[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"antenatal-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:antenatal-depression":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,89,122,144],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642741","stronger-together-antenatal-depressive-symptoms---prevalence-and-digital-treatment-100642741",false,"NCT07639164","Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment","Inclusion Criteria:\n\n* fluent in written and spoken Finnish or Swedish\n* access to computer or mobile phone with internet\n* between 12 and 22 weeks pregnant\n* screening and baseline score on the EPDS ≥10 points\n\nExclusion Criteria:\n\n* lifetime history of psychotic disorder (e.g. schizophrenia, schizoaffective disorder, bipolar disorder, psychotic depression)\n* active suicidal ideation\n* severe substance abuse or dependence\n* participates in another intervention study aiming at treating the symptoms of antenatal depression","FEMALE","18 Years","55 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The main objective of the current research project is to evaluate the usability, satisfaction of the antenatal iCBT program including telephone coaching for antenatal and postnatal depressive symptoms and collect nationally representative data on population-based screening of antenatal depressive and anxiety symptoms. The overarching hypothesis is that iCBT, with easy access and affordability, is user friendly and well accepted. In addition to examining the treatment response by questionnaires, we will study the infant development comprehensively as well as potential physiological changes associated with antenatal depression or its treatment.",[26,27],"Depression \u002F Major Depressive Disorder","Antenatal Depression",[29,30,31],"Digital intervention","Cognitive Behaviour Therapy","Antenatal depression","NOT_YET_RECRUITING","2026-06-05",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":20},"2026-08-01",{"date":40,"type":20},"2030-12-30",{"name":42,"class":43},"University of Turku","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":44},"100591340","pilot-study-of-personalized-aperiodic-transcranial-alternating-current-stimulation-in-antenatal-depression-panda-tacs-100591340","NCT06979154","Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)","Pilot Study Using Endogenous Aperiodic Brain Activity to Personalize Transcranial Alternating Current Stimulation as a Treatment for Antenatal Depression: PandA-tACS","PandA-tACS","Inclusion Criteria:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Female aged 18 - 45\n* Capacity to understand all relevant risks and potential benefits of the study as determined by study staff (provision of informed consent)\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Low suicide risk (defined for this study as no active suicidal ideation in the past month and no suicide attempts, preparatory actions, or significant non-suicidal self-harm in the previous 2 years). Risk will be assessed utilizing the C-SSRS screen and triage version with further exploration of positive responses.\n\nFor healthy control population:\n\n* Use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation, according to NIH Therapeutics Research Program Guidelines.\n\nAdditional for antenatal depression population:\n\n* Between weeks 14-32 of viable singleton pregnancy\n* Established obstetric care through UNC\n* Pre-identified DSM-5 diagnosis of unipolar, non-psychotic MDD which is confirmed by the DIAMOND\n* HDRS-17 score ≥8\n\nExclusion Criteria:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* DSM-5 diagnosis of severe alcohol use disorder (AUD) within the last 12 months, as evidenced by the DIAMOND\n* DSM-5 diagnosis of moderate to severe substance use disorder (excluding tobacco) within the last 12 months, as evidenced by the DIAMOND\n* Lifetime history of bipolar disorder, as evidenced by DIAMOND\n* Schizophrenia spectrum and other psychotic disorders, as evidenced by DIAMOND\n* History of autism spectrum disorder\n* Initiated any new psychotropic medication in the 6 weeks prior to screening or had a dose change in the preceding 6 weeks\n* Initiated a new course of psychotherapy in the 6 weeks preceding screening\n* Received any neurostimulation treatment in the 6 weeks preceding screening\n* History of seizures (excluding febrile seizures in childhood or Electroconvulsive Therapy (ECT) induced seizures)\n* Neurological disorders that would increase risk of participation or present a significant confounder in the opinion of the investigator (for example, dementia, history of stroke, Parkinson's disease, multiple sclerosis, history of traumatic brain injury with prolonged loss of consciousness, ruptured cerebral aneurysm, previous CNS radiation)\n* Previously failed to respond to ECT or transcranial magnetic stimulation (TMS)\n* Prior brain surgery and\u002For brain implants\n* Implanted medical device that uses electricity\n* Currently enrolled in another clinical trial for depression\n* Unstable medical disorder or anything that would place the participant at increased risk or preclude the participant's full compliance with or completion of the study, in the opinion of the Investigator\n\nAdditional for the healthy control population:\n\n* Current pregnancy or lactation (as determined by urine pregnancy test)\n* History of depression, as evidenced by DIAMOND\n\nAdditional for the antenatal depression population:\n\n* History of any of the following conditions:\n\n  * Diabetes (gestational or general history)\n  * Pre-term delivery (\\\u003C37 weeks)\n  * Eclampsia\n  * Pre-eclampsia with severe features\n  * Asthma requiring daily medication\n  * Chronic hypertension\n  * Immune thrombocytopenia (ITP)\n  * Hyperthyroidism requiring medication\n  * Pre-pregnancy BMI 40 or more\n  * In vitro fertilization (IVF)\n  * Mullerian anomaly of uterus\n  * Organ transplant\n  * Prior history of deep vein thrombosis\u002Fpulmonary embolism (DVT\u002FPE) or plan for anticoagulation during pregnancy\n  * Fetus with autoimmune hydrops\n  * Abnormal placenta\n* Current pregnancy:\n\n  * HIV\u002FHep B\u002FHep C with detectable viral loads\n  * Anemia \\[Hemoglobin under 11.0\\] upon entry to prenatal care\n  * No scheduled prenatal visits by 15 weeks\n  * Placenta previa\n  * Placenta accreta spectrum (PAS)\n  * Pre-eclampsia\n  * Gestational diabetes\n  * Gestational hypertension\n  * Fetus with abnormal chromosomes\n  * Cervical length \\\u003C 2.5 cm\n  * Presence of cerclage or vaginal progesterone to decrease chance of pre-term labor\n  * Fetal growth restriction\n  * Macrosomia\n  * Polyhydramnios\n  * Oligohydramnios\n  * Rupture of membranes\n  * Hyperemesis Gravidarum (HEG)\n  * Confirmation testing for Tri 13\u002F18\u002F21\n  * Congenital anomalies on anatomy ultrasound that do not resolve with follow-up ultrasound\n* Other cause of markedly high-risk pregnancy as determined by the Investigator",true,"45 Years",{"count":56,"type":20},10,[23],"The purpose of this study is to develop the safety, feasibility, and tolerability of a personalized transcranial alternating current stimulation (tACS) approach in antenatal depression.",[27,60,61,62],"Major Depressive Disorder","Major Depressive Disorder in Pregnancy","Healthy Controls",[64,65,66,67,68,60,69,70,71,72,73,74,75,76,77,62,78],"Behavioral Symptoms","Mood Disorders","Mental Disorders","Depression","Depressive Disorder","Antenatal diagnoses","Prenatal diagnoses","Pregnancy","Electric Stimulation","non-invasive brain stimulation","transcranial alternating current stimulation","tACS","EEG","antenatal depression","Aperiodic brain activity","RECRUITING","2026-04-08",{"date":82,"type":36},"2026-04-09",{"date":84,"type":36},"2025-08-12",{"date":86,"type":20},"2026-12-01",{"name":88,"class":43},"University of North Carolina, Chapel Hill",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":53,"sex":15,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":21,"phases":99,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":121},"100551147","integration-of-stepped-care-for-perinatal-mood-and-anxiety-disorders-among-women-attending-mch-clinics-100551147","NCT06456307","Integration of Stepped Care for Perinatal Mood and Anxiety Disorders Among Women Attending MCH Clinics","IPMH","Inclusion Criteria:\n\n* Pregnant and ≥28 weeks gestation\n* Attending ANC care at the facility\n* ≥14 years old\n* Screen positive for PMAD symptoms (PHQ-2≥3 and\u002For GAD-2≥3)\n* Willing to return to the MCH and PMTCT clinic for study visits\n\nExclusion Criteria:\n\n* Less than 28 weeks gestation\n* Any woman at high risk of self-harm based on a study self-harm assessment protocol,\n* Has cognitive impairments or psychotic symptoms","14 Years",{"count":98,"type":20},2970,[23],"Perinatal mood and anxiety disorders (PMAD), defined as depression and anxiety during pregnancy or up to 1 year postpartum, account for substantial morbidity and mortality among birthing people globally especially in low- and middle-income countries. Several evidence-based interventions are recommended for identification and management of PMAD by non-specialist providers in resource-limited settings. This cluster-randomized trial seeks to evaluate the effect of a stepped-care intervention for screening and treatment of PMAD among perinatal women, on clinical and implementation outcomes.",[102,27,103],"Depression, Anxiety","Postnatal Depression",[105,106,107,108,71,109,67,110],"perinatal mood and anxiety disorders","telepsychiatry","Problem management plus","Integrated Perinatal Mental Health","Postpartum","Anxiety","2025-12-03",{"date":113,"type":36},"2025-12-10",{"date":115,"type":36},"2025-02-17",{"date":117,"type":20},"2028-03",{"name":119,"class":120},"Kenyatta National Hospital","OTHER_GOV",2,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":53,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":143},"100560568","happymums-mobile-application-study-100560568","NCT06578845","HappyMums Mobile Application Study","HappyMums - Can Data Collected by a Mobile App be Used to Help Learn More About Mental Health Symptoms in Pregnant Women and Birthing People at Risk of Depression in Pregnancy?","HappyMums","Inclusion Criteria:\n\n* Pregnant people, aged 18 or older and up to 28 weeks' gestation.\n* Satisfactory understanding of English\u002Fnational language of host country, in order to give fully informed consent.\n* Either suffering with depressive symptoms currently, or who have at least one risk factor for antenatal depression.\n* Owning a smartphone capable of downloading and running HappyMums application\n\nExclusion Criteria:\n\n* Inability to give informed consent.",{"count":19,"type":20},"OBSERVATIONAL","The goal of this study is to investigate whether pregnant people at risk of, or currently suffering from antenatal depression, find it acceptable to use the 'HappyMums' mobile application during their pregnancy. This app will collect data relevant to their mental health passively and through active engagement from the user. After the study is complete, these data will be put together to determine if such data types could be used in future to help predict and identify antenatal depression, and aid better treatment decisions.",[71,27],"2025-12-02",{"date":136,"type":36},"2025-12-09",{"date":138,"type":36},"2025-02-18",{"date":140,"type":20},"2026-10-31",{"name":142,"class":43},"King's College London",7,{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":21,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":44},"100480219","internet-cbt-for-antenatal-depression-100480219","NCT05533138","Internet CBT for Antenatal Depression","Guided-internet Cognitive Behavioral Therapy for Antenatal Depression - Treatment Effects, Assessment Modalities and Extra Support.","Inclusion Criteria:\n\n* Mild to moderate major depression\n* Pregnant at treatment start\n* Regular contact with maternity mental health clinic\n* \\> 18 years old\n* Being able to start the treatment earliest in gestational week 8 and latest in gestational week 30\n* Stable medication for depression and\u002For other psychiatric conditions for at least 3 weeks.\n* Being able to participate in the treatment during the treatment time and having access to and being able to use the internet and mobile phone during the treatment time\n* Being able to understand the Swedish language orally and in writing\n\nExclusion Criteria:\n\n* Montgomery-Åsberg Depression Rating Scale-Self report version (MADRS-S) score below 15 (symptoms of depression to low) or above 35 (severe depression)\n* High risk of self harm or suicide (based on semi-structured clinical suicide risk assessment)\n* Psychiatric comorbidity, disability, somatic disorder, or pregnancy complications that prevent treatment participation or that can be negatively affected or compose a risk for the fetus by treatment participation\n* Ongoing psychological treatment with similar content",{"count":152,"type":20},415,[23],"Pregnant women in pregnancy week 8-29 screening positive for antenatal depression will be randomized to either choose or to be allotted by chance to different forms of diagnostic assessment; i.e. telephone, video or face-to-face assessment.\n\nThose diagnosed with mild to moderate major depression will then be randomized to treatment with therapist-guided Internet-delivered Cognitive Behavioral Therapy (ICBT) adapted for women suffering from antenatal depression or to the same treatment with addition of up to three contacts with extra support by a midwife or experienced perinatal mental health nurse.\n\nThe primary aim is to assess whether extrasupport in addition to internet-guided pregnancy adapted ICBT decreases depressive symptoms more than internet-guided pregnancy adapted ICBT only. Secondary aims include effects of extrasupport and assessment mode on treatment satisfaction, fidelity and credibility.",[27],[157,158,159,160],"Cognitive behavior therapy","Internet treatment","Self-help treatment","Perinatal support","2024-06-24",{"date":163,"type":36},"2024-06-25",{"date":165,"type":36},"2021-02-25",{"date":167,"type":20},"2027-12-31",{"name":169,"class":43},"Karolinska Institutet"]