[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ankle-sprains\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ankle-sprains":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,48,76,102,125,151,175,197,221,245,267,289,319,346,371],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100632013","distinct-directional-postural-stability-deficits-across-lower-limb-musculoskeletal-disorders-100632013",false,"NCT07508163","Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders","Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders: Evidence From Lateral Ankle Sprain and Patellofemoral Pain Syndrome","LAS-PFPS","Inclusion Criteria:\n\nInclusion criteria for the lateral ankle sprain group will include participants with a clinically confirmed history of unilateral lateral ankle sprain, who are at least three months post-injury to avoid acute inflammatory effects, and who report residual symptoms such as pain or functional limitation. Participants in the patellofemoral pain syndrome group will have a clinical diagnosis of patellofemoral pain syndrome characterized by anterior or retropatellar knee pain aggravated by functional activities such as stair climbing, squatting, or prolonged sitting, with symptoms persisting for at least three months. Healthy control participants will have no history of lower limb musculoskeletal injury, pain, or functional impairment within the past three months and will be matched to the patient groups based on age and sex. All participants across groups will be able to stand independently without assistive devices and will demonstrate sufficient cognitive ability to understand and follow study instructions\n\nExclusion Criteria:\n\nExclusion criteria for all groups will include a history of lower limb fracture or surgery, neurological or vestibular disorders that may affect balance or postural control, uncorrected visual impairments, systemic inflammatory or rheumatological diseases, and metabolic or neurological conditions known to influence neuromuscular performance. Participants currently engaged in structured balance, proprioceptive, or neuromuscular training programs, as well as those taking medications that may affect balance or postural stability, will also be excluded from the study.",true,"ALL","20 Years","30 Years",{"count":22,"type":23},90,"ESTIMATED","OBSERVATIONAL","Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System",[27,28],"Ankle Sprains","Patellofemoral Pain Syndrome",[30,31,32,33,34,35],"Postural stability","APSI","MLSI","OASI","LAS","PFPS","NOT_YET_RECRUITING","2026-04-07",{"date":39,"type":40},"2026-04-09","ACTUAL",{"date":42,"type":23},"2026-03-30",{"date":44,"type":23},"2026-04-27",{"name":46,"class":47},"Cairo University","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100336664","addressing-neuromuscular-deficits-for-improved-outcomes-in-ankle-rehabilitation-100336664","NCT03663361","Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation","Inclusion Criteria:\n\n* initiating rehabilitation for a first time acute grade I, II, or III LAS\n* have sustained within 72 hours of study enrollment\n* diagnosed by a physician, medic, athletic trainer, physical therapist, or other providing medical coverage in operational environments as having sustained a LAS\n\nExclusion Criteria:\n\n* personal or familial history of epilepsy or seizures\n* history of migraine headaches\n* ocular foreign body, increased intracranial pressure, open head injury or significant closed head injury\n* cochlear implants\n* implanted brain stimulators, aneurysm clips or other metal in the head (except mouth)\n* implanted medication pumps, pacemakers or intracardiac lines\n* current medication with tricyclic anti-depressants, neuroleptic agents or other drugs that lower seizure threshold\n* history of diagnosed major psychiatric disorder\n* history of illicit drug use\n* current alcohol abuse or currently withdrawing from alcohol abuse\n* history of heart disease","18 Years","44 Years",{"count":57,"type":23},150,"INTERVENTIONAL",[60],"NA","The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at producing successful one-year outcomes and lower rates of re-injury and improved health. This will address the identified needs for evidence-support and reintegration strategies to improve understanding of the management of patient rehabilitation strategies throughout the rehabilitation process following neuromusculoskeletal injury. The project will validate an innovative rehabilitation approach while providing metrics of success using a variety of clinical and innovative markers.",[27],[64],"ankle sprain, sensorimotor, rehabilitation, osteoarthritis","RECRUITING","2026-02-18",{"date":68,"type":40},"2026-02-20",{"date":70,"type":40},"2019-11-12",{"date":72,"type":23},"2026-07",{"name":74,"class":47},"Phillip Gribble",2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":58,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100617498","comparison-of-the-effects-of-hip-and-ankle-focused-progressive-exercise-training-on-lower-extremity-function-in-athletes-with-chronic-ankle-instability-100617498","NCT07319403","Comparison of the Effects of Hip and Ankle Focused Progressive Exercise Training on Lower Extremity Function in Athletes With Chronic Ankle Instability","Inclusion Criteria:\n\nProfessional athletes aged between 18 and 40 years\n\nParticipation in sports for at least 3 years\n\nHistory of at least one lateral ankle sprain that occurred at least 12 months prior to enrollment\n\nAt least two episodes of perceived ankle \"giving way\" and\u002For at least two recurrent lateral ankle sprains within the past 6 months, and\u002For a subjective feeling of ankle instability on the injured side\n\nExclusion Criteria:\n\nHistory of lower extremity surgery\n\nHistory of fracture involving the lower extremity\n\nAny lower extremity injury within the past 3 months that limited physical activity for more than one day","40 Years",{"count":84,"type":23},36,[60],"Chronic ankle instability refers to a combination of persistent mechanical and functional instability symptoms following an ankle sprain. Along with these symptoms, decreased proprioception, reduced neuromuscular control, poor postural control, limited dorsiflexion range of motion, decreased ankle strength, and altered lower-extremity biomechanics during functional activities are also observed. In addition, individuals with chronic ankle instability have been shown to exhibit limitations in energy transfer across the lower extremity. These symptoms may hinder patients' physical activity levels and athletic performance and negatively affect their quality of life. Since the lower extremity functions as a unit, changes in adaptive strategies at the ankle can lead to kinematic alterations in proximal joints. Although the instability originates at the ankle, higher-level joints are also affected, and it has even been reported that in this population, lower-extremity stability is primarily achieved through the hip joint. While the effectiveness of hip-focused exercises has begun to be investigated in the literature, the superiority of different muscle groups has not yet been compared.",[27],[89,90,91],"Ankle Injuries","Muscle Strength","Exercise Training","2025-12-21",{"date":94,"type":40},"2026-01-06",{"date":96,"type":23},"2026-01-15",{"date":98,"type":23},"2026-08-04",{"name":100,"class":47},"Hacettepe University",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":17,"sex":18,"minAge":54,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":58,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":75},"100582823","auditory-biofeedback-gait-training-individuals-with-chronic-ankle-instability-100582823","NCT06868316","Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability","Optimizing Retention on Duty in Patients With Chronic Ankle Instability Using Auditory Biofeedback Gait Training: A Multisite Randomized Controlled Trial","Inclusion Criteria:\n\n* Physically active adults (defined as participants reporting a score of =4 on the National Aeronautics and Space Administration (NASA) Activity Instrument and indicating they can run for at least 20 consecutive minutes)\n* History of ankle sprain\n* 2 episodes of \"giving way\" in the past 6-months\n* must answer \"yes\" to =5 questions on the Ankle Instability Instrument (AII) and =11 on the Identification of Functional Ankle Instability (IdFAI)\n\nExclusion Criteria:\n\n* an ankle sprain in the previous four weeks or lower extremity neuromusculoskeletal injury other than to the ankle in the last 12 months\n* history of surgery in the lower extremity\n* fracture to the lower extremity in the past 12 months or a fracture that required open-reduction internal fixation\n* history of neurological disease, vestibular or visual disturbance or any other pathology that would impair sensorimotor performance or gait\n* current participation in a formal ankle joint rehabilitation program\n* a concussion in the last 12 months\n* report a cardiovascular, metabolic, or renal disease, or signs and symptoms that suggest such condition or have been told by a medical provider not to engage in vigorous physical activity (such as running).","45 Years",{"count":111,"type":23},100,[60],"The goal of this randomized clinical controlled trial is examine the effects of gait training with auditory biofeedback (AudFB) on gait biomechanics, clinical measures of ankle joint health, and patient-centered outcomes. The following specific aims will achieve this objective:\n\n* Specific Aim 1: Determine if a 6-week gait training with AudFB intervention improves lower extremity biomechanics compared to a Control condition in participants with CAI.\n* Specific Aim 2: Determine if a 6-week gait training with AudFB reduces talar cartilage deformation compared to a Control condition in participants with CAI.\n* Specific Aim 3: Determine if a 6-week gait training with AudFB reduces episodes of ankle giving-way and reduces self-perceived severity of symptoms relative to a Control condition in participants with CAI.\n\nParticipants will:\n\n* Complete 12 intervention sessions over a 6-week period of walking, ruck marching, and runninig.\n* Complete testing sessions before and after the intervention, then after 6 and 12-months following the intervention.",[27,115],"Ankle Injuries and Disorders","2025-10-01",{"date":118,"type":40},"2025-10-07",{"date":120,"type":40},"2025-05-27",{"date":122,"type":23},"2028-09",{"name":124,"class":47},"University of Kentucky",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":58,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":101},"100559723","neurocognitive-exercises-for-ankle-instability-100559723","NCT06567847","Neurocognitive Exercises for Ankle Instability","Is a Neurocognitively Enriched Exercise Effective in Reducing Re-Injury Risk and Improving Balance and Proprioception in Individuals With Lateral Ankle Instability?","Inclusion Criteria:\n\n* The documented unilateral ankle instability confirmed through clinical examinations (drawer test, talar tilt test) and MRI in cases requiring differential diagnosis.\n* A history of an initial ankle sprain occurring at least 6 months ago.\n* The presence of a recurrent sense of giving way that started at least 6 months ago and has been intermittently persistent.\n\nExclusion Criteria:\n\n* Presence of a history of previous surgery in the lower extremity.\n* Identification of organic and non-organic lesions such as cartilage injuries, periarticular tendon tears, and impingement syndromes.\n* The existence of a fracture accompanying instability in the foot-ankle.\n* Presence of congenital deformities in the foot-ankle.\n* Diagnosis of talus osteochondral lesion.\n* Diagnosis of ankle arthritis.\n* Presence of medial ligament lesion.\n* Existence of peripheral neuropathy.\n* Presence of additional rheumatological diseases.\n* Regular moderate-level exercise for at least 3 days a week in the last 6 months.","55 Years",{"count":84,"type":23},[60],"In the general population, 19.0-26.6 per 1000 cases of ankle instability have been reported, while in the athletic population, the rate is 11.3 per 1000. Ankle instability also predisposes individuals to recurrent instability, leading to persistent symptoms. After ankle injuries, temporary increases in afferent activity, along with long-term deficits in somatosensory information from ligaments, may cause central neuroplasticity that affects sensorimotor function. This central neuroplasticity can lead to permanent dysfunctions in the affected limb, thereby increasing the likelihood of developing and maintaining chronic ankle instability (CAI). In addition to the association between impaired balance and reduced proprioception with CAI, it has been reported that the central nervous system may fail to manage joint stress due to its inability to discern load on the ligaments.\n\nImpaired neurocognition has been linked to decreased performance and higher rates of re-injury. Deficiencies in neuromuscular control, motor learning, or other neurocognitive components related to an individual's performance and safety may affect the ability to respond appropriately in a dynamic environment. Any deficiencies in these neurocognitive processes can hinder the successful completion of tasks.\n\nThe aim of this study is to comparatively examine the effects of neurocognitively enriched rehabilitation versus traditional rehabilitation on re-injury risk, balance, and proprioception in individuals with a history of ankle instability.",[27],[138,139,140,141],"Neuroplasticity","Reinjury","Chronic ankle instability","Physiotherapy","2025-08-08",{"date":144,"type":40},"2025-08-11",{"date":146,"type":23},"2025-11",{"date":148,"type":23},"2028-02",{"name":150,"class":47},"Istanbul University - Cerrahpasa",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":17,"sex":18,"minAge":159,"maxAge":109,"enrollmentInfo":160,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100587374","the-applicability-of-the-cumberland-ankle-instability-tool-in-basketball-athletes-100587374","NCT06927557","The Applicability of the Cumberland Ankle Instability Tool in Basketball Athletes.","The Applicability of the Cumberland Ankle Instability Tool in Basketball Athletes: Validity and Reliability Study","The CAIT","Inclusion Criteria:\n\n* Age between 16 and 45\n* History of ankle sprain\n* Participation in basketball training at least once per week\n\nExclusion Criteria:\n\n* Participation in basketball training at least once per week","16 Years",{"count":111,"type":23},"The aim of our study is to evaluate the applicability, validity, and reliability of the Cumberland Ankle Instability Tool (CAIT) in basketball athletes. Given that a significant proportion of injuries in basketball occur in the ankle, our study holds importance for instability assessments conducted in this population. If the Cumberland Ankle Instability Tool is found to be applicable in basketball athletes, it may be utilized in future research.",[89,27],[164,165,166],"ankle instability","validity study","reliability study","2025-04-14",{"date":169,"type":40},"2025-04-15",{"date":171,"type":23},"2025-05-20",{"date":173,"type":23},"2025-07-20",{"name":100,"class":47},{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":101},"100492922","comparison-of-mbr--suture-tape-mbr-and-anatomic-reconstruction-for-clai-in-gjl-cases-a-prospective-cohort-study-100492922","NCT05698446","Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study","Comparison of Modified Broström Repair + Suture Tape and Anatomic Reconstruction for CLAI in Chronic Lateral Ankle Instability in Generalized Joint Laxity Cases: A Prospective Cohort Study","Inclusion Criteria:\n\n* Clinical diagnosis of lateral ankle pain and instability Beighton score ≥4 Age with 18 to 60 years\n\nExclusion Criteria:\n\n* Patients with an acute or subacute ankle injury (within 3 months) Injury of the deltoid ligament Alignment of lower extremity greater than 5 degrees Fractures of the lower extremity Stage III or IV osteoarthritis Patients who refused to participate in the study","60 Years",{"count":184,"type":23},114,"GJL is a risk factor for postoperative recurrent instability following an MBR for CLAI. BPR with suture tape augmentation and anatomic reconstruction may provide more strength and stability. However, BPR with suture tape augmentation may lead to rejection of the suture tape, while anatomic reconstruction may be associated with more trauma. In addition, the outcomes between the BPR with suture tape augmentation and anatomic reconstruction were unknown.",[27,187],"Hypermobility Syndrome","2025-04-08",{"date":190,"type":40},"2025-04-11",{"date":192,"type":40},"2021-11-01",{"date":194,"type":23},"2025-06-01",{"name":196,"class":47},"Peking University Third Hospital",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":182,"enrollmentInfo":204,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":205,"conditions":206,"keywords":209,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":215,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":101},"100454389","the-clinical-outcomes-of-the-modified-brostrm-vs-anatomic-reconstruction-operation-in-clai-and-gjl-100454389","NCT05196906","The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL","The Clinical Outcomes Comparing the Modified Broström vs Anatomic Reconstruction Operation in Chronic Lateral Ankle Instability and Generalized Joint Laxity","Inclusion Criteria:\n\nClinical diagnosis of lateral ankle pain and instability Beighton score ≥4 Age with 18 to 60 years\n\nExclusion Criteria:\n\nPatients with an acute or subacute ankle injury (within 3 months) Injury of the deltoid ligament Alignment of lower extremity greater than 5 degrees Fractures of the lower extremity Stage III or IV osteoarthritis Patients who refused to participate in the study",{"count":111,"type":23},"Investigators designed this prospective cohort study to compare the clinical outcomes of modified Broström operation and anatomical reconstruction for the treatment of CLAI and GJL.",[27,207,208],"Instability, Joint","Joint Hypermobility",[210,211,212,213,214],"chronic lateral ankle instability","generalized joint laxity","re-injury","modified Brostrom operation","anatomic reconstruction",{"date":190,"type":40},{"date":217,"type":40},"2020-01-01",{"date":219,"type":23},"2025-12-31",{"name":196,"class":47},{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":58,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":75},"100585145","spinal-and-supraspinal-control-in-chronic-ankle-instability-100585145","NCT06898554","Spinal and Supraspinal Control in Chronic Ankle Instability","Cross-Education Effect of Structured Balance Training Program on Spinal and Supraspinal Control in Athletes With Chronic Ankle Instability","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being an athlete between the ages of 18-25,\n* Being a player in a field team sport such as basketball, volleyball, and handball,\n* Having a history of at least 2 significant grade II LAS diagnosed by a physician,\n* Related inflammatory symptoms, \"giving away\" sensation, obtaining a score ≤25 from the Cumberland Ankle Instability Tool (CAIT),\n* A score \\\u003C90% for the activities of daily living subscale and \\\u003C80% for the sport subscale from the Foot and Ankle Ability Measure,\n* Recurrent episodes of LAS of the injured ankle which occurred within at least 12 months.\n\nExclusion Criteria:\n\n* Acute injury of lower extremity musculoskeletal structures in the last three months,\n* Orthopedic surgery in any of the lower extremities,\n* Bilateral ankle instability,\n* Vestibular or balance disorder","25 Years",{"count":230,"type":23},30,[60],"Ankle sprains are common sports injuries that often lead to chronic ankle instability (CAI). Patients with CAI experience deficits in neuromuscular control (NMC), including proprioception and strength. It is believed that damage to the ankle's ligament mechanoreceptors and the peroneal nerve after the initial ankle sprain can cause alterations in NMC, resulting in postural control and dynamic joint stability dysfunction. Inflammation related to recurrent ankle sprains may also contribute to neuromuscular impairments. Evidence suggests that bilateral postural control deficits occur after an ankle sprain, suggesting alterations in the central nervous system (CNS). Rehabilitation for CAI has been shown to lead to bilateral improvements in NMC, potentially due to neural alterations at both the spinal and supraspinal levels. Cross-education, which refers to the muscular crossed effect of unilateral training, has also been proposed as a mechanism for improving contralateral strength in neurologically healthy individuals. While the exact mechanisms underlying cross-education are not yet fully understood, evidence suggests that it involves neural adaptations at both spinal and supraspinal levels. This study aims to investigate the cross-education effect of a 6-week, unilateral balance training on corticomotor excitability, motor neuron pool excitability, and static and dynamic balance in athletes with chronic ankle instability.",[89,27],[235],"ankle, joint instability, cross-education, rehabilitation","2025-03-21",{"date":238,"type":40},"2025-03-27",{"date":240,"type":40},"2024-11-15",{"date":242,"type":23},"2025-07-31",{"name":244,"class":47},"Ayca Yagcioglu",{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":17,"sex":18,"minAge":252,"maxAge":54,"enrollmentInfo":253,"targetDuration":4,"studyType":58,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":4},"100556050","motor-control-prevention-strategies-in-basketball-players-100556050","NCT06520046","Motor Control Prevention Strategies in Basketball Players","Motor Control Prevention Strategies for Ankle Sprains in Basketball Players","Inclusion Criteria:\n\n* Basketball players aged between 10-18 years old who play regularly in one of the basketball clubs in the city of Salamanca.\n\nExclusion Criteria:\n\n* previous injuries\n* fractures\n* use of orthoses and technical aids","10 Years",{"count":230,"type":23},[60],"Ankle sprains have always been considered as isolated injury entities, in which the passive ankle stabilisation system suffered an elongation due to trauma. Today, this concept of an isolated injury has evolved into a more holistic concept, interrelated with various components from different sources.",[27,257],"Motor Disorders","2024-12-04",{"date":260,"type":40},"2024-12-09",{"date":262,"type":23},"2024-12-15",{"date":264,"type":23},"2025-06-30",{"name":266,"class":47},"University of Salamanca",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":18,"minAge":274,"maxAge":109,"enrollmentInfo":275,"targetDuration":4,"studyType":58,"phases":277,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":101},"100564631","effect-of-acl-reconstruction-in-biomechanical-properties-of-ankle-joint-complex-100564631","NCT06631690","Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex","Effect of ACL Reconstruction Using Peroneus Longus Versus Hamstring Autografts on Biomechanical Properties of Ankle Joint Complex","Inclusion Criteria:\n\n* Age ranging between 15- 45 years\n* Having unilateral isolated ACL tear with no concomitant tear of other ligaments of the knee\n* Having no evidence of meniscal repair\n* Having bilateral healthy ankle before surgery.\n\nExclusion Criteria\n\n* Pre-existing ankle injury or ankle instability\n* Associated ligament injury, chondral damage, meniscal injury, fracture around the knee, and presence of pathologic condition in the lower extremity or an abnormal contralateral knee joint.\n* Visible mal-alignments in the lower extremities.\n* Previous surgery to the affected knee.","15 Years",{"count":276,"type":23},40,[60],"BACKGROUND:\n\nAnterior cruciate ligament (ACL) is an important ligamentous structure in the knee joint which contributes in maintaining stability. ACL injury contribute to approximately 50% of knee injuries .The incidence of ACL ruptures is estimated to be between 30 and 78 per 100,000 people per year .\n\nThe incidence of ACL ruptures varies depending on a number of factors, including age, sex, sport participation, and genetics. ACL ruptures are most common in young adults, particularly women. The risk of an ACL rupture has been reported as 2-8 times higher for women than for men. A systematic review study found that the risk of ACL injury was highest in football, followed by soccer, basketball, and skiing .\n\nNowadays, Peroneus longus tendon (PLT) autograft is used in orthopaedic surgeries. Some studies reported that PLT graft had maintained a possible more efficient ACL substitute for its tensile strength and regeneration ability after being inserted post-surgery . The PLT graft has additional benefit as it does not cause secondary injury to the knee and its adjacent structures .\n\nAnkle proprioception is one of the crucial components contributing to postural control . PLT graft for ACL reconstruction might affect the already compromised body balance by influencing postural stability and ankle stability at the donor ankle site. So, this study will be conducted to assess and compare the effect of ACLreconstruction with PLT graft to the effect of ACL reconstruction with HT graft on ankle stability and postural control .",[280,27],"Anterior Cruciate Ligament Tear","2024-10-06",{"date":283,"type":40},"2024-10-08",{"date":285,"type":40},"2023-12-10",{"date":287,"type":23},"2024-12-10",{"name":46,"class":47},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":58,"phases":299,"briefSummary":300,"conditions":301,"keywords":304,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":75},"100335169","arthroscopic-versus-open-brostrom-for-ankle-instability-100335169","NCT03643926","Arthroscopic Versus Open Brostrom for Ankle Instability","Arthroscopic Versus Open Brostrom for Ankle Instability: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Individuals must be older than 18 and younger than 65 years of age, both genders;\n* Participants must be experiencing instability symptoms at the ankle over the last six months;\n* Clinical diagnosis of ankle instability, defined as the presence of at least one previous ankle sprain associated with a current instability sensation by the patient and the presence of a positive anterior drawer test; the previous lateral ligament injury must be confirmed by Magnetic Resonance Imaging (MRI) findings.\n\nExclusion Criteria:\n\n* Previous surgery involving the affected foot or ankle;\n* History or documented evidence of autoimmune or peripheral vascular diseases;\n* History or documented evidence of peripheral neuropathy (nervous compression syndrome, tarsal tunnel syndrome) or systemic inflammatory disease a (rheumatoid arthritis, spondylitis, Reiter Syndrome, etc.);\n* Associated injuries, such as osteochondral lesions, tendon ruptures and fractures.\n* Associated instability, such as syndesmotic and medial instability.\n* Cavovarus foot;\n* BMI over 35;\n* Previous infiltration in the ankle over the six months preceding the initial assessment;\n* Pregnancy;\n* Any condition that represents a contraindication of the proposed therapies;\n* Impossibility or incapacity to sign the informed Consent Form;\n* History or documented evidence of blood coagulation disorders (including treatment with anti-coagulants, but excluding aspirin);\n* Use of heart pacemaker;\n* Presence of infectious process (superficial on skin and cellular tissue, or deep in the bone) in the region to be treated;","65 Years",{"count":298,"type":23},98,[60],"Background: Ankle sprains are among the most prevalent lesions in primary care. A substantial number of these ligament lesions will develop ankle instability and require a surgical procedure. The Brostrom-Gould technique is the standard surgical approach for this condition, providing excellent results over the years. Thru the last decades, the arthroscopic Brostrom has gain popularity and support by several studies. Yet, there is no consensus regarding the best procedure to treat ankle instability nowadays.\n\nHypothesis: The arthroscopic Brostrom technique will present better levels of pain and function when compared to the standard open approach.\n\nDesign: blinded, in parallel groups, multicentric, randomized, clinical trial.\n\nMaterials and Methods: 98 patients with a diagnosis of chronic ankle instability, referred from primary or secondary health care services, will be assessed and enrolled in this study. Participants will be divided in two groups (randomized by sequentially numbered identical envelopes, which will be administered serially to participants), one containing the open Brostrom repair technique and the other comprehending the arthroscopic Brostrom approach. The assessments will occur in 3, 6, 12, 24 and 48 weeks. Patients will be evaluated primarily by complications and secondarily the Cumberland Ankle Instability Tool (CAIT), American Orthopedic Foot and Ankle Society (AOFAS), the Visual Analogue Scale (VAS), the Foot Function Index (FFI) and the 36 Item Short Form Health Survey (SF-36). The investigators will use Comparison of Two Proportions via relative frequency analysis, the Pearson Correlation the Chi-Square test and the ANOVA for statistical analyses.\n\nDiscussion: This study intends to establish if the arthroscopic Brostrom technique can produce excellent and reliable results when treating chronic ankle instability. A shorter surgical time, a better cosmetic appearance and a smaller soft tissue injury would support the choice for this procedure if the outcomes could be compared to the open approach.",[27,207,302,303],"Ligament Injury","Surgery",[305,306,307,308,309],"ankle","instability","brostrom","open","arthroscopic","2024-09-26",{"date":312,"type":40},"2024-09-27",{"date":314,"type":40},"2019-06-01",{"date":316,"type":23},"2027-12-05",{"name":318,"class":47},"Federal University of São Paulo",{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":18,"minAge":327,"maxAge":20,"enrollmentInfo":328,"targetDuration":4,"studyType":58,"phases":330,"briefSummary":331,"conditions":332,"keywords":333,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":101},"100499613","a-mobile-recovery-guidance-app-for-children-and-young-adults-with-acute-ankle-inversion-injuries-100499613","NCT05785533","A Mobile Recovery Guidance App for Children and Young Adults With Acute Ankle Inversion Injuries","A Mobile Recovery Guidance App for Children and Young Adults With Acute Ankle Inversion Injuries: a Randomized Controlled Trial","SPRAIN","Inclusion Criteria:\n\n* Age 12-30 years\n* Presenting to the Paediatric Emergency Department of the Children's Hospital or Adult Emergency Department, London Health Sciences Centre, London, or ntario, St. Joseph Urgent Care Centre, London, Ontario, with a unilateral acute (\\\u003C= 48 hours) ankle injury based on clinical diagnosis by ED physician\n* Able to use a WiFi enabled smartphone with either an iOS or Android operating system with enough memory capability to host the App.\n\nExclusion Criteria:\n\n* Unable to read or understand English above at least a grade 8 literacy level in the absence of a native language interpreter\n* Not independently ambulatory prior to injury (without the use of an assistive device)\n* Developmental disability precluding the full comprehension of study-related procedures\n* Multi-system or multi-limb injuries\n* Concomitant radiographically proven lower extremity fracture or dislocation (with the exception of a suspected Salter-Harris type I injury)","12 Years",{"count":329,"type":23},250,[60],"Ankle sprains are the most common musculoskeletal complaint of children presenting to the emergency department (ED). Healing can often be protracted, leading to prolonged pain, missed school and work, and delayed return to a normal activity level. Smartphone apps have been shown to be associated with greater caregiver knowledge and improved outcomes in a number of conditions but have not been explored in ankle sprains. We would like to know if using a smartphone app for children with ankle inversion injuries leads to improved functional outcomes such as pain, mobility, and return to activity. We will be comparing a smartphone app that provides education and daily management reminders to a paper handout to see if the former leads to improved functional recovery.",[27],[334,335,336],"Ankle inversion injury","Mobile app","Recovery guidance","2024-09-20",{"date":339,"type":40},"2024-09-23",{"date":341,"type":40},"2024-08-24",{"date":343,"type":23},"2026-12-31",{"name":345,"class":47},"Naveen Poonai",{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":182,"enrollmentInfo":352,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":354,"conditions":355,"keywords":356,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":101},"100427492","interest-of-ultrasound-in-the-diagnosis-of-severity-of-lateral-ankle-sprain-100427492","NCT04846712","Interest of Ultrasound in the Diagnosis of Severity of Lateral Ankle Sprain","Inclusion Criteria:\n\n* First ankle sprain with sport or work disability\n\nExclusion Criteria:\n\n* Patient with fractures, dislocation or hyperlaxity\n* Previous ankle sprain",{"count":353,"type":23},50,"Ankle sprain is a frequent and widely trivialized trauma. Misdiagnosed or poorly treated, it can recur and thus develop into chronic ankle instability. It can be associated with complications which, if not detected early, can lead to long-term sequelae.",[27],[357,358,359,360,361],"Ankle","sprain","diagnosis","ultrasound","MRI","2024-08-28",{"date":364,"type":40},"2024-08-29",{"date":366,"type":40},"2021-12-01",{"date":368,"type":23},"2027-09",{"name":370,"class":47},"Centre Hospitalier Universitaire de Saint Etienne",{"id":372,"slug":373,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":17,"sex":18,"minAge":54,"maxAge":378,"enrollmentInfo":379,"targetDuration":4,"studyType":58,"phases":381,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":101},"100554503","the-effect-of-taping-on-plantar-pressure-distribution-in-players-with-chronic-ankle-instability-100554503","NCT06499935","The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability","The Immediate Effects of Rigid Taping Versus Kinesio-Taping on Plantar Pressure Distribution in Basketball Players With Chronic Ankle Instability","Inclusion Criteria:\n\n* A history of at least 1 significant ankle sprain\n* The initial sprain must have occurred at least 12 months before study enrollment\n* A history of the previously injured ankle joint \"giving way\" and\u002For recurrent sprain and\u002For \"feelings of instability.\"\n* Cumberland Ankle Instability Tool: score of 24 or less\n\nExclusion Criteria:\n\n* A history of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves) in either lower extremity\n* A history of a fracture in either lower extremity requiring realignment\n* Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous 3 months that impacted joint integrity and function (i.e., sprains, fracture) resulting in at least 1 interrupted day of desired physical activity.","28 Years",{"count":380,"type":23},88,[60],"The goal of this study is to investigate whether there exists a difference in baropdometric readings of plantar pressure between individuals with chronic ankle instability and normal health individuals, in addition another goal of this study is to investigate the effect of rigid taping vs. kinesio taping on plantar pressure distribution as well as stability markers in individuals with chronic ankle instability.\n\nThe main questions aimed to answer are:\n\n1. Is there a difference in plantar pressure distribution between individuals with chronic ankle instability and individuals without chronic ankle instability?\n2. What effect do rigid and kinesio taping have on plantar pressure distribution and ankle stability markers?\n3. Which tape affects plantar pressure distribution and ankle stability better?\n\nParticipants will:\n\nFirstly be divided into two macro groups, one with chronic ankle instability and one without, with an observational part of the study to be carried out to investigate the differences in plantar pressure between both groups.\n\nSecondly, the group with chronic ankle instability will be divided into two micro groups one receiving rigid taping and the other receiving kinesio taping, and the immediate effects of these tapes in terms of plantar pressure and ankle stability will be recorded and compared before and after within groups, and after between both groups.",[89,115,27],"2024-07-07",{"date":386,"type":40},"2024-07-15",{"date":388,"type":40},"2024-05-24",{"date":390,"type":23},"2024-10-25",{"name":46,"class":47}]