[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-knee-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-knee-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100636187","effects-of-isometric-isotonic-and-eccentric-vmo-exercises-in-patellofemoral-pain-syndrome-100636187",false,"NCT07562425","Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome","Comparison of the Effects of Isometric, Isotonic, and Eccentric Vastus Medialis Oblique Strengthening Exercises Applied in Terminal Knee Extension Range on Pain, Function, and Muscle Architecture in Individuals With Patellofemoral Pain Syndrome: A Randomized Controlled Trial","VMO-PFPS","Inclusion Criteria:\n\n* Aged between 18 and 40 years\n* Clinically diagnosed with patellofemoral pain syndrome\n* Presence of anterior knee pain for at least 3 months\n* Pain during activities such as stair climbing, squatting, running, or prolonged sitting\n* Pain intensity of at least 3\u002F10 on the Visual Analog Scale (VAS)\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of knee trauma or surgery\n* Meniscal injury, ligament injury, or knee instability\n* Advanced osteoarthritis\n* Neurological disorders\n* Rheumatologic diseases\n* Participation in a structured knee rehabilitation program within the last 6 months\n* Pregnancy","ALL","18 Years","50 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS.\n\nThis study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS.\n\nParticipants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks.\n\nOutcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging.\n\nThe results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.",[28,29],"Patellofemoral Pain Syndrome","Anterior Knee Pain",[31,32,33,34,35,36,37],"Vastus Medialis Oblique","Knee Pain","Exercise Therapy","Isometric Exercise","Isotonic Exercise","Eccentric Exercise","Muscle Architecture","NOT_YET_RECRUITING","2026-05-07",{"date":41,"type":42},"2026-05-12","ACTUAL",{"date":44,"type":22},"2026-05-20",{"date":46,"type":22},"2026-08",{"name":48,"class":49},"Firat University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100590759","diagnostic-validity-ofclinical-tests-for-infrapatellar-fat-pad-impingement-syndrome-100590759","NCT06971601","Diagnostic Validity Ofclinical Tests for Infrapatellar Fat Pad Impingement Syndrome","Diagnostic Validity of Infrapatellar Fat Pad Impingement Syndrome: Performance of Clinical Tests Compared to MRI Imaging","ETICHOFFA","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Presence of anterior knee pain with an intensity of ≥3\u002F10 on the Numerical Rating Scale (NRS), on most days over the past month\n* MRI of the knee performed within a maximum of 15 days before or after the clinical examination.\n\nExclusion Criteria:\n\n* History of corticosteroid injection treatment within the previous 12 months;\n* Known allergy or skin intolerance to medical adhesives or rigid tape;\n* History of hip or lumbar spine surgery;\n* History of neurological disorders or a diagnosis of fibromyalgia;\n* Contraindication to MRI (e.g., metallic foreign body, incompatible implantable device)","70 Years",{"count":61,"type":22},50,"OBSERVATIONAL","The ETICHOFFA study is a clinical research project aiming to improve the diagnosis of Infrapatellar fat pad impingement syndrome, a common source of anterior knee pain. Although MRI remains the gold standard for diagnosis, clinical testing strategies lack validation. This observational study has two main objectives: to assess the diagnostic accuracy of a cluster of standardized clinical provocation tests for IFP impingement compared to MRI findings, and to identify clinical and subjective characteristics associated with IFP involvement confirmed by imaging.\n\nThis observational study will recruit 50 patients aged 18 to 70 years with anterior knee pain rated at least 3 out of 10 in intensity. Participants will complete a secure online questionnaire documenting symptoms, pain distribution, aggravating and relieving factors, and pain intensity at rest, during activity, and daily life. They will also complete three validated scales: the Anterior Knee Pain Scale (AKPS), the Knee injury and Osteoarthritis Outcome Score (KOOS), and the Tampa Scale for Kinesiophobia (TSK).\n\nA standardized clinical examination will be performed, including subpatellar skin temperature measurement, knee swelling assessment, passive range of motion testing, and a series of provocation tests targeting Hoffa's fat pad. Tests will be randomized to reduce bias and considered positive if they reproduce the patient's typical pain with an intensity of at least 2\u002F10. Each participant must also undergo a standardized MRI of the knee within two weeks of the clinical assessment, interpreted blindly by an independent musculoskeletal radiologist.\n\nAll data will be anonymized, stored securely, and analyzed using SPSS software. Diagnostic accuracy of clinical tests will be evaluated through sensitivity, specificity, predictive values, and likelihood ratios. Functional outcomes related to taping will also be analyzed.\n\nThe study has received ethical approval and adheres to GDPR standards for data protection. Participation is voluntary, with the right to withdraw at any time. The ETICHOFFA study is expected to enhance clinical diagnostic pathways for anterior knee pain associated with Infrapatellar fat pad involvement.",[29],[66,67,68,69],"Hoffa's fat pad","Infrapatellar fat pad","Diagnosis","MRI","RECRUITING","2026-02-18",{"date":73,"type":42},"2026-02-20",{"date":75,"type":42},"2025-06-17",{"date":77,"type":22},"2026-06",{"name":79,"class":49},"Hopitaux de Saint-Maurice"]