[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-acl-tear\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-acl-tear":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,84,109,140,165],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642040","prospective-cohort-study-of-villarreal-cf-youth-players-100642040",false,"NCT07653633","Prospective Cohort Study of Villarreal CF Youth Players","A Single-season Prospective Observational Cohort Study of the Villarreal CF Male Youth Academy\"","VILLAREALFC","Inclusion Criteria:\n\n* Active federation license with Villarreal CF during the study period.\n* Regular participation in training sessions and official competitions.\n* Aged between 10 and 45 years (encompassing academy, youth development, and first-team categories).\n* For participants under 18 years of age: mandatory written informed consent from a parent or legal guardian.\n* For minor participants aged ≥12 years: written informed assent must be provided by the athlete in addition to parental consent.\n\nExclusion Criteria:\n\n* Previous bilateral anterior cruciate ligament (ACL) reconstruction.\n* Active severe musculoskeletal injury that prevents the execution of biomechanical or physiological testing.\n* Systemic disease or medical condition that limits sports participation or interferes with the study's biological\u002Fphysiological parameters.\n* Deregistration or transfer to another sports club during the prospective follow-up period. Refusal or inability to comply with the protocol's testing procedures or long-term follow-up requirements.","ALL","10 Years","45 Years",{"count":21,"type":22},200,"ESTIMATED","4 Years","OBSERVATIONAL","Anterior cruciate ligament (ACL) injuries represent a highly relevant issue in both grassroots and professional sports, with a particularly high incidence in young and female populations. The objective of this project is to develop and validate a multiscale predictive algorithm for ACL injury risk in athletes from Villarreal CF (aged 10-45), integrating biomechanical, physiological, genetic, and gut microbiome biomarkers.\n\nThe study, with a prospective and longitudinal design (4 years), will include a cohort of 200-250 players from the academy and first team. The following assessments will be conducted: biomechanical analysis of jumps using force platforms (instrumented LESS), physiological monitoring through resting heart rate and nocturnal heart rate variability (HRV), genotyping from saliva samples, and characterization of the gut microbiome 16 rRNA sequencing. The systematic recording of training, exposures, and injuries will follow OSTRC criteria and will be supervised by the club's medical team.\n\nThe expected outcome is a multivariate predictive model, validated in a professional sports setting, capable of identifying individual risk profiles and generating a personalized score to guide preventive interventions (exercise, strength training, nutritional or probiotic strategies). This approach aims to reduce the incidence of ACL injuries, optimize performance, and translate biomedical knowledge into clinical and sports practice.",[27,28],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament (ACL)",[30,31,32,33,34,35],"Anterior cruciate ligament","injuries","COL1A1","COL5A1","PIEZO1\u002F2","gut microbiome","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2027-05",{"name":46,"class":47},"Cardenal Herrera University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":48},"100643107","augmented-reality-in-surgery-100643107","NCT07636278","Augmented Reality in Surgery","Artificial Intelligence-Based Identification of the Target Zone on Arthroscopic Images During Knee Anterior Cruciate Ligament Reconstruction: An Observational Study","ARS","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for primary arthroscopic anterior cruciate ligament reconstruction at IRCCS Galeazzi-Sant'Ambrogio\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Revision anterior cruciate ligament reconstruction\n* Arthroscopic video quality judged inadequate by the investigator (artefacts, insufficient illumination, uninterpretable images)\n* Failure to sign informed consent, or withdrawal of consent","18 Years",{"count":59,"type":22},100,"The goal of this observational study is to learn whether an artificial-intelligence software can reliably recognise the anatomical landmarks used to guide femoral bone tunnel placement on the arthroscopic monitor image during anterior cruciate ligament (ACL) reconstruction in adults. The main questions it aims to answer are:\n\nCan the software automatically tell when the arthroscopic image is clean enough to allow identification of these landmarks? Can the software accurately outline the key bony and cartilaginous landmarks on the femur that guide correct tunnel positioning?\n\nParticipants will undergo their clinically indicated ACL reconstruction without modifications: short video sequences of the operative field will be recorded from the arthroscopic camera already used in routine practice, and used to train and validate the algorithms. No additional devices, manoeuvres or operative time are required.",[27],[63,64,65,66,67,68,69,70,71,72,73],"Anterior Cruciate Ligament Reconstruction","Arthroscopy","Artificial Intelligence","Deep Learning","Computer Vision","Semantic Segmentation","Augmented Reality","Surgery, Computer-Assisted","Image Processing","Femoral Tunnel","Decision Support Systems","RECRUITING","2026-06-03",{"date":77,"type":40},"2026-06-09",{"date":79,"type":40},"2026-05-26",{"date":81,"type":22},"2027-05-31",{"name":83,"class":47},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":19,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100625525","effects-of-a-preoperative-cognitive-behavioral-intervention-on-kinesiophobia-and-function-in-anterior-cruciate-ligament-reconstruction-100625525","NCT07423767","Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Patients aged 18 to 45 years with a diagnosis of anterior cruciate ligament (ACL) rupture.\n2. ACL rupture within 3 months prior to enrollment.\n3. First-time ACL rupture with a scheduled reconstruction surgery at this institution.\n4. The affected knee shows no significant redness, swelling, pain, or inflammation, with basic activities of daily living restored.\n5. No injury or only mild (grade I) injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament.\n\nExclusion Criteria:\n\n1. Body mass index (BMI) less than 18.5 or greater than 35 kg\u002Fm².\n2. Age older than 45 years or younger than 18 years.\n3. ACL rupture with a duration exceeding 3 months.\n4. Concurrent severe injury (greater than grade I sprain) to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament. (Note: Grade II indicates partial tear with ligament thickening, laxity, and partial fiber disruption; Grade III indicates complete rupture).\n5. Concurrent severe meniscal tear.\n6. History of prior knee surgery (e.g., meniscal repair, ligament reconstruction, joint replacement, arthroscopic debridement).\n7. Presence of other significant knee pathologies, such as: knee osteoarthritis, knee tumor, rheumatoid arthritis, tuberculosis, or active infectious\u002Finflammatory diseases of the knee.\n8. Concurrent fracture, dislocation, or other osseous injuries involving the knee.\n9. Unwillingness to receive the treatment protocol of this study.",{"count":91,"type":22},44,"INTERVENTIONAL",[94],"NA","This study aims to systematically elucidate the integrative effects of psychological rehabilitation on the \"brain-psychology-motor\" triad in patients with anterior cruciate ligament (ACL) rupture. We plan to recruit 44 patients (aged 18-45) diagnosed with ACL rupture and scheduled for reconstruction surgery at Peking University Third Hospital, who will be randomly assigned to two groups. Through synchronous acquisition of questionnaire scores, motor performance data (gait, jogging, postural stability), and central neural activity (EEG), this research seeks to establish a foundation for developing neuroscience evidence-based, precision rehabilitation strategies.",[27],[98],"Anterior cruciate ligament; Cognitive-Behavioral Intervention","2026-04-08",{"date":101,"type":40},"2026-04-13",{"date":103,"type":40},"2026-02-14",{"date":105,"type":22},"2027-08-01",{"name":107,"class":47},"Peking University Third Hospital",2,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":17,"minAge":57,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":48},"100617411","clinical-and-functional-outcomes-after-acl-reconstruction-versus-primary-repair-100617411","NCT07318272","Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair","Comparison of Clinical and Functional Outcomes After Anterior Cruciate Ligament Reconstruction and Primary Repair Surgery","Inclusion Criteria for the ACL Reconstruction Group\n\n* Age 18-40 years\n* History of complete ACL rupture treated with ACL reconstruction\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* At least 12 months postoperative at the time of evaluation\n* Ability to comply with all study procedures\n* Signed informed consent\n\nExclusion Criteria for the ACL Reconstruction Group\n\n* Previous surgery for partial or chronic ACL tear\n* Concomitant multi-ligament knee injuries\n* Prior surgery on the ipsilateral or contralateral knee\n* Lower extremity malalignment (e.g., significant varus\u002Fvalgus)\n* Tibial avulsion-type ACL injury\n* Neurological or musculoskeletal disorders affecting lower limb function\n* Any medical condition that may interfere with test performance or safety\n\nInclusion Criteria for the Primary ACL Repair Group\n\n* Age 18-40 years\n* Complete ACL rupture treated with arthroscopic primary ACL repair\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* Minimum 12 months postoperative at the time of assessment A-bility to follow and complete study procedures\n* Signed informed consent\n\nExclusion Criteria for the Primary ACL Repair Group\n\n* Previous surgery for partial or chronic ACL injury\n* Multi-ligament knee injuries\n* History of surgery on either knee\n* Lower extremity malalignment\n* Tibial avulsion-type ACL rupture\n* Neuromuscular or musculoskeletal diseases affecting lower limb function or balance\n* Any condition that may affect participation or compromise safety\n\nInclusion Criteria for the Healthy Control Group\n\n* Age 18-40 years\n* No significant lower-extremity malalignment (e.g., varus\u002Fvalgus deformity)\n* No history of lower-extremity injury within the past 12 months\n* No known chronic systemic disease\n* No history of knee surgery or diagnosed knee pathology\n* Ability to understand and comply with study procedures\n* Signed informed consent\n\nExclusion Criteria for the Healthy Control Group\n\n* Presence of clinically significant lower-extremity malalignment\n* Lower-extremity musculoskeletal injury within the last 12 months\n* Any chronic systemic or metabolic disease\n* History of knee injury, knee surgery, or diagnosed knee pathology\n* Neurological, vestibular, or musculoskeletal disorder affecting balance or gait\n* Inability to complete study procedures",true,"40 Years",{"count":119,"type":22},45,"The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint. Although ACL reconstruction has long been considered the gold standard among surgical interventions following ACL injury, arthroscopic primary repair techniques have recently regained interest. With advances in minimally invasive surgical procedures, refined patient selection criteria, and improved rehabilitation strategies, the clinical effectiveness of primary repair is once again being re-evaluated. However, there remains a limited body of literature directly comparing the medium- to long-term effects of these two surgical techniques on neuromuscular performance, fatigue tolerance, and functional outcomes.\n\nThe aim of this study is to comparatively investigate postoperative muscle strength and endurance, isokinetic fatigue response, muscle oxygenation, proprioception, knee stability, postural control, and patient-reported outcome measures in individuals who have undergone ACL reconstruction or primary repair. Assessments will include low- and high-velocity tests performed on the Cybex Norm isokinetic dynamometer, a 33-repetition fatigue protocol at 300°\u002Fs, muscle oxygenation analysis using Train.Red NIRS, knee laxity measurement via the GNRB arthrometer, single-leg balance and landing evaluations using the KFORCE force platform, and subjective outcome measures (IKDC, ACL-RSI).\n\nThe findings of this study are expected to provide a more comprehensive understanding of how surgical technique influences physiological, biomechanical, and functional outcomes. This knowledge may contribute to the development of individualized rehabilitation approaches and evidence-based return-to-sport criteria.",[27,63,122],"Isokinetic Test",[124,125,126,127,128,129,130],"ACL Injury","Anterior Cruciate Ligament","ACL Reconstruction","ACL Primary Repair","Postoperative Outcomes","Muscle Oxygenation","Isokinetic Testing","2025-12-28",{"date":133,"type":40},"2026-01-05",{"date":135,"type":22},"2026-01-01",{"date":137,"type":22},"2027-08-30",{"name":139,"class":47},"Gazi University",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":147,"targetDuration":4,"studyType":92,"phases":149,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":48},"100583369","phase-3-acb-vs-no-block-for-pediatric-acl-reconstruction-100583369","NCT06875427","ACB vs no Block for Pediatric ACL Reconstruction","Comparing Preoperative Adductor Canal vs. No Block for Quality of Recovery After Anterior Cruciate Ligament Reconstruction in Patients Younger Than 18 Years of Age: A Randomized Controlled Feasibility Trial","Inclusion Criteria:\n\n* Patients ASA I, II and III\n* 10-18 years of age\n* scheduled for ACL reconstruction\n* agreeable to regional block and follow-ups\n\nExclusion Criteria:\n\n* Contraindications to adductor canal block.\n* Patients with coagulopathies, preexisting neurologic deficit\n* Significant comorbidities that may impact recovery or interfere with the study.\n* Refusal to regional techniques.\n* Moderate to severe cognitive deficit (patients who are unable to complete the questionnaire)\n* Patients with history of malignant hyperthermia",{"count":148,"type":22},38,[150],"PHASE3","The goal of this randomized controlled feasibility clinical trial is to assess the feasibility of conducting a randomized trial of adding a perioperative single-shot adductor canal block to standard of care general anesthesia compared to non-regional techniques in pediatric patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The main clinical question it aims to answer is does ACB result in improved Quality of Recovery-15 questionnaire scores on postoperative day 2 , postoperative day 14, and postoperative day 42. Secondary questions this study will address are will use of a single-shot adductor canal block result in: less total opioid consumption; shorter post anesthetic care unit (PACU) length of stay; better pain scores at rest and with movement at time of postoperative phone call; and patient satisfaction score at 2 weeks (postoperative day 14). Researchers will compare the scores to patients undergoing the same surgery who will not have a single-shot ACB. All patients will receive the same pre-, peri-, and postoperative care with the exception of being randomized to block or no block. Participants will be asked to answer the Quality of Recovery-15 questionnaire and rate their pain on a scale of 0-10 on the day of surgery, at postoperative day 2 (by telephone) and at postoperative day 14 and postoperative day 42 during regular orthopedic clinic follow-up. Patients and caregivers will rate their satisfaction at postoperative day 42, using a 5-item Likert scale (ranging from completely dissatisfied to completely satisfied).",[125,27],[154,155],"single-shot adductor canal block","anterior cruciate ligament reconstruction","2025-09-23",{"date":158,"type":40},"2025-09-26",{"date":160,"type":40},"2025-07-01",{"date":162,"type":22},"2027-01",{"name":164,"class":47},"Isabella Jaramillo",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":92,"phases":176,"briefSummary":178,"conditions":179,"keywords":183,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":48},"100559054","phase-2-evaluation-of-pain-management-after-surgery-when-using-nerve-blocks-in-the-pediatric-population-100559054","NCT06559137","Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population","Prospective Evaluation of Post-operative Pain Management Using Peripheral Nerve Blocks in the Pediatric Population","Inclusion Criteria:\n\n* Must be aged 13+ years at time of surgery\n* Must present with injury requiring an ACLR procedure with a Bone Patellar Tendon Bone or Quadriceps graft\n* Ability to provide assent, legally appointed representative available to provide informed consent\n\nExclusion Criteria:\n\n* Patient \\\u003C13 years old\n* Requires fracture repair or another non-standardized surgery\n* Any ACLR that requires the use of a graft type other than Bone Patellar Tendon Bone or Quadriceps tendon\n* Any lower extremity procedure that is not primarily an ACLR\n* Patient pregnancy\n* Inability to provide assent or legally appointed representative to provide informed consent\n* Prior history of hypersensitivity to Ropivacaine or any local anesthesia\n* BMI ≥ 40","13 Years","21 Years",{"count":175,"type":22},160,[177],"PHASE2","The goal of this randomized clinical trial is to determine if single-shot ropivacaine peripheral nerve blocks (PNB - perineural injections) for anterior cruciate ligament (ACL) reconstruction procedures in pediatric orthopaedic sports medicine patients provides significant pain relief and decreased narcotic use. The main questions it aims to answer are:\n\n* Does ropivacaine significantly reduce Visual Analog Scale (VAS) pain scores and pain levels up to one week postoperatively?\n* Does ropivacaine significantly decrease narcotic use (number of pills taken) up to one week postoperatively?\n\nResearchers will compare the pain outcomes and narcotic use of participants who receive a single-shot ropivacaine peripheral nerve block to those of participants who do not receive a single-shot ropivacaine peripheral nerve block for their ACL reconstruction surgery. The goal is to understand if there is a significant difference in participant pain outcomes and narcotic use outside the first 24 hours postoperatively.\n\nParticipants will:\n\n* receive either a single-shot ropivacaine peripheral nerve block intraoperatively or no peripheral nerve block during their ACL Quadriceps tendon graft or bone patellar tendon bone graft reconstruction surgery.\n* receive and complete questionnaires at postoperative days 1, 4, and 7 regarding their pain scores, levels, and outcomes, effective pain treatments, overall pain interference, narcotic use (number of pills taken), and overall pain treatment satisfaction\n* receive and complete secondary outcome measures of functional and psychological outcomes regarding their ACL reconstruction surgery at postoperative day 1",[27,180,181,182],"Sports Injuries in Children","Analgesia","Pain, Postoperative",[184,185,186,187,188],"Narcotic use","Postoperative pain management","ACL reconstruction","Visual Analog Scale (VAS) pain scores","Multimodal pain management protocol","2025-09-09",{"date":191,"type":40},"2025-09-16",{"date":193,"type":22},"2025-09",{"date":195,"type":22},"2028-09",{"name":197,"class":47},"Texas Scottish Rite Hospital for Children"]