[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anterior-pituitary-hyposecretion-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anterior-pituitary-hyposecretion-syndrome":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100371853","phase-2-growth-hormone-replacement-therapy-for-retried-professional-football-players-100371853",false,"NCT04121780","Growth Hormone Replacement Therapy for Retried Professional Football Players","Interventional Study of Growth Hormone Replacement Therapy in Retired Professional Football Players With Growth Hormone Deficiency","Inclusion Criteria:\n\n* The subject is willing to provide a signed and dated informed consent indicating that he understands the purpose and procedures required for the study and is willing to participate in the study.\n* Former NFL player\n* At least one year since retirement from football\n* Less than 76 years of age\n* Diagnosis of GHD on clinical grounds by a neurologist and an endocrinologist GHD\n\nExclusion Criteria:\n\n* History of pre-existing brain disease other than concussion or TBI\n* History of a premorbid disabling condition that interferes with outcome assessments\n* Contraindication to GH therapy\n* Type I and II Diabetes mellitus\n* Active malignant disease\n* Acute critical illness, heart failure, or acute respiratory failure\n* Subjects who are deficient in cortisol, testosterone or thyroid at screening will be excluded until hormone abnormalities have been corrected.","MALE","18 Years","76 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).",[27,28,29,30,31,32],"TBI (Traumatic Brain Injury)","Concussion, Brain","Sport Injury","Anterior Pituitary Hyposecretion Syndrome","Hypopituitarism","Growth Hormone Deficiency",[34,35,36,37,38],"TBI","GHD","Growth Hormone","Norditropin Flexpro","cognition disorders","RECRUITING","2023-02-06",{"date":42,"type":43},"2023-02-08","ACTUAL",{"date":45,"type":43},"2019-10-08",{"date":47,"type":21},"2026-09",{"name":49,"class":50},"Center for Neurological Studies","OTHER"]