[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cerebral-artery-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cerebral-artery-stroke":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100627536","phase-2-safety-and-efficacy-of-baricitinib-after-endovascular-treatment-in-acute-anterior-circulation-large-vessel-occlusion-a-multicenter-randomized-controlled-clinical-trial-100627536",false,"NCT07449910","Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial","Safety and Efficacy of Baricitinib Combined With Acute Large Vessel Occlusion Recanalization : A Multicenter, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age is 18 years old or above.\n2. Diagnosed as anterior circulation large vessel occlusion stroke by CTA, MRA or DSA.\n3. Randomized within 24h after the onset.\n4. The NIHSS score is above 5 and the ASPECT score is above 3 points while receiving imaging examination;\n5. The mTICI score after endovascular treatment (EVT) is above 2b.\n6. informed consent.\n\nExclusion Criteria:\n\n1. Intracranial hemorrhage confirmed by CT or MRI.\n2. mRS score\\>2 for patients \\\u003C80 years, or mRS score\\>1 for those ≥80 years before onset.\n3. Pregnant or lactating women.\n4. Allergic to contrast agents.\n5. Allergic to baricitinib or having contraindications for using baricitinib.\n6. Participating in other clinical studies.\n7. Systolic blood pressure \\>185 mmHg or diastolic blood pressure \\>110 mmHg, and unable to be controlled by oral antihypertensive drugs.\n8. Genetic or acquired bleeding diathesis, lack of anticoagulant factors or having taken oral anticoagulants and INR \\>1.7.\n9. Hemoglobin value \\\u003C8g\u002FL.\n10. Recent history of using other JAK inhibitors or potent immunosuppressants, including but not limited to the combined use with potent immunosuppressive drugs such as azathioprine, tacrolimus, tofacitinib and fedratinib, etc. Tortuous arteries make the thrombectomy device unable to reach the target blood vessel.\n11. Previous history of diagnosed viral hepatitis and tuberculosis.","ALL","18 Years",{"count":19,"type":20},750,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE2","PHASE3","The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with priority, and to elucidating the mechanism of JAK\u002FSTAT pathway inhibition on neuroprotection and inflammatory regulation.",[27,28,29],"Acute Ichemic Stroke","Anterior Cerebral Artery Stroke","Baricitinib","NOT_YET_RECRUITING","2026-02-27",{"date":33,"type":34},"2026-03-04","ACTUAL",{"date":36,"type":20},"2026-03-17",{"date":38,"type":20},"2028-01-31",{"name":40,"class":41},"The First Affiliated Hospital of University of Science and Technology of China","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":63,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":72,"locationsCount":42},"100593973","a-prospective-evaluation-of-clinical-outcomes-in-acute-ischemic-stroke-after-endovascular-treatment-wdoppler-100593973","NCT07013396","A Prospective Evaluation of Clinical Outcomes in Acute Ischemic Stroke After Endovascular Treatment w\u002FDoppler","A Prospective Evaluation of Clinical Outcomes in Acute Ischemic Stroke After Endovascular Treatment Using Transcranial","Inclusion Criteria:\n\n* Anterior circulation stroke including ACA, MCA or ICA stroke that underwent EVT including tandem occlusions.\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Difficulty in detecting the acoustic window by TCD\n* Pregnancy\n* Incarcerated patients",{"count":51,"type":20},100,[53],"NA","Endovascular therapy (EVT) has proven to be more beneficial for patients with AIS caused by large vessel occlusions (LVO) than medical management alone. A recent meta-analysis of 5 RCTs showed that EVT significantly reduced disability at 90 days compared to medical management \\[1\\]. Despite its obvious benefits, patients may have neurological deterioration despite successful thrombectomy due to ischemia progression, intracranial hemorrhage, re-occlusion, or vasogenic edema. The incidence of early neurological deterioration (END) following EVT for acute stroke has been reported to be ranging from 14.1-35.2% with some studies defining END up to 7 days and some restricting the definition between 6-72 hours post thrombectomy. A small proportion of these patients, approximately 5.9-10.5%, experienced sICH following EVT. Whether END occurs due to ischemic or hemorrhagic it leads to worse outcomes.",[56,28,57,58,59,60,61,62],"Anterior Cerebral Artery Syndrome","Acute Ischemic Stroke","Coronary Artery Disease","Cardioembolic Stroke","Congestive Heart Failure","Diabetes","Vasogenic Cerebral Edema",[64,65],"systolic blood pressure","Transcranial Doppler","2025-11-21",{"date":68,"type":34},"2025-11-25",{"date":70,"type":20},"2027-02",{"date":70,"type":20},{"name":73,"class":41},"Virginia Commonwealth University"]