[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-acl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-acl":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100642040","prospective-cohort-study-of-villarreal-cf-youth-players-100642040",false,"NCT07653633","Prospective Cohort Study of Villarreal CF Youth Players","A Single-season Prospective Observational Cohort Study of the Villarreal CF Male Youth Academy\"","VILLAREALFC","Inclusion Criteria:\n\n* Active federation license with Villarreal CF during the study period.\n* Regular participation in training sessions and official competitions.\n* Aged between 10 and 45 years (encompassing academy, youth development, and first-team categories).\n* For participants under 18 years of age: mandatory written informed consent from a parent or legal guardian.\n* For minor participants aged ≥12 years: written informed assent must be provided by the athlete in addition to parental consent.\n\nExclusion Criteria:\n\n* Previous bilateral anterior cruciate ligament (ACL) reconstruction.\n* Active severe musculoskeletal injury that prevents the execution of biomechanical or physiological testing.\n* Systemic disease or medical condition that limits sports participation or interferes with the study's biological\u002Fphysiological parameters.\n* Deregistration or transfer to another sports club during the prospective follow-up period. Refusal or inability to comply with the protocol's testing procedures or long-term follow-up requirements.","ALL","10 Years","45 Years",{"count":21,"type":22},200,"ESTIMATED","4 Years","OBSERVATIONAL","Anterior cruciate ligament (ACL) injuries represent a highly relevant issue in both grassroots and professional sports, with a particularly high incidence in young and female populations. The objective of this project is to develop and validate a multiscale predictive algorithm for ACL injury risk in athletes from Villarreal CF (aged 10-45), integrating biomechanical, physiological, genetic, and gut microbiome biomarkers.\n\nThe study, with a prospective and longitudinal design (4 years), will include a cohort of 200-250 players from the academy and first team. The following assessments will be conducted: biomechanical analysis of jumps using force platforms (instrumented LESS), physiological monitoring through resting heart rate and nocturnal heart rate variability (HRV), genotyping from saliva samples, and characterization of the gut microbiome 16 rRNA sequencing. The systematic recording of training, exposures, and injuries will follow OSTRC criteria and will be supervised by the club's medical team.\n\nThe expected outcome is a multivariate predictive model, validated in a professional sports setting, capable of identifying individual risk profiles and generating a personalized score to guide preventive interventions (exercise, strength training, nutritional or probiotic strategies). This approach aims to reduce the incidence of ACL injuries, optimize performance, and translate biomedical knowledge into clinical and sports practice.",[27,28],"Anterior Cruciate Ligament (ACL) Tear","Anterior Cruciate Ligament (ACL)",[30,31,32,33,34,35],"Anterior cruciate ligament","injuries","COL1A1","COL5A1","PIEZO1\u002F2","gut microbiome","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-17","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2027-05",{"name":46,"class":47},"Cardenal Herrera University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":48},"100624591","preoperative-rehabilitation-for-patient-with-an-acl-injury-100624591","NCT07411625","Preoperative Rehabilitation for Patient With an ACL Injury","Comparison of Two Programs Delivered During Rehabilitation Before an Anteriror Cruciate Ligament Reconstruction : a Randomised Controlled Trial K-POP","K-POP","Inclusion Criteria:\n\n* Being over 18 years\n* A first episode of an ACL injury\n* An ACLR scheduled at least 10 weeks later, with a surgical technique using hamstring, gracilis, or quadriceps\u002Fpatellar tendon autograft\n* A minimum passive range of motion of the knee between 10° of extension deficit, and 80° of flexion\n* A medical prescription for prehabilitation\n* Possibility to attend prehabilitation program and post-ACLR rehabilitation in one of the 15 clinics","18 Years",{"count":59,"type":22},84,"INTERVENTIONAL",[62],"NA","Muscle qualities are critical for the recovery after an anterior cruciate ligament (ACL) injury. Before ACL reconstruction (ALCR), resistance training aims to maintain patient strength and volume in order to optimize recovery. Unanswered questions remain on the modalities of resistance training before ACLR. This protocol details a pragmatic clinical trial that primary aims to increase the maximal strength of knee extensors and flexors and to induce hypertrophy before ACLR. Participants awaiting ACLR will be recruited from outpatient rehabilitation clinics and will be randomly allocated to one group to attend a 9-weeks rehabilitation program before ACLR. Participants of 'resistance training' group will perform a training program built on the principles of strength training to increase knee muscles strength and volume. Three blocks of 3 weeks will induce a progressive increase in training load, with exercises performed close to failure. Participants of 'usual group' will perform traditional exercises including: balance\u002Fproprioceptive exercises, weight-balances exercises, and body-weight resistance training exercises. Groups will be compared on muscle strength (primary outcome), clinical outcomes (muscle volume, stiffness, knee mobility, effusion) and self-reported outcomes (quality of life, perception of knee function, pain, anxiety and depression, exertion, health consumption, participations in activities) before and after ACLR. Outcomes will be collected by a blinded assessor before and after the resistance training program (before ACLR); 4 and 9 months after the ACLR.",[28],[66,67,68,69,70],"Rehabilitation","Preoperative resistance training","Strength","Voluntary activation","Muscle Volume","RECRUITING","2026-03-19",{"date":74,"type":40},"2026-03-20",{"date":76,"type":40},"2026-03-17",{"date":78,"type":22},"2027-08-15",{"name":80,"class":47},"Nantes University Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":19,"enrollmentInfo":88,"targetDuration":4,"studyType":60,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":48},"100625118","comparison-of-standard-acl-reconstruction-versus-tars-augmented-reconstruction-100625118","NCT07418476","Comparison of Standard ACL Reconstruction Versus TARS-Augmented Reconstruction","Comparison of Standard Anterior Cruciate Ligament Reconstruction and Tape Active Reconstruction System (TARS)-Augmented Reconstruction: A Prospective Randomized Controlled Study","Inclusion Criteria\n\n* Age between 18 and 44 years\n* Diagnosis of complete ACL rupture confirmed by clinical examination and imaging\n* Planned primary single-bundle anatomic ACL reconstruction using hamstring autograft\n* Intact contralateral knee\n* Provision of written informed consent\n\nExclusion Criteria\n\n* Cartilage lesions grade 2 or higher according to the Outerbridge classification\n* Combined ligament injuries or inflammatory arthritis\n* Tibial slope greater than 12 degrees\n* Advanced knee laxity\n* Revision ACL reconstruction\n* Requirement for additional surgical procedures during the same operation\n* Inability to comply with follow-up protocol",{"count":89,"type":22},80,[62],"This study is designed to compare standard anterior cruciate ligament (ACL) reconstruction using hamstring autograft with ACL reconstruction augmented using the Tape Active Reconstruction System (TARS). Eligible patients aged 18 to 44 years with a complete ACL rupture will be prospectively enrolled and randomized in a 1:1 ratio into two study groups. Participants will be evaluated preoperatively and postoperatively at regular follow-up visits, with the final assessment performed at 12 months after surgery. Outcome assessments will include patient-reported outcome measures, objective clinical examination of knee stability, instrumented laxity measurements, and radiological evaluation.",[28],[94,95,96],"anterior cruciate ligament","suture tape augmentation","t2 mapping","2026-02-28",{"date":99,"type":40},"2026-03-03",{"date":97,"type":40},{"date":102,"type":22},"2027-07-30",{"name":104,"class":47},"Samsun University"]