[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cervical-discectomy-and-fusion-acdf\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cervical-discectomy-and-fusion-acdf":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100626017","screw-integrated-vs-traditional-cervical-cages-in-acdf-for-degenerative-disc-disease-100626017",false,"NCT07430163","Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease","Comparative Study Between Cervical Cage With Screws and Traditional Cage in Anterior Cervical Discectomy and Fusion (ACDF) for Treatment of Cervical Degenerative Disc Disease (CDDD)","Inclusion Criteria:\n\n* Patients aged above 18 years old.\n* Clinical diagnosis of cervical degenerative disc disease (CDDD).\n* Single or double level cervical degenerative disc disease (CDDD) confirmed by MRI\n* Failure of conservative treatment for at least 6 weeks.\n* Patients indicated for Anterior Cervical Discectomy and Fusion (ACDF).\n* Availability of complete preoperative and postoperative clinical and radiological data.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Previous cervical spine surgery.\n* Mutli-level (more than double level) cervical degenerative disc disease (CDDD).\n* Significant cervical instability requiring additional posterior fixation\n* Cervical trauma, fracture, or spinal infection.\n* Cervical tumors or inflammatory spinal disease.\n* Severe cervical deformity (fixed kyphosis)\n* Osteoporosis or metabolic bone disease.\n* Pregnancy\n* Psychiatric illness or substance abuse that would compromise follow-up","ALL","19 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study is a prospective, comparative clinical trial conducted at Assiut University Hospitals to evaluate the effectiveness of two different interbody fusion devices in patients with Cervical Degenerative Disc Disease (CDDD). The primary objective is to compare cervical cages with integrated screws against traditional stand-alone cervical cages during single or double-level Anterior Cervical Discectomy and Fusion (ACDF). While ACDF is the gold standard for CDDD, traditional cages can sometimes lead to complications like subsidence or incomplete fusion; integrated screw designs aim to provide immediate stability and reduce these risks.\n\nInvestigators will assess 40 patients over a 12-month follow-up period, focusing on primary outcomes of radiological interbody fusion using the Daniel Riew grading system.\n\nSecondary outcomes include the maintenance of cervical alignment (Ishihara Index), change in segmental angles (Cobb's method), disc height restoration, and clinical improvements in pain and function measured by the Visual Analog Scale (VAS) and Neck Disability Index (NDI). The study's rationale is to provide clearer evidence on whether screw-integrated cages offer superior radiological and clinical outcomes to help guide future surgical preferences",[26,27,28],"Cervical Cage With Screw","Cervical Degenerative Disc Disease","Anterior Cervical Discectomy and Fusion (ACDF)","NOT_YET_RECRUITING","2026-02-18",{"date":32,"type":33},"2026-02-24","ACTUAL",{"date":35,"type":20},"2026-03-15",{"date":37,"type":20},"2027-12-30",{"name":39,"class":40},"Assiut University","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100553786","phase-4-dexmedetomidine-and-nalbuphine-as-analgesic-adjuvants-to-bupivacaine-in-superficial-cervical-block-100553786","NCT06490614","Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block.","Comparative Study Between Dexmedetomidine and Nalbuphine as Analgesic Adjuvants to Bupivacaine in Superficial Cervical Block for Patients Undergoing Anterior Cervical Discectomy and Fusion (ACDF) Surgery A Double Blinded Randomized Trial","Inclusion Criteria:\n\n* Physical status ASA I and ASA ll.\n* Both males and females\n* Age 21- 60 years.\n* Patients undergoing elective anterior cervical discectomy and fusion for 1 or 2 levels.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients undergoing anterior cervical vertebrectomy and reconstruction.\n* Patients with a history of allergy to local anesthetics or any used drugs in study.\n* Infection at the site of the block.\n* Patients with multiple cervical spine traumas.\n* Patients having surgery for malignant tumors.\n* Pre-existing peripheral neuropathies.\n* Pregnant female.\n* Patients with uncontrolled hypertension or cardiac problems as (heart block, sick sinus syndrome and ischemic heart disease).\n* Patients with coagulopathy (INR\\>1.5).\n* Patients with failed block.","21 Years","60 Years",{"count":51,"type":20},30,[53],"PHASE4","Anterior cervical discectomy and fusion (ACDF) nowadays is considered a common procedure.postoperative pain can hinder recovery and prolong hospital stay. The superficial cervical plexus block (SCPB) is a safe and simple technique that had been found to allow good pain relief in neck surgeries. The main drawback of SCPB was short duration, so adjuvants as dexmedetomidine and opioids has been used to increase analgesic duration and decrease the use of opioids.\n\nThe current study will compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to bupivacaine in SCPB in anterior cervical fusion surgeries.",[28],"2024-07-05",{"date":58,"type":33},"2024-07-08",{"date":60,"type":20},"2024-07",{"date":62,"type":20},"2024-11",{"name":64,"class":40},"Kasr El Aini Hospital"]