[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ankle-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ankle-disease":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100610297","a-prospective-randomized-single-blind-controlled-multi-center-study-to-assess-the-safety-and-performance-of-magnetostm-compared-to-autogenous-bone-graft-in-patients-undergoing-hindfoot-or-ankle-fusions-100610297",false,"NCT07225751","A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.","A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions","ASTRA","Inclusion:\n\n1. Patient is able to read\u002Fbe read, understand, and provide written informed consent and has signed the IRB approved informed consent.\n2. Male or female patient ≥ 18 (considered skeletally mature) up to and including 75 years old\n3. Patients requiring one of the following hindfoot fusion procedures, using surgical technique, necessitating rigid hardware fixation and supplemental bone graft\u002F substitute: ankle fusion (tibiotalar) subtalar fusion (talocalcaneal), calcaneocuboid fusion, talonavicular fusion, OR double fusion (any combination of any two of the following: subtalar, talonavicular and calcaneocuboid joints).\n4. Hardware parameters - rigid fixation using screws, plates, staples, nails or a combination.\n\nExclusion:\n\n1. Expected to need secondary intervention within one year following surgery.\n2. Had prior fusion or attempted fusion of the joints to be fused.\n3. Patient is not ambulatory.\n4. Surgical technique where bone graft is not expected to be used.\n5. Conditions at the surgeon's discretion in which general bone grafting is not advisable.\n6. Radiographic evidence of fractures or pathologies around the fusion that could negatively impact the fusion process (e.g., growth plate fracture around the fusion or bone cysts).\n7. Significant vascular impairment proximal to the graft site.\n8. Acute and\u002For chronic infections in the operated area (soft tissue infections; bacterial bone diseases; osteomyelitis)\n9. Pre-existing sensory impairment (e.g. diabetes, Charcot). Diabetics patients with HbA1c greater than 7.0 OR that were not sensitive to the 5.07 monofilament will be excluded.\n10. Metabolic disorders know to adversely affect the skeleton (e.g., renal osteodystrophy or hypercalcemia).\n11. If intraoperative soft tissue coverage is not planned or possible.\n12. Receiving treatment with medication interfering with calcium metabolism (chronic use of glucocorticoid and use high dose NSAIDs 800 mg TID for \\> the first 6 weeks post-op).\n13. Has benign or malignant tumor at the surgical site.\n14. Has history or presence of active malignancy (non-invasive skin cancer is allowed).\n15. Has known substance abuse, psychiatric disorder, or a condition which, in the opinion of the investigator, may influence the healing or ability to comply with protocol requirements (e.g. prisoners, physically or mentally compromised, etc.).\n16. Is involved in active litigation relating to his\u002Fher foot and ankle condition.\n17. Participation in an investigational study within 30 days prior to surgery for study devices.\n18. Patient with body mass index (BMI) \\> 50.\n19. Patient cannot comply with all post-operative evaluation and visits .\n20. Any pre-existing condition that the surgeon determines could interfere with the patient's ability to perform objective functional measurements.\n21. Women who are or intend to become pregnant within the next 12 months.","ALL","18 Years","75 Years",{"count":21,"type":22},126,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a phase IV post-marketing study for MagnetOs Putty and MagnetOs Easypack Putty. MagnetOs is a synthetic bone graft extender product that is routinely used by surgeon as treatment for hindfoot and ankle disorders.\n\nIn this study, MagnetOs Putty and MagnetOs Easypack Putty will be use according to the latest Instructions For Use, standalone in the foot and ankle.",[28,29,30,31,32,33],"Ankle Arthrodesis or Arthroplasty","Hindfoot Fusion","Ankle Deformity","Ankle Disease","Hindfoot Arthrodesis","Hindfoot Pathologies",[35,36],"ankle arthrodesis","hindfoot fusion","RECRUITING","2026-04-08",{"date":40,"type":41},"2026-04-09","ACTUAL",{"date":43,"type":41},"2025-11-25",{"date":45,"type":22},"2028-12",{"name":47,"class":48},"Kuros Biosurgery AG","INDUSTRY",5,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100615208","dexamethasone-vs-dexmedetomidine-vs-combination-as-adjuvants-to-popliteal-sciatic-nerve-block-in-children-100615208","NCT07289620","Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children","A Randomized, Double-Blinded, Controlled Trial Comparing Perineural Dexamethasone, Dexmedetomidine, and Their Combination as Adjuvants to Ropivacaine for Popliteal Sciatic Nerve Block in Pediatric Patients","Inclusion Criteria:\n\n* Children aged 3 to 12 years.\n* Scheduled for elective unilateral lower limb surgery (foot, ankle, or distal lower leg) under general anesthesia with a popliteal sciatic nerve block planned for postoperative analgesia.\n* ASA physical status I-III.\n* Ability of parents or legal guardians to understand the study procedures and provide written informed consent.\n* Child and parents\u002Fguardians available for telephone follow-up at 1 week and 1 month after surgery.\n\nExclusion Criteria:\n\n* Refusal of the parents\u002Flegal guardians to provide informed consent or refusal of the child to cooperate with anesthesia or study procedures.\n* Known allergy or hypersensitivity to ropivacaine, dexamethasone, dexmedetomidine, or any component of the study medications.\n* Pre-existing neurological deficit or neuromuscular disease affecting the lower limbs (motor or sensory).\n* Coagulopathy or current therapeutic anticoagulation that contraindicates regional anesthesia.\n* Local infection, inflammation, or skin lesions at the planned block site.\n* Severe cardiac, hepatic, renal, or respiratory disease that, in the investigator's opinion, increases the risk of study participation.\n* History of clinically significant arrhythmias, severe bradycardia, or second\u002Fthird degree atrioventricular block not treated with a pacemaker.\n* Developmental delay or severe cognitive impairment that precludes reliable pain assessment or follow-up.\n* Chronic use of opioid analgesics or sedatives (≥ 2 weeks of daily use before surgery).\n* Participation in another interventional clinical trial within the last 30 days.\n* Any other condition considered by the investigator to interfere with protocol adherence, safety monitoring, or reliable outcome assessment.","3 Years","12 Years",{"count":60,"type":22},120,[25],"This clinical study will evaluate three commonly used medications that can be added to local anesthetic during a popliteal sciatic nerve block in children undergoing surgery of the lower leg or foot. These medications-dexamethasone, dexmedetomidine, or a combination of both-may help the nerve block last longer and provide better postoperative pain control.\n\nAll participating children will receive a standard popliteal sciatic nerve block with ropivacaine, a commonly used local anesthetic. They will then be randomly assigned to one of three groups: (1) ropivacaine with dexamethasone, (2) ropivacaine with dexmedetomidine, or (3) ropivacaine with both dexamethasone and dexmedetomidine. Neither the children, parents, nor the clinical staff assessing pain will know which medication was given.\n\nThe goal of this study is to determine whether the combination of dexamethasone and dexmedetomidine provides longer pain relief and reduces the need for additional pain medication compared with either medication alone. The results may help identify the most effective and safest strategy for improving postoperative comfort in pediatric patients receiving regional anesthesia.",[31,64],"Foot Diseases","2026-01-29",{"date":67,"type":41},"2026-02-02",{"date":69,"type":41},"2026-01-16",{"date":71,"type":22},"2027-01-31",{"name":73,"class":74},"Poznan University of Medical Sciences","OTHER",1]