[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-cruciate-ligament\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-cruciate-ligament":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,70,94,124,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100635537","randomized-arthrex-nano-arthroscopy-in-arthroscopic-acl-vs-conventional-arthroscopy-100635537",false,"NCT07553975","Randomized Arthrex Nano Arthroscopy in Arthroscopic ACL vs Conventional Arthroscopy","Randomized Study Evaluating Cost of Arthrex Nano Arthroscopy Products in Arthroscopic Knee ACL Surgery Versus Conventional Arthroscopy","Inclusion Criteria:\n\n* Subject is 18 - 60 years of age.\n* Subject body mass index (BMI) is 40 or lower (BMI ≤ 40).\n* Subject signed informed consent and is willing and able to comply with all study requirements and follow-up visits.\n* Confirmed ACL injury by MRI and physical exam as per standard of care.\n* Subjects not excluded for having meniscal pathology that requires resection or repair.\n* Subjects not excluded for having lateral-extra-articular tenodesis\n\nExclusion Criteria:\n\n* Revision ACL case.\n* Current bilateral knee injury.\n* Insufficient quantity or quality of bone.\n* Blood supply limitations and previous infections which may retard healing.\n* Subjects that are skeletally immature.\n* Advanced Osteoarthritis; Kellgren Lawrence ≥ 2\n* Fracture of the lower extremities within 6 months prior to screening.\n* Previous surgery on the affected knee within 12 months related to the ACL reconstruction, prior to screening.\n* Sensitivity to silicone, polyester, nylon, FD\\&C Blue No. 2 dye and beeswax.\n* Other concomitant disease that would interfere with study outcomes.\n* Subject is included in a vulnerable population (child, prisoner, etc.).\n* Conditions that tend to limit the patient's ability or willingness to restrict activities, follow directions, or perform online subject assessments during the healing period.\n* Subject is requesting or receiving Worker's compensation related to the knee injury.",true,"ALL","18 Years","60 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study is a pilot study designed to generate preliminary data regarding the cost of ACL surgery using NanoScope versus conventional arthroscopy in a traditional operating room (OR) setting.",[28],"Anterior Cruciate Ligament","NOT_YET_RECRUITING","2026-04-20",{"date":32,"type":33},"2026-04-28","ACTUAL",{"date":35,"type":22},"2026-05-01",{"date":37,"type":22},"2029-05-01",{"name":39,"class":40},"University of Colorado, Denver","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":23,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100583369","phase-3-acb-vs-no-block-for-pediatric-acl-reconstruction-100583369","NCT06875427","ACB vs no Block for Pediatric ACL Reconstruction","Comparing Preoperative Adductor Canal vs. No Block for Quality of Recovery After Anterior Cruciate Ligament Reconstruction in Patients Younger Than 18 Years of Age: A Randomized Controlled Feasibility Trial","Inclusion Criteria:\n\n* Patients ASA I, II and III\n* 10-18 years of age\n* scheduled for ACL reconstruction\n* agreeable to regional block and follow-ups\n\nExclusion Criteria:\n\n* Contraindications to adductor canal block.\n* Patients with coagulopathies, preexisting neurologic deficit\n* Significant comorbidities that may impact recovery or interfere with the study.\n* Refusal to regional techniques.\n* Moderate to severe cognitive deficit (patients who are unable to complete the questionnaire)\n* Patients with history of malignant hyperthermia","10 Years",{"count":50,"type":22},38,[52],"PHASE3","The goal of this randomized controlled feasibility clinical trial is to assess the feasibility of conducting a randomized trial of adding a perioperative single-shot adductor canal block to standard of care general anesthesia compared to non-regional techniques in pediatric patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction. The main clinical question it aims to answer is does ACB result in improved Quality of Recovery-15 questionnaire scores on postoperative day 2 , postoperative day 14, and postoperative day 42. Secondary questions this study will address are will use of a single-shot adductor canal block result in: less total opioid consumption; shorter post anesthetic care unit (PACU) length of stay; better pain scores at rest and with movement at time of postoperative phone call; and patient satisfaction score at 2 weeks (postoperative day 14). Researchers will compare the scores to patients undergoing the same surgery who will not have a single-shot ACB. All patients will receive the same pre-, peri-, and postoperative care with the exception of being randomized to block or no block. Participants will be asked to answer the Quality of Recovery-15 questionnaire and rate their pain on a scale of 0-10 on the day of surgery, at postoperative day 2 (by telephone) and at postoperative day 14 and postoperative day 42 during regular orthopedic clinic follow-up. Patients and caregivers will rate their satisfaction at postoperative day 42, using a 5-item Likert scale (ranging from completely dissatisfied to completely satisfied).",[28,55],"Anterior Cruciate Ligament (ACL) Tear",[57,58],"single-shot adductor canal block","anterior cruciate ligament reconstruction","RECRUITING","2025-09-23",{"date":62,"type":33},"2025-09-26",{"date":64,"type":33},"2025-07-01",{"date":66,"type":22},"2027-01",{"name":68,"class":40},"Isabella Jaramillo",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":69},"100607226","clinical-outcome-of-intra-articular-injection-of-autologous-platelet-rich-plasma-in-anterior-cruciate-ligament-injury-100607226","NCT07185802","Clinical Outcome of Intra Articular Injection of Autologous Platelet Rich Plasma in Anterior Cruciate Ligament Injury.","ACL","Inclusion criteria:\n\n* Patients of both sexes who are older than 18 years and younger than 50 years\n* 3 or Less than 3-months history of knee injuries\n* ACL injury MRI Grade 1 (Low) and medium Grade 2 (Medium) grade\n* ACL injury associated with Grade 1 or 2 Posterior cruciate ligament (PCL) tear and\u002For Grade 1 or 2 meniscal tear\n* The Complete Blood Count (CBC) report shows a hemoglobin \\> 10gm\u002Fdl and platelet count \\>150,000\u002Fmicroliter prior to the procedure\n* Capable of comprehending informed consent\n\nExclusion criteria:\n\n* Patients who have had intra articular corticosteroid injections in the index knee during the last 12 weeks\n* Patients who are taking systemic steroid\n* Patients who are younger than 18 and older than 50 years\n* Those with a history of platelet disorders or on the therapeutic anticoagulant or anti platelet drugs\n* Hemoglobin below 10 gm\u002Fdl\n* Platelet count \\\u003C150000\u002Fmicroliter\n* Complete tear of both bundles on MRI\n* Grade 3 or more PCL and meniscal tear on MRI\n* Previous or concurrent ligament reconstruction in the index knee joint.\n* Connective tissue disorders like Marfan Syndrome, Ehler-Danlos Syndrome etc.\n* Any inflammatory disease like Rheumatoid Arthritis, spondyloarthritis, gout, pseudogout etc involving the knee joint.","50 Years",{"count":79,"type":22},52,[25],"This clinical trial will evaluate the effectiveness of platelet-rich plasma (PRP) injections for patients with anterior cruciate ligament (ACL) injury. ACL injuries commonly cause knee instability, pain, and reduced function, and rehabilitation alone may not fully restore recovery in all patients. PRP is prepared from a small sample of the patient's own blood and contains natural growth factors that may promote healing and improve joint function.\n\nIn this study, participants will be randomly assigned to one of two groups. The experimental group will receive a single ultrasound-guided injection of PRP into the knee joint along with a standard rehabilitation program. The control group will receive the rehabilitation program alone.\n\nParticipants will be followed up at 3 weeks, 8 weeks, and 16 weeks after treatment. At each follow-up visit, knee function, pain level, and physical performance will be assessed using validated outcome measures. The primary aim is to determine whether PRP provides additional benefit compared with rehabilitation alone in improving function and reducing symptoms in ACL-injured patients.\n\nThis study will provide new evidence about the role of PRP in ACL management, which may help guide future treatment decisions.",[28],[84],"PRP in ACL injury","2025-09-19",{"date":87,"type":33},"2025-09-22",{"date":89,"type":33},"2025-08-27",{"date":91,"type":22},"2026-08-26",{"name":93,"class":40},"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":69},"100556790","michigan-split-belt-treadmill-training-program-to-improve-long-term-knee-biomechanics-after-acl-reconstruction-100556790","NCT06529692","Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction","Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)","Mi-SPA","Inclusion Criteria:\n\n* aged 14-45 years\n* suffered an acute, complete ACL rupture as confirmed by MRI and physical exam\n* have undergone ACL reconstruction w autograft within the past 10 months\n* willingness to participate in testing and follow-up as outlined in the protocol\n* English-speaking\n\nExclusion Criteria:\n\n* inability to provide written informed consent\n* female subjects who are pregnant or are planning to become pregnant (self-reported)\n* previous ACL injury\n* previous surgery to either knee\n* bony fracture accompanying ACL injury\n* patients who experienced a knee dislocation\n* patients who had their ACL reconstructed with an allograft\n* patients who underwent a multi-ligamentous and\u002For staged ACL reconstruction","14 Years","45 Years",{"count":105,"type":22},9,[25],"The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group.\n\nThe goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention.\n\nThe investigators' main question for this aim is:\n\n1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group?\n2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?",[75,28,109],"ACL Injury",[111,112,113,114],"Biomechanics","Knee Loading","Split-Belt Treadmill","Asymmetric Walking","2025-09-04",{"date":117,"type":33},"2025-09-08",{"date":119,"type":33},"2025-08-13",{"date":121,"type":22},"2026-08",{"name":123,"class":40},"University of Michigan",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":17,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100599586","robot-assisted-versus-conventional-arthroscopic-acl-reconstruction-a-prospective-comparative-study-100599586","NCT07086417","Robot-Assisted Versus Conventional Arthroscopic ACL Reconstruction: A Prospective Comparative Study","A Prospective Controlled Study on Robot-Assisted Versus Conventional Arthroscopic Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Age over 16 years old; Primary anterior cruciate ligament (ACL) rupture confirmed by physical examination and MRI; Surgery scheduled within 3 months of injury; Patients eligible for autograft ACL reconstruction using 8S-ST\u002FG technique; Normal range of motion in the contralateral knee; Willingness to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Previous surgery on either knee; Multi-ligament injuries or complex injuries requiring additional procedures; History of rheumatologic or systemic inflammatory joint diseases; Moderate to severe osteoarthritis (Kellgren-Lawrence grade ≥ 2); Poor general health or contraindications to surgery; Refusal to participate or inability to follow up.","16 Years",{"count":133,"type":22},120,[25],"This study aims to evaluate the clinical efficacy and biomechanical accuracy of a newly developed robot-assisted system for anterior cruciate ligament (ACL) reconstruction. ACL injuries are among the most common sports-related injuries in active individuals and athletes, and reconstruction surgery is considered the gold standard for treatment. However, failure rates remain substantial-up to 10.3% in the general population and as high as 40% among high-demand patients, such as young athletes. One of the key technical factors contributing to graft failure is improper placement of the femoral and tibial bone tunnels during surgery, which affects graft isometry, kinematics, and long-term function.\n\nThis prospective, randomized, controlled clinical trial will include 120 adult patients with confirmed ACL rupture. Subjects will be randomly assigned to two groups: an experimental group undergoing robot-assisted arthroscopic ACL reconstruction, and a control group receiving traditional arthroscopic ACL reconstruction. The investigational robot system is a custom-designed platform that integrates three primary modules: (1) preoperative planning, (2) intraoperative surgical assistance, and (3) biomechanical evaluation. The robot is designed to support precise tunnel positioning using CT\u002FMRI fusion, dynamic motion tracking during surgery, and post-placement assessment of graft trajectory, potential impingement, and mechanical stability.\n\nPreoperative planning includes 3D reconstruction from CT and MRI imaging to identify optimal anatomical positions for the femoral and tibial tunnels. During surgery, the robot allows the surgeon to perform the procedure in a semi-active \"cooperative control\" mode, combining robotic precision with the surgeon's decision-making and dexterity. Unlike existing robotic platforms, this system enables limited patient limb movement and real-time position tracking, making it uniquely suited for arthroscopic procedures.\n\nThe primary endpoint of the study is anterior tibial translation at 2 years postoperatively, measured using the KT-1000 arthrometer to compare surgical and contralateral knees. Secondary endpoints include subjective knee function scores (Lysholm, Kujala, and Tegner), CT and MRI evaluation of tunnel placement and graft integration, and physical examination results. Follow-up will occur preoperatively and at 2 years postoperatively via in-person visits.\n\nSample size was calculated based on differences in Lysholm scores from prior navigation-assisted studies. With an alpha level of 0.05, a power of 0.90, and a 20% expected loss to follow-up, 60 patients will be enrolled in each group. Data will be analyzed using SPSS v22.0. Parametric and non-parametric tests will be applied as appropriate, including ANOVA, Bonferroni post-hoc comparisons, and Cochran's Q for repeated categorical variables. A p-value \\\u003C0.05 will be considered statistically significant.\n\nThis study is conducted by the Department of Sports Medicine at Beijing Jishuitan Hospital, a leading orthopedic and trauma care center in China, affiliated with Capital Medical University. The project is supported by the Capital Clinical Special Diagnosis and Treatment Technology Research and Translational Application Program and involves collaboration with Beijing Tiansing Bomed Medical Devices Co., Ltd., which is responsible for the robotic platform development and maintenance.\n\nEthical approval has been obtained from the Institutional Review Board of Beijing Jishuitan Hospital. All patients will provide written informed consent before enrollment. The study complies with the Declaration of Helsinki, Good Clinical Practice (GCP) guidelines, and local regulations.\n\nExpected outcomes of this study include evidence of improved tunnel placement accuracy, enhanced functional recovery, and potentially reduced failure rates with robot-assisted ACL reconstruction. If successful, this research may contribute to broader adoption of robotic technology in arthroscopic sports medicine surgery and support future innovations in orthopedic surgical robotics.",[28],"2025-07-18",{"date":139,"type":33},"2025-07-25",{"date":141,"type":22},"2025-08-01",{"date":143,"type":22},"2027-12",{"name":145,"class":40},"Chunyan Jiang",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":103,"enrollmentInfo":153,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":69},"100475427","arabic-version-of-marx-activity-rating-and-knee-stability-in-sportscutting-pivoting-ability-scales-100475427","NCT05470790","Arabic Version of Marx Activity Rating and Knee Stability in Sports\u002FCutting-Pivoting Ability Scales","Cross-Cultural Adaptation and Psychometric Properties Analysis of Arabic Version of Marx Activity Rating Scale and Knee Stability in Sports\u002FCutting-Pivoting Ability Scale for Saudi Athletes With Anterior Cruciate Ligament Injury","Inclusion Criteria:\n\n1. An athlete with an orthopedic diagnosis of unilateral ACL injury\n2. Age from 18 years to 45 years old\n3. Participants who read and write in Arabic\n4. Healthy participants that do not have lower limb injury limited participation in physical activity for at least six months.\n\nExclusion Criteria:\n\n* 1 Patients with other lower limbs or different musculoskeletal injuries such as lower back pain may affect physical activity",{"count":154,"type":22},150,"OBSERVATIONAL","Anterior cruciate ligament (ACL) injuries are among the most common knee ligament injuries, causing joint instability and impairments. Besides being challenging, this type of injury greatly affects the athlete's passion and wellbeing, and it is associated with several risk factors. Injuries to the ACL are estimated to occur within 80,000 to 250,000 young, active and healthy athletes each year. This cross-sectional observational study aimed at translating, adapting cross-culturally, and investigating the psychometric properties of the Marx Activity Rating Scale (MARS) and the Knee Stability in Sports\u002FCutting-Pivoting Ability (KSS\u002FCPA) scale in Saudi patients with anterior cruciate ligament injuries. For this study, a convenient sample size of 100 athletes with ACL injuries and healthy participants will be selected from different Saudi hospitals and clubs. Study participants will be informed about the study and a consent form will be obtained before they participate. A number of scales will be used as outcome measures, including the MARS, KSS\u002FCPA scale, Knee Injury, and Osteoarthritis Outcome Score, Lysholm Knee Score, and International Knee Documentation Committee Subjective Knee Form. Internal consistency of both the MARS and KSS\u002FCPA scales will be tested using Cronbach's alpha. A construct's validity will be measured by Spearman's correlation coefficient. Content validity can be determined by examining whether there are floor and ceiling effects. A significance level of 0.05 will be used to determine whether the data is significant. Ultimately, the study will help patients with ACL injuries to make informed decisions about their treatment, empower healthcare professionals to understand patients' concerns, and facilitate research.",[28,158],"Injuries",[160,161,162,163,164],"Knee Injury","Sports Ability","Activity Level","Patient Report Outcome","Rating Scales","2025-05-11",{"date":167,"type":33},"2025-05-14",{"date":169,"type":33},"2022-05-01",{"date":171,"type":22},"2026-12-01",{"name":173,"class":40},"Imam Abdulrahman Bin Faisal University"]