[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anorectal-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anorectal-diseases":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,83,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100643888","glp-1-receptor-agonists-and-early-proctologic-effects-in-morbid-obesity-100643888",false,"NCT07668765","GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity","Early Proctologic Effects of GLP-1 Receptor Agonist Therapy in Morbidly Obese Patients: A Prospective Cohort Study With Baseline and 3-Month Proctologic Assessment","GLP-PROCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Morbid obesity (BMI ≥40 kg\u002Fm² or BMI ≥35 kg\u002Fm² with obesity-related comorbidities)\n* Newly prescribed GLP-1 receptor agonist therapy\n* Ability and willingness to provide written informed consent\n* Ability to attend 3-month follow-up visit\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Perianal Crohn's disease\n* History of anorectal malignancy\n* Previous pelvic radiotherapy\n* Anorectal surgery within the previous 3 months\n* Pregnancy\n* Neurogenic bowel dysfunction\n* Inability to comply with follow-up visits\n* Discontinuation of GLP-1 receptor agonist therapy before follow-up assessment\n* Active anorectal infection or abscess","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","3 Months","OBSERVATIONAL","Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients. Participants will undergo baseline and 3-month anorectal symptom assessment and proctologic examination to evaluate newly developed proctologic diseases and changes in pre-existing symptoms.",[26,27,28,29,30],"Morbid Obesity","Anorectal Diseases","Drug-Related Side Effects and Adverse Reactions","Constipation","Diarrhea",[32,33,34,35,36,37,38,39,40,41,42,43],"GLP-1 receptor agonist","obesity","anorectal symptoms","hemorrhoids","anal fissure","constipation","semaglutide","tirzepatide","proctologic examination","bowel habits","anorectal disease","proctology","NOT_YET_RECRUITING","2026-06-23",{"date":47,"type":48},"2026-06-25","ACTUAL",{"date":50,"type":21},"2026-08",{"date":52,"type":21},"2027-05",{"name":54,"class":55},"Gazi University","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":70,"conditions":71,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":56},"100642940","phase-1-research-on-the-efficacy-and-mechanism-of-shouhui-tongbian-capsules-in-treating-postoperative-constipation-of-benign-anal-and-rectal-diseases-based-on-gut-microbiota-analysis-100642940","NCT07648394","Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota Analysis","Inclusion Criteria: Age between 18 and 75 years old, male or female. Undergoing surgery for benign anorectal diseases (e.g., mixed hemorrhoids, anal fistula, anal fissure).\n\nMeeting the diagnostic criteria for postoperative constipation (e.g., fewer than 3 spontaneous bowel movements per week, or difficulty in defecation).\n\nAble to understand the study procedures and voluntarily sign the informed consent form.\n\nAble to cooperate with medication administration, follow-up visits, and data collection.\n\nExclusion Criteria:Severe organic diseases of the heart, liver, kidney, or other vital organs.\n\nHistory of inflammatory bowel disease, irritable bowel syndrome, or severe chronic constipation unrelated to surgery.\n\nHistory of gastrointestinal surgery (other than the planned anorectal surgery) within the past 3 months.\n\nPregnancy, breastfeeding, or planned pregnancy during the study period (for female participants).\n\nKnown allergy or contraindication to the study drugs (Shouhui Tongbian Capsules or lactulose).\n\nCurrent use of other laxatives, prokinetic drugs, or traditional Chinese medicine for constipation within 1 month before enrollment.\n\nSevere mental disorders, cognitive impairment, or inability to communicate effectively.\n\nParticipation in other clinical trials within the past 3 months. Any other condition judged by the investigator to make the participant unsuitable for this study.","75 Years",{"count":65,"type":21},120,"INTERVENTIONAL",[68,69],"PHASE1","PHASE2","Study Title A study to learn how Shouhui Tongbian Capsules works to relieve constipation after anorectal surgery, and explore its effects linked to gut bacteria.\n\nWhy we do this study Constipation is a common problem after surgery for hemorrhoids, anal fistula and other benign anorectal diseases. It causes pain, slows wound healing and lowers quality of life. Traditional laxatives may lead to stomach pain, electrolyte problems and drug dependence.\n\nShouhui Tongbian Capsules is a traditional Chinese herbal medicine. It can ease constipation and protect the intestinal tract at the same time. This research aims to check how well this medicine works for post-surgery constipation, whether it reduces pain, and find out its working mechanism related to gut microbiota. We also want to collect evidence for better combined traditional Chinese and Western medicine treatment in clinic.\n\nWho can take part Adults aged 18 to 75 who receive surgery for benign anorectal diseases and have constipation Fully aware of the study and willing to sign an informed consent form People with severe organ diseases, mental illness, cancer, bleeding disorders, pregnancy or other conditions will not be included.\n\nHow the study works\n\nThis is a prospective, randomized, controlled clinical trial. A total of 120 patients will be randomly divided into two groups (60 people each):\n\nTest group: Take Shouhui Tongbian Capsules, 2 pills three times a day for 8 weeks.\n\nControl group: Take lactulose oral solution, the common medicine for constipation.\n\nWe will assess symptoms regularly before, during and after treatment. We will record constipation severity, traditional Chinese medicine symptom scores, pain scores (VAS), quality of life (SF-36), physical signs and blood test results. We will also test gut bacteria and inflammation levels to analyze the medicine's mechanism.\n\nSafety All participants will be closely monitored throughout the study. We will record any discomfort or side effects in a timely manner to ensure safety.\n\nExpected benefits This study will confirm the effectiveness and safety of Shouhui Tongbian Capsules for post-anorectal surgery constipation. It may help relieve your constipation and post-operative pain, speed up recovery and improve daily life. The results will also help doctors choose better treatments for similar patients in the future.\n\nStudy timeline May - June 2026: Complete ethical review and study preparation July - September 2026: Recruit participants and start treatment Late 2026 - Early 2027: Finish data collection, analysis and paper writing",[72,27,73,29],"Intestinal Flora","Surgery","2026-06-10",{"date":76,"type":48},"2026-06-15",{"date":78,"type":21},"2026-08-01",{"date":80,"type":21},"2027-06-30",{"name":82,"class":55},"China-Japan Friendship Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":92,"studyType":23,"phases":4,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":56},"100624064","hemorrhoid-suture-mucopexy-combined-with-laser-hemorrhoidoplasty-100624064","NCT07404774","Hemorrhoid Suture Mucopexy Combined With Laser Hemorrhoidoplasty","Prospective Evaluation of Hemorrhoid Suture Mucopexy (SM) Combined With Laser Hemorrhoidoplasty (LHP) for Symptomatic Hemorrhoidal Disease: A Cohort Study","HeMuLa","Inclusion Criteria:\n\n* Adults (\\>18 years).\n* Symptomatic Hemorrhoidal Disease (Goligher Grades II, III, IV).\n* Patients with or without recurrent disease after prior procedures (e.g., RBL, infrared coagulation, Milligan-Morgan, etc).\n\nExclusion Criteria:\n\n* Acutely thrombosed hemorrhoids.\n* Concomitant anal fistula or abscess requiring separate surgical management.\n* IBD (Crohn's\u002FUlcerative Colitis) with active rectal involvement.\n* Previous Stapled Haemorrhoidopexy (SH\u002FLongo).",{"count":20,"type":21},"12 Months","This prospective cohort study evaluates whether combining \"suture mucopexy\" (a simple stitch-based lift of prolapsed tissue) with Laser Hemorrhoidoplasty (LHP) can effectively relieve pain, bleeding and prolapse in adults with moderate-to-severe hemorrhoids (Grades II-IV). Participants will undergo the combined, non-Doppler-guided procedure and be followed for one year. The primary question is how long patients need post-operative pain medication and if they first experience complete symptom relief; secondary questions examine quality-of-life, safety (bleeding, urinary retention, stenosis) and the rate of hemorrhoid recurrence\u002Fre-operation.",[95,96,97,27],"Haemorrhoid","Haemorrhoidal Bleeding","Anorectal Surgeries",[99,100,101,102,103,104],"haemorrhoid","laser","mucopexy","suture mucopexy","LHP","haemorrhoidoplasty","RECRUITING","2026-02-08",{"date":108,"type":48},"2026-02-11",{"date":110,"type":48},"2026-01-01",{"date":112,"type":21},"2029-01",{"name":114,"class":55},"National and Kapodistrian University of Athens",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":122,"maxAge":18,"enrollmentInfo":123,"targetDuration":4,"studyType":66,"phases":125,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100598761","physiotherapy-applications-in-children-with-bladder-and-bowel-symptoms-after-anorectal-malformation-surgery-100598761","NCT07075692","Physiotherapy Applications in Children With Bladder and Bowel Symptoms After Anorectal Malformation Surgery","Effects of Physiotherapy Applications in Children With Bladder and Bowel Symptoms After Anorectal Malformation Surgery","Inclusion Criteria:\n\n* Children aged 5-18 years with bladder bowel symptoms after anorectal malformation surgery\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Presence of a congenital and\u002For chronic disease\n* Having a history of any additional neurological, orthopedic or psychiatric disease that will affect the evaluation parameters\n* Mental retardation\n* Having received physiotherapy within the last 1 year","5 Years",{"count":124,"type":21},20,[126],"NA","The aim of our study was to investigate the effects of physiotherapy applications in children with bladder and bowel symptoms after anorectal malformation surgery.",[27],"2025-07-11",{"date":131,"type":48},"2025-07-20",{"date":131,"type":21},{"date":134,"type":21},"2025-12-20",{"name":136,"class":55},"Ankara Yildirim Beyazıt University"]