[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-reconstruction-rehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-reconstruction-rehabilitation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,44,76,103,130,162,187,210,238,262,288,317,342,369],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100641159","dry-needling-and-quad-strength-after-anterior-cruciate-ligament-reconstructon-100641159",false,"NCT07657195","Dry Needling and Quad Strength After Anterior Cruciate Ligament Reconstructon","Effects of Dry Needling on Quadriceps Muscle Strength in Acute Post-Operative Anterior Cruciate Ligament Reconstruction With Quadriceps Autograft in the Pediatric Population.","ACLR","Inclusion Criteria:\n\n* Status post subacute quadriceps autograft 6 weeks or less\n* Ages 10-20 years\n* English and\u002For Spanish speaking\n\nExclusion Criteria:\n\n* History of surgery on the knee or hip on the testing lower extremity.\n* Any surgical intervention to other ligamentous or meniscus structures during time of ACLR\n* Any post-surgical complications such as infection\n* Current pregnancy","ALL","10 Years","20 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Dry needling is a skilled intervention provided by trained physical therapists to treat pain, myofascial dysfunction, and a variety of other diagnosis. While there is research demonstrating the benefits of dry needling in reduction of pain and improvement in strength, research in regards the pediatric population is very limited. I recently completed a retrospective chart review regarding dry needling trends and outcomes in the pediatric orthopedic population. We now know the pediatric population is tolerating this treatment and seeing benefits. Physical therapists are already pushing the boundaries and finding additional benefits in the use of dry needling with our current patients. A diagnosis frequently seen in sports medicine is surgical reconstruction of the anterior cruciate ligament (ACL). Over the last couple of years, therapists have seen an increase in the use of quadriceps tendon autograft for reconstruction following ACL tears due to lower incidence rate of retears. These patients have been struggling to regain strength of the quadriceps to meet desired outcomes. The quadricep muscles are one of the major stabilizers of the knee and with a reduction in strength places the patient at a significant increase of retear.\n\nSubjects will be categorized into an experimental group (dry needling intervention + physical therapy) or the control group (physical therapy only) with a N of 20 in each group.\n\nThe goal for this research is to determine if dry needling use in the subacute phase of post-operative ACLR following quadriceps autograft can assist with increasing quad strength and improve post-surgical outcomes.",[28,29,30],"Anterior Cruciate Ligament Reconstruction Rehabilitation","Dry Needling","Strength","NOT_YET_RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-18","ACTUAL",{"date":37,"type":22},"2026-07-01",{"date":39,"type":22},"2027-06-30",{"name":41,"class":42},"Children's Mercy Hospital Kansas City","OTHER",3,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100602829","determining-the-effects-of-non-invasive-brain-stimulation-to-improve-quadriceps-muscle-function-after-acl-reconstruction-100602829","NCT07128602","Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction","Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction.","Inclusion Criteria:\n\n\\- females 2-6 months after ACL reconstruction\n\nExclusion Criteria:\n\n* multiple ligament reconstruction\n* osteochondral procedures\n* any previous lower extremity surgery\n* previous ACL injury\n* Metal or implants in the head or neck\n* history of neurological disease\n* seizures\n* severe migraines\n* concussion within the last 6 months","FEMALE","18 Years","35 Years",{"count":55,"type":22},42,[25],"After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.",[28,59],"Quadriceps Muscle Function",[61,62,63,64],"acl","acl reconstruction","corticospinal excitability","non-invasive brain stimulation","RECRUITING","2026-05-05",{"date":68,"type":35},"2026-05-07",{"date":70,"type":35},"2025-06-06",{"date":72,"type":22},"2028-03-01",{"name":74,"class":42},"Arcadia University",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":75},"100636754","effectiveness-of-stimulation-on-the-sciatic-nerve-in-aclr-100636754","NCT07569796","Effectiveness of Stimulation on the Sciatic Nerve in ACLR","\"Effectiveness of Percutaneous Electrical Nerve Stimulation on the Sciatic Nerve in Patients Undergoing Surgical Reconstruction of the Anterior Cruciate Ligament. A Randomized Clinical Trial\".","Inclusion Criteria:\n\n* Use of the Semitendinous and Gracilis tendons for ACL Reconstruction\n* Joint Range of Motion greater than or equal to 90\n* Primary ACL injury in the leg to be treated\n\nExclusion Criteria:\n\n* Chronic or rheumatic joint disease\n* Central nervous system disorder\n* Heart disease (pacemaker)\n* Neoplasms\n* Epilepsy\n* Coagulopathies (use of anticoagulants)\n* History of spinal surgery or lumbar disease\n* History of neurological disorders\n* Prosthesis or osteosynthesis in the operated leg\n* Structural discrepancy in lower-limb length\n* Belonephobia (overwhelming fear of needles)\n* Neuropathic pain or bilateral symptoms\n* Use of analgesics\n* Quadriceps tendon graft harvest\n* Body mass index \\\u003C20 or \\>30 kg\u002Fm²\n* Acute muscle injuries\n* Knee joint instability\n* Acute joint inflammation","60 Years",{"count":85,"type":22},62,[25],"After randomization, the control group will receive conventional physiotherapy, including manual therapy and therapeutic exercise for ACL rehabilitation. The first experimental group will undergo percutaneous electrical nerve stimulation of the sciatic nerve, while the second experimental group will receive a placebo stimulation. Both interventions aim to improve isometric strength, muscle activation, joint range of motion, and thigh circumference, as well as reduce pain and intra-articular effusion. The procedure involves needle insertion into the sciatic nerve epineurium, placement of a surface electrode on the hamstrings, and connection to an electrostimulator.",[28],[90,91,92,93],"PENS","ACL surgery","ACL rehabilitation","Sciatic Nerve","2026-05-04",{"date":96,"type":35},"2026-05-06",{"date":98,"type":35},"2025-12-01",{"date":100,"type":22},"2026-12",{"name":102,"class":42},"Universidad de Murcia",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":75},"100592266","acl-reconstruction-rehabilitation-with-exercise-and-psychological-support-100592266","NCT06991192","ACL Reconstruction Rehabilitation With Exercise and Psychological Support","ACLR-REPS","Inclusion Criteria:\n\n* Age 15 to 21 years at the time of surgery;\n* Pre-injury Tegner Activity Rating60 ≥ 5 (5=recreational sports, 10=elite sports);\n* Sports participation at least 100 hours\u002Fyear prior to injury;\n* Intent to resume a pre-injury sport that requires cutting, jumping, or pivoting;\n* ACL reconstruction performed ≤ 6 months from injury;\n* ACL reconstruction performed with bone-patellar tendon-bone autograft or quadriceps tendon autograft; and\n* Able to complete rehabilitation at one of the 4 participating TRIA locations.\n\nExclusion Criteria:\n\n* Previous ACL injury or surgery to either limb;\n* Concomitant ligamentous injury \\> Grade II or requiring surgery; and\n* Surgical procedure to articular cartilage requiring non-weight-bearing after surgery.","15 Years","21 Years",{"count":113,"type":22},60,[25],"The purpose of this study is to examine ACLR Rehabilitation with Exercise and Psychological Support (REPS), comparing two approaches for providing psychological support along with exercise during ACL reconstruction rehabilitation. In one group, physical therapists have received training that may boost emotional support during rehabilitation. In the other group, physical therapists will not have the training. Both groups will get similar exercises and participate in the same testing. Both groups will also watch short videos during rehabilitation that are specific to their group. Participants will not know to which group they are assigned until the end of the study. Participation will attend a total of four study visits over the course of 6 months, including 1 visit before the surgery and 3 visits during follow-up.",[28],[118,119,120,121],"ACL Reconstruction","Anterior Cruciate Ligament","Rehabilitation","Psychological","2026-05-01",{"date":66,"type":35},{"date":125,"type":35},"2025-05-01",{"date":127,"type":22},"2027-08-31",{"name":129,"class":42},"HealthPartners Institute",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":75},"100633220","effect-of-graft-type-on-knee-muscle-strength-after-acl-reconstruction-100633220","NCT07523854","Effect of Graft Type on Knee Muscle Strength After ACL Reconstruction","Effect of Graft Type on Knee Muscle Strength Development After Anterior Cruciate Ligament Reconstruction","GRAFT-ACL","Inclusion Criteria:\n\n* Age 13 to 45 years\n* Undergoing anterior cruciate ligament reconstruction with either hamstring tendon autograft or quadriceps tendon autograft\n* Unilateral anterior cruciate ligament injury\n* Complete ACL tear with accompanying minimal collateral ligament injury and first-degree meniscal tear\n* Tegner Activity Score of 5 or higher\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Anterior cruciate ligament reconstruction with patellar tendon autograft or allograft\n* Revision surgery\n* Systemic or neurological disease\n* Multiple ligament injuries\n* Grade III lateral or medial collateral ligament tear or significant articular cartilage lesion\n* Failure to regularly attend the rehabilitation program during the first 3 postoperative months\n* History of lower extremity injury in the contralateral limb within the last 12 months\n* Hypertension, cardiovascular disease, peripheral vascular disease, history of deep vein thrombosis, neurological disease, systemic inflammation, diabetes, cancer, or obesity","13 Years","45 Years",{"count":141,"type":22},80,"OBSERVATIONAL","This prospective observational study will compare recovery after anterior cruciate ligament reconstruction using quadriceps tendon autograft or hamstring tendon autograft. The main goal is to examine differences in knee muscle strength recovery during the early and mid-term postoperative period. Participants aged 13 to 45 years who undergo unilateral ACL reconstruction and meet the eligibility criteria will be followed at Hacettepe University. Knee extensor and flexor strength will be assessed using isometric testing at postoperative weeks 4, 8, and 12 and month 6, and with isokinetic concentric testing at months 3 and 6. Functional outcomes and kinesiophobia will also be evaluated at month 6 using IKDC, KOOS, and the Tampa Scale for Kinesiophobia. All participants will receive the same standard postoperative rehabilitation program under physiotherapist supervision. The study aims to clarify whether graft type is associated with different patterns of muscle strength recovery and functional improvement after ACL reconstruction",[28,145,146],"Strength Outcomes","Anterior Cruciate Ligament (ACL) Reconstruction Surgery",[148,149,150,151,152],"ACL reconstruction","quadriceps tendon autograft","hamstring tendon autograft","knee muscle strength","rehabilitation","2026-04-11",{"date":155,"type":35},"2026-04-15",{"date":157,"type":35},"2026-01-23",{"date":159,"type":22},"2027-02-25",{"name":161,"class":42},"Hacettepe University",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":169,"sex":17,"minAge":52,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":75},"100630273","validating-the-speckle-tracking-methods-on-soft-tissue-strain-displacement-and-roles-in-physical-therapy-100630273","NCT07485530","Validating the Speckle Tracking Methods on Soft Tissue Strain, Displacement, and Roles in Physical Therapy","Validating the Speckle Tracking Methods on Soft Tissue Strain, Displacement, and Roles in Physical Therapy: Ligaments (Sports), Tendons (Dysfunction), and Muscles (Exercise Intervention)","Inclusion Criteria:\n\nStudy 1\n\n* male pitchers aged between 18 and 35 years\n* more than five years of pitching experience\n* at least 200 counts of pitching training per week\n\nStudy 2\n\n* Age between 20 and 65 years\n* diagnosed with grade II posterior tibial tendon dysfunction and recommended by a physician for surgical intervention\n\nStudy 3\n\n* The participants were between 18 and 45 years old\n* had undergone unilateral anterior cruciate ligament semitendinosus tendon autograft reconstruction surgery within the past 6 years\n* were able to fully participate in the sports and training they had before their injury\n\nExclusion Criteria:\n\nStudy 1\n\n* diagnosed with partial or full thickness tears of the UCL by arthrographic\u002F nonarthrographic MR techniques in past medical records\n* having a positive result in the \"moving valgus stress test\" screening24\n* unable to participate in regular baseball pitching training or absent from the competition during the March 2023 to March 2025 season\n* found to show suspicious signs, such as hypoechoic foci and calcification, which suggest UCL injury under ultrasound screening4\n* with a \\\u003C80% compliance rate in the eight-week BFRT\n\nStudy 2\n\n* The lower extremities have undergone surgical intervention\n* The lower extremities have a known history of nerve or vascular injury\n* The ankles and feet have known ligament tears\n* Fixed deformities of the foot joints\n* The patient has a known physical condition that would affect the conduct of the experiment\n\nStudy 3\n\n* Having any orthopedic condition that prevents them from participating in the competition, such as arthritis or knee pain\n* having a history of hamstring muscle strain in the knee within the past 3 months\n* having an attendance rate of less than 80% in the subsequent eight weeks of training",true,"65 Years",{"count":141,"type":22},[25],"This three-year research project aims to test the hypothesis that strain and displacement characteristics of human soft tissues are influenced by (1) habitual physical activity, (2) functional impairment, and (3) training interventions. Over the three years, the ulnar collateral ligament of the elbow, the ankle tendon, and the hamstring muscles will be investigated sequentially. Ultrasound speckle-tracking techniques will be employed to verify these hypotheses and to provide a basis for clinical risk assessment of injury, development of therapeutic strategies, and evaluation of rehabilitation outcomes.\n\nIn the first year, strain and displacement of the medial ulnar collateral ligament (MUCL) in both longitudinal and transverse directions during passive isokinetic elbow valgus loading will be analyzed in baseball pitchers at high and low injury risk and in healthy controls. The results will be compared with ultrasonic shear-wave elastography. Participants will then undergo an 8-week low- to moderate-intensity blood-flow restriction resistance training program. This phase is expected to characterize ligament mechanical adaptations to long-term sports training, elucidate the relationship between such adaptations and injury risk, and evaluate the effects of resistance training on enhancing medial elbow joint stability.\n\nIn the second year, individuals with posterior tibial tendon dysfunction and healthy controls will be examined. Longitudinal strain and displacement, as well as transverse rotation and displacement of the tibialis posterior tendon during active ankle movements will be quantified and compared with shear-wave elastography measurements. These results are expected to clarify the relationship between tendon strain-displacement behavior and tendon dysfunction, provide mechanistic insights into tendon pathology, and inform optimal therapeutic strategies.\n\nIn the third year, patients following anterior cruciate ligament (ACL) reconstruction will be investigated. Longitudinal strain and displacement of the hamstring graft donor site, specifically the semitendinosus muscle-tendon unit, following eccentric training will be assessed and compared with shear-wave elastography and electromyography. This phase is expected to characterize post-harvest semitendinosus muscle activity patterns and their associations with postoperative muscle strength deficits.\n\nBy integrating findings across the three phases, the anticipated clinical implications of this project include determining whether:\n\n1. adaptive responses of ligaments to repetitive tensile loading during long-term sports participation (including strain behavior and mechanical properties) can serve as screening indicators for injury risk, and evaluating the effects of blood-flow restriction resistance training in these populations;\n2. three-dimensional strain, displacement, and rotation of tendons in response to muscle contraction and joint motion are associated with tendon dysfunction; and\n3. strain and displacement characteristics of the semitendinosus muscle (in relation to muscle recruitment) can be improved through postoperative functional training following its use as a graft source.",[175,176,28,177],"Ulnar Collateral Ligament Sprain","Tibialis Posterior Dysfunction","Ultrasound Evaluation","2026-03-16",{"date":180,"type":35},"2026-03-20",{"date":182,"type":22},"2026-03",{"date":184,"type":22},"2027-03",{"name":186,"class":42},"National Taiwan University Hospital",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":75},"100574677","effectiveness-of-blood-flow-restriction-in-postoperative-rehabilitation-for-anterior-cruciate-ligament-injuries-a-pilot-study-100574677","NCT06762392","Effectiveness of Blood Flow Restriction in Postoperative Rehabilitation for Anterior Cruciate Ligament Injuries. A Pilot Study.","Inclusion Criteria:\n\n* Patients aged between 18 and 45 years.\n* Patients who have undergone anterior cruciate ligament (ACL) reconstruction surgery\n\nExclusion Criteria:\n\n* Cardiovascular comorbidities\n* Severe metabolic disorders or postoperative complications\n* Previous joint disorders requiring surgery on the affected leg\n* Pregnancy\n* Coagulation disorders",{"count":21,"type":22},[25],"The goal of this clinical trial is to evaluate the effectiveness of adding Blood Flow Restriction (BFR) therapy to a standardized rehabilitation protocol in patients undergoing postoperative rehabilitation following anterior cruciate ligament (ACL) repair surgery.\n\nThe main questions it aims to answer are:\n\nDoes combining BFR therapy with a standardized rehabilitation protocol improve functional recovery compared to rehabilitation alone?\n\nDoes the addition of BFR therapy enhance muscle strength and reduce recovery time in patients after ACL repair surgery?\n\nParticipants will undergo their assigned rehabilitation protocol and will be assessed prior to and after the intervention to determine if the addition of BFR therapy to the standard rehabilitation programme significantly improves functional recovery, muscle strength, and overall rehabilitation outcomes following ACL repair surgery.",[28],[198,120,119,199,200],"Physical Therapy","Blood Flow Restriction","Randomized Clinical Trial","2026-03-04",{"date":203,"type":35},"2026-03-05",{"date":205,"type":35},"2025-01-01",{"date":207,"type":22},"2027-01-01",{"name":209,"class":42},"University of Valencia",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":216,"minAge":52,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":23,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":75},"100617154","the-effects-of-neuromuscular-training-on-knee-biomechanics-during-jump-landing-among-college-basketball-players-post-acl-reconstruction-and-rehabilitation-100617154","NCT07314931","The Effects of Neuromuscular Training on Knee Biomechanics During Jump-Landing Among College Basketball Players Post ACL Reconstruction and Rehabilitation","Inclusion Criteria:Male college basketball players\n\nAge 18-25 years\n\nHistory of anterior cruciate ligament (ACL) reconstruction surgery at least 12 months before enrollment\n\nCleared by physician for sports participation\n\nWilling to provide informed consent and comply with study procedures\n\nExclusion Criteria:Previous ACL injury on the contralateral knee\n\nOther major lower-limb injuries (e.g., meniscus, cartilage, fractures) in the past 12 months\n\nCurrent knee pain, swelling, or instability that prevents safe participation\n\nNeurological, cardiovascular, or systemic conditions that may affect training safety\n\nParticipation in another structured neuromuscular training program within the past 6 months","MALE","25 Years",{"count":219,"type":22},30,[25],"Basketball players often injure the anterior cruciate ligament (ACL), a key structure that stabilizes the knee. Even after surgery and standard rehabilitation, many athletes continue to have problems with knee stability, movement control, and performance during jumping and landing. These issues increase the risk of re-injury and can limit their ability to return to competition.\n\nNeuromuscular training (NMT) is a type of exercise program that focuses on improving balance, muscle coordination, and movement patterns. It uses activities such as jump-landing drills, balance tasks, agility exercises, and core training. Previous research shows that NMT can help athletes land more safely, reduce harmful knee movements, and improve sport performance. However, little is known about its long-term benefits in college basketball players who are more than one year post-ACL surgery.\n\nThis study aims to evaluate whether a 12-week NMT program, added to standard basketball training, can improve knee biomechanics, stability, and performance in college basketball players with a history of ACL reconstruction. Thirty participants will be randomly assigned to either an NMT group or a control group. Both groups will complete basketball training, but only the NMT group will receive the additional neuromuscular exercises.\n\nKnee movement will be measured using 3D motion capture and force plates, and performance will be tested through vertical jumps and other sport-specific tasks. The main outcomes will include knee angles during landing, ground reaction forces, dynamic stability, and jump height.\n\nThe expected outcome is that athletes who undergo NMT will demonstrate safer landing strategies, better knee control, and improved performance compared to those who only receive standard basketball training. These findings may help coaches and healthcare providers design safer, more effective rehabilitation programs for athletes after ACL surgery.",[28,223,224,225,226,227,228],"Knee Injuries","Biomechanical Data","Athletic Performance","Physical Fitness","Neuromuscular Training","Basketball Players","2026-01-06",{"date":231,"type":35},"2026-01-07",{"date":233,"type":22},"2025-12-10",{"date":235,"type":22},"2026-05-15",{"name":237,"class":42},"Universiti Sains Malaysia",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":170,"enrollmentInfo":245,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":75},"100616855","effect-of-blood-flow-restriction-rraining-on-rehabilitation-after-anterior-cruciate-ligament-reconstruction-100616855","NCT07311031","Effect of Blood Flow Restriction Rraining on Rehabilitation After Anterior Cruciate Ligament Reconstruction","Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Knee Biomechanics and Rehabilitation After Anterior Cruciate Ligament Reconstruction in Active Workers","Inclusion Criteria:\n\n* Male or female (18-65 years of age); must be skeletally mature with closed physes\n* Worker active\n* Diagnosis of acute (\\\u003C8 weeks), unilateral ACL tear with planned surgery confirmed via clinical examination and MRI\n* No previous ACL injury or reconstruction on the involved limb\n* Planned graft: autologous ipsilateral hamstring graft for ACL reconstruction\n* Planned fixation: suspensory cortical femoral device and tibial interference screw\n\nExclusion Criteria:\n\n* Completed knee dislocation or multiligament injury (PCL, MCL, LCL)\n* ACL Graft diameter \\\u003C 8mm\n* Meniscal suture or meniscal root reattachment\n* Post-surgical immobilization\n* Any current or previous conditions or surgeries that might affect gait\n* Pregnant\n* Spinal fusion\n* Any implanted medical device or other contraindications for MRI\n* History of deep vein thrombosis and\u002For varicose veins or familiy history of deep vein thrombosis\n* Taking anti-coagulant drugs for any blood, cardiac or congenital disease that may cause coagulation disorders\n* Taking bone and muscle metabolism-modulation drugs or muscle supplements (e.g., creatine, amino acids, whey protein,…)\n* Recent inflammation, bleeding disorders, active bleeding, or infection within the lower limbs\n* Diabetic or have uncontrolled hypertension\n* Diminished capacity to provide informed consent\n* Unfeasible to attend regular physical therapy and study visits",{"count":113,"type":22},[25],"Importance: Following anterior cruciate ligament reconstruction (ACLR), patients often experience quadriceps muscle weakness and atrophy, frequently leading to long-term complications. A promising rehabilitation program based on blood flow restriction training (BFRT) seems to be particularly valuable for patients who may be unable to train with heavy loads due recent surgery. Previous studies have demonstrated that BFRT promotes strength gains and muscle mass increases, with adaptations comparable to traditional high-intensity training, despite using low-load resistance exercises.\n\nObjective: to evaluate the effect of blood flow restriction training on quadriceps strength and knee biomechanics in a 4-month rehabilitation program of patients who have had an ACL reconstruction.\n\nDesign: The study will be a two-arm superiority randomized controlled clinical trial.\n\nSetting: The trial will be conducted at a work-related injuries specialised hospital, MAZ Hospital, Zaragoza, Spain.\n\nParticipants: Participants will be active workers who have suffered an acute ACL tear and they have undergone ACL reconstruction (n=60).\n\nIntervention: Patients will recieve a 14-16-week supervised accelerated early rehabilitation protocol; one group will complete it applying blood flow restriction training and the other will not.\n\nMain Outcome and Measure: The primary outcomes will be peak quadriceps strength and rate of torque development measured both isometrically and isokinetcally with a Isokinetic Dynamometer CON-TREX MG.\n\nLimitations: Potential limitations include patients and physiotherapists are not blinded.\n\nConclusions: The focus of the research will examine the impact of blood flow restriction rehabilitation on patients who have undergone ACLR.\n\nRelevance: The study has potential to restore quadriceps strength to a greater extent than standard rehabilitation protocol. Moreover, patients will spend less time in the rehabilitation process to return to work compared to standard care.",[28,249],"Blood Flow Restriction (BFR) Training Effects",[251,252,92],"KAATSU","Knee injury","2025-12-30",{"date":255,"type":35},"2026-01-05",{"date":257,"type":22},"2025-12-20",{"date":259,"type":22},"2027-09-01",{"name":261,"class":42},"Hospital MAZ",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":11,"sex":17,"minAge":269,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":276,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":75},"100578969","effects-of-tdcs-on-motor-cortex-during-acl-recovery-100578969","NCT06818201","Effects of tDCS on Motor Cortex During ACL Recovery","Effects of Transcranial Direct Current Stimulation Over Motor Cortex During Recovery of ACL Patients","Inclusion Criteria:\n\n* Diagnosis complete ACL tear through clinical evaluation and MRI imaging.\n* Patients who have received surgical intervention.\n* Aged between 16 and 40 years.\n* Tegner activity level of 4 or higher.\n\nExclusion Criteria:\n\n* Rupture, such as tendons, cartilage, bones, or ligaments.\n* Absence of any pre-existing or current lower limb pathologies, such as open surgeries, knee arthroscopies, or femur\u002Ftibia fractures.\n* Neuromuscular or metabolic diseases.\n* Concussion within the past six months are not eligible.\n* Cranial surgery or have intracranial metal clips are ineligible.\n* Taking medications that affect neuronal activity.\n* Neurological diseases or disorders are not eligible for participation.","16 Years","40 Years",{"count":272,"type":22},54,[25],"Anterior Cruciate Ligament (ACL) is a prevalent injury, particularly among young and physically active individuals. The efficacy of transcranial direct current stimulation (tDCS) and exercise-based rehabilitation on neuromuscular control in post-ACL reconstruction patients is evaluated, and these techniques are combined.",[28],[277,119,278,279],"motor control","exercise","tDCS",{"date":281,"type":35},"2025-12-02",{"date":283,"type":35},"2025-11-28",{"date":285,"type":22},"2027-12-27",{"name":287,"class":42},"Fundación Universidad Católica de Valencia San Vicente Mártir",{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":53,"enrollmentInfo":296,"targetDuration":4,"studyType":23,"phases":298,"briefSummary":299,"conditions":300,"keywords":303,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":75},"100611665","fractal-vs-isochronous-cueing-in-athletes-after-acl-reconstruction-100611665","NCT07243535","Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction","Comparison Between a Session of Walking Synchronized to Fractal- VS Isochronous-Based Cues on Gait Variability and Corticospinal Measures in Athletes With a Reconstructed Anterior Cruciate Ligament: A Crossover Randomized Controlled Trial","SyncGait","Inclusion Criteria:\n\n* Undergone unilateral ACL reconstruction less than 2 years ago;\n* Have medical release for the full load on the injury limb for at least 2 weeks;\n* Be independently pain-free walking;\n* Being sports athletes according to an athlete description: Training regularly to improve performance, actively participating in competitions or formally registering in a sports federation or association;\n* Must be able to understand and perform the requested task.\n\nExclusion Criteria:\n\n* Participants with previous surgery on either knee;\n* Those with more than 3 months between ACL injury and surgery;\n* More than 2 weeks between surgery and the start of physical therapy;\n* Had another musculoskeletal injury in the lower limb within the past 6 months;\n* Another musculoskeletal surgery within the past 18 months;\n* Participants with a history of movement system pathologies, such as nervous system, cardiovascular, pulmonary, integumentary, or endocrine conditions;\n* Participants with vestibular or somatosensory system pathologies or visual impairments limiting their ability to see the metronome required for the task;\n* Use of medications that could affect locomotion and balance.",{"count":297,"type":22},36,[25],"Anterior cruciate ligament (ACL) injuries are among the most prevalent and functionally limiting knee injuries in sports, particularly those that involve pivoting movements. Despite advancements in surgical reconstruction and physical rehabilitation, many athletes continue to exhibit persistent motor control deficits and increased gait variability, both of which are closely linked to a heightened risk of re-injury and long-term joint degeneration. These deficits arise from biomechanical impairments and disrupt proprioceptive input that requires cortical reorganization, contributing to maladaptive neuroplasticity. However, conventional rehabilitation strategies often overlook this neural dimension. Recent findings emphasize the importance of fostering motor variability and promoting neuroplasticity through external focus strategies, including sensorimotor synchronization. While isochronous cues, an invariant stimulus, are commonly used, they do not reflect the natural fluctuations of healthy gait and may reduce its complexity. Fractal-based cues, in contrast, introduce structured variability resembling the natural dynamics of locomotion and have been shown to restore gait complexity in clinical populations. However, no study has yet explored their acute effects on gait variability and corticospinal function following ACL reconstruction (ACLR). This crossover randomized controlled trial aims to compare the acute effects of a single session of treadmill walking synchronized to either fractal or isochronous-based visual cues on gait variability and corticospinal measures in athletes with ACLR. The investigators hypothesize that fractal-based cueing will acutely restore gait variability and enhance corticospinal excitability, evidenced by increased corticospinal excitability and intracortical facilitation, and reduced short-interval intracortical inhibition, thus promoting adaptive neuroplasticity. Conversely, isochronous cueing is expected to maintain or decrease gait complexity without improving corticospinal measures. This study may provide insights that could be highly valuable as a way to promote neuroplasticity and optimize gait rehabilitation after ACLR, also allowing an objective quantification and aiming to restore variability to levels close to those observed in healthy individuals, thus contributing to reducing the re-injury rate.",[301,28,302],"Anterior Cruciate Ligament Reconstruction","Athlete",[304,305,306,307,120],"Complexity","Excitability","Metronome","Neuroplasticity","2025-11-17",{"date":310,"type":35},"2025-11-24",{"date":312,"type":35},"2025-10-03",{"date":314,"type":22},"2026-02",{"name":316,"class":42},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":328,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":75},"100590916","evaluation-of-home-based-telerehabilitation-platform-to-augment-orthopedic-rehabilitation-100590916","NCT06973642","Evaluation of Home-based Telerehabilitation Platform to Augment Orthopedic Rehabilitation","Inclusion Criteria:\n\n* Patients that are candidates for anterior cruciate ligament reconstruction.\n\nExclusion Criteria:\n\n* Visual impairment greater than 20\u002F200 with the use of corrective lenses\n* Does not own or have consistent access to a phone with data capabilities\n* Has been informed by their healthcare provider that they should not participate in physical therapy services\n* Participants can be excluded from the study at any time if the physical therapist determines the patient is not an appropriate candidate for telehealth therapy.",{"count":324,"type":22},15,[25],"The goal of this study is to assess the feasibility of utilizing a telehealth rehabilitation platform to increase patient access for individuals who have undergone orthopedic surgery.\n\nPatient participants will be seen via telehealth until they are able to be seen by an in-person physical therapist of their choice.\n\nProvider participants will be the physical therapist who are providing physical therapy services through the telehealth application.\n\nData collection:\n\nPatient and provider post surveys Home program and scheduled visit compliance rate Healthcare information in keeping with Stand of care physical therapy practices\n\nFeasibility criteria will be assessed to determine whether this modality improves physical therapy access for patients living in rural areas.",[28],[329,330,331,332],"telerehabilitation","telehealth","physical therapy","Anterior Cruciate Ligament Rehabilitation","2025-07-22",{"date":335,"type":35},"2025-07-24",{"date":337,"type":35},"2025-06-01",{"date":339,"type":22},"2026-12-31",{"name":341,"class":42},"University of Mississippi Medical Center",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":270,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":353,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":365,"leadSponsor":366,"locationsCount":368},"100585694","effects-of-eccentric-training-in-the-rehabilitation-of-patients-undergoing-anterior-cruciate-ligament-reconstruction-a-randomized-controlled-trial-100585694","NCT06905691","Effects of Eccentric Training in the Rehabilitation of Patients Undergoing Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.",{"count":349,"type":22},34,[25],"This study aims to investigate the effects of eccentric training on the functional rehabilitation of patients undergoing Anterior Cruciate Ligament Reconstruction (ACL-R). Thirty-four participants undergoing ACL-R will be randomly assigned to two groups: the Conventional Training Group (CTG) and the Eccentric Training Group (ETG). Both groups will adhere to the same post-surgical rehabilitation program, commencing in the first week after ACL-R and continuing until the criteria for sports resumption are achieved. The rehabilitation program will be structured into four phases: immediate post-operative, preparatory, general acquisition, and specific acquisition. The key distinction between the groups lies in their exercise regimen: ETG will prioritize the eccentric phase of movement, whereas CTG will engage in conventional exercises, maintaining uniform load across both movement phases. Assessment procedures will be conducted at three intervals for all participants: immediately post-operative, at 12 weeks post-ACL-R surgery (before the initiation of the training protocol), and at 25 weeks post-ACL-R surgery (upon completion of the training protocol). The primary outcome measure will be the maximum isometric strength of knee extensors. Secondary outcomes will encompass functional status, maximum isometric strength of knee flexors, peak dynamic strength during leg press, quadriceps muscle atrophy, performance in jump tests, and psychological readiness.",[28,301],[354,355,356,357,358,359],"Knee","Physiotherapy","Quadriceps","Anterior cruciate ligament reconstruction","Eccentric Exercise","Eccentric","2025-04-22",{"date":362,"type":35},"2025-04-24",{"date":364,"type":35},"2025-03-01",{"date":100,"type":22},{"name":367,"class":42},"Federal University of Health Science of Porto Alegre",2,{"id":370,"slug":371,"hasResults":11,"nctId":372,"briefTitle":373,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":270,"enrollmentInfo":375,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":379,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":387,"locationsCount":368},"100536064","neuromuscular-electrical-stimulation-superimposed-or-not-on-voluntary-contraction-after-reconstruction-of-the-anterior-cruciate-ligament-a-randomized-controlled-trial-100536064","NCT06259968","Neuromuscular Electrical Stimulation Superimposed or Not on Voluntary Contraction After Reconstruction of the Anterior Cruciate Ligament: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Failure to attend the pre-surgery assessment session;\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.",{"count":21,"type":22},[25],"This study aims to evaluate the effectiveness of neuromuscular electrical stimulation with superimposed voluntary contraction (NMES+ group) compared to NMES without voluntary contraction (NMES group) during the initial month of rehabilitation post anterior cruciate ligament reconstruction (ACLR). Forty patients will be randomly assigned to either the NMES group or the NMES+ group. Both groups will follow an identical rehabilitation regimen in the first month after surgery, which includes interventions for symptom management, inflammation control, edema reduction, improved joint motion range, and restoration of muscle function.\n\nAll participants will undergo identical assessment protocols at four time points: pre-surgery evaluation, and assessments at 2, 15, and 30 days post-ACLR. The primary outcome of the study is the maximal isometric strength of knee extensors. Secondary outcomes encompass thigh muscle atrophy, self-reported functional impairments, knee pain, knee edema, joint range of motion, and quadriceps activation status.",[28,301],[380,354,355,356,357],"Neuromuscular Electrical Stimulation","2025-03-31",{"date":383,"type":35},"2025-04-01",{"date":385,"type":35},"2024-05-01",{"date":339,"type":22},{"name":367,"class":42}]