[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,53,84,110,144,172,197,231],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100644569","quadriceps-tendon-vs-peroneus-longus-tendon-in-acl-reconstruction-100644569",false,"NCT07671729","Quadriceps Tendon vs Peroneus Longus Tendon in ACL Reconstruction","A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes","Inclusion Criteria:\n\n* Patients diagnosed with anterior cruciate ligament rupture\n* Patients scheduled for primary anterior cruciate ligament reconstruction\n* Age between 18 and 50 years\n* Ability to provide informed consent\n* Willingness to comply with postoperative rehabilitation and follow-up evaluations\n\nExclusion Criteria:\n\n* Previous ligament reconstruction surgery on the affected knee\n* Multi-ligament knee injuries requiring additional ligament reconstruction\n* Severe osteoarthritis of the knee\n* Revision anterior cruciate ligament reconstruction\n* Neuromuscular disorders affecting lower extremity function\n* Active infection\n* Inability to comply with follow-up protocol","ALL","18 Years","50 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Clinical examination findings, return-to-sport outcomes, ankle muscle strength, ankle-related functional scores, and gait analysis parameters will be evaluated at 6 months and 12 months postoperatively. The study aims to investigate both knee-related functional outcomes and donor site morbidity associated with graft harvesting techniques.",[27,28],"Anterior Cruciate Ligament Injury","Anterior Cruciate Ligament Rupture",[30,31,32,33,34,35,36,37,38,39],"ACL reconstruction","Anterior cruciate ligament","Quadriceps tendon autograft","Peroneus longus tendon autograft","Gait analysis","Return to sport","Knee stability","Ankle muscle strength","Functional outcomes","Randomized controlled trial","RECRUITING","2026-06-23",{"date":43,"type":44},"2026-06-26","ACTUAL",{"date":46,"type":44},"2026-05-01",{"date":48,"type":21},"2027-12",{"name":50,"class":51},"Acibadem University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100643190","effectiveness-of-a-digital-prehabilitation-programme-before-acl-reconstruction-100643190","NCT07643480","Effectiveness of a Digital Prehabilitation Programme Before ACL Reconstruction","Effectiveness of a Digital Prehabilitation Programme Compared With Usual Care in Patients Awaiting Anterior Cruciate Ligament Reconstruction: A Randomised Controlled Superiority Trial","Inclusion Criteria:\n\n* Adults 18-55 years\n* Diagnosed ACL rupture\n* Scheduled for primary ACL reconstruction\n* Waiting ≥4 weeks before surgery\n\nExclusion Criteria:\n\n* Multiligament injury\n* Severe comorbidities\n* Previous ACL surgery same knee","55 Years",{"count":20,"type":21},[24],"Background Prehabilitation prior to anterior cruciate ligament reconstruction (ACLR) has been shown to improve preoperative knee function, enhance quadriceps strength, and optimize postoperative recovery. However, access to supervised prehabilitation programmes remains limited. Digital health interventions may improve accessibility, adherence, and continuity of care.\n\nObjective To determine whether a structured digital prehabilitation programme is more effective than usual care in improving quadriceps strength and functional outcomes after ACL reconstruction.\n\nMethods\u002Fdesign This study is a single-centre, parallel-group, assessor-blinded randomised controlled trial. Adult participants scheduled for primary ACL reconstruction will be randomly allocated to either a usual care group or a digital prehabilitation group. The intervention group will complete a 4-week structured digital prehabilitation programme prior to surgery. Outcomes will be assessed preoperatively and up to 12 weeks postoperatively.\n\nExpected Results The digital prehabilitation programme is expected to improve preoperative knee status and enhance postoperative quadriceps strength and functional recovery compared to usual care.",[27],[66,67,68,69,70,71,72,73],"Anterior Cruciate Ligament","ACL Reconstruction","Prehabilitation","Digital Health","Exercise Therapy","Telerehabilitation","Quadriceps Strength","Knee Function","NOT_YET_RECRUITING","2026-06-08",{"date":77,"type":44},"2026-06-11",{"date":79,"type":21},"2026-09-15",{"date":81,"type":21},"2026-12-31",{"name":83,"class":51},"Alejandro Caña Pino",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":52},"100479760","virtual-reality-mindfulness-meditation-after-acl-reconstruction-100479760","NCT05527171","Virtual Reality Mindfulness Meditation After ACL Reconstruction","Virtual Reality Mindfulness Meditation in Patients After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Female\n* Ages 14-25 years\n* Have self-reported levels of fear on the Tampa Scale of Kinesiophobia-11\n* Have poor jump-landing movement quality as measured by the Landing Error Scoring System-Real Time\n* Injured their knee playing or training for sports (recreational or organized)\n* Right-hand dominant\n* 6 months to 10-years post-ACLR\n* Demonstrate magnetic resonance imaging (MRI) compliance\n\nExclusion Criteria:\n\n* Male\n* Concussion in the past 3 months\n* Presence of metal fragments, pins, plates, or clips, shrapnel, permanent makeup, body piercings that cannot be removed, surgical implants, or orthodontics that cannot be removed\n* On any medication that affects the central nervous system\n* Any neurological conditions (i.e. epilepsy)\n* Claustrophobia\n* Under the influence of alcohol or other recreational drugs\n* Pregnancy or suspicion of pregnancy","FEMALE","14 Years","25 Years",{"count":95,"type":21},48,[24],"To evaluate the effect of virtual reality mindfulness meditation on patients after ACLR, the investigators will determine the effect of virtual reality mindfulness meditation to 1) decrease self-reported injury-related fear, 2) improve poor jump-landing movement patterns, and 3) improve brain activity in women 1 to 5 years post-ACLR when compared to a virtual reality sham group.",[27],[100,101],"Neurosciences","Rehabilitation","2026-04-29",{"date":46,"type":44},{"date":105,"type":44},"2023-09-05",{"date":107,"type":21},"2026-06-30",{"name":109,"class":51},"University of North Carolina, Chapel Hill",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":118,"sex":91,"minAge":119,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":52},"100633168","effects-of-a-targeted-prevention-program-on-change-of-direction-biomechanics-and-performance-in-elite-female-soccer-players-100633168","NCT07523178","Effects of a Targeted Prevention Program on Change-of-Direction Biomechanics and Performance in Elite Female Soccer Players","Impact of a Targeted Prevention Program on Biomechanics and Performance During Change-of-Direction Tasks in Elite Female Soccer Players: An Interventional Study","PREV-COD-FF","Inclusion Criteria:\n\n* Female soccer players aged 13 to 16 years\n* Female soccer players training at least 3 times per week\n* Ability to provide informed consent (parental consent required for minors)\n\nExclusion Criteria:\n\n* Previous lower-limb surgery\n* Current musculoskeletal injury\n* Refusal to participate or withdrawal of consent",true,"13 Years","16 Years",{"count":122,"type":21},51,[24],"Anterior cruciate ligament (ACL) injuries are common in female soccer and frequently occur during change-of-direction (COD) movements without contact. Biomechanical deficits during these movements are considered important risk factors.\n\nThis study aims to evaluate the effects of a targeted injury-prevention program on biomechanical movement quality and performance during change-of-direction tasks in female soccer players.\n\nParticipants will perform a 90° cutting task during which biomechanical movement quality will be assessed using the Cutting Movement Assessment Score (CMAS), while performance will be evaluated using cutting time measured with photoelectric timing gates. Participants will also perform the 505 Agility Test to assess additional change-of-direction performance.\n\nIn addition, subjective perceptions of functional confidence and performance will be collected using Likert-scale questionnaires.\n\nThe study will assess whether a structured prevention program integrated into regular training can improve biomechanical movement patterns and change-of-direction performance.",[27],[127,128,129,130,131,132,133,134],"Injury Prevention","ACL Injury Prevention","Female soccer","Change of Direction","Cutting Task","CMAS","505 Agility Test","Neuromuscular Training","2026-04-13",{"date":137,"type":44},"2026-04-17",{"date":139,"type":21},"2026-03-30",{"date":141,"type":21},"2026-05-18",{"name":143,"class":51},"University of Liege",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":52},"100629490","comparison-of-bone-patellar-tendon-bone-and-patellar-tendon-bone-grafts-in-acl-reconstruction-100629490","NCT07475351","Comparison of Bone-patellar Tendon-bone and Patellar Tendon-bone Grafts in ACL Reconstruction","Comparison of Morbidity and Functional Outcomes After Anterior Cruciate Ligament Reconstruction With Bone-Tendon-Bone Graft Versus Patellar Tendon Graft Without Patellar Bone Plug in Competitive Athletes","Inclusion Criteria:\n\n* Time for injury to surgery of less than six months.\n* Active athletes (federated or recreational)\n* Patellar tendon length \\> 42mm measured by MRI.\n* Age between 12 and 40 years old\n* Genders eligible for Study: both\n\nExclusion Criteria:\n\n* Previous surgery or history of ligamentous knee injuries.\n* Concomitant knee ligament injury\n* Major meniscal injury (more than 50% of the lateral or medial meniscus)\n* Chondral injury greater than Outerbridge Grade I-II","12 Years","40 Years",{"count":154,"type":21},110,[24],"The purpose of this randomized study is to compare donor site morbidity and clinical and functional outcomes of both surgery techniques (bone-patellar tendon-bone (BPTB) graft versus bone-patellar tendon without patellar bone plug (PT) graft) for anterior cruciate ligament reconstruction (ACLR) in athletes. The main questions it aims to answer are:\n\n* Does PT graft reduce donor site morbidity compared to the standard BPTB graft?\n* Does PT technique provide clinical and functional results comparable to the BPTB technique? Researchers will compare the incidence of complications and clinical and functional outcomes between the BPTB and PT grafts groups.\n\nPatients will:\n\n* Undergo ACLR surgical intervention using one of the two assigned techniques (BPTB or PT)\n* Follow a two-year assessment program, including visits at three, eight, 12 and 24 months after surgery.",[158,27],"Anterior Cruciate Ligament (ACL) Reconstruction",[160,161,162],"ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION","BONE PATELLAR TENDON BONE","PATELLAR TENDON","2026-03-18",{"date":165,"type":44},"2026-03-23",{"date":167,"type":44},"2026-01-01",{"date":169,"type":21},"2028-03",{"name":171,"class":51},"Universidad de Granada",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":196},"100625529","sports-rehabilitation-therapy-for-knee-joint-sports-injuries-a-case-study-of-anterior-cruciate-ligament-injury-and-patellar-chondromalacia-100625529","NCT07423819","Sports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Patellar Chondromalacia","Inclusion Criteria:\n\n1. Age 18-50 years.\n2. Clinical symptoms, signs, and MRI diagnosis confirming ACL rupture.\n3. First-time unilateral ACL rupture.\n4. Clinical symptoms, signs, and MRI diagnosis confirm patellofemoral cartilage injury.\n5. Presence of at least one of the following manifestations:\n\n   1. Initially, unilateral knee presents with dull pain, soreness, or a sense of weakness, followed by increased knee pain predominantly located behind the patella. Pain worsens after exertion, with difficulty climbing up or down stairs, and alleviates or disappears after rest. The pain VAS score is ≤6 points.\n   2. Positive unilateral knee patellar grind test and\u002For positive patellar compression test and\u002For positive squat test.\n6. Ability to understand and sign the informed consent form, voluntarily participate in the study, and cooperate with follow-up.\n\nExclusion Criteria:\n\n1. Body Mass Index (BMI) less than 18.5 or greater than 35 kg\u002Fm²;\n2. Age greater than 50 years or less than 18 years;\n3. History of knee surgery or presence of other conditions, such as tumors, rheumatoid arthritis, tuberculosis, etc.;\n4. Severe cardiopulmonary dysfunction, neurological disorders, or other conditions unsuitable for exercise rehabilitation;\n5. Pregnant or lactating women;\n6. Individuals unwilling to undergo this treatment method.",{"count":179,"type":21},160,[24],"The primary objective of this clinical trial is to verify the superiority of a digital diagnosis and treatment system for the conservative management of knee sports injuries-based on wearable sensors, machine vision, and large language models-over conventional off-site rehabilitation in terms of functional outcomes. The secondary objectives include assessing safety and adverse events, compliance and feasibility, algorithm evaluation accuracy and usability, and generating clinical evidence to support the registration of a Class II medical device. Participants will undergo a six-month intervention comprising knee muscle strengthening exercises, lower limb balance and stability training, and stretching exercises. Follow-up assessments will be conducted every four weeks, recording IKDC and Lysholm subjective knee function scores, VAS pain scores, SF-36 quality of life scores, knee range of motion, and MRI findings.",[27,183],"Patellofemoral Pain Syndrome",[31,185,186],"patella","Sports rehabilitation","2026-02-13",{"date":189,"type":44},"2026-02-20",{"date":191,"type":21},"2026-03-15",{"date":193,"type":21},"2026-11-30",{"name":195,"class":51},"Peking University Third Hospital",4,{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":22,"phases":206,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":52},"100543532","acl-reconstruction-with-shark-screw-or-biocomposite-interference-screws-100543532","NCT06357091","ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws","ACL Reconstruction With Human Allograft Cortical Bone Screw (Shark Screw®) or Biocomposite-interference Screws - a Prospective, Randomized, Controlled Trial.","Inclusion Criteria:\n\n* MRI-verified rupture of the anterior cruciate ligament\n* Indication for replacement surgery\n* Surgery within 6 months of injury\n* Uninjured contralateral knee\n\nExclusion Criteria:\n\n* Previous rupture of the anterior cruciate ligament on the side to be operated on (rerupture)\n* Primary bone disease\n* inflammatory disease\n* Unstable meniscus\n* complete rupture of a collateral ligament\n* early rerupture during the examination period (early rerupture)",{"count":205,"type":21},80,[24],"The goal of this clinical trial is to compare the outcome of 2 different screws for Anterior cruciate ligament reconstruction. The main question is if the human allogeneic cortical bone screw reduces tunnel widening in comparison to conventional treatment with a biocomposite screw. Additional the re-rupture rate will be evaluated and knee scores will be recorded before surgery and after surgery. Participants will have MRI before and after surgery, 3, 6, 12, and 24 months after surgery and Computertomography after surgery, 3, 6 and 24 months after surgery. Questionnaires (Knee-scores) will be recorded before surgery, 6, 12, 24 months after surgery.\n\nthe investigators hope that with the human cortical bone screw the tunnel widening is reduced and the re-rupture rate is low",[28,209,27],"Anterior Cruciate Ligament Reconstruction",[211,212,213,214,215,216,217,218,219,220,221],"ACL","tunnel widening","human allogeneic cortical bone screw","Shark Screw®","biotenodese screw","re-rupture rate","IKDC","KOOS","Lysholm Knee Score","Tegner Activity Score","range of motion (ROM)","2026-01-17",{"date":224,"type":44},"2026-01-21",{"date":226,"type":21},"2026-02-16",{"date":228,"type":21},"2034-01-31",{"name":230,"class":51},"Alexander Rofner-Moretti",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":238,"maxAge":18,"enrollmentInfo":239,"targetDuration":4,"studyType":241,"phases":4,"briefSummary":242,"conditions":243,"keywords":247,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":52},"100591427","comparison-of-quadriceps-and-semitendinosus-grafts-in-acl-reconstruction-using-data-from-the-danish-knee-ligament-reconstruction-registry-dkrr-100591427","NCT06980285","Comparison of Quadriceps and Semitendinosus Grafts in ACL Reconstruction Using Data From the Danish Knee Ligament Reconstruction Registry (DKRR)","ACL Reconstruction With Quadriceps Tendon Graft vs. Quadrupled Semitendinosus Graft: A Comparison of Patients From the Danish National ACL Reconstruction Database","Inclusion Criteria:\n\n* Primary ACL reconstruction registered in the Danish Knee Ligament Reconstruction Registry (DKRR)\n* Known graft type: quadriceps tendon or semitendinosus tendon Minimum 1-year follow-up with completed patient-reported outcome measures (KOOS and\u002For Tegner score)\n* Age between 15 and 50 years at the time of surgery (optional subgroup analysis)\n\nExclusion Criteria:\n\n* Revision ACL reconstruction\n* Multiligament knee reconstruction\n* Missing or incomplete PROMs or key clinical data","15 Years",{"count":240,"type":21},2500,"OBSERVATIONAL","This study looks at two different types of tendon (tissue) used in knee surgery to repair a torn anterior cruciate ligament (ACL), which is a common injury in active people. The two types are taken from different muscles in the thigh: one from the front (quadriceps) and one from the back (semitendinosus). We will use information already collected in a national health registry to see how patients recover after surgery. The study will compare knee function, activity level, and how often patients need another operation.",[27,244,245,246],"Knee Injury","Ligament Reconstruction","Sports Injuries",[30,248,249,250,251,252,253],"Quadriceps tendon graft","Semitendinosus graft","DKRR","Knee ligament injury","Orthopaedic surgery","Registry study","2025-05-12",{"date":256,"type":44},"2025-05-20",{"date":258,"type":21},"2025-06-01",{"date":260,"type":21},"2025-11-30",{"name":262,"class":51},"Abdirahman Hassan Omar"]