[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament-tear\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament-tear":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,43,68,96,120,144,170,195,220,243,271],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100555372","phase-4-intraosseous-morphine-administration-during-anterior-cruciate-ligament-reconstruction-100555372",false,"NCT06511232","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction","Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft\n* Patients aged between 18-40 years old at the time of surgery\n\nExclusion Criteria:\n\n* Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB\n* Patients younger than 18 years old or older than 40 years old\n* Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status\n* Patients with a history of substance abuse\n* Vulnerable populations\n* Patients on chronic pain medication within the last 6 months\n* BMI \\>\u002F= 35\n* Allergy to morphine\n* Unwilling to participate\n* Any additional reason the PI deems reasonable","ALL","18 Years","40 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.",[27,28,29],"Anterior Cruciate Ligament Tear","Anterior Cruciate Ligament Injuries","Anterior Cruciate Ligament Rupture","RECRUITING","2026-04-07",{"date":33,"type":34},"2026-04-09","ACTUAL",{"date":36,"type":34},"2024-08-19",{"date":38,"type":21},"2029-07-31",{"name":40,"class":41},"The Methodist Hospital Research Institute","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":42},"100609125","therapeutic-benefits-of-a-motor-imaging-protocol-following-anterior-cruciate-ligament-reconstruction-surgery-100609125","NCT07210489","Therapeutic Benefits of a Motor Imaging Protocol Following Anterior Cruciate Ligament Reconstruction Surgery","Therapeutic Benefits of a Motor Imaging Protocol After Anterior Cruciate Ligament Reconstruction Surgery: Study of Lower Limb Symmetry During Various Functional Tests","IMAGERIEMOTR","Inclusion Criteria:\n\n* Patients aged 18 to 45;\n* Individuals who have undergone anterior cruciate ligament reconstruction for the first time on the operated leg;\n* All types of surgery (harvesting of the new gracilis or patellar tendon) within 3 months prior to inclusion;\n* Patients able to understand and read French;\n* Affiliation with a social insurance plan;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Recurrence or rupture of the contralateral anterior cruciate ligament;\n* Osteotomy;\n* Cognitive disorders observed by the investigator;\n* Vestibular disorders known to the patient or observed by the investigator;\n* Post-surgical complications (infection, early graft rupture);\n* Patient participating in another interventional clinical trial, or in a period of exclusion from another interventional study;\n* Patient under guardianship or conservatorship;\n* Pregnant or breastfeeding women.","45 Years",{"count":53,"type":21},70,[55],"NA","The purpose of this study is to compare changes in lower limb symmetry during functional and strength tests, before and after the motor imagery program, in patients who received the 3-week motor imagery program starting 3 months post-surgery versus patients who did not receive the motor imagery program.",[27],"NOT_YET_RECRUITING","2026-03-27",{"date":61,"type":34},"2026-03-30",{"date":63,"type":21},"2026-07",{"date":65,"type":21},"2027-03",{"name":67,"class":41},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":42},"100477764","vibration-on-patellofemoral-joint-pain-after-aclr-100477764","NCT05501210","Vibration on Patellofemoral Joint Pain After ACLR","The Effect of Whole-Body Vibration on Patellofemoral Joint Pain After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Age between 18 to 60\n2. Unilateral ACLR\n3. Persisting PFJ pain\n4. Isolated symptomatic site or pathology\n\nExclusion Criteria:\n\n1. Age \\> 60\n2. Bilateral ACLR\n3. Revision ACLR\n4. Any rheumatological diseases\n5. Previous contralateral knee injury\n6. Any knee osteoarthritis","60 Years",{"count":77,"type":21},50,[55],"Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing in direction while running, cutting and pivoting on a planted foot have resulted in a majority of ACL injuries. Even after ACL reconstruction (ACLR) surgeries, study has reported a 30-50% prevalence of developing patellofemoral joint (PFJ) pain in 1-2 years post-operation. Whole body vibration (WBV) therapy has been gaining attention as an effective method of training in recent years. It has been proved to have a positive effect on improving muscle strength, muscle activities, muscle power and loading during drop jump. Though duration of WBV may differ according to the effect of interest, several studies have had positive results with a 8 week WBV therapy in increasing muscle strength, proprioception, and post-ACLR knee functions. Further investigation on the underlying mechanism and possible application are to be continued to explore more possibilities with the WBV therapy.",[28,29,27,81],"Patellofemoral Pain",[83,84,85,86],"ACLR","Patellofemoral joint","Whole Body vibration","Knee function","2026-03-17",{"date":89,"type":34},"2026-03-18",{"date":91,"type":34},"2022-03-01",{"date":93,"type":21},"2029-09-01",{"name":95,"class":41},"Chinese University of Hong Kong",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":16,"minAge":105,"maxAge":18,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":42},"100385164","sequar-semitendinosus-vs-quadriceps-in-anterior-cruciate-ligament-reconstruction-100385164","NCT04295148","SEQUAR SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction","SEQUAR - SEmitendinosus vs QUadriceps in Anterior Cruciate Ligament Reconstruction - a Prospective Randomized Study","SEQUAR","Inclusion Criteria:\n\n* Pre-injury Tegner Activity Scale≥7\n* Intended return to sports to prior sport and Tegner Activity Scale Level\n* Time between injury and inclusion not more than 6 months\n* MR verified ACL rupture\n\nExclusion Criteria:\n\n* Previous knee injury with symptoms before ACL injury\n* Neurological disease, inflammatory disease, connective tissue disease or balance disorder\n* Previous lower limb fracture or surgery\n* Laxity in the medial collateral ligament (MCL) and lateral collateral ligament (LCL) \\> grade 1\n* PCL rupture or Multiligament knee injury (MLKI)\n* Radiographic sign of osteoarthritis (OA)\n* Previous knee surgery or ligament injury in contralateral knee\n* Beighton score ≥ 5",true,"16 Years",{"count":107,"type":21},200,[55],"Randomized control trial comparing two different Anterior Cruciate Ligament (ACL) grafts in Anterior Cruciate Ligament Reconstruction: the semitendinosus hamstrings graft and the quadriceps graft. Capio Artro Clinic (Stockholm) has vast experience in ACL surgery using both semitendinosus and quadriceps grafts.",[28,29,27],"2025-09-12",{"date":113,"type":34},"2025-09-18",{"date":115,"type":34},"2020-02-10",{"date":117,"type":21},"2035-05-31",{"name":119,"class":41},"Karolinska Institutet",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":42},"100543256","bone-marrow-aspirate-concentrate-for-anterior-cruciate-ligament-tear-treatment-100543256","NCT06353503","Bone Marrow Aspirate Concentrate for Anterior Cruciate Ligament Tear Treatment.","Using Autologous Bone Marrow Aspirate Concentrate to Treat Complete Anterior Cruciate Ligament Tear.","Inclusion Criteria:\n\n1- Confirmed diagnosis of complete or partial ACL tear via clinical examination and imaging studies.\n\n2\\. Aged between 20 and 55 years, to encompass the typical age range of patients with sports-related ACL injuries.\n\nExclusion Criteria:\n\n1- Patients with a history of bleeding disorders, as this could complicate the aspiration and injection procedures.\n\n2\\. Individuals with a history of malignancy, due to the potential risks associated with growth factors present in BMAC.\n\n3\\. Critically ill patients or those with comorbidities","20 Years","55 Years",{"count":130,"type":21},20,[55],"A single armed multicenter study enrolling 20 patients using autologous bone marrow aspirate concentrate (which is done under local or general anesthesia to aspirate around 1-2 cc\u002Fkg body weight then concentration which is done by using centrifugation and special disposable kit) local injection of 4 cc per joint under ultrasonic guidance ,completely sterile field with local anesthesia.",[27],"2025-08-02",{"date":136,"type":34},"2025-08-07",{"date":138,"type":34},"2024-04-02",{"date":140,"type":21},"2026-09-27",{"name":142,"class":143},"abdulmajeed hammadi","INDUSTRY",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":4},"100584598","prognosis-analysis-of-three-surgical-techniques-for-arthroscopic-anterior-cruciate-ligament-reconstruction-100584598","NCT06891430","Prognosis Analysis of Three Surgical Techniques for Arthroscopic Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\nDiagnosed with anterior cruciate ligament (ACL) rupture; Age between 18-50 years; All patients must have isolated anterior cruciate ligament (ACL) rupture; Knee joint degeneration \\\u003C KL grade II, and intraoperative cartilage injury \\\u003C ICRS grade III; All isolated ACL rupture patients must not have other ligament injuries; If accompanied by meniscus injury, the proportion of medial or lateral meniscus resection during surgery must not exceed 40%; The duration of the condition must be within one year after injury; No restriction on body weight; The cause of ACL rupture must be sports-related trauma or twisting injuries, excluding car accident injuries.\n\nExclusion Criteria:\n\nPatients with other surgical contraindications; Patients with poor compliance; Patients planning pregnancy; Patients deemed unsuitable for inclusion by the researchers.","50 Years",{"count":152,"type":21},180,[55],"This study hypothesizes that the tunnel positioning and drilling direction in two single-bundle reconstruction techniques (Anatomical Single-Bundle Reconstruction, ASBR, and Central Axial Single-Bundle Reconstruction, CASBR) influence the biomechanical environment of the graft, thereby affecting graft remodeling and maturation, ultimately impacting postoperative outcomes. Studies have shown that the graft bending angle (GBA) is a critical factor affecting graft ligamentization. ASBR, with a higher GBA, may result in poorer graft maturation, while CASBR, with a lower GBA, may provide a more favorable biomechanical environment. Additionally, graft volume has been identified as an important factor influencing postoperative graft maturation. Therefore, this study also examines the double-bundle reconstruction (DBR) technique, which has a GBA similar to CASBR.\n\nThe Impact of Three Techniques on Graft Maturation Anatomical Single-Bundle Reconstruction (ASBR)\n\nASBR involves drilling a single tunnel at both the femoral and tibial ends, with the tunnel positioned at the center of the dense fiber area of the ACL footprint. The femoral tunnel is positioned at 90° knee flexion and drilled at 120°, while the tibial tunnel is positioned at 70° knee flexion. Due to the higher GBA in ASBR, the graft may experience greater bending stress during motion, leading to impaired graft maturation, limited ligamentization, and increased stress concentration around the tunnel, potentially causing tunnel widening.\n\nCentral Axial Single-Bundle Reconstruction (CASBR)\n\nCASBR also involves drilling a single tunnel at both ends, but the tunnel is positioned in the posterior region of the dense fiber area of the ACL footprint, mimicking the central axis of the native ACL. The femoral tunnel is positioned at 90° knee flexion and drilled at 120°, while the tibial tunnel is positioned at 70° knee flexion. Compared to ASBR, CASBR's lower GBA results in more uniform graft stress distribution, promoting better graft maturation and reducing the risk of stress concentration and tunnel widening.\n\nDouble-Bundle Reconstruction (DBR)\n\nDBR involves drilling two tunnels at both the femoral and tibial ends, targeting the dense fiber areas of the anterior medial bundle (AMB) and posterior lateral bundle (PLB) of the ACL footprint. The positioning of the PLB tunnel is similar to CASBR, while the AMB tunnel is located in the anterior region of the footprint. DBR provides a more anatomically accurate distribution of forces, leading to a more even biomechanical environment. However, the increased number of tunnels may complicate stress distribution.\n\nImpact on Postoperative Outcomes ASBR, with its higher GBA, may lead to poor graft maturation and increased tunnel widening. CASBR, with a lower GBA, offers a more favorable biomechanical environment for graft maturation. While DBR ensures a more uniform force distribution, the additional tunnels may introduce complexities in stress distribution, potentially affecting postoperative recovery and return to sports (RTS).",[27],[157,158,159,160],"tunnel widening","Anterior Cruciate Ligament","double-bundle reconstruction","single-bundle reconstruction","2025-03-17",{"date":163,"type":34},"2025-03-24",{"date":165,"type":21},"2025-04-01",{"date":167,"type":21},"2025-06-01",{"name":169,"class":41},"Beijing Tsinghua Chang Gung Hospital",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":42},"100452676","phase-2-vitamin-d-to-improve-quadricep-muscle-strength-100452676","NCT05174611","Vitamin D to Improve Quadricep Muscle Strength","Vitamin D as an Intervention for Improving Quadricep Muscle Strength in Patients After Anterior Cruciate Ligament Reconstruction: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n1. Aged 18-40 with unilateral ACL injury\n2. Sporting injury with a Tegner score of 7\n3. Pre-op serum vitamin D level \\\u003C20 ng\u002Fml\n4. 4 months post-ACLR with serum Vitamin D level remained \\\u003C20ng\u002Fml\n5. LSI for quadriceps strength \\\u003C70% of contralateral leg at 4-month isokinetic assessment\n6. Both knees without history of injury\u002Fprior surgery\n\nExclusion Criteria:\n\n1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively\n2. Pre-operative radiographic signs of arthritis\n3. Metal implants that would cause interference on MRI\n4. Non-HS graft for ACLR\n5. Patient non-compliant to the rehabilitation program\n6. Regular sunbed users",{"count":178,"type":21},60,[180],"PHASE2","Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury.\n\nQuadriceps muscle atrophy after ACLR is well documented. This can be due to a decreased ability to regain muscle mass with rehabilitation. Athletes are one of the high-risk groups for vitamin D insufficiencies. Vitamin D deficiency can potentially result in decreased hypertrophy when exercising the muscle, leading to a poorer outcome in rehabilitation. Vitamin D has long been recognized for its effect on musculoskeletal health. It can have a direct effect on muscle hypertrophy by acting on specific vitamin D receptors (VDRs) on myocytes, and sufficient or increased levels of vitamin D in patients have been found to correlate with an increase in the size, number, and strength of muscle fibres. Quadriceps muscle hypertrophy after ACLR is triggered by exercise training, facilitated by diet and a number of intrinsic factors. As the rehabilitation programs and diets are similar in patients with varying extents of quadriceps muscle atrophy, individual responses (intrinsic factors) to exercise training may account for the resulting persistent quadriceps muscle atrophy. In this study, the investigators hypothesize that the deficiency of vitamin D may contribute to persistent quadriceps atrophy and weakness.\n\nWith a stringent double-blinded randomized-controlled-trial (RCT) research design, our proposal will then address the research questions: 'Does vitamin D supplements improve the vitamin D deficiency status in patients after ACL reconstruction?', and 'Does vitamin D supplements improve quadriceps muscle strength for patients after ACLR?'",[28,183,29,27],"Quadriceps Muscle Atrophy",[185,186,187,188],"ACL Reconstruction","Vitamin D","Quadricep muscle strength","Quadricep muscle atrophy",{"date":190,"type":34},"2025-03-18",{"date":161,"type":34},{"date":193,"type":21},"2029-09-17",{"name":95,"class":41},{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":150,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":42},"100567120","over-the-top-vs-anteromedial-aclr-with-lateral-extraarticular-tenodesis-100567120","NCT06664047","Over-the-Top vs. Anteromedial ACLR With Lateral Extraarticular Tenodesis","Radiological and Clinical Outcomes of Over-the-Top ACL Reconstruction vs. Anteromedial ACL Reconstruction With Additional Lateral Extraarticular Tenodesis: A Prospectively Randomized Controlled Trial","Inclusion Criteria:\n\n* Presence of an isolated anterior cruciate ligament (ACL) tear (isolated ligament injury).\n* Age between 18 and 50 years.\n* No previous history of surgery on the same knee.\n* MRI and CT scans performed at the end of the first postoperative year.\n\nExclusion Criteria:\n\n* Presence of additional ligamentous injury (e.g., posterior cruciate ligament or collateral ligament) along with the ACL tear.\n* Incomplete clinical scores.\n* History of previous surgery on the same knee.\n* Presence or history of infection.",{"count":203,"type":21},150,[55],"This study aims to compare the over-the-top (OTT) anterior cruciate ligament (ACL) reconstruction (ACL-R) technique with the anteromedial ACL-R + lateral extraarticular tenodesis (LET). It aims to provide valuable insights into two different surgical approaches aimed at enhancing knee stability. The over-the-top ACL-R technique, which involves routing the graft over the posterior aspect of the lateral femoral condyle, is known for its simplicity and ability to preserve the anatomical footprint of the ACL. Although a non-anatomical reconstruction, the OTT technique has shown comparable clinical results and good return to sports (RTS) ratios when compared to the conventional ACLR alone. It is also favored in revision surgeries or when there is difficulty accessing the femoral tunnel through conventional approaches. However, concerns regarding its ability to fully restore rotational stability persist, especially in high-demand athletes.\n\nIn contrast, the anteromedial portal technique for ACL-R, combined with LET, has gained popularity due to its effectiveness in controlling both anterior tibial translation and rotational instability. LET augments the intra-articular reconstruction by providing additional restraint against pivot shifts, which can be critical in patients with high-risk profiles for re-injury, such as those participating in pivoting sports. Comparing these two approaches in terms of clinical outcomes, graft integrity, rotational control, and return-to-sport rates with a prospectively randomized controlled trial will help clarify their roles in contemporary ACL surgery and could guide surgeons in choosing the most appropriate method based on patient-specific factors.",[29,28,27],[208,209,210],"Anterior cruciate ligament rupture","Over-the-top reconstruction","Lateral extra-articular tenodesis","2024-10-30",{"date":213,"type":34},"2024-10-31",{"date":215,"type":34},"2024-10-24",{"date":217,"type":21},"2028-11-01",{"name":219,"class":41},"Ankara City Hospital Bilkent",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":227,"maxAge":51,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":42},"100564631","effect-of-acl-reconstruction-in-biomechanical-properties-of-ankle-joint-complex-100564631","NCT06631690","Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex","Effect of ACL Reconstruction Using Peroneus Longus Versus Hamstring Autografts on Biomechanical Properties of Ankle Joint Complex","Inclusion Criteria:\n\n* Age ranging between 15- 45 years\n* Having unilateral isolated ACL tear with no concomitant tear of other ligaments of the knee\n* Having no evidence of meniscal repair\n* Having bilateral healthy ankle before surgery.\n\nExclusion Criteria\n\n* Pre-existing ankle injury or ankle instability\n* Associated ligament injury, chondral damage, meniscal injury, fracture around the knee, and presence of pathologic condition in the lower extremity or an abnormal contralateral knee joint.\n* Visible mal-alignments in the lower extremities.\n* Previous surgery to the affected knee.","15 Years",{"count":229,"type":21},40,[55],"BACKGROUND:\n\nAnterior cruciate ligament (ACL) is an important ligamentous structure in the knee joint which contributes in maintaining stability. ACL injury contribute to approximately 50% of knee injuries .The incidence of ACL ruptures is estimated to be between 30 and 78 per 100,000 people per year .\n\nThe incidence of ACL ruptures varies depending on a number of factors, including age, sex, sport participation, and genetics. ACL ruptures are most common in young adults, particularly women. The risk of an ACL rupture has been reported as 2-8 times higher for women than for men. A systematic review study found that the risk of ACL injury was highest in football, followed by soccer, basketball, and skiing .\n\nNowadays, Peroneus longus tendon (PLT) autograft is used in orthopaedic surgeries. Some studies reported that PLT graft had maintained a possible more efficient ACL substitute for its tensile strength and regeneration ability after being inserted post-surgery . The PLT graft has additional benefit as it does not cause secondary injury to the knee and its adjacent structures .\n\nAnkle proprioception is one of the crucial components contributing to postural control . PLT graft for ACL reconstruction might affect the already compromised body balance by influencing postural stability and ankle stability at the donor ankle site. So, this study will be conducted to assess and compare the effect of ACLreconstruction with PLT graft to the effect of ACL reconstruction with HT graft on ankle stability and postural control .",[27,233],"Ankle Sprains","2024-10-06",{"date":236,"type":34},"2024-10-08",{"date":238,"type":34},"2023-12-10",{"date":240,"type":21},"2024-12-10",{"name":242,"class":41},"Cairo University",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":250,"targetDuration":252,"studyType":253,"phases":4,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":42},"100549189","exploring-prolonged-amr-in-acl-reconstructed-patients-100549189","NCT06430775","Exploring Prolonged AMR in ACL Reconstructed Patients","Exploring Prolonged Arthrogenic Muscle Responses and Associated Factors After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscular or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":251,"type":21},190,"5 Months","OBSERVATIONAL","The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:\n\n1\\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.\n\n2\\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.\n\n3\\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and\u002For postsurgical pain levels may exhibit a higher degree of long-lasting AMR.\n\n4\\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.\n\nParticipants will:\n\n* Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:\n\n  * Demopgraphical information\n  * Knee Injury and Osteoarthritis Outcome Score (KOOS)\n  * Lysholm Score (only question 1)\n  * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery)\n  * Numeric Rating Score (NRS) for pain levels during the day \\& during the night\n  * ACL-Return to Sport after Injury Scale (ACL-RSI)\n* Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.",[28,29,27,256,257,258,259,260,261],"ACL","ACL Injury","ACL Tear","Anterior Cruciate Ligament Reconstruction","Arthrogenic Muscle Inhibition","Arthrogenic Muscle Responses","2024-06-28",{"date":264,"type":34},"2024-07-01",{"date":266,"type":34},"2023-10-15",{"date":268,"type":21},"2026-05",{"name":270,"class":41},"University Ghent",{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":150,"enrollmentInfo":278,"targetDuration":4,"studyType":22,"phases":280,"briefSummary":281,"conditions":282,"keywords":283,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":42},"100512484","tunnel-widening-in-augmented-acl-integration-via-prp-enriched-collected-autologous-bone-vs-standard-acl-technique-100512484","NCT05953051","Tunnel Widening in Augmented ACL Integration Via PrP Enriched Collected Autologous Bone vs Standard ACL Technique","A Single-center, Patient-blinded, Randomized, 2-year, Parallel-group, Superiority Study to Compare the Efficacy of Augmented ACL Integration Via Platelet-rich-plasma Enriched Collected Autologous Bone Versus Standard ACL Technique","Inclusion Criteria:\n\n* Age 18-50 years\n* Primary ACL rupture\n* Time from injury to surgery: 4 weeks to 6 months\n* Single ACL rupture (isolated rupture)\n* ACL surgery with one of the participating senior surgeons\n* Informed Consent as documented by signature\n\nExclusion Criteria:\n\n* Concomitant ligamentous instability\u002Frupture\n* Requirement for Meniscus suture (partial resection accepted, hoop and roots remain intact)\n* Requirement for cartilage invasive treatment (debridement accepted)\n* Osteoarthritis at index knee joint\n* Leg axis deviation over 3° valgus or 4° varus\n* Claustrophobia (contra-indication for the MRI)\n* Women who are pregnant or breast feeding or intention to become pregnant during the study\n* Known or suspected non-compliance, drug or alcohol abuse\n* Inability of the patient to follow the study procedures, e.g. language problems, psychological disorders, dementia, etc.",{"count":279,"type":21},107,[55],"The purpose of this clinical study is to compare the outcomes of two surgical techniques for reconstruction of the anterior cruciate ligament (ACL) after a single, primary ACL rupture.\n\nThe main question to be answered is:\n\n\\- Does less widening of the tibial tunnel occur when a bone\u002FPlatelet rich plasma (PrP) composite material is placed directly into the tibial tunnel after fixation of the implant (experimental group) compared to the same surgery without the use of the composite material (control group)?\n\nParticipants will be randomized into one of the two groups and they will not know which group they belong to. After 12 months they will undergo CT, MRI, medical examination and functional knee testing. They will have a further medical examination and functional knee testing at 24 months. Patient Reported Outcomes will be collected before surgery, 6, 12 and 24 months after surgery.",[27],[259,284,285],"Platelet-Rich Plasma","Bone Tunnel Widening","2024-01-26",{"date":288,"type":34},"2024-01-29",{"date":290,"type":21},"2024-01",{"date":292,"type":21},"2027-08",{"name":294,"class":41},"Schulthess Klinik"]