[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-rupture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-rupture":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,31,0,25,[9,54,78,108,140,161,185,213,241,273,294,316,340,368,388,413,437,463,485,509,531,553,576,598,623],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644569","quadriceps-tendon-vs-peroneus-longus-tendon-in-acl-reconstruction-100644569",false,"NCT07671729","Quadriceps Tendon vs Peroneus Longus Tendon in ACL Reconstruction","A Prospective Randomized Clinical Trial Comparing Quadriceps Tendon and Peroneus Longus Tendon Autografts in Anterior Cruciate Ligament Reconstruction: Clinical, Functional, and Gait Analysis Outcomes","Inclusion Criteria:\n\n* Patients diagnosed with anterior cruciate ligament rupture\n* Patients scheduled for primary anterior cruciate ligament reconstruction\n* Age between 18 and 50 years\n* Ability to provide informed consent\n* Willingness to comply with postoperative rehabilitation and follow-up evaluations\n\nExclusion Criteria:\n\n* Previous ligament reconstruction surgery on the affected knee\n* Multi-ligament knee injuries requiring additional ligament reconstruction\n* Severe osteoarthritis of the knee\n* Revision anterior cruciate ligament reconstruction\n* Neuromuscular disorders affecting lower extremity function\n* Active infection\n* Inability to comply with follow-up protocol","ALL","18 Years","50 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This prospective randomized clinical trial aims to compare quadriceps tendon and peroneus longus tendon autografts in anterior cruciate ligament reconstruction. Patients with anterior cruciate ligament injury undergoing primary reconstruction surgery will be randomly assigned to one of the two graft groups. Clinical examination findings, return-to-sport outcomes, ankle muscle strength, ankle-related functional scores, and gait analysis parameters will be evaluated at 6 months and 12 months postoperatively. The study aims to investigate both knee-related functional outcomes and donor site morbidity associated with graft harvesting techniques.",[28,29],"Anterior Cruciate Ligament Injury","Anterior Cruciate Ligament Rupture",[31,32,33,34,35,36,37,38,39,40],"ACL reconstruction","Anterior cruciate ligament","Quadriceps tendon autograft","Peroneus longus tendon autograft","Gait analysis","Return to sport","Knee stability","Ankle muscle strength","Functional outcomes","Randomized controlled trial","RECRUITING","2026-06-23",{"date":44,"type":45},"2026-06-26","ACTUAL",{"date":47,"type":45},"2026-05-01",{"date":49,"type":22},"2027-12",{"name":51,"class":52},"Acibadem University","OTHER",1,{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100638297","effectiveness-of-enhanced-recovery-after-surgery-eras-protocols-for-arthroscopic-anterior-cruciate-ligament-reconstruction-in-an-ambulatory-surgery-setting-100638297","NCT07602231","Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols for Arthroscopic Anterior Cruciate Ligament Reconstruction in an Ambulatory Surgery Setting","Evaluation of Clinical Outcomes and Feasibility of Enhanced Recovery After Surgery (ERAS) Protocols for Arthroscopic Anterior Cruciate Ligament Reconstruction in an Ambulatory Surgery Setting: A Non-randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of anterior cruciate ligament (ACL) rupture with indication for primary arthroscopic reconstruction\n* Voluntary agreement to participate in the study and signing of the informed consent form\n\nExclusion Criteria:\n\n* Patients with concomitant knee pathologies requiring additional surgical procedures in the same session\n* Presence of contraindications for ambulatory (day) surgery\n* Failure to adhere to the scheduled follow-up visits",{"count":62,"type":22},115,[25],"The anterior cruciate ligament (ACL) is a critical component for maintaining knee stability by resisting anterior tibial translation and internal rotation. ACL rupture is one of the most common orthopedic injuries, with an estimated incidence of 70 cases per 100,000 people annually. Since its inception, arthroscopic anterior cruciate ligament reconstruction (AACLR) has proven to be the gold standard, providing excellent outcomes in terms of graft longevity, return to sports, and patient satisfaction. Modern medical trends are shifting toward day-surgery protocols, where patients are discharged within 24 hours without an overnight stay. This model is identified as a major factor in enhancing the quality of postoperative recovery and patient satisfaction.\n\nThe Enhanced Recovery After Surgery (ERAS) program utilizes evidence-based multimodal interventions to reduce surgical stress and accelerate functional recovery. While day-surgery for AACLR has been proven feasible globally, its implementation in Vietnam remains limited due to systemic barriers. At the University Medical Center Ho Chi Minh City, although ERAS has been applied since 2022, the average length of stay for AACLR is 2.57 days, indicating significant room for optimization. This study aims to evaluate the current compliance with ERAS and the effectiveness of fully implementing these protocols to enable a day-surgery model.\n\nThe research is designed in two phases, including a descriptive cohort and a clinical intervention. The intervention focuses on 06 core ERAS measures:\n\n* Comprehensive preoperative counseling and education.\n* Reducing preoperative fasting by using Maltodextrin 2 hours before surgery.\n* Standardized anesthesia combined with local infiltration analgesia (LIA).\n* Multimodal analgesia to minimize opioid consumption.\n* Early drainage removal within 6-8 hours postoperatively.\n* Immediate postoperative rehabilitation starting in the recovery unit. Effectiveness will be measured through various outcomes: the quality of early recovery via the QoR-15 score, mechanical knee function via the Lysholm Knee Scoring Scale (LKSS), and health-related quality of life via the EQ-5D-5L. Furthermore, a cost-effectiveness analysis (CEA) will be conducted using the Incremental Cost-Effectiveness Ratio (ICER). The study expects to demonstrate that strict ERAS adherence makes day-surgery AACLR feasible, reduces hospital-acquired infections, optimizes operating room productivity, and lessens the financial burden on both patients and the healthcare system.",[29,66,67],"Enhanced Recovery After Surgery (ERAS) Protocol","Ambulatory Surgery","NOT_YET_RECRUITING","2026-05-22",{"date":71,"type":45},"2026-05-28",{"date":73,"type":22},"2026-05-18",{"date":75,"type":22},"2027-06-30",{"name":77,"class":52},"University Medical Center Ho Chi Minh City (UMC)",{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":53},"100589586","cross-bracing-protocol-versus-surgery-for-acute-anterior-cruciate-ligament-rupture-100589586","NCT06956339","Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture","Evaluating Non-surgical Management of Acute Anterior Cruciate Ligament Rupture With a Novel BRACE Protocol Versus Early Surgical Reconstruction - a Comparative Effectiveness Randomised Controlled Trial","EMBRACE","Inclusion Criteria:\n\n* Aged 16 to 40 years;\n* Have a primary and acute ACL rupture (complete tear) confirmed by MRI scan;\n* At least moderately active before the ACL injury (a score of 5 to 10 on the Tegner Activity Scale before the injury);\n* Willing and able to give informed consent and participate fully in the interventions and assessment procedures;\n* Willing and able to cover the out-of-pocket costs associated with ACLR surgery.\n\nExclusion Criteria:\n\n* Have not completed the baseline questionnaire within 16 days of their initial ACL injury;\n* Inability to read and speak English\n* Concomitant knee injury diagnosed on MRI that requires surgical opinion and\u002For alterative treatment:\n\n  i) Loose body ii) Unstable osteochondral defect iii) Intra-articular fracture that extends into the articular surface and requires reduction iv) Displaced and\u002For unstable meniscal tear v) Grade 2 and 3 posterolateral corner injury vi) High-grade medial collateral ligament (MCL) injury that requires treatment with a knee brace and\u002For surgery vii) Posterior cruciate ligament (PCL) injury (partial discontinuity with some preserved fibers or complete disruption)\n* Severe disruption of ACL tissue visible on MRI:\n\n  i) Gap distance ≥8mm and ≥ 25% of tissue displaced outside of intercondylar notch ii) Gap distance ≥8mm and ≥ 25% of femoral footprint avulsed iii) ≥ 25% of femoral footprint avulsed and ≥ 25% of tissue displaced outside of intercondylar notch iv) Complete femoral or tibial avulsion\n* Concomitant patellofemoral joint dislocation diagnosed on MRI and\u002For self-reported history of recurrent patellofemoral joint instability or ≥1 patellofemoral joint dislocation;\n* Self-reported episode of instability (i.e. 'giving way') since initial MRI that resulted in increased pain, swelling and reduced function (without a subsequent MRI to re-determine eligibility);\n* Open growth plate of the femur and\u002For tibia visible on MRI;\n* Past history of ACL injury on the ACL-injured knee;\n* Past history of any surgery on ACL-injured knee;\n* Breastfeeding, pregnancy or planned pregnancy within the first 12 weeks of the trial;\n* Health conditions\u002Fmedications that are contraindications for ACLR, CBP and\u002For use of anticoagulant (rivaroxaban) medication:\n\n  i) Current deep vein thrombosis (DVT); ii) Past history of DVT and\u002For pulmonary embolism; iii) Diagnosed hypercoagulable disease (e.g., Protein C and Protein S deficiency, Factor 5 Leiden); iv) Significant renal\u002Fhepatic impairment (creatinine clearance \\\u003C15mL\u002Fmin, Child-Pugh score 10-15 (Class C)); v) Restless Legs Syndrome; vi) Current use of contraindicated medication (such as other anticoagulants, antiviral or oral anti-fungal medications); vii) Clinically significant active and\u002For recent bleeding (e.g., gastrointestinal, intracranial or haematuria); viii) At increased risk of clinically significant bleeding (e.g., significant inherited bleeding disorders, uncontrolled high blood pressure); ix) Other conditions requiring significant medical monitoring while anticoagulated, such as rheumatoid arthritis, type I or type II diabetes, autoimmune diseases; x) Self-reported body mass index (BMI) ≥40kg\u002Fm2, except in competitive athletes (defined as a pre-injury Tegner Activity Scale score of 7-10 and\u002For undertakes strength training\u002Fweightlifting two or more times per week); xi) Any known cardiovascular disease (history of stroke, coronary vascular disease); xii) Chronic obstructive pulmonary disease and\u002For chronic respiratory disease, except for controlled asthma; xiii) Acute infection of the knee or affected limb; xiv) Inflammatory arthropathy\u002Farthritis; xv) knee osteoarthritis in the ACL-injured knee (assessed on acute knee MRI, defined as focal partial thickness cartilage loss or greater (at least ACLOAS grade 2 cartilage lesion2626) plus one or more definite osteophyte (at least ACLOAS grade 2 osteophyte26 xvi) Concurrent immunosuppressive illness (e.g., AIDS, cancer) and\u002For immunosuppressant usage; xvii) Connective tissue disorders (such as Ehlers-Danlos syndrome); xviii) Current systemic steroid usage; xix) Intravenous drug users and\u002For substance addiction.","16 Years","40 Years",{"count":89,"type":22},180,[25],"The aim of the EMBRACE clinical trial is to compare outcomes (knee pain, symptoms, function and quality of life) between people with anterior cruciate ligament (ACL) rupture who are managed with either a novel bracing protocol (Cross Bracing Protocol), or with ACL reconstruction surgery. The main question that the trial aims to answer is:\n\nIn individuals with acute ACL rupture, is management with the Cross Bracing Protocol more clinically effective and cost effective compared to early ACL reconstruction surgery?\n\n180 people across five Australian cities, with a recent ACL injury, will be randomly allocated to one of two treatments.\n\n1. Cross Bracing Protocol\n\n   People who are allocated to the bracing treatment will:\n   * wear a knee brace for 12 weeks\n   * see a sports doctor\n   * have 23 visits to a physiotherapist who will supervise their knee rehab over 12 months.\n   * have two knee scans; 3 and 18 months after they enrol\n2. Anterior Cruciate Ligament Reconstruction Surgery\n\nPeople who are allocated to the surgery group will:\n\n* have surgery within 8 weeks of enrolling in the study\n* have 15 visits to a physiotherapist for their knee rehab over 12 months after surgery.\n* have one knee scan 18 months after they enrol.\n\nAll participants will:\n\n* complete surveys at the beginning and 3, 6, 12 and 18 months later so the main trial outcomes can be collected, as well as additional information about their knee.\n* have knee imaging (Magnetic Resonance Imaging or MRI scan) so the overall condition of their knee can be assessed, as well as whether their ACL has healed.",[29],[94,95,96,97,98],"anterior cruciate ligament","cross bracing","ACL healing","ACL","ACL reconstruction surgery","2026-05-06",{"date":101,"type":45},"2026-05-07",{"date":103,"type":45},"2025-08-07",{"date":105,"type":22},"2030-03",{"name":107,"class":52},"University of Melbourne",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":139},"100464113","optimized-rehabilitation-after-anterior-cruciate-ligament-before-returning-to-sport-100464113","NCT05323474","Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport","Optimized Rehabilitation After Anterior Cruciate Ligament Reconstruction at the First Step of Return to Sport","ORACL-Run","Inclusion Criteria:\n\n* Affiliation to the French Social Security system\n* Patient who has had an ACL reconstruction regardless of the standard surgical technique used\n* Patient with a sports activity, pivot and\u002For contact (e.g. soccer, basketball, handball, rugby, judo...) and practiced in competition (Tegner sports activity scores \\>7 and Marx scores \\>11 before the accident.\n* Patient wishing to return to competitive sport\n* Consent signed by the patient\n\nExclusion Criteria:\n\n* Contralateral or bilateral involvement or operated on for a re-injury of the ACL\n* Patients with a medical contraindication to the performance of one of the tests\n* Patients suffering from a neurological (motor and\u002For sensitive), vestibular or rheumatic pathology\n* Patient performing rehabilitation with a physiotherapist who does not wish to participate in the study.\n* Pregnant or breastfeeding woman\n* Patient under guardianship or curators","25 Years",{"count":118,"type":22},432,[25],"Following reconstruction of the anterior cruciate ligament (ACL), a standardized rehabilitation protocol is carried out by a physiotherapist. In France, a well-established rehabilitation consensus guides the first phase of 3 months postoperatively and patient compliance is generally excellent. The next phase should allow a return to sport (RTS) following a continuum depending on the objectives of the sport's patient, starting with a return to running activities (RTR) and a preparatory phase for a RTS which may be authorized at 6 months post-op.\n\nThis multicentre randomized control trial aims to evaluate the effectiveness of an individualized and optimized rehabilitation program guided by monthly assessments carried out by physiotherapists from the 3rd to the 6th month postoperatively to reduce the risk of new ACL injuries (operated or healthy knee), compared to standard management.",[122,29],"Ligament Knee Injury",[124,125,126,127,128,129],"Physiotherapy","Rehabilitation","Orthopedic surgery","Knee joint","Ligament","Anterior Cruciate Ligament Reconstruction","2026-04-21",{"date":132,"type":45},"2026-04-24",{"date":134,"type":45},"2022-11-14",{"date":136,"type":22},"2029-12",{"name":138,"class":52},"Centre Hospitalier Universitaire de Saint Etienne",8,{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":53},"100510264","effects-of-preoperative-rehabilitation-on-tendon-healing-bone-mineral-density-and-cartilage-after-aclr-and-patellar-dislocation-100510264","NCT05924178","Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation","A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation","Inclusion Criteria:\n\n1. Age 18\\~40 years old, diagnosed ACL rupture or Patellar Dislocation by MRI;\n2. The first unilateral ligamenta reconstruction at our hospital;\n\nExclusion Criteria:\n\n1. Be older than 40 years, or less than 18 years old\n2. Severe injury to other knee ligaments\n3. History of knee trauma","45 Years",{"count":21,"type":22},[25],"To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.",[29],"2026-04-12",{"date":154,"type":45},"2026-04-15",{"date":156,"type":45},"2023-07-10",{"date":158,"type":22},"2026-06-01",{"name":160,"class":52},"Peking University Third Hospital",{"id":162,"slug":163,"hasResults":12,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":168,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":53},"100555372","phase-4-intraosseous-morphine-administration-during-anterior-cruciate-ligament-reconstruction-100555372","NCT06511232","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft\n* Patients aged between 18-40 years old at the time of surgery\n\nExclusion Criteria:\n\n* Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB\n* Patients younger than 18 years old or older than 40 years old\n* Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status\n* Patients with a history of substance abuse\n* Vulnerable populations\n* Patients on chronic pain medication within the last 6 months\n* BMI \\>\u002F= 35\n* Allergy to morphine\n* Unwilling to participate\n* Any additional reason the PI deems reasonable",{"count":169,"type":22},84,[171],"PHASE4","The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.",[174,175,29],"Anterior Cruciate Ligament Tear","Anterior Cruciate Ligament Injuries","2026-04-07",{"date":178,"type":45},"2026-04-09",{"date":180,"type":45},"2024-08-19",{"date":182,"type":22},"2029-07-31",{"name":184,"class":52},"The Methodist Hospital Research Institute",{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":53},"100477764","vibration-on-patellofemoral-joint-pain-after-aclr-100477764","NCT05501210","Vibration on Patellofemoral Joint Pain After ACLR","The Effect of Whole-Body Vibration on Patellofemoral Joint Pain After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Age between 18 to 60\n2. Unilateral ACLR\n3. Persisting PFJ pain\n4. Isolated symptomatic site or pathology\n\nExclusion Criteria:\n\n1. Age \\> 60\n2. Bilateral ACLR\n3. Revision ACLR\n4. Any rheumatological diseases\n5. Previous contralateral knee injury\n6. Any knee osteoarthritis","60 Years",{"count":194,"type":22},50,[25],"Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing in direction while running, cutting and pivoting on a planted foot have resulted in a majority of ACL injuries. Even after ACL reconstruction (ACLR) surgeries, study has reported a 30-50% prevalence of developing patellofemoral joint (PFJ) pain in 1-2 years post-operation. Whole body vibration (WBV) therapy has been gaining attention as an effective method of training in recent years. It has been proved to have a positive effect on improving muscle strength, muscle activities, muscle power and loading during drop jump. Though duration of WBV may differ according to the effect of interest, several studies have had positive results with a 8 week WBV therapy in increasing muscle strength, proprioception, and post-ACLR knee functions. Further investigation on the underlying mechanism and possible application are to be continued to explore more possibilities with the WBV therapy.",[175,29,174,198],"Patellofemoral Pain",[200,201,202,203],"ACLR","Patellofemoral joint","Whole Body vibration","Knee function","2026-03-17",{"date":206,"type":45},"2026-03-18",{"date":208,"type":45},"2022-03-01",{"date":210,"type":22},"2029-09-01",{"name":212,"class":52},"Chinese University of Hong Kong",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":17,"minAge":86,"maxAge":147,"enrollmentInfo":221,"targetDuration":4,"studyType":23,"phases":223,"briefSummary":224,"conditions":225,"keywords":226,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":4},"100627677","are-clinical-outcomes-unchanged-by-all-fixation-at-0-or-30-of-knee-flexion-in-combined-acl-all-reconstruction-despite-numerous-technical-descriptions-of-anterolateral-procedures-there-is-limited-knowledge-regarding-the-effect-of-knee-flexion-angle-during-graft-fixation-100627677","NCT07451743","Are Clinical Outcomes Unchanged by ALL Fixation at 0° or 30° of Knee Flexion in Combined ACL-ALL Reconstruction? Despite Numerous Technical Descriptions of Anterolateral Procedures, There is Limited Knowledge Regarding the Effect of Knee Flexion Angle During Graft Fixation.","Are Clinical Outcomes Unchanged by ALL Fixation at 0° or 30° of Knee Flexion in Combined ACL-ALL Reconstruction?","ACL ALL","inclusion Criteria:\n\n* Patients with a unilateral anterior cruciate ligament (ACL) rupture confirmed by clinical examination and magnetic resonance imaging (MRI)\n* Persistent knee instability despite conservative treatment\n* Ability to understand the study procedures and provide written informed consent\n* Willingness to comply with the postoperative rehabilitation protocol and follow-up schedule\n\nExclusion Criteria:\n\n* Previous ACL reconstruction or revision surgery on the affected knee\n* Bilateral ACL injuries\n* Concomitant knee osteoarthritis greater than Kellgren-Lawrence grade 1\n* Concomitant ligament injuries requiring additional surgical procedures (except meniscal treatment)\n* History of neurological, vestibular, or visual disorders affecting balance or gait\n* Inflammatory joint disease or systemic musculoskeletal disorders\n* Incomplete baseline clinical data\n* Inability to complete patient-reported outcome questionnaires or attend follow-up visits",{"count":222,"type":22},100,[25],"This study evaluates whether the knee flexion angle used during fixation of the anterolateral ligament (ALL) affects clinical outcomes in patients undergoing combined anterior cruciate ligament (ACL) and ALL reconstruction.\n\nCombined ACL and ALL reconstruction is increasingly used to improve rotational knee stability and reduce the risk of graft failure after ACL injury. However, the optimal knee position for fixing the ALL graft during surgery remains unclear. In this study, patients were treated with ALL fixation performed either in full knee extension (0 degrees) or at 30 degrees of knee flexion.\n\nClinical outcomes, knee stability, patient-reported function, and graft failure rates were compared between the two groups at a minimum follow-up of two years. Outcomes were assessed using validated questionnaires, clinical examinations, and objective measurements of knee stability.\n\nThe study aims to determine whether the knee flexion angle at the time of ALL fixation influences postoperative function, stability, or complication rates, and to provide clinical evidence to guide surgical technique in combined ACL and ALL reconstruction.",[29],[227,228,229,230],"acl","all","antepor cruciate ligament","anterolateral ligament","2026-03-02",{"date":233,"type":45},"2026-03-05",{"date":235,"type":22},"2026-03-30",{"date":237,"type":22},"2029-01",{"name":239,"class":240},"ASL Lecce","OTHER_GOV",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":250,"briefSummary":251,"conditions":252,"keywords":253,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":53},"100543532","acl-reconstruction-with-shark-screw-or-biocomposite-interference-screws-100543532","NCT06357091","ACL Reconstruction With Shark Screw® or Biocomposite-interference Screws","ACL Reconstruction With Human Allograft Cortical Bone Screw (Shark Screw®) or Biocomposite-interference Screws - a Prospective, Randomized, Controlled Trial.","Inclusion Criteria:\n\n* MRI-verified rupture of the anterior cruciate ligament\n* Indication for replacement surgery\n* Surgery within 6 months of injury\n* Uninjured contralateral knee\n\nExclusion Criteria:\n\n* Previous rupture of the anterior cruciate ligament on the side to be operated on (rerupture)\n* Primary bone disease\n* inflammatory disease\n* Unstable meniscus\n* complete rupture of a collateral ligament\n* early rerupture during the examination period (early rerupture)",{"count":249,"type":22},80,[25],"The goal of this clinical trial is to compare the outcome of 2 different screws for Anterior cruciate ligament reconstruction. The main question is if the human allogeneic cortical bone screw reduces tunnel widening in comparison to conventional treatment with a biocomposite screw. Additional the re-rupture rate will be evaluated and knee scores will be recorded before surgery and after surgery. Participants will have MRI before and after surgery, 3, 6, 12, and 24 months after surgery and Computertomography after surgery, 3, 6 and 24 months after surgery. Questionnaires (Knee-scores) will be recorded before surgery, 6, 12, 24 months after surgery.\n\nthe investigators hope that with the human cortical bone screw the tunnel widening is reduced and the re-rupture rate is low",[29,129,28],[97,254,255,256,257,258,259,260,261,262,263],"tunnel widening","human allogeneic cortical bone screw","Shark Screw®","biotenodese screw","re-rupture rate","IKDC","KOOS","Lysholm Knee Score","Tegner Activity Score","range of motion (ROM)","2026-01-17",{"date":266,"type":45},"2026-01-21",{"date":268,"type":22},"2026-02-16",{"date":270,"type":22},"2034-01-31",{"name":272,"class":52},"Alexander Rofner-Moretti",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":280,"sex":17,"minAge":281,"maxAge":87,"enrollmentInfo":282,"targetDuration":4,"studyType":23,"phases":283,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":290,"leadSponsor":292,"locationsCount":53},"100618551","investigation-of-the-effects-of-proprioceptive-exercises-after-anterior-cruciate-ligament-surgery-100618551","NCT07333092","Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery","Investigation of the Effects of Proprioceptive Exercises on Balance, Kinesiophobia, and Functionality After Anterior Cruciate Ligament Surgery: A Randomized Controlled Trial","Inclusion Criteria\n\n* Being between 20-40 years of age\n* Having undergone anterior cruciate ligament (ACL) surgery\n* Being in the 2nd week of rehabilitation after ACL surgery\n\nExclusion Criteria\n\n* Having a concomitant meniscus injury\n* Having a concomitant medial collateral ligament injury\n* Being in the 1st week of rehabilitation after ACL surgery",true,"20 Years",{"count":194,"type":22},[25],"The aim of this study is to investigate the effects of proprioceptive exercises on balance, kinesiophobia, and functionality after anterior cruciate ligament surgery.",[175,29],"2026-01-15",{"date":288,"type":45},"2026-01-20",{"date":286,"type":45},{"date":291,"type":22},"2026-08-20",{"name":293,"class":52},"Uskudar University",{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":280,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":302,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":53},"100385164","sequar-semitendinosus-vs-quadriceps-in-anterior-cruciate-ligament-reconstruction-100385164","NCT04295148","SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction","SEQUAR - SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction - a Prospective Randomized Study","SEQUAR","Inclusion Criteria:\n\n* Pre-injury Tegner Activity Scale≥7\n* Intended return to sports to prior sport and Tegner Activity Scale Level\n* Time between injury and inclusion not more than 6 months\n* MR verified ACL rupture\n\nExclusion Criteria:\n\n* Previous knee injury with symptoms before ACL injury\n* Neurological disease, inflammatory disease, connective tissue disease or balance disorder\n* Previous lower limb fracture or surgery\n* Laxity in the medial collateral ligament (MCL) and lateral collateral ligament (LCL) \\> grade 1\n* PCL rupture or Multiligament knee injury (MLKI)\n* Radiographic sign of osteoarthritis (OA)\n* Previous knee surgery or ligament injury in contralateral knee\n* Beighton score ≥ 5",{"count":303,"type":22},200,[25],"Randomized control trial comparing two different Anterior Cruciate Ligament (ACL) grafts in Anterior Cruciate Ligament Reconstruction: the semitendinosus hamstrings graft and the quadriceps graft. Capio Artro Clinic (Stockholm) has vast experience in ACL surgery using both semitendinosus and quadriceps grafts.",[175,29,174],"2025-09-12",{"date":309,"type":45},"2025-09-18",{"date":311,"type":45},"2020-02-10",{"date":313,"type":22},"2035-05-31",{"name":315,"class":52},"Karolinska Institutet",{"id":317,"slug":318,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":328,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":339},"100594761","comparison-of-clinical-outcomes-between-all-inside-and-complete-tibial-tunnel-techniques-in-anterior-cruciate-ligament-reconstruction-among-patients-with-acl-ruptures-100594761","NCT07023653","Comparison of Clinical Outcomes Between All-Inside and Complete Tibial Tunnel Techniques in Anterior Cruciate Ligament Reconstruction Among Patients With ACL Ruptures","Inclusion Criteria:\n\n* Patients with anterior cruciate ligament rupture\n* Patients within the age range of 18 to 65 years\n\nExclusion Criteria:\n\n* Patients with Multiple Ligament Injuries in the Knee Joint\n* Patients with a pregnancy condition\n* Patients with Severe Osteochondral Defect (ICRS 4)\n* Patients with signs of inflamation in knee joint","65 Years",{"count":324,"type":22},40,[25],"This study aims to compare the functional outcomes of patients with ACL rupture following ACL reconstruction surgery using hamstring grafts, between the all-inside technique and the complete tibial tunnel technique. The hamstring graft, which serves as the tissue substitute for the damaged ACL, is harvested from the posterior thigh of the patient and used to replace the torn ligament during reconstruction",[29],[329],"All-inside Techniques","2025-06-09",{"date":332,"type":45},"2025-06-17",{"date":334,"type":45},"2024-10-15",{"date":336,"type":22},"2026-12-01",{"name":338,"class":52},"Indonesia University",2,{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":17,"minAge":86,"maxAge":322,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":354,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":53},"100591390","a-comparison-of-outcomes-after-anterior-cruciate-ligament-acl-or-anterior-cruciate-ligament-and-meniscus-aclmeniscus-surgery-using-semiconductor-fabric-products-100591390","NCT06979804","A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products","A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products: A Randomized, Double-Blinded, Placebo-Controlled Prospective Clinical Study","Inclusion Criteria:\n\n* Patients undergoing ACL or ACL+Meniscus surgery\n* Age 16 - 65\n* Patients with Body Mass Index (BMI) \\\u003C40\n* Patients who are willing and able to adhere to follow-up schedule and protocol guidelines.\n* Patients who are willing and able to sign corresponding research subject consent\u002Fassent form.\n\nExclusion Criteria:\n\n* Patient has a history of neurological conditions, including multiple sclerosis or Parkinson's disease\n* Patient has severe medical condition, including recent myocardial infarction, unstable angina, heart failure, severe anemia\n* Patient has had prior surgical treatment of the knee in the last 5 years or injection treatment(s) in the last 6 months\n* Patient has chronic pain conditions unrelated to knee condition\n* Patient has auto-immune or auto-inflammatory diseases\n* Patient has poorly controlled diabetes (HgA1c \\> 7.5)\n* Patient has BMI \\> 39.9\n* Patient has varicosities on the operative leg\n* Patient has severe peripheral artery disease (ABI \\\u003C 0.6)\n* Patient is considered a pain management patient\n* Patient has had previous blood clots or stroke\n* Patient has used tobacco within the last 90 days\n* Patient is not within the ages of 16-65\n* Patient has an active infection (local or systemic), or an open (non-surgical) wound in the areas of product application\n* Patient is unwilling or unable to sign the corresponding research subject consent\u002Fassent form\n* Patient meets any other criteria or has any other condition that, in the opinion of the investigator, would prevent them from completing the study or that, in the opinion of the investigator, would confound study results.",{"count":348,"type":22},135,[25],"The goal of this clinical trial is to determine the effect of semiconductor sleeves on the treatment of Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) arthroscopic surgery. The effect of the sleeves will be analyzed through patient reported and clinically measured outcomes. The main questions it aims to answer are:\n\n* Do the semiconductor sleeves improve the functional outcomes compared to the placebo?\n* Will patients experience improved functional outcomes in a shorter period of time compared to the placebo?\n\nResearchers will compare semiconductor fabric sleeves to a placebo (a look-alike sleeve that contains no semiconductor material) to see if the semiconductor fabric better treats ACL and ACL+meniscus surgical patients.\n\nParticipants will:\n\n* Wear semiconductor or placebo leg sleeve for 4 weeks and knee sleeve for the following 12 weeks\n* Complete patient reported outcome surveys",[352,353,29],"ACL Reconstruction","Meniscus Tears",[97,355,356,357,358,31],"Meniscus tear","ACL tear","Compression sleeve","Semiconductor fabric","2025-05-19",{"date":361,"type":45},"2025-05-22",{"date":363,"type":45},"2024-09-11",{"date":365,"type":22},"2026-10-01",{"name":367,"class":52},"Illinois Center for Orthopaedic Research and Education",{"id":369,"slug":370,"hasResults":12,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":374,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":386,"locationsCount":53},"100589485","effect-of-the-hockey-slideboard-training-combined-with-blood-flow-restriction-bfr-in-the-rehabilitation-following-anterior-cruciate-ligament-surgical-reconstruction-acl-r-100589485","NCT06955026","Effect of the Hockey Slideboard Training Combined With Blood Flow Restriction (BFR) in the Rehabilitation Following Anterior Cruciate Ligament Surgical Reconstruction (ACL-R)","Inclusion Criteria:\n\n* having undergone ACL-R following a unilateral rupture, with reconstructive surgical technique by bone-patellar tendon-bone autograft (BPTB) or semitendinosus-gracilis autograft (STG)\n* ACL-R including associated meniscal lesions treated with selective meniscectomy and\u002For non-complex meniscal suture\n\nExclusion Criteria:\n\n* not having undergone ACL-R following a unilateral rupture, with reconstructive surgical technique by bone-patellar tendon-bone autograft (BPTB) or semitendinosus-gracilis autograft (STG)",{"count":375,"type":22},30,[25],"ACL injuries represent a major health and economic burden. The overall incidence of ACL injuries has increased and is likely to continue to increase, in part due to increased sports participation.\n\nIn the acute post-surgical phase there is a period of physiologic recovery from the surgical injury and subsequent relative muscle disuse that is associated with atrophy loss of strength and anterior knee pain. Therefore, improvement of muscle function is a priority in the rehabilitation and reathletization process.\n\nTo achieve significant muscle hypertrophy as well as a possible subsequent increase in strength, it is widely accepted that resistance exercises with relevant load (\\~70% of the one repetition maximum - 1RM) are necessary; however, in patients undergoing anterior cruciate ligament reconstruction (ACL-R), exercises with high loads are considered unsafe in the early stages and could increase the risk of re-injury.\n\nBFR training is an established muscle training and rehabilitation technique in which the blood supply to and from the muscles involved in the exercise is restricted using an external device.\n\nAlthough the physiological mechanisms related to this intervention are not yet well understood, it is thought that in BFR training, despite the low level of mechanical tension, the main driver of myocellular hypertrophy could be metabolic stress that is realized by local accumulation of metabolites. Thus, it seems that hypertrophic adaptations can be induced with much lower exercise intensities using BFR. In fact, when combined with low-load resistance training (e.g., 20% 1RM), training with BFR has shown positive results in increasing muscle volume and strength after ACL-R in complete safety comparable to standard training without BFR.\n\nIt has also already been demonstrated how incorporating the use of the hockey slideboard into the rehabilitation procedure following ACL-R gives benefits in terms of strength recovery of the extensor muscles of the operated limb with the same safety profiles as standard rehabilitation.",[29,379],"Rehabilitation After ACL Reconstruction","2025-04-24",{"date":382,"type":45},"2025-05-02",{"date":384,"type":45},"2025-04-10",{"date":154,"type":22},{"name":387,"class":52},"Spitalul Municipal Odorheiu Secuiesc",{"id":389,"slug":390,"hasResults":12,"nctId":391,"briefTitle":392,"officialTitle":393,"acronym":4,"eligibilityCriteria":394,"healthyVolunteers":12,"sex":17,"minAge":395,"maxAge":87,"enrollmentInfo":396,"targetDuration":4,"studyType":23,"phases":398,"briefSummary":399,"conditions":400,"keywords":401,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":339},"100554933","combined-intra--and-extra-articular-acl-reconstruction-versus-isolated-intra-articular-acl-reconstruction-100554933","NCT06505525","Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction","Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction: Prospective Multicenter Randomized Clinical Trial With Hamstring Autograft","Inclusion Criteria\n\nPatients from the hospital's demand (emergency care and outpatient care) and from CROSS (Center for Regulation of Health Service Offers) who present one or more risk factors will be included:\n\n* Age (Female 14 years - 25 years and Male 16 years - 25 years);\n* Pivot-shift test \\> 2;\n* Chronic ACL injury (\\>12 months);\n* Athlete (Tegner Scale ≥ 7);\n* Tibial slope \\> 12 degrees;\n* Recurvatum \\> 5 degrees and \\\u003C 15 degrees (asymmetric);\n* Ligamentous Hypermobility (Beighton Scale \\> 5).\n\nNon-Inclusion Criteria\n\n* Individuals over 40 years of age will not be included;\n* ACL revision;\n* PCL injury (grade 2 and 3);\n* MCL injury (grade 2 and 3) or (grade 1 with valgus aligned axis);\n* CPL injury (grade 2 and 3 according to Fanelli classification);\n* Recurrent patellar dislocation;\n* Severe chondral lesion (ICRS grade 3 and 4) larger than 1cm2;\n* Previous ipsilateral knee surgery;\n* Kellgren Lawrence grade 3 or more;\n* Autoimmune\u002Frheumatologic inflammatory disease;\n* Contralateral knee ligament injury;\n* Malalignment \\> 5 degrees clinical asymmetry between limbs or symmetric \\> 10 degrees axis deviation to varus (corresponding to \\> 4 degrees varus between the anatomical axis of the femur and the anatomical axis of the tibia in the clinical examination) or \\> 10 degrees axis deviation to valgus (corresponding to \\> 16 degrees valgus between the anatomical axis of the femur and the anatomical axis of the tibia in the clinical examination);\n* Graft diameter \\\u003C 7 mm;\n* BMI \\> 35 or \\\u003C 18;\n* Active or undergoing treatment for malignant neoplasia;\n* Pregnancy or suspected pregnancy;\n* Psychiatric disorders.\n\nExclusion Criteria\n\nLeave of absence from work due to disability or reduced income assistance (worker's compensation) whenever one of the investigators considers that the participant may be simulating a worse health condition than reality in order to receive financial assistance with work leave.","14 Years",{"count":397,"type":22},146,[25],"Abstract\n\nIntroduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons. One can prioritize increasing the diameter of an isolated intra-articular graft or alternatively, using one graft limb as an extra-articular reinforcement via the anterolateral ligament (ALL) reconstruction, with both options aiming to reduce the re-rupture rate relative to traditional quadrupled hamstring grafts.\n\nObjective: To compare, through a prospective and randomized clinical trial, intra and extra-articular ACL reconstruction with ALL using hamstring autograft versus isolated anatomical ACL reconstruction using quintuple or sextuple hamstring autograft.\n\nMethods: 146 patients will be randomized into two groups of 73 patients. Patients included in the study will be evaluated preoperatively and after surgery at 3, 6, 9, 12, and 24 months postoperatively. The primary outcomes will be clinical failure rate and graft rerupture rate. Secondary outcomes will include functional capacity assessed through IKDC, Lysholm KOOS, and Tegner scores, pain using the VAS, as well as stability assessed by digital rolimeter and objective IKDC. Kinesiophobia and anxiety will be measured using the Tampa scale and Anxiety and Depression scale.\n\nKeywords: Rupture, Anterior Cruciate Ligament, Anterior Cruciate Ligament Reconstruction",[29,122],[402,403,129],"Rupture","Anterior Cruciate Ligament","2025-03-29",{"date":406,"type":45},"2025-04-03",{"date":408,"type":45},"2022-08-01",{"date":410,"type":22},"2027-06-01",{"name":412,"class":52},"Federal University of São Paulo",{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":420,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":423,"conditions":424,"keywords":426,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":434,"leadSponsor":436,"locationsCount":53},"100452676","phase-2-vitamin-d-to-improve-quadricep-muscle-strength-100452676","NCT05174611","Vitamin D to Improve Quadricep Muscle Strength","Vitamin D as an Intervention for Improving Quadricep Muscle Strength in Patients After Anterior Cruciate Ligament Reconstruction: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n1. Aged 18-40 with unilateral ACL injury\n2. Sporting injury with a Tegner score of 7\n3. Pre-op serum vitamin D level \\\u003C20 ng\u002Fml\n4. 4 months post-ACLR with serum Vitamin D level remained \\\u003C20ng\u002Fml\n5. LSI for quadriceps strength \\\u003C70% of contralateral leg at 4-month isokinetic assessment\n6. Both knees without history of injury\u002Fprior surgery\n\nExclusion Criteria:\n\n1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively\n2. Pre-operative radiographic signs of arthritis\n3. Metal implants that would cause interference on MRI\n4. Non-HS graft for ACLR\n5. Patient non-compliant to the rehabilitation program\n6. Regular sunbed users",{"count":21,"type":22},[422],"PHASE2","Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury.\n\nQuadriceps muscle atrophy after ACLR is well documented. This can be due to a decreased ability to regain muscle mass with rehabilitation. Athletes are one of the high-risk groups for vitamin D insufficiencies. Vitamin D deficiency can potentially result in decreased hypertrophy when exercising the muscle, leading to a poorer outcome in rehabilitation. Vitamin D has long been recognized for its effect on musculoskeletal health. It can have a direct effect on muscle hypertrophy by acting on specific vitamin D receptors (VDRs) on myocytes, and sufficient or increased levels of vitamin D in patients have been found to correlate with an increase in the size, number, and strength of muscle fibres. Quadriceps muscle hypertrophy after ACLR is triggered by exercise training, facilitated by diet and a number of intrinsic factors. As the rehabilitation programs and diets are similar in patients with varying extents of quadriceps muscle atrophy, individual responses (intrinsic factors) to exercise training may account for the resulting persistent quadriceps muscle atrophy. In this study, the investigators hypothesize that the deficiency of vitamin D may contribute to persistent quadriceps atrophy and weakness.\n\nWith a stringent double-blinded randomized-controlled-trial (RCT) research design, our proposal will then address the research questions: 'Does vitamin D supplements improve the vitamin D deficiency status in patients after ACL reconstruction?', and 'Does vitamin D supplements improve quadriceps muscle strength for patients after ACLR?'",[175,425,29,174],"Quadriceps Muscle Atrophy",[352,427,428,429],"Vitamin D","Quadricep muscle strength","Quadricep muscle atrophy","2025-03-17",{"date":432,"type":45},"2025-03-18",{"date":430,"type":45},{"date":435,"type":22},"2029-09-17",{"name":212,"class":52},{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":441,"acronym":4,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":443,"enrollmentInfo":444,"targetDuration":4,"studyType":23,"phases":446,"briefSummary":447,"conditions":448,"keywords":449,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":53},"100582101","assessing-the-efficacy-of-a-preoperative-navigation-system-in-anterior-cruciate-ligament-reconstruction-100582101","NCT06858930","Assessing the Efficacy of a Preoperative Navigation System in Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Preoperatively, the participant or guardian is willing and able to sign the informed consent form;\n2. Patients aged 18 to 80 years (inclusive of 18 and 80 years), regardless of gender;\n3. Patients who meet the diagnostic criteria for anterior cruciate ligament (ACL) tear and have no contraindications for implantation;\n4. Patients with mature skeletons;\n5. Good compliance and willingness and ability to participate in follow-up observations as required.\n\nExclusion Criteria:\n\n* (1) Participants who have previously participated in other clinical studies of drugs, biological agents, or medical devices but did not meet the primary study endpoint within the specified timeframe; (2) Patients with a known allergy to one or more implanted materials; (3) Patients who are physically frail or unable to tolerate surgery due to other systemic diseases; (4) Presence of active infectious lesions in the knee joint or other parts of the body; (5) Obesity with a BMI \\> 35; (6) Patients with severe diabetes (acute complications of diabetes, preoperative random blood glucose ≥ 16.7 mmol\u002FL with or without altered consciousness, such as diabetic ketoacidosis, suspected diabetic ketoacidosis, hyperglycemic hyperosmolar state, or lactic acidosis; chronic complications of diabetes leading to severe target organ damage requiring urgent treatment, such as acute cardiovascular and cerebrovascular diseases, renal insufficiency, severe vision loss due to retinal disease, intermittent claudication and ischemic symptoms due to peripheral vascular disease, diabetic foot); (7) Women who are pregnant or breastfeeding; (8) Drug users and substance abusers; (9) Patients who are mentally incapacitated or unable to understand the requirements for participating in the study, making cooperation difficult; (10) Those expected to have poor compliance, unwilling or unable to follow postoperative therapy and\u002For rehabilitation program instructions; (11) Other comorbid conditions that limit participation in the study, hinder compliance with follow-up, or affect the scientific integrity of the study; (12) Other conditions judged by the investigator to be unsuitable for inclusion.","80 Years",{"count":445,"type":22},76,[25],"The ACL surgery robot features a preoperative navigation system that enhances the precision of bone tunnel placement. As the first dual-bundle reconstruction surgical robot developed in China, it integrates advanced technology to ensure accurate anatomical alignment. This multi-center study aims to evaluate the robot's effectiveness in improving surgical outcomes and reducing complications, demonstrating the potential of domestic innovations in orthopedic surgery. With its high accuracy in locating bone tunnel footprints, this robot represents a significant advancement in ACL reconstruction techniques.\n\nThe trial is designed as a randomized controlled trial (RCT) led by a prospective randomized cohort. The study is initiated by Tsinghua University's long-term professor, Yu Jiakuo, and the product has received China's Class III clinical registration certificate.",[29],[450,31,451,452,453],"Anterior cruciate ligament rupture","Surgical Navigation","Robotic Surgery","Bone Tunnel Footprint Localization Accuracy","2025-02-28",{"date":456,"type":45},"2025-03-05",{"date":458,"type":45},"2025-01-24",{"date":460,"type":22},"2029-01-24",{"name":462,"class":52},"Beijing Tsinghua Chang Gung Hospital",{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":469,"targetDuration":4,"studyType":471,"phases":4,"briefSummary":472,"conditions":473,"keywords":474,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":53},"100562840","effect-of-preoperative-exercise-habits-on-knee-function-and-recurrence-rate-after-anterior-cruciate-ligament-reconstruction-100562840","NCT06608394","Effect of Preoperative Exercise Habits on Knee Function and Recurrence Rate After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Patients with anterior cruciate ligament rupture in Department of Sports Medicine, Peking University Third Hospital\n\nExclusion Criteria:\n\n* Severe other knee disorders (e.g., arthritis) are present.\n* Prior history of other knee surgeries\n* Inability to complete a postoperative rehabilitation program or long-term follow-up",{"count":470,"type":22},361,"OBSERVATIONAL","The aim of this study is to compare the knee function between patients with and without preoperative exercise habits at 1, 2 and 5 years after ACL surgery, and further analyze the effect of maintaining exercise habits on knee function and recurrence rate",[29],[475,476],"anterior cruciate ligament injuries","exercise habit","2025-02-10",{"date":479,"type":45},"2025-02-12",{"date":481,"type":45},"2024-11-30",{"date":483,"type":22},"2025-12-31",{"name":160,"class":52},{"id":486,"slug":487,"hasResults":12,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":4,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":492,"enrollmentInfo":493,"targetDuration":4,"studyType":471,"phases":4,"briefSummary":495,"conditions":496,"keywords":497,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":53},"100530702","anterior-cruciate-ligament-reconstruction-with-a-periosteal---patellar-tendon---bone-autograft---the-kocabey-press-fit-technique-100530702","NCT06190223","Anterior Cruciate Ligament Reconstruction With a Periosteal - Patellar Tendon - Bone Autograft - The Kocabey Press-Fit Technique","Anatomic Single Bundle Anterior Cruciate Ligament Reconstruction With a Press-fit Tibial Fixation Technique Using Periosteal - Patellar Tendon - Bone Autograft","Inclusion Criteria:\n\n* patients who underwent anatomical single-bundle anterior cruciate ligament reconstruction with periosteal - patellar tendon - bone autograft and press-fit tibial fixation technique after anterior cruciate ligament rupture\n* patients with at least 1 year of clinical and radiological follow-up\n* patients who did not undergo a revision\n\nExclusion Criteria:\n\n* Patients who underwent a secondary arthroscopy for any reason after primary surgery\n* Patients with a history of septic arthritis (before and after the surgery)\n* Those with a history of trauma after primary surgery to the operated knee\n* Patients who have not completed at least 1 year of follow-up","55 Years",{"count":494,"type":22},150,"This study aims to evaluate the clinical and radiological outcomes of patients undergoing anatomical single-bundle anterior cruciate ligament reconstruction with periosteal-patellar tendon-bone autograft and press-fit tibial fixation technique. The study also aims to compare these outcomes with other reconstruction techniques in the literature. The research investigates the results of a novel surgical technique, providing a minimally invasive and faster rehabilitation for patients undergoing surgery due to anterior cruciate ligament rupture. The technique does not use any screws or staples for tibial fixation, but it carries similar risks as existing techniques. The technique, similar to the well-known bone-patellar tendon-bone (BPTB) autograft technique, creates minimal bone defect at the tibial tuberosity. Over time, the defect remodels and causes minimal clinical discomfort. Despite these limitations, the authors expect patients operated with the investigated new technique to experience less postoperative swelling, less pain, faster mobilization, and earlier rehabilitation.",[29],[450,498,499],"Press-fit fixation","Patellar tendon graft","2025-01-27",{"date":502,"type":45},"2025-01-29",{"date":504,"type":45},"2023-11-23",{"date":506,"type":22},"2025-11-25",{"name":508,"class":52},"Ankara City Hospital Bilkent",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":519,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":53},"100571468","benefits-of-ballistic-tests-after-the-anterior-cruciate-ligament-surgery-100571468","NCT06720649","Benefits of Ballistic Tests After the Anterior Cruciate Ligament Surgery","Benefits of Ballistic Tests in the Decision to Return to Sport After the Ruptured Anterior Cruciate Ligament Surgery","BALLCA","Inclusion Criteria:\n\n* Adult patient (\\> 18 years),\n* Patient who has undergone ACL reconstruction of the hamstrings with or without associated extra-articular plastic surgery:\n\n  * Isolated ACL sprain without injury to the collateral ligaments or the PCL,\n  * ACL reconstruction without associated meniscal injury or with repaired or menisctomized meniscal injury,\n* Having to perform a K-STARTS test and an isokinetic test,\n* Having the Tegner score before the rupture.\n\nExclusion Criteria:\n\n* Patient with high cardio-respiratory risk,\n* Osteoarticular and neuromuscular traumatic sequelae of the lower limbs,\n* Degenerative neuromuscular diseases,\n* Connective Tissue and Collagen Disease (e.g. Marfan),\n* Follow-up of a medical treatment that may influence the neuro-muscular system (e.g., antidepressants, etc.) during the tests,\n* Pregnant, parturient or breastfeeding patient.",{"count":518,"type":22},140,[25],"During physical activities, the time available to produce a force is infinitely shorter than the time required to reach maximal muscle capacity.\n\nPrevious studies have observed that the time elapsed between ground contact and ACL rupture is on average 50-60 ms, suggesting that this is the time window available for any attempt at dynamic stabilization of the joint through muscle contraction.\n\nSports movements include ballistic movements, defined as very fast movements whose objective is to accelerate a moving mass as much as possible so that it reaches a high speed in a very short time. This is the case for vertical jumps, running and most movements performed in physical and sporting activities.\n\nThus; (1) isokinetic tests do not allow a rigorous analysis of the components related to the speed of the movement; (2) functional tests such as jumping, which only give a distance between one leg and the other, do not allow the calculation of precise and reproducible variables concerning the force and speed of the movement, in particular during the first milliseconds of the movement, and do not provide information on compensation phenomena. It is therefore interesting to use the ballistic tests developed to monitor the movements of athletes as a new possible indicator of the return to sport.\n\nThe main objective of this study is to evaluate the performance of ballistic tests in predicting failure to return to physical activity 24 months after ACL surgery.",[175,29],"2024-12-03",{"date":524,"type":45},"2024-12-06",{"date":526,"type":22},"2024-12-15",{"date":528,"type":22},"2028-06-15",{"name":530,"class":52},"Almaviva Sante",{"id":532,"slug":533,"hasResults":12,"nctId":534,"briefTitle":535,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":538,"targetDuration":4,"studyType":23,"phases":539,"briefSummary":540,"conditions":541,"keywords":542,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":53},"100567120","over-the-top-vs-anteromedial-aclr-with-lateral-extraarticular-tenodesis-100567120","NCT06664047","Over-the-Top vs. Anteromedial ACLR With Lateral Extraarticular Tenodesis","Radiological and Clinical Outcomes of Over-the-Top ACL Reconstruction vs. Anteromedial ACL Reconstruction With Additional Lateral Extraarticular Tenodesis: A Prospectively Randomized Controlled Trial","Inclusion Criteria:\n\n* Presence of an isolated anterior cruciate ligament (ACL) tear (isolated ligament injury).\n* Age between 18 and 50 years.\n* No previous history of surgery on the same knee.\n* MRI and CT scans performed at the end of the first postoperative year.\n\nExclusion Criteria:\n\n* Presence of additional ligamentous injury (e.g., posterior cruciate ligament or collateral ligament) along with the ACL tear.\n* Incomplete clinical scores.\n* History of previous surgery on the same knee.\n* Presence or history of infection.",{"count":494,"type":22},[25],"This study aims to compare the over-the-top (OTT) anterior cruciate ligament (ACL) reconstruction (ACL-R) technique with the anteromedial ACL-R + lateral extraarticular tenodesis (LET). It aims to provide valuable insights into two different surgical approaches aimed at enhancing knee stability. The over-the-top ACL-R technique, which involves routing the graft over the posterior aspect of the lateral femoral condyle, is known for its simplicity and ability to preserve the anatomical footprint of the ACL. Although a non-anatomical reconstruction, the OTT technique has shown comparable clinical results and good return to sports (RTS) ratios when compared to the conventional ACLR alone. It is also favored in revision surgeries or when there is difficulty accessing the femoral tunnel through conventional approaches. However, concerns regarding its ability to fully restore rotational stability persist, especially in high-demand athletes.\n\nIn contrast, the anteromedial portal technique for ACL-R, combined with LET, has gained popularity due to its effectiveness in controlling both anterior tibial translation and rotational instability. LET augments the intra-articular reconstruction by providing additional restraint against pivot shifts, which can be critical in patients with high-risk profiles for re-injury, such as those participating in pivoting sports. Comparing these two approaches in terms of clinical outcomes, graft integrity, rotational control, and return-to-sport rates with a prospectively randomized controlled trial will help clarify their roles in contemporary ACL surgery and could guide surgeons in choosing the most appropriate method based on patient-specific factors.",[29,175,174],[450,543,544],"Over-the-top reconstruction","Lateral extra-articular tenodesis","2024-10-30",{"date":547,"type":45},"2024-10-31",{"date":549,"type":45},"2024-10-24",{"date":551,"type":22},"2028-11-01",{"name":508,"class":52},{"id":554,"slug":555,"hasResults":12,"nctId":556,"briefTitle":557,"officialTitle":557,"acronym":4,"eligibilityCriteria":558,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":559,"targetDuration":4,"studyType":471,"phases":4,"briefSummary":560,"conditions":561,"keywords":562,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":568,"lastUpdatePostDateStruct":569,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":53},"100422522","follow-up-of-anterior-cruciate-ligament-reconstruction-100422522","NCT04781920","Follow-up of Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Patients having undergone an Anterior Cruciate Ligament (ACL) reconstruction\n\nExclusion Criteria:\n\n* None",{"count":303,"type":22},"Rupture of Anterior Cruciate Ligament (ACL) is a common pathology, but is subject to variability of associated lesions, surgical management and rehabilitation.",[29],[403,563,564,565,566,567],"reconstruction","Operative report","Consultation report","Isokinetic tests","Clinical surveys","2024-08-28",{"date":570,"type":45},"2024-08-29",{"date":572,"type":45},"2021-03-01",{"date":574,"type":22},"2027-09",{"name":138,"class":52},{"id":577,"slug":578,"hasResults":12,"nctId":579,"briefTitle":580,"officialTitle":580,"acronym":4,"eligibilityCriteria":581,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":582,"targetDuration":4,"studyType":471,"phases":4,"briefSummary":584,"conditions":585,"keywords":586,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":597,"locationsCount":53},"100545239","anterior-cruciate-ligament-acl-revision-surgery-french-national-study-100545239","NCT06379308","Anterior Cruciate Ligament (ACL) Revision Surgery: French National Study","Inclusion Criteria:\n\n* Patient with an anterior cruciate ligament (ACL) revision, defined as \"all surgical procedures involving replacement of the anterior cruciate ligament (ACL) graft with a new graft\".\n\nExclusion Criteria:\n\n* multil-igament injuries\n* any procedure where the ACL was not revised and where any additional graft was inserted\n* Patients who had already undergone their first revision anterior cruciate ligament (ACL) procedure",{"count":583,"type":22},300,"This is a national multicentric study led by the French Arthroscopy Society (SFA) evaluating clinical practice in anterior cruciate ligament (ACL) revision surgery (epidemiological data, morphological data, operative data, clinical and functional outcomes, and surgical complication rates).",[29],[587,97,588,589],"Knee","revision","surgery","2024-07-19",{"date":592,"type":45},"2024-07-22",{"date":594,"type":45},"2024-01-01",{"date":596,"type":22},"2027-04",{"name":138,"class":52},{"id":599,"slug":600,"hasResults":12,"nctId":601,"briefTitle":602,"officialTitle":603,"acronym":4,"eligibilityCriteria":604,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":605,"targetDuration":607,"studyType":471,"phases":4,"briefSummary":608,"conditions":609,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":53},"100549189","exploring-prolonged-amr-in-acl-reconstructed-patients-100549189","NCT06430775","Exploring Prolonged AMR in ACL Reconstructed Patients","Exploring Prolonged Arthrogenic Muscle Responses and Associated Factors After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscular or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":606,"type":22},190,"5 Months","The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:\n\n1\\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.\n\n2\\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.\n\n3\\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and\u002For postsurgical pain levels may exhibit a higher degree of long-lasting AMR.\n\n4\\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.\n\nParticipants will:\n\n* Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:\n\n  * Demopgraphical information\n  * Knee Injury and Osteoarthritis Outcome Score (KOOS)\n  * Lysholm Score (only question 1)\n  * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery)\n  * Numeric Rating Score (NRS) for pain levels during the day \\& during the night\n  * ACL-Return to Sport after Injury Scale (ACL-RSI)\n* Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.",[175,29,174,97,610,611,129,612,613],"ACL Injury","ACL Tear","Arthrogenic Muscle Inhibition","Arthrogenic Muscle Responses","2024-06-28",{"date":616,"type":45},"2024-07-01",{"date":618,"type":45},"2023-10-15",{"date":620,"type":22},"2026-05",{"name":622,"class":52},"University Ghent",{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":12,"sex":17,"minAge":86,"maxAge":631,"enrollmentInfo":632,"targetDuration":4,"studyType":23,"phases":634,"briefSummary":635,"conditions":636,"keywords":639,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":650,"locationsCount":339},"100531102","stopping-osteoarthritis-after-an-acl-tear-100531102","NCT06195423","Stopping OsteoARthritis After an ACL Tear","The Stop Osteoarthritis (SOAR) Hybrid Effectiveness-Implementation Type 1 Randomized Controlled Trial for Young People At-High-Risk of Early Onset Knee Osteoarthritis","SOAR","Inclusion Criteria:\n\n* Currently live in British Columbia, Canada\n* 16-35 years of age (inclusive)\n* 9-36-months past a first-time ACLR performed ≤12-months of first-time ACL tear\n* Currently not receiving knee care from a health or fitness provider and have no scheduled surgical procedures (any part of the body) that would interfere with exercise during the study.\n* Score below a KOOS4 PASS (\\\u003C79 points)\n* Have daily access to an email address and a computer with internet\n* Are willing to wear an activity tracker during the study\n\nExclusion Criteria:\n\n* Inability to communicate in English\n* No medical attention (healthcare provider) time-loss (missed physical activity, sport or work ≥2 occasions) injury to the ACLR knee before the ACL tear\n* Previous physician diagnosis of index knee osteoarthritis\n* Inflammatory arthritis or other systemic condition\n* Lower limb injury, surgery, or intra-articular injection in the past 6-months\n* Current pregnancy\n* MRI contraindications (i.e., Weight over 400 lbs (MRI machine limit); Pacemaker or any other implanted medical device (i.e., wires, defibrillator, artificial heart valve, an electronic device like a drug infusion pump, electrical stimulator for nerves or bones, coil, catheter, or filter in any blood vessel, ear or eye implant, or stainless steel intrauterine device (IUD); Brain or ferromagnetic aneurysm clip; any other metallic prostheses or shrapnel, bullets, or other metal fragments; injury where a piece of metal lodged in the eye or orbit, or; surgery, medical procedure or tattoos (including tattooed eyeliner) in the last 6 weeks).","35 Years",{"count":633,"type":22},210,[25],"By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will develop osteoarthritis by 40 years of age. These young people with old knees face knee pain and disability for much of their adult lives, interfering with parenting, work, and recreation. Yet, most do not know about osteoarthritis or how to reduce their risk.\n\nIn this clinical trial, people who have torn the Anterior Cruciate ligament in their knee and had reconstruction surgery 9-36 months previously will be randomized to receive either a 6-month virtual education and exercise therapy program called Stop OsteoARthritis (SOAR) or a minimal intervention control program. Researchers will test if those who received the SOAR program have larger gains in knee health, including pain, symptoms, function, and quality of life at 6, 12, and 24 months. Researchers will also use MRIs (baseline and 24 months) to assess how the SOAR program influences knee cartilage degeneration and its cost-effectiveness.",[637,29,638],"Knee Injuries","Osteoarthritis, Knee",[40,640,587,641,642,125],"Post-traumatic osteoarthritis","Osteoarthritis prevention","Exercise","2024-05-08",{"date":645,"type":45},"2024-05-10",{"date":647,"type":45},"2024-05-01",{"date":649,"type":22},"2028-12-30",{"name":651,"class":52},"University of British Columbia"]