block to standard anesthesia can provide better pain relief, reduce opioid consumption, and improve comfort and recovery in living kidney donors.",[115,116,89,117,118,119],"Postoperative Pain","Analgesics, Opioid","Anesthesia Regional","Living Donors","Nephrectomy,Kidney Donation",[121,122,123,124],"Hand-assisted laparoscopic donor nephrectomy","Transversalis fascia plane block","Regional anesthesia","Opioid consumption","2026-02-02",{"date":127,"type":39},"2026-02-09",{"date":129,"type":39},"2025-07-25",{"date":131,"type":21},"2026-03-03",{"name":133,"class":46},"Koç University"]