[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-reconstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-reconstruction":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,55,86,117,140,164,185,207,242,274,300,324,356,380,409,433,451,471,498,518,543,569,590,612,633],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100594505","phase-2-brain-computer-interface-visualization-training-to-optimize-muscle-activation-following-orthopaedic-surgery-100594505",false,"NCT07020312","Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery","Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery: A Blinded Randomized Controlled Trial","iBrainTechRCT","Participants\n\n* Inclusion Criteria:\n\n  * Patient age \\>18 years\n  * Ability to complete neurofeedback training and follow study follow-ups\n  * Indicated for one of the four investigated orthopedic procedures\n* Exclusion Criteria:\n\n  * Inability to participate in neurofeedback training\n  * Lack of decisional capability\n  * History of stroke, movement disorder (e.g. Parkinson's), peripheral neuropathy\n  * Cardiac pacemaker or other internal electronic device\n  * BMI \\>35\n  * Previous surgery or specific pathology on the affected joint (refer to procedure specific indications below)\n\nProcedure Specifics:\n\nAnterior cruciate ligament reconstruction (ACLR) Procedure-specific Inclusion Criteria\n\n* Patients undergoing primary ACLR with autograft or allograft tissue\n* Adjunct lateral Extra-articular tenodesis will be included\n* Additional meniscus debridement and repair will be included Procedure-specific exclusion criteria\n* Revision ACL surgery\n* Moderate to Severe arthritis - Kellgren-Lawerence (KL) Grade \\> 3\n* Patients with meniscus root repair\n* Non-weight-bearing status exceeding 1 week postoperatively\n\nTotal knee arthroplasty (TKA) Procedure specific inclusion criteria\n\n* Patients undergoing primary TKA\n* Preoperative total knee range of motion of at least 100 degrees (combined flexion and extension)\n* Prior extensor mechanism tendon repair, quadriceps or patella tendon. Procedure specific exclusion criteria\n* Revision surgery\n* Hinged implant\n* Any open procedure involving the knee joint\n* Symptomatic arthritis in the contralateral knee with planned or expected total knee arthroplasty within 6 months\n* Inflammatory Arthritis\n\nTotal hip arthroplasty (THA) Procedure Specific Inclusion Criteria\n\n* Patients undergoing primary THA Procedure Specific Exclusion Criteria\n* Revision Surgery\n* Any open procedure involving the hip joint\n* Bilateral THA procedures\n* Inflammatory Arthritis\n\nHip arthroscopy (HA) for femoroacetabular impingement syndrome (FAIS) Procedure Specific Inclusion Criteria\n\n· Patients undergoing HA for FAIS Procedure Specific Exclusion Criteria\n\n* Revision Surgery\n* Diagnosis of hip dysplasia","ALL","18 Years",{"count":21,"type":22},240,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","After orthopedic surgeries like knee or hip replacement, some patients struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). AMI can slow recovery and make physical therapy less effective. This clinical trial is testing whether a special type of brain training-called neurofeedback visualization training-can help improve muscle activation and speed up recovery.\n\nIn this study, patients will receive standard physical therapy after surgery. Half of them will also use a device that helps them \"visualize\" exercises while wearing a cap that reads brain signals (EEG). The cap tracks brain activity when patients imagine doing specific movements. A computer then shows a virtual avatar performing the movements, giving feedback in real time-like a video game controlled by the brain.\n\nThe study includes patients recovering from one of four surgeries:\n\n1. Anterior cruciate ligament reconstruction (ACLR)\n2. Total knee arthroplasty (TKA)\n3. Total hip arthroplasty (THA)\n4. Hip arthroscopy (HA) for femoroacetabular impingement (FAI)\n\nThe goal is to see if this training improves muscle strength, movement, and daily function more than standard therapy alone. The study will take place at Rush University Medical Center in Chicago and enroll 240 adults, with 60 patients per type of surgery. Each participant will be followed for up to 6 months after surgery and complete strength tests, movement assessments, and questionnaires about their recovery.\n\nThe hope is that combining brain training with physical therapy will lead to faster, more complete recoveries and improve how patients move after surgery.",[28,29,30,31],"Anterior Cruciate Ligament Reconstruction","Total Hip Arthroplasty (THA)","Total Knee Arthroplasty","Hip Arthroscopy",[33,34,35,31,36,37,38,39,40,41],"ACLR","THA","TKA","Arthrogenic muscle inhibition","Electroencephalography","Gait","Motion Analysis","Biomechanics","Strength","RECRUITING","2026-06-17",{"date":45,"type":46},"2026-06-18","ACTUAL",{"date":48,"type":46},"2025-08-14",{"date":50,"type":22},"2028-08-01",{"name":52,"class":53},"Rush University Medical Center","OTHER",1,{"id":56,"slug":57,"hasResults":12,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100579084","tourniquet-vs-dual-flow-arthroscopy-sheath-in-anterior-cruciate-ligament-acl-reconstruction-100579084","NCT06819696","Tourniquet vs. Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction","A Prospective, Randomized Controlled Study Comparing Tourniquet Use Versus a Dual-flow Arthroscopy Sheath in Anterior Cruciate Ligament (ACL) Reconstruction Surgery.","RELICA","Inclusion Criteria:\n\n* Primary ACL reconstruction\n* Age 18 years or older\n* Provided informed consent prior to study participation\n* Affiliated to or beneficiary of a social security regimen\n\nExclusion Criteria:\n\n* Multi-ligamentous surgery\n* Revision ACL surgery\n* Presence of a meniscal and\u002For chondral lesion not allowing immediate weight-bearing postoperatively\n* Bleeding disorder\n* Pregnant, parturient or breastfeeding women\n* Patient under legal guardianship\n* Any other reason which, in the opinion of the investigator, could interfere with the evaluation of the objectives of the study objectives",{"count":64,"type":22},128,[66],"NA","This is a prospective randomized study comparing tourniquet use versus a dual-flow arthroscopy sheath in Anterior Cruciate Ligament (ACL) reconstruction surgery.\n\nThe ACL is largely responsible for knee stability and contributes to central pivot with the posterior cruciate ligament. ACL rupture is associated with a violent twisting motion of the knee, which is usually irreparable without surgical intervention.\n\nACL reconstruction via arthroscopy is the gold standard treatment for young, active patients with knee instability. Reconstruction is commonly performed using a thigh tourniquet to improve intraoperative visibility, reduce bleeding, and shorten procedure time. However, numerous studies associate tourniquet use with an increased risk of postoperative complications such as increased pain, muscle injury, postoperative bleeding, and deep vein thrombosis. Therefore, it seems relevant to conduct further investigations into the benefits of new methods to replace tourniquet. In this context, the dual-flow arthroscopy sheath could improve postoperative recovery after ACL reconstruction and could limit the risk of complications, thus improving ambulatory care for patients.\n\nThis study propose to compare two groups of patients undergoing ACL reconstruction: those operated on with a tourniquet versus those operated on using the dual-flow arthroscopy sheath.",[28],[70,71,72,73,74,75],"Anterior Cruciate Ligament","Arthroscopy","Dual-flow arthroscopy sheath","Tourniquet","pain","Surgery","2026-06-15",{"date":78,"type":46},"2026-06-16",{"date":80,"type":46},"2025-05-12",{"date":82,"type":22},"2028-04",{"name":84,"class":53},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer",3,{"id":87,"slug":88,"hasResults":12,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":12,"sex":18,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":54},"100609671","prospective-evaluation-of-silk-fibroin-incision-dressings-in-acl-reconstruction-100609671","NCT07217613","Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction","Prospective Evaluation of Silk Fibroin Versus 2-Octyl Cyanoacrylate Incision Dressings Following ACL Reconstruction","Inclusion Criteria:\n\n* Age 14 to 60 years\n* Scheduled for primary or revision ACL reconstruction (ACLR)\n* Able and willing to provide informed consent (≥18 years) or assent with parental\u002Fguardian permission (ages 14-17)\n* Able and willing to comply with all study-related procedures and follow-up visits\n\nExclusion Criteria:\n\n* Active dermatologic conditions at or near the surgical site (e.g., eczema, psoriasis, dermatitis, open wounds)\n* Immunocompromised state (e.g., uncontrolled HIV, ongoing chemotherapy, chronic corticosteroid therapy)\n* Known or suspected allergy or hypersensitivity to silk fibroin or cyanoacrylate adhesives\n* Uncontrolled diabetes (defined as most recent HbA1c ≥ 8.0, if available; not measured for study purposes)\n* Active systemic infection at the time of enrollment","14 Years","60 Years",{"count":96,"type":22},100,[66],"The purpose of this study is to compare the incidence of early postoperative skin complications including allergic contact dermatitis, blistering, and erythema between silk fibroin incision dressings and cyanoacrylate closure in patients undergoing anterior cruciate ligament reconstruction.",[28],[101,102,103,104,105,106,107],"ACL reconstruction","silk fibroin","cyanoacrylate","sports medicine","SYLKE","wound dressing","allergic contact dermatitis","2026-05-06",{"date":110,"type":46},"2026-05-08",{"date":112,"type":46},"2025-10-14",{"date":114,"type":22},"2026-07",{"name":116,"class":53},"NYU Langone Health",{"id":118,"slug":119,"hasResults":12,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100635663","the-impact-of-superimposed-vibration-on-the-recovery-of-muscle-strength-and-function-following-anterior-cruciate-ligament-surgery-100635663","NCT07555613","The Impact of Superimposed Vibration on the Recovery of Muscle Strength and Function Following Anterior Cruciate Ligament Surgery","VIBRA-LCA","Inclusion Criteria:\n\n* Men or women who have undergone anterior cruciate ligament reconstruction (using the Kenneth Jones method or a hamstring graft) on the right or left leg\n* Be between the ages of 18 and 45\n* Be enrolled in or eligible for a social security program\n* Have signed an informed consent form\n\nExclusion Criteria:\n\n* Patients who have previously undergone anterior cruciate ligament reconstruction\n* Patients not currently under care at the Dracy-le-Fort Orthopedic Center\n* Patients with chronic sensorimotor disorders\n* Patients who have previously undergone ligament reconstruction on the knee currently being operated on\n* Patients undergoing surgery more than one year after a cruciate ligament rupture\n* Pregnant women, women in labor, or breastfeeding women\n* Individuals subject to legal protection measures (judicial protection, guardianship, or conservatorship)\n* Individuals deprived of liberty by judicial or administrative order\n* Individuals receiving psychiatric care\n* Individuals subject to a period of exclusion for another study\n* Non-consenting subjects who cannot give consent, or cannot return for scheduled visits as per the protocol","45 Years",{"count":126,"type":22},62,[66],"Restoring muscle strength following knee ligament reconstruction (of the anterior cruciate ligament, ACL) is a major challenge for the functional success of rehabilitation. Despite advances in rehabilitation protocols, many patients still experience persistent strength deficits several months after surgery. Current rehabilitation strategies rely primarily on neuromuscular training programs aimed at restoring maximum strength and joint range of motion. However, these approaches exhibit significant interindividual variability and do not always fully resolve persistent muscle inhibition. In this context, local vibration appears to be a promising tool. This project aims to evaluate the benefits of repeated application of local vibration superimposed on muscle strengthening exercises (recovery of quadriceps strength, single-leg balance, quadriceps power, perception of effort and pain, knee range of motion) performed during the first six weeks of post-ligamentoplasty rehabilitation. The underlying hypothesis is that the addition of sensory stimulation via vibration, superimposed on rehabilitation exercises, could facilitate muscle activation and, ultimately, accelerate the functional recovery of the quadriceps.The expected results could help validate the use of this approach as a standardized tool within post-ACL rehabilitation protocols, by promoting faster muscle recovery and reducing the duration of functional disability.",[28],"NOT_YET_RECRUITING","2026-04-21",{"date":133,"type":46},"2026-04-29",{"date":135,"type":22},"2026-04-01",{"date":137,"type":22},"2027-12-01",{"name":139,"class":53},"Centre orthopédique de Dracy-le-Fort",{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":124,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":152,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":54},"100554035","the-effect-of-hyperbaric-oxygen-therapy-for-acceleration-recovery-after-anterior-cruciate-ligament-reconstructionaclr-100554035","NCT06493851","The Effect of Hyperbaric Oxygen Therapy for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction(ACLR)","The Effect of Hyperbaric Oxygen Therapy (HBOT) for Acceleration Recovery After Anterior Cruciate Ligament Reconstruction (ACLR): a Prospective, Randomized Control Study.","Inclusion Criteria:\n\n1. Subjects willing and able to read, understand and sign an informed consent\n2. Age 18-45\n3. Anterior cruciate ligament tear for reconstruction (with or without meniscal repair).\n\nExclusion Criteria:\n\n1. Inability to attend scheduled clinic visits and\u002For comply with the study protocol\n2. Additional injury\n3. An inability to perform MRI.\n4. Active malignancy\n5. Chest pathology incompatible with pressure changes (including active asthma)\n6. Ear or sinus pathology incompatible with pressure changes\n7. History of epilepsy\n8. Claustrophobia\n9. Previous knee surgery\n10. Participation in another study",{"count":148,"type":22},40,[66],"The aim of the current study is to evaluate the effect of HBOT for acceleration recovery after ACLR.",[28],[153],"hyperbaric oxygen therapy","2026-04-19",{"date":156,"type":46},"2026-04-22",{"date":158,"type":46},"2024-09-15",{"date":160,"type":22},"2028-01-01",{"name":162,"class":163},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":54},"100577463","phase-1-anterior-cruciate-ligament-acl-reconstruction-with-autologous-fat-pad-derived-mesenchymal-stem-cells-100577463","NCT06798623","Anterior Cruciate Ligament (ACL) Reconstruction With Autologous Fat Pad Derived Mesenchymal Stem Cells","Inclusion Criteria:\n\n* Patients 18 years of age or older who are scheduled to undergo anterior cruciate ligament (ACL) reconstruction with bone-to-bone (BTB) patellar tendon autograft with the Principal Investigator (PI).\n* Receiving post-surgery physical therapy at a Houston Methodist physical therapy (PT) clinic.\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Prior surgery on affected knee\n* Diabetes\n* Root repair, inflammatory arthropathy, or any other concomitant procedure that cannot follow an accelerated PT protocol or any concomitant procedure that the PI deems exclusionary\n* Unable to attend physical therapy at Houston Methodist\n* Vulnerable populations\n* Immunocompromised patients such as those being treated for cancer, kidney failure, etc.\n* Heart disease (including systolic blood pressure \\>180 mm Hg or heart failure)\n* Active infections\n* Non-English-speaking patients\n* Any known metal implants or allergy to contrast agents\n* Pregnancy (as part of standard of care, all female participants will be administered a urine pregnancy test prior to surgery. A negative result is required to proceed with surgery per SOC and thus, participate in the study) and those planning to become pregnant during the duration of the study\n* Any condition with known bleeding disorders, thrombus formation risk factors, or overlying wound and skin infections\n* Any condition in the opinion of the primary investigator that would compromise the integrity of the data collection or outcomes being assessed\n* Any other medical condition that in the opinion of the primary investigator would constitute a relative contraindication to study participation (e.g., Ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, SLE, scleroderma, polymyositis, Ehlers-Danlos syndrome, osteoporosis)",{"count":171,"type":22},15,[173],"PHASE1","This study is designed as a prospective, open label, single arm pilot clinical study that will establish the safety and efficacy of a single injection of mesenchymal stromal cells in patients. Each subject will receive one intra-articular injection of autologous mesenchymal stromal cells derived from infrapatellar fat pad (FP-MSC) tissue samples collected from the subject during anterior cruciate ligament (ACL) reconstruction surgery.",[28],"2026-04-15",{"date":178,"type":46},"2026-04-16",{"date":180,"type":46},"2026-03-24",{"date":182,"type":22},"2030-03",{"name":184,"class":53},"The Methodist Hospital Research Institute",{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":54},"100328173","phase-2-the-effects-of-tranexamic-acid-on-joint-inflammation-and-cartilage-health-in-anterior-cruciate-ligament-injured-patients-100328173","NCT03552705","The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients","Novel Strategies to Combat Post-Traumatic Osteoarthritis (PTOA):The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients","Inclusion Criteria:\n\n* age 18-30 years\n* within 4 days of unilateral ACL injury\n* presence of effusion\u002Fhemarthrosis.\n\nExclusion Criteria:\n\n* inflammatory arthritis, radiographic osteoarthritis (K-L Grade 2 or higher), gout\u002F pseudogout\n* systemic or acute illness requiring medications\n* concomitant knee injury aside from meniscus tear and MCL tear not requiring surgery\n* prior surgery to either knee\n* prior injury to either knee requiring crutches\n* history of thromboembolic disease\n* current use of combination hormonal contraception\n* chronic NSAID use\n* cortisone injection to either knee within the prior 3 months\n* not indicated for or unable to undergo ACLR within 3 months of injury","30 Years",{"count":194,"type":22},50,[25],"Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medication that reduces bleeding right after ACL injury and reconstructive surgery reduces inflammation and improves joint health as a new strategy to prevent or delay the onset of PTOA.",[28],"2026-02-25",{"date":200,"type":46},"2026-02-27",{"date":202,"type":46},"2019-08-01",{"date":204,"type":22},"2027-01-14",{"name":206,"class":53},"Stanford University",{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":23,"phases":216,"briefSummary":217,"conditions":218,"keywords":221,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":54},"100543532","acl-reconstruction-with-shark-screw-or-biocomposite-interference-screws-100543532","NCT06357091","ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws","ACL Reconstruction With Human Allograft Cortical Bone Screw (Shark Screw®) or Biocomposite-interference Screws - a Prospective, Randomized, Controlled Trial.","Inclusion Criteria:\n\n* MRI-verified rupture of the anterior cruciate ligament\n* Indication for replacement surgery\n* Surgery within 6 months of injury\n* Uninjured contralateral knee\n\nExclusion Criteria:\n\n* Previous rupture of the anterior cruciate ligament on the side to be operated on (rerupture)\n* Primary bone disease\n* inflammatory disease\n* Unstable meniscus\n* complete rupture of a collateral ligament\n* early rerupture during the examination period (early rerupture)",{"count":215,"type":22},80,[66],"The goal of this clinical trial is to compare the outcome of 2 different screws for Anterior cruciate ligament reconstruction. The main question is if the human allogeneic cortical bone screw reduces tunnel widening in comparison to conventional treatment with a biocomposite screw. Additional the re-rupture rate will be evaluated and knee scores will be recorded before surgery and after surgery. Participants will have MRI before and after surgery, 3, 6, 12, and 24 months after surgery and Computertomography after surgery, 3, 6 and 24 months after surgery. Questionnaires (Knee-scores) will be recorded before surgery, 6, 12, 24 months after surgery.\n\nthe investigators hope that with the human cortical bone screw the tunnel widening is reduced and the re-rupture rate is low",[219,28,220],"Anterior Cruciate Ligament Rupture","Anterior Cruciate Ligament Injury",[222,223,224,225,226,227,228,229,230,231,232],"ACL","tunnel widening","human allogeneic cortical bone screw","Shark Screw®","biotenodese screw","re-rupture rate","IKDC","KOOS","Lysholm Knee Score","Tegner Activity Score","range of motion (ROM)","2026-01-17",{"date":235,"type":46},"2026-01-21",{"date":237,"type":22},"2026-02-16",{"date":239,"type":22},"2034-01-31",{"name":241,"class":53},"Alexander Rofner-Moretti",{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":249,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":254,"conditions":255,"keywords":258,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":54},"100617411","clinical-and-functional-outcomes-after-acl-reconstruction-versus-primary-repair-100617411","NCT07318272","Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair","Comparison of Clinical and Functional Outcomes After Anterior Cruciate Ligament Reconstruction and Primary Repair Surgery","Inclusion Criteria for the ACL Reconstruction Group\n\n* Age 18-40 years\n* History of complete ACL rupture treated with ACL reconstruction\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* At least 12 months postoperative at the time of evaluation\n* Ability to comply with all study procedures\n* Signed informed consent\n\nExclusion Criteria for the ACL Reconstruction Group\n\n* Previous surgery for partial or chronic ACL tear\n* Concomitant multi-ligament knee injuries\n* Prior surgery on the ipsilateral or contralateral knee\n* Lower extremity malalignment (e.g., significant varus\u002Fvalgus)\n* Tibial avulsion-type ACL injury\n* Neurological or musculoskeletal disorders affecting lower limb function\n* Any medical condition that may interfere with test performance or safety\n\nInclusion Criteria for the Primary ACL Repair Group\n\n* Age 18-40 years\n* Complete ACL rupture treated with arthroscopic primary ACL repair\n* Surgery performed at Gazi University Department of Orthopedics and Traumatology\n* Minimum 12 months postoperative at the time of assessment A-bility to follow and complete study procedures\n* Signed informed consent\n\nExclusion Criteria for the Primary ACL Repair Group\n\n* Previous surgery for partial or chronic ACL injury\n* Multi-ligament knee injuries\n* History of surgery on either knee\n* Lower extremity malalignment\n* Tibial avulsion-type ACL rupture\n* Neuromuscular or musculoskeletal diseases affecting lower limb function or balance\n* Any condition that may affect participation or compromise safety\n\nInclusion Criteria for the Healthy Control Group\n\n* Age 18-40 years\n* No significant lower-extremity malalignment (e.g., varus\u002Fvalgus deformity)\n* No history of lower-extremity injury within the past 12 months\n* No known chronic systemic disease\n* No history of knee surgery or diagnosed knee pathology\n* Ability to understand and comply with study procedures\n* Signed informed consent\n\nExclusion Criteria for the Healthy Control Group\n\n* Presence of clinically significant lower-extremity malalignment\n* Lower-extremity musculoskeletal injury within the last 12 months\n* Any chronic systemic or metabolic disease\n* History of knee injury, knee surgery, or diagnosed knee pathology\n* Neurological, vestibular, or musculoskeletal disorder affecting balance or gait\n* Inability to complete study procedures",true,"40 Years",{"count":252,"type":22},45,"OBSERVATIONAL","The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint. Although ACL reconstruction has long been considered the gold standard among surgical interventions following ACL injury, arthroscopic primary repair techniques have recently regained interest. With advances in minimally invasive surgical procedures, refined patient selection criteria, and improved rehabilitation strategies, the clinical effectiveness of primary repair is once again being re-evaluated. However, there remains a limited body of literature directly comparing the medium- to long-term effects of these two surgical techniques on neuromuscular performance, fatigue tolerance, and functional outcomes.\n\nThe aim of this study is to comparatively investigate postoperative muscle strength and endurance, isokinetic fatigue response, muscle oxygenation, proprioception, knee stability, postural control, and patient-reported outcome measures in individuals who have undergone ACL reconstruction or primary repair. Assessments will include low- and high-velocity tests performed on the Cybex Norm isokinetic dynamometer, a 33-repetition fatigue protocol at 300°\u002Fs, muscle oxygenation analysis using Train.Red NIRS, knee laxity measurement via the GNRB arthrometer, single-leg balance and landing evaluations using the KFORCE force platform, and subjective outcome measures (IKDC, ACL-RSI).\n\nThe findings of this study are expected to provide a more comprehensive understanding of how surgical technique influences physiological, biomechanical, and functional outcomes. This knowledge may contribute to the development of individualized rehabilitation approaches and evidence-based return-to-sport criteria.",[256,28,257],"Anterior Cruciate Ligament (ACL) Tear","Isokinetic Test",[259,70,260,261,262,263,264],"ACL Injury","ACL Reconstruction","ACL Primary Repair","Postoperative Outcomes","Muscle Oxygenation","Isokinetic Testing","2025-12-28",{"date":267,"type":46},"2026-01-05",{"date":269,"type":22},"2026-01-01",{"date":271,"type":22},"2027-08-30",{"name":273,"class":53},"Gazi University",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":281,"targetDuration":4,"studyType":23,"phases":283,"briefSummary":284,"conditions":285,"keywords":286,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":54},"100613596","proprioceptive-training-for-gait-and-knee-function-after-anterior-cruciate-ligament-reconstruction-100613596","NCT07268651","Proprioceptive Training for Gait and Knee Function After Anterior Cruciate Ligament Reconstruction","The Effect of Proprioceptive Training on Gait Performance and Knee Function in Patients With Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Adults aged 18-40 years who have undergone primary unilateral anterior cruciate ligament reconstruction (ACLR) using an autograft.\n* At least 3 weeks postoperatively and currently engaged in the early-stage rehabilitation phase following ACLR.\n* Demonstrate near-full passive knee extension (≤ 5° loss) and at least 90° of passive knee flexion in the operated limb.\n* Able to walk independently without assistive devices and perform basic functional tasks (e.g., normal walking, single-leg stance).\n* No prior surgery or major injury to the contralateral knee or other lower limb joints.\n* No neurological, vestibular, or systemic conditions affecting proprioception, motor control, or physical performance.\n* Not currently participating in any structured proprioceptive or neuromuscular training programs.\n* Willing and able to comply with the intervention protocol and follow-up, and able to provide written informed consent.\n\nExclusion Criteria:\n\n* History of revision anterior cruciate ligament surgery, bilateral ACLR, or concurrent reconstruction of other knee ligaments (e.g., posterior cruciate ligament, medial collateral ligament, lateral collateral ligament) in the affected knee.\n* Meniscal repair or other intra-articular procedures that restrict knee range of motion beyond 3 weeks postoperatively.\n* Diagnosed osteoarthritis, rheumatoid arthritis, or other chronic joint diseases affecting the lower limbs.\n* Significant injury, surgery, or persistent pain in the contralateral knee, hip, ankle, or spine that could interfere with training or gait.\n* History or current diagnosis of neurological disorders (e.g., stroke, multiple sclerosis, Parkinson's disease) or vestibular dysfunction.\n* Any cardiopulmonary or systemic condition that contraindicates structured physical exercise.\n* Participation in other structured rehabilitation or proprioceptive training programs within the past 3 weeks.\n* Cognitive impairment or psychiatric conditions that may interfere with understanding instructions or complying with the protocol.",{"count":282,"type":22},30,[66],"Anterior cruciate ligament reconstruction (ACLR) is commonly performed to restore knee stability after injury, but many patients continue to experience gait abnormalities and reduced knee function during rehabilitation. Proprioceptive training is frequently included in rehabilitation programs to improve joint position sense, neuromuscular control, and movement coordination, yet its specific effects on gait performance and knee function after ACLR are not fully understood.\n\nThis study aims to investigate the effects of a 12-week proprioceptive training program on gait performance and knee function in patients who have undergone ACLR. Patients who meet the inclusion criteria will undergo baseline assessments, including gait analysis and knee function tests. They will then participate in a structured 12-week proprioceptive training program as part of their rehabilitation, followed by post-intervention assessments using the same measures.\n\nThe primary outcomes include changes in gait performance, such as walking speed, step length, cadence, support time, knee motion, and knee joint angles and moments during walking. Secondary outcomes include changes in knee function, including isokinetic muscle strength, joint position sense, and patient-reported outcomes measured by the Lysholm score and the International Knee Documentation Committee (IKDC) questionnaire. The findings from this study may help to clarify the functional benefits of proprioceptive training and support the development of more targeted and effective rehabilitation strategies for patients recovering from Anterior cruciate ligament (ACL) injuries.",[28],[287,288,289,290],"Proprioceptive Training","Gait Performance","Knee Function","Joint Position Sense","2025-12-04",{"date":293,"type":46},"2025-12-08",{"date":295,"type":22},"2025-12",{"date":297,"type":22},"2026-04",{"name":299,"class":53},"Universiti Sains Malaysia",{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":249,"sex":18,"minAge":19,"maxAge":94,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":323},"100440260","immunometabolic-mechanisms-of-blood-flow-restriction-bfr-training-after-anterior-cruciate-ligament-reconstruction-100440260","NCT05012982","Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction","Immunometabolic Mechanisms of Blood Flow Restriction Training After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form\n2. Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart\n3. All genders, between 18 and 60 years of age\n4. In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury\u002Fillness by participating in the study\n\nExclusion Criteria:\n\n1. Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.\n2. Multiple ligament ruptures or trauma\n3. Rheumatoid arthritis or other significant comorbidities\n4. Lower extremity vascular pathology, including history of deep vein thrombosis\n5. Those with a history of sickle cell trait or disease\n6. Use of anticoagulant medications\n7. Pregnancy\n8. Treatment with another investigational drug or other intervention within one month of Study Day 1\n9. Current smoker or tobacco use within 3 months of Study Day 1\n10. Febrile illness within 2 weeks of Study Day 1",{"count":308,"type":22},20,[66],"This is a crossover phase 4 study to evaluate the impact of blood flow restriction on immunometabolism and gene expression in immune cells in individuals undergoing rehabilitation from anterior cruciate ligament reconstruction.",[28],[313],"AirBand","2025-12-01",{"date":316,"type":46},"2025-12-03",{"date":318,"type":46},"2023-02-16",{"date":320,"type":22},"2026-05",{"name":322,"class":53},"Yale University",2,{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":18,"minAge":332,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":54},"100611665","fractal-vs-isochronous-cueing-in-athletes-after-acl-reconstruction-100611665","NCT07243535","Fractal vs Isochronous Cueing in Athletes After ACL Reconstruction","Comparison Between a Session of Walking Synchronized to Fractal- VS Isochronous-Based Cues on Gait Variability and Corticospinal Measures in Athletes With a Reconstructed Anterior Cruciate Ligament: A Crossover Randomized Controlled Trial","SyncGait","Inclusion Criteria:\n\n* Undergone unilateral ACL reconstruction less than 2 years ago;\n* Have medical release for the full load on the injury limb for at least 2 weeks;\n* Be independently pain-free walking;\n* Being sports athletes according to an athlete description: Training regularly to improve performance, actively participating in competitions or formally registering in a sports federation or association;\n* Must be able to understand and perform the requested task.\n\nExclusion Criteria:\n\n* Participants with previous surgery on either knee;\n* Those with more than 3 months between ACL injury and surgery;\n* More than 2 weeks between surgery and the start of physical therapy;\n* Had another musculoskeletal injury in the lower limb within the past 6 months;\n* Another musculoskeletal surgery within the past 18 months;\n* Participants with a history of movement system pathologies, such as nervous system, cardiovascular, pulmonary, integumentary, or endocrine conditions;\n* Participants with vestibular or somatosensory system pathologies or visual impairments limiting their ability to see the metronome required for the task;\n* Use of medications that could affect locomotion and balance.","15 Years","35 Years",{"count":335,"type":22},36,[66],"Anterior cruciate ligament (ACL) injuries are among the most prevalent and functionally limiting knee injuries in sports, particularly those that involve pivoting movements. Despite advancements in surgical reconstruction and physical rehabilitation, many athletes continue to exhibit persistent motor control deficits and increased gait variability, both of which are closely linked to a heightened risk of re-injury and long-term joint degeneration. These deficits arise from biomechanical impairments and disrupt proprioceptive input that requires cortical reorganization, contributing to maladaptive neuroplasticity. However, conventional rehabilitation strategies often overlook this neural dimension. Recent findings emphasize the importance of fostering motor variability and promoting neuroplasticity through external focus strategies, including sensorimotor synchronization. While isochronous cues, an invariant stimulus, are commonly used, they do not reflect the natural fluctuations of healthy gait and may reduce its complexity. Fractal-based cues, in contrast, introduce structured variability resembling the natural dynamics of locomotion and have been shown to restore gait complexity in clinical populations. However, no study has yet explored their acute effects on gait variability and corticospinal function following ACL reconstruction (ACLR). This crossover randomized controlled trial aims to compare the acute effects of a single session of treadmill walking synchronized to either fractal or isochronous-based visual cues on gait variability and corticospinal measures in athletes with ACLR. The investigators hypothesize that fractal-based cueing will acutely restore gait variability and enhance corticospinal excitability, evidenced by increased corticospinal excitability and intracortical facilitation, and reduced short-interval intracortical inhibition, thus promoting adaptive neuroplasticity. Conversely, isochronous cueing is expected to maintain or decrease gait complexity without improving corticospinal measures. This study may provide insights that could be highly valuable as a way to promote neuroplasticity and optimize gait rehabilitation after ACLR, also allowing an objective quantification and aiming to restore variability to levels close to those observed in healthy individuals, thus contributing to reducing the re-injury rate.",[28,339,340],"Anterior Cruciate Ligament Reconstruction Rehabilitation","Athlete",[342,343,344,345,346],"Complexity","Excitability","Metronome","Neuroplasticity","Rehabilitation","2025-11-17",{"date":349,"type":46},"2025-11-24",{"date":351,"type":46},"2025-10-03",{"date":353,"type":22},"2026-02",{"name":355,"class":53},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":249,"sex":18,"minAge":363,"maxAge":19,"enrollmentInfo":364,"targetDuration":4,"studyType":23,"phases":366,"briefSummary":368,"conditions":369,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":54},"100561456","phase-4-anterior-femoral-and-adductor-canal-nerve-blocks-in-peds-knees-100561456","NCT06590402","Anterior Femoral and Adductor Canal Nerve Blocks in Peds Knees","A Pilot Study Comparing Anterior Femoral Cutaneous Nerve Blocks to Adductor Canal Blocks in Pediatric Ambulatory Knee Surgeries","Inclusion Criteria:\n\n* 8-18 years old at the time of surgery\n* Patients 40kg and above\n* ACL reconstruction of MPFL reconstruction surgery with participating surgeons\n\nExclusion Criteria:\n\n* revision surgery\n* bilateral surgery\n* general anesthesia\n* contraindications to any part of the study protocol\n* relevant pre-existing neurological deficit\n* chronic pain","8 Years",{"count":365,"type":22},60,[367],"PHASE4","The goal of this pilot clinical trial is to compare anterior femoral cutaneous nerve block (AFCN) to adductor canal block ACB) for pediatric patients undergoing either anterior cruciate ligament (ACL) or medial patellofemoral ligament (MPFL). The aims of this trial are:\n\n* To measure postoperative functional outcomes in patients who received AFCNB vs. ACB.\n* To calculate postoperative opioid requirements in pediatric knee surgeries that received AFCNB vs. ACB.\n* To calculate pain intensity levels at rest and with ambulation in patients who received AFCNB vs. ACB.\n* To quantify sensory deficits in patients who received AFCNB vs. ACB.\n* To assess patient-reported outcome measures (e.g., pain expectation scale, pain management satisfaction, PROMIS Pediatric Short Form v1.0 - Physical Activity, PROMIS Scale v1.2 - Global Health) in patients 8-18 years of age who received AFCNB vs. ACB.\n\nSubjects undergoing ACL procedures will be compared between those who received the adductor canal block to those who received the anterior femoral cutaneous nerve block. The researchers will also compare individuals who underwent MPFL procedures and received an anterior femoral cutaneous nerve block with those who received the adductor canal block.\n\nParticipants will:\n\n* Be randomized to receive either the AFCNB or ACB in addition to standard of care analgesia.\n* Maintain a patient diary to document daily pain meds\u002Fpain scores\n* Complete follow up surveys\u002Fquestionnaires via telephone and during their office visits with surgeons.",[28,370],"Medial Patellofemoral Ligament Reconstruction","2025-10-01",{"date":373,"type":46},"2025-10-06",{"date":375,"type":46},"2025-06-06",{"date":377,"type":22},"2028-01",{"name":379,"class":53},"Hospital for Special Surgery, New York",{"id":381,"slug":382,"hasResults":12,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":386,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":23,"phases":389,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":54},"100542309","comparison-between-combined-allr-with-single-bundle-and-double-bundle-anterior-cruciate-ligament-reconstruction-100542309","NCT06341192","Comparison Between Combined ALLR With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction","Clinical Comparison and Motion Analysis of Sports Function Between Combined Anterolateral Ligament Reconstruction With Single Bundle and Double Bundle Anterior Cruciate Ligament Reconstruction","ALLR","Inclusion Criteria:\n\n* Patients plan to receive ACL surgery\n* at least 18 years old\n\nExclusion Criteria:\n\n* Presented history of the injured leg or congenital abnormality",{"count":148,"type":22},[66],"The goal of this clinical trial is to test and compare different surgical techniques in patients with anterior cruciate ligament (ACL) injuries. The main questions it aims to answer are:\n\n* What are the optimal criteria for selecting between single-bundle ACL reconstruction combined with anterolateral ligament (ALL) reconstruction versus double-bundle ACL reconstruction combined with ALL reconstruction?\n* How do these two surgical techniques compare in terms of post-operative knee stability, functional outcomes, and reducing re-tear rates?\n\nParticipants will:\n\n* Undergo pre-operative MRI imaging, ligament stability testing, and motion analysis evaluations\n* Be randomly assigned to either:\n\n  * Single-bundle ACL + ALL reconstruction\n  * Double-bundle ACL + ALL reconstruction\n* Receive the assigned surgical procedure\n* Participate in post-operative follow-ups, ligament stability testing, and motion analysis at 6 months and 1 year\n\nResearchers will compare the single-bundle ACL + ALL group and the double-bundle ACL + ALL group to see if one technique demonstrates superior knee stability, functional outcomes (e.g. return to sport ability), and lower ACL re-tear rates.",[392,28],"Anterior Cruciate Ligament Injuries",[394,395,396,397,398,399],"anterior cruciate ligament","anterolateral ligament","single bundle","double bundle","optical motion capture","graft rupture","2025-09-24",{"date":402,"type":46},"2025-09-25",{"date":404,"type":46},"2024-06-26",{"date":406,"type":22},"2026-10-31",{"name":408,"class":53},"Chang Gung Memorial Hospital",{"id":410,"slug":411,"hasResults":12,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":12,"sex":18,"minAge":332,"maxAge":333,"enrollmentInfo":416,"targetDuration":4,"studyType":23,"phases":417,"briefSummary":418,"conditions":419,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":429,"leadSponsor":431,"locationsCount":54},"100603928","bfr-training-for-post-aclr-100603928","NCT07142889","BFR Training for Post ACLR","The Effectiveness of Blood Flow Restriction Training on Patellar Position, Muscle Morphology, and Lower Limb Function in Patients After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Ages 15-35 years old.\n* History of a unilateral ACL injury, underwent ACL reconstruction surgery more than 6 months ago, and completed rehabilitation with physiotherapy.\n* Adults participating in recreational or competitive sports at a minimum of level 3 on the Tegner Activity Scale.\n* No prior history of a grade 3 sprain\u002Fstrain injury to other tissues in the knee and foot.\n* No recurring knee injuries after the ACL reconstruction surgery.\n* Willing to be a research subject from start to finish by signing an informed consent form.\n\nExclusion Criteria:\n\n* Hypertension, circulatory disorders, sickle cell anemia, obesity, diabetes, kidney disorders, venous thromboembolism, cancer, and tumors are contraindications for BFR application.\n* Experiencing a disability or being disabled.",{"count":365,"type":22},[66],"This randomized clinical trial is designed to compare three different rehabilitation methods for patients who have undergone anterior cruciate ligament (ACL) reconstruction. The study aims to determine whether low-load blood flow restriction training (LL-BFRt) is more effective than high-load eccentric training (HL-Et) and a sham LL-BFRt in improving three key areas: patellar position, muscle morphology, and leg function.\n\nStudy Design and Interventions\n\nParticipants will be randomly assigned to one of the three intervention groups. All groups will perform eccentric exercises, including single leg squats, single leg deadlifts, lateral step downs, and single leg calf raises. The key differences lie in the load and the use of blood flow restriction:\n\nLL-BFRt Group: Participants will train at 30% of their repetition maximum (RM) while a cuff restricts blood flow to 70% of their artery occlusion pressure (AOP).\n\nHL-Et Group: Participants will train at a higher intensity, using 70% of their repetition maximum (RM), with no blood flow restriction.\n\nSham LL-BFRt Group: Participants will perform the same exercises as the LL-BFRt group at 30% of their RM, but the cuff will not be inflated to a pressure that restricts blood flow.\n\nAfter the training period, the researchers will compare the outcomes across all three groups to see which method leads to the most significant improvements in patella position, muscle morphology, and leg function.",[420,421,422,28,423],"Blood Flow Restriction Training","Patella Position","Muscle Morphology","Leg Function","2025-08-26",{"date":426,"type":46},"2025-08-27",{"date":428,"type":22},"2025-09-01",{"date":430,"type":22},"2026-09-01",{"name":432,"class":53},"Udayana University",{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":192,"enrollmentInfo":439,"targetDuration":4,"studyType":23,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":54},"100513688","assessment-of-gait-adaptation-due-to-an-asymmetric-walking-protocol-100513688","NCT05968729","Assessment of Gait Adaptation Due to an Asymmetric Walking Protocol","Inclusion Criteria:\n\n1. Able to read and speak English\n2. Age 18 - 30 years old\n3. Undergone ACLR surgery at the UConn Musculoskeletal Institute\n4. Must not have any concomitant surgeries or injuries\n5. Must be cleared to return-to-sport by a physician after they have completed rehabilitation\n6. Must be within 1 month of having been cleared for return-to-sport\n7. Must present with between-limb gait differences in load rate greater than 10%\n\nExclusion Criteria:\n\n1. Participants who have any recent inflammation, bleeding disorders, active bleeding, or infection within the lower limbs.\n2. History of injuries to their patellar tendon\n3. Cannot walk for extended periods of time\n4. Cannot have had any back and\u002For lower extremity injury that affects their ability to move.\n5. Cannot have difficulty or pain with walking, raising your arms, jogging, or jumping\n6. Must not be allergic to tape.",{"count":148,"type":22},[66],"The purpose of this work is to conduct a comparative research-focused study to evaluate the effectiveness of how purposefully induced asymmetric walking protocols restore healthy, symmetric limb loading in individuals following post-anterior cruciate ligament reconstruction (ACLR) surgery. Additionally, computational modeling and machine learning to model knee loading in the clinic to determine the optimal asymmetric walking protocol to restore healthy gait in post-ACLR individuals.",[28],"2025-08-20",{"date":426,"type":46},{"date":446,"type":46},"2022-09-01",{"date":448,"type":22},"2027-07-31",{"name":450,"class":53},"University of Connecticut",{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":4,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":333,"enrollmentInfo":458,"targetDuration":4,"studyType":253,"phases":4,"briefSummary":460,"conditions":461,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":54},"100557490","proprioception-muscle-strength-and-kinesiophobia-after-anterior-cruciate-ligament-reconstruction-100557490","NCT06538792","Proprioception, Muscle Strength and Kinesiophobia After Anterior Cruciate Ligament Reconstruction","Effect of Proprioception and Muscle Strength on Kinesiophobia After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Between the ages of 18-35\n* History of ACL reconstruction surgery at least 6 months ago\n\nExclusion Criteria:\n\n* History of previous lower extremity surgery\n* History of lower extremity injury within the last 6 months\n* Having a vestibular or neurologic pathology that would affect balance",{"count":459,"type":22},52,"Fear of re-injury after anterior cruciate ligament reconstruction surgery (ACLR) affects individuals' return to sports and physical activity negatively. The aim of this study is to evaluate the effects of proprioception and muscle strength on kinesiophobia in patients who have undergone anterior cruciate ligament reconstruction surgery.",[28],"2025-07-07",{"date":464,"type":46},"2025-07-10",{"date":466,"type":46},"2024-11-09",{"date":468,"type":22},"2026-06",{"name":470,"class":53},"Bezmialem Vakif University",{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":475,"acronym":4,"eligibilityCriteria":476,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":477,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":482,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":323},"100585694","effects-of-eccentric-training-in-the-rehabilitation-of-patients-undergoing-anterior-cruciate-ligament-reconstruction-a-randomized-controlled-trial-100585694","NCT06905691","Effects of Eccentric Training in the Rehabilitation of Patients Undergoing Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.",{"count":478,"type":22},34,[66],"This study aims to investigate the effects of eccentric training on the functional rehabilitation of patients undergoing Anterior Cruciate Ligament Reconstruction (ACL-R). Thirty-four participants undergoing ACL-R will be randomly assigned to two groups: the Conventional Training Group (CTG) and the Eccentric Training Group (ETG). Both groups will adhere to the same post-surgical rehabilitation program, commencing in the first week after ACL-R and continuing until the criteria for sports resumption are achieved. The rehabilitation program will be structured into four phases: immediate post-operative, preparatory, general acquisition, and specific acquisition. The key distinction between the groups lies in their exercise regimen: ETG will prioritize the eccentric phase of movement, whereas CTG will engage in conventional exercises, maintaining uniform load across both movement phases. Assessment procedures will be conducted at three intervals for all participants: immediately post-operative, at 12 weeks post-ACL-R surgery (before the initiation of the training protocol), and at 25 weeks post-ACL-R surgery (upon completion of the training protocol). The primary outcome measure will be the maximum isometric strength of knee extensors. Secondary outcomes will encompass functional status, maximum isometric strength of knee flexors, peak dynamic strength during leg press, quadriceps muscle atrophy, performance in jump tests, and psychological readiness.",[339,28],[483,484,485,486,487,488],"Knee","Physiotherapy","Quadriceps","Anterior cruciate ligament reconstruction","Eccentric Exercise","Eccentric","2025-04-22",{"date":491,"type":46},"2025-04-24",{"date":493,"type":46},"2025-03-01",{"date":495,"type":22},"2026-12",{"name":497,"class":53},"Federal University of Health Science of Porto Alegre",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":502,"acronym":4,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":505,"briefSummary":506,"conditions":507,"keywords":508,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":323},"100536064","neuromuscular-electrical-stimulation-superimposed-or-not-on-voluntary-contraction-after-reconstruction-of-the-anterior-cruciate-ligament-a-randomized-controlled-trial-100536064","NCT06259968","Neuromuscular Electrical Stimulation Superimposed or Not on Voluntary Contraction After Reconstruction of the Anterior Cruciate Ligament: a Randomized Controlled Trial","Inclusion Criteria:\n\n\\- Individuals of both genders, aged between 18 and 40 years, scheduled for ACL reconstruction surgery during the data collection period.\n\nExclusion Criteria:\n\n* Failure to attend the pre-surgery assessment session;\n* Delay of more than 7 days after surgery to initiate the rehabilitation program proposed by the study;\n* Presence of injuries related to the rupture of the ACL that hinder partial weight-bearing in the first week after surgery, either due to medical recommendation or the patient inability\u002Fdisposition.",{"count":148,"type":22},[66],"This study aims to evaluate the effectiveness of neuromuscular electrical stimulation with superimposed voluntary contraction (NMES+ group) compared to NMES without voluntary contraction (NMES group) during the initial month of rehabilitation post anterior cruciate ligament reconstruction (ACLR). Forty patients will be randomly assigned to either the NMES group or the NMES+ group. Both groups will follow an identical rehabilitation regimen in the first month after surgery, which includes interventions for symptom management, inflammation control, edema reduction, improved joint motion range, and restoration of muscle function.\n\nAll participants will undergo identical assessment protocols at four time points: pre-surgery evaluation, and assessments at 2, 15, and 30 days post-ACLR. The primary outcome of the study is the maximal isometric strength of knee extensors. Secondary outcomes encompass thigh muscle atrophy, self-reported functional impairments, knee pain, knee edema, joint range of motion, and quadriceps activation status.",[339,28],[509,483,484,485,486],"Neuromuscular Electrical Stimulation","2025-03-31",{"date":512,"type":46},"2025-04-01",{"date":514,"type":46},"2024-05-01",{"date":516,"type":22},"2026-12-31",{"name":497,"class":53},{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":4,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":23,"phases":526,"briefSummary":527,"conditions":528,"keywords":529,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":54},"100582052","mental-imagery-to-improve-quadriceps-strength-post-anterior-cruciate-ligament-reconstruction-a-feasibility-study-100582052","NCT06858293","Mental Imagery to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study","Mental Imagery of Open and Closed Chain Exercises to Improve Quadriceps Strength Post Anterior Cruciate Ligament Reconstruction: a Feasibility Study","Inclusion Criteria:\n\n* post anterior cruciate ligament reconstruction (ACLR) surgery\n* cleared to participate in physical therapy\n* currently in physical therapy related to ACLR\n\nExclusion Criteria:\n\n* greater than 9 months post ACLR surgery\n* history of lower back of hip pain that would limit lower limb motor testing\n* current neurological condition that limits muscle strength\n* history of substance abuse in the last 5 years\n* any uncontrolled medical condition\n* inability to follow 2-step commands",{"count":308,"type":22},[66],"The goal of this clinical trial is to understand if people recovering from anterior cruciate ligament reconstruction (ACLR) surgery will complete mental imagery training and if this will improve their injured leg's strength. The main questions are:\n\n* Will people complete a five-day mental imagery exercise schedule while in physical therapy for ACLR?\n* Does mental imagery exercise help raise leg strength during ACLR recovery? Researchers will also compare if different mental imagery exercises involving leg extension or squats will change leg strength.\n\nParticipants will be asked to:\n\n* Participate in two testing sessions to make measurements of leg function\n* Complete about 10 minutes of mental imagery exercises once per day for five days at home and write down whether they complete the exercises.",[28],[530,531,532,533],"Mental Imagery","knee","strength","physical therapy","2025-03-05",{"date":536,"type":46},"2025-03-10",{"date":538,"type":46},"2025-02-14",{"date":540,"type":22},"2026-01-28",{"name":542,"class":53},"Marquette University",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":551,"enrollmentInfo":552,"targetDuration":4,"studyType":23,"phases":554,"briefSummary":555,"conditions":556,"keywords":558,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":565,"leadSponsor":567,"locationsCount":54},"100514007","graft-maturity-after-blood-flow-restriction-training-in-acl-reconstruction-100514007","NCT05972876","Graft Maturity After Blood Flow Restriction Training in ACL Reconstruction","MRI-based Graft Maturity After Blood Flow Restriction Training in Bone-patellar Tendon-bone Anterior Cruciate Ligament Reconstruction: a Randomized Controlled Study","TimeToMature","Inclusion Criteria:\n\n* Patients (18-64 years) who will undergo primary BPTB reconstruction at Zuyderland Medical Center and rehabilitation at Knie-Heup centrum Plus.\n\nExclusion Criteria:\n\n* venous thromboembolism, sickle cell anemia, severe hypertension, contra-indication for accelerated rehabilitation, contra-indication for MRI scan or not willing\u002Fable to participate.","65 Years",{"count":553,"type":22},46,[66],"Rationale Graft maturity is correlated with strength and biomechanical properties of the reconstructed ACL. There are concerns that heavy-load resistance training (HLRT) may have detrimental effects on ACL graft maturation. Therefore, low-load blood flow restriction training (LL-BFRT) has been suggested as an alternative to HLRT. As LL-BFRT is an increasingly popular method for the rehabilitation after an ACL reconstruction, it is important to evaluate the value of this treatment.\n\nObjectives The main objective is to evaluate the effect of LL-BFRT on MRI-based graft maturity after ACL reconstruction compared to HLRT. The secondary objectives are the effect of LL-BFRT on donor-site morbidity, range of motion, knee stability, patient reported outcome measurements, muscle strength, safe return to pre-injury level of sport and patient satisfaction. Furthermore, feasibility and safety of rehabilitation will be assessed.\n\nStudy design Randomized controlled trial . Study population Patients who will undergo primary bone-patellar tendon-bone ACL reconstruction and rehabilitation at Knie-Heup centrum Plus will be assessed for eligibility. The exclusion criteria are: venous thromboembolism, sickle cell anemia, severe hypertension, contra-indication for accelerated rehabilitation, contra-indication for MRI scan or patients who are not willing\u002Fable to participate.\n\nIntervention LL-BFRT includes 12 weeks of biweekly strength training and starts two weeks after surgery.\n\nComparison HLRT includes 12 weeks of biweekly strength training and starts two weeks after surgery.\n\nMain study endpoints The main endpoints are MRI-based graft maturity defined as signal-to-noise quotient three and nine months after surgery.",[28,557],"Bone-Patellar Tendon-Bone Grafting",[559],"Blood Flow Restriction Therapy","2025-01-30",{"date":562,"type":46},"2025-02-04",{"date":564,"type":46},"2024-04-17",{"date":566,"type":22},"2027-09",{"name":568,"class":53},"Zuyderland Medisch Centrum",{"id":570,"slug":571,"hasResults":12,"nctId":572,"briefTitle":573,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":577,"briefSummary":578,"conditions":579,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":54},"100531930","the-effects-of-cognitive-dual-tasking-in-later-stages-of-rehabilitation-after-acl-reconstruction-100531930","NCT06206200","The Effects of Cognitive Dual-Tasking in Later Stages of Rehabilitation After ACL Reconstruction","AMIRA","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscle or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":215,"type":22},[66],"Anterior cruciate ligament (ACL) injuries are common in sports and often require a long and challenging rehabilitation process. Athletes who sustain these injuries typically engage in pivoting and cutting sports, where these motor tasks must be performed simultaneously with cognitive tasks such as decision-making and keeping an eye on the opponent. Directing attention to both cognitive and motor tasks leads to cognitive-motor interference, which is associated with movement patterns that increase the risk of ACL (re)injury.\n\nTherefore, it is crucial that before returning to such demanding sports after ACL reconstruction, athletes sufficiently develop and automate safe yet efficient motor skills to free up attentional capacity for decision-making, thereby reducing the risk of suboptimal movement patterns and reinjury.\n\nHowever, current rehabilitation programs often primarily focus on the motor component in a single-task manner, giving insufficient attention to the cognitive component that is inseparable from sports.\n\nThis randomized controlled trial aims to investigate the effects of implementing motor-cognitive dual tasks in the end phase rehabilitation after ACL reconstruction on muscle function, functional outcomes, and patient-reported outcomes.",[28,580,259],"Athrogenic Muscle Responses","2024-07-12",{"date":583,"type":46},"2024-07-15",{"date":585,"type":46},"2023-10-15",{"date":587,"type":22},"2027-04-01",{"name":589,"class":53},"University Ghent",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":250,"enrollmentInfo":597,"targetDuration":599,"studyType":253,"phases":4,"briefSummary":600,"conditions":601,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":610,"leadSponsor":611,"locationsCount":54},"100549189","exploring-prolonged-amr-in-acl-reconstructed-patients-100549189","NCT06430775","Exploring Prolonged AMR in ACL Reconstructed Patients","Exploring Prolonged Arthrogenic Muscle Responses and Associated Factors After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscular or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":598,"type":22},190,"5 Months","The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:\n\n1\\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.\n\n2\\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.\n\n3\\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and\u002For postsurgical pain levels may exhibit a higher degree of long-lasting AMR.\n\n4\\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.\n\nParticipants will:\n\n* Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:\n\n  * Demopgraphical information\n  * Knee Injury and Osteoarthritis Outcome Score (KOOS)\n  * Lysholm Score (only question 1)\n  * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery)\n  * Numeric Rating Score (NRS) for pain levels during the day \\& during the night\n  * ACL-Return to Sport after Injury Scale (ACL-RSI)\n* Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.",[392,219,602,222,259,603,28,604,605],"Anterior Cruciate Ligament Tear","ACL Tear","Arthrogenic Muscle Inhibition","Arthrogenic Muscle Responses","2024-06-28",{"date":608,"type":46},"2024-07-01",{"date":585,"type":46},{"date":320,"type":22},{"name":589,"class":53},{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":4,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":619,"targetDuration":4,"studyType":23,"phases":620,"briefSummary":621,"conditions":622,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":54},"100551793","to-investigate-the-effect-of-pemf-for-pateitns-after-anterior-cruciate-ligament-reconstruction-with-hamstring-autograft-100551793","NCT06464705","To Investigate the Effect of PEMF for Pateitns After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft","Effect of Pulsed Electromagnetic Fields on Promoting Hamstring Muscle Strength After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial","Inclusion Criteria:\n\n1. Male and female with age ≥ 18 years at the time of surgery\n2. First ACLR with HT autograft\n3. Both knees without a history of injury\u002Fprior surgery\n4. LSI for hamstring strength \\\u003C85% of contralateral leg at 4-month isokinetic assessment (70)\n5. Voluntarily agreed to participate and signed the informed consent form\n\nExclusion Criteria:\n\n1. Any concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-op\n2. Preoperative radiographic signs of arthritis\n3. Other associated injuries (fractures and other ligament involvement such as neurovascular bundles injury)\n4. Patient with a pacemaker, an implantable defibrillator, neurosurgical clips, a neurostimulator, cochlear implant, a stent, an insulin pump\n5. Pregnant or breastfeeding\n6. Inability to give informed consent",{"count":365,"type":22},[66],"Anterior cruciate ligament (ACL) tear is common. It accounts for over 50% of all knee injuries. Anterior cruciate ligament reconstruction (ACLR) with hamstring tendon (HT) autograft is the common graft choice for ACLR. However, the outcomes of donor site healing and recovery of muscle strength of HT are not satisfactory, resulting in hamstring muscle weakness and hamstring strength deficit during deep knee flexion, which may lead to hamstring strain after ACLR. Moreover, activation of the hamstring muscle is vital for maintaining dynamic knee joint stability and preventing excessive ACL shear forces. The presence of hamstring muscle deficits after surgery therefore affects the function of the reconstruction ACL. A previous study has reported that the hamstring muscle showed nearly 20% strength deficit at 4 months after ACLR with hamstring autograft\n\nPulsed electromagnetic field (PEMF) treatment is a non-invasive therapy that has been shown to enhance muscle cell activity and accelerate tissue repair. In clinic, PEMF treatment has been reported to be safe.\n\nThis study aims to conduct a double-blinded, placebo-controlled randomised clinical trial to investigate the effects of PEMF therapy for improving the tissue regeneration and strength of the HT donor site in ACLR patients with HT autograft.",[28,623],"Hamstring Muscle","2024-06-17",{"date":626,"type":46},"2024-06-20",{"date":628,"type":46},"2024-06-13",{"date":630,"type":22},"2027-03-31",{"name":632,"class":53},"Chinese University of Hong Kong",{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":637,"acronym":4,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":639,"targetDuration":4,"studyType":23,"phases":640,"briefSummary":641,"conditions":642,"keywords":4,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":650,"locationsCount":54},"100540530","operation-acl-rehabilitation-after-anterior-cruciate-ligament-reconstruction-100540530","NCT06318039","Operation ACL: Rehabilitation After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Athletes or recreational athletes that have undergone ACLR\n\nExclusion Criteria:\n\n* Patients that have undergone ACLR that are nor athletes or recreational athletes",{"count":96,"type":22},[66],"Scientific Research Question\n\nOverall Purpose:\n\nRegarding rehabilitation after anterior cruciate ligament reconstruction (ACLR), there is a knowledge gap - a lack of evidence. Important questions such as how rehabilitation should be structured, what it should include, and how it should be evaluated are currently not clear. Therefore, the investigators plan to conduct a two-year follow-up randomized controlled trial (RCT) on post-ACLR rehabilitation.\n\nMoreover, detailed information on how\u002Funder what circumstances the ACL injury occurred is not satisfactorily described in the literature. Therefore, the investigators are planning a new survey that can identify, explain, and prevent the risk factors causing a person to suffer from an anterior cruciate ligament injury.\n\nSpecific Objectives:\n\nHow should guidelines for rehabilitation after ACLR be structured, what should they include, and how should they be evaluated to best restore knee function in the patient? Can a detailed and comprehensive survey identify, explain, and prevent the risk factors causing a person to suffer from an ACL injury?",[28],"2024-04-05",{"date":645,"type":46},"2024-04-08",{"date":647,"type":22},"2024-10-01",{"date":649,"type":22},"2027-10-01",{"name":651,"class":53},"Linnaeus University"]