[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anthocyanins\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anthocyanins":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100594860","short-term-effects-of-caffeine-and-a-multi-ingredient-pre-workout-on-exercise-performance-100594860",false,"NCT07024940","Short-term Effects of Caffeine and a Multi-ingredient Pre-workout on Exercise Performance","Acute Effects of Coffee, Anthocyanin-Caffeine Supplement and Placebo on Exercise Performance Markers","Inclusion Criteria:\n\n* Are a healthy male or female adult aged 18-35 years old\n* Regularly engaged in resistance training or aerobic exercise at least 3 times per week, at least 30 minutes a week for the past 6 months\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Have a history of or currently have a cardiovascular or metabolic disease (e.g., diabetes, prediabetes, hypertension, arrhythmia, heart attack, stroke, non-alcoholic fatty liver disease, chronic kidney disease)\n* History of seizure disorder\n* Currently taking prescription medications (e.g., beta-blockers, antidepressants, anti-anxiety, pain killers)\n* Currently pregnant, breastfeeding, pregnant within the past year, or a chance of being pregnant\n* Recent participation in another clinical trial\n* Any sensitivities to caffeine, coffee, berries, maltodextrin, monk fruit extract, or any known food allergies\n* Currently undertaking serious exercise training (6 or more days of the week)\n* Recently started taking creatine or beta-alanine daily within the past 3 months. (If greater than 3 months taken consistently is okay)",true,"ALL","18 Years","35 Years",{"count":21,"type":22},12,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators are conducting a study to see how a commercial pre-workout supplement, coffee, and water affect how well people perform. The study is conducted across four visits. The first visit is to assess the participants, and the next three visits are for testing. Each participant will drink a randomly assigned beverage 45 minutes before testing. Throughout the study, the participants will complete three testing days-each at least three days apart-so they can try all three drinks. The first test is the Wingate test, where the participants pedal as fast as they can for 30 seconds against a set resistance. The second test is a 1-mile treadmill run\u002Fwalk on an incline, where the participant tries to complete the distance as fast as possible. The third test measures reaction time using light-up buttons to see how quickly a participant responds by touching them. These tests will help determine if any of the drinks improve performance. The results can help people choose the best drink for their workouts or races.",[28,29,30],"Coffee","Anthocyanins","Exercise Performance",[28,32,33,34,35,36,37,38],"Caffeine","Wingate","Anthocyanin-Caffeine","1-mile","VO2 max","pre-workout","supplement","RECRUITING","2025-08-15",{"date":42,"type":43},"2025-08-19","ACTUAL",{"date":45,"type":43},"2025-04-25",{"date":47,"type":22},"2026-09-01",{"name":49,"class":50},"St. Louis University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":51},"100597144","effects-of-an-elderberry-based-functional-beverage-on-exercise-performance-muscle-structure-and-the-gut-muscle-axis-100597144","NCT07054671","Effects of an Elderberry-Based Functional Beverage on Exercise Performance, Muscle Structure, and the Gut-Muscle Axis","Investigating the Effects of Elderberry-Based Functional Beverage on Exercise Performance, Muscle Structure, and Gut-Muscle Axis: A Randomized Controlled Intervention Trial","Inclusion Criteria:\n\n* Engaging in regular physical activity at least 2 days per week\n* Body Mass Index (BMI) between 18.5 and 29.9 kg\u002Fm²\n* No use of antibiotics, probiotics, or prebiotics within the past 3 months\n* No history of chronic illness or autoimmune disorders\n* Physically able and eligible to participate in exercise training\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Known food allergies\n* Regular use of medications such as corticosteroids, NSAIDs, or immunosuppressants\n* Professional-level athletes\n* All participants will be instructed to avoid consuming any products containing berries (fresh, frozen, dried, jam, juice, or supplements) during the intervention period. A \"berry-free diet\" will be implemented as part of the study protocol. At baseline, a short Food Frequency Questionnaire (FFQ) will be administered to assess participants' berry consumption habits over the past month. The FFQ will include 10 commonly consumed berries in Türkiye: strawberry, raspberry, blackberry, blueberry, elderberry, mulberry, redcurrant, blackcurrant, aronia, and goji berry. Each item will be scored on a scale from 0 (never) to 4 (daily), and the total score will represent the individual's berry consumption score. Participants with a total baseline score of ≥10 will be excluded to minimize confounding from prior polyphenol exposure. The FFQ will only be used to assess baseline habits and ensure compliance with the berry-free protocol; it will not be used in primary outcome analyses.","45 Years",{"count":61,"type":22},54,[25],"Introduction: Increasing sedentary lifestyle, microbiota imbalance and exercise-induced muscle fatigue are among the main causes of metabolic stress and performance decline, even in young individuals. The potential effects of functional foods-particularly polyphenol and anthocyanin-rich beverages-on both gut microbiota and muscle performance have attracted attention in recent years. In this context, intervention studies focused on the gut-muscle axis represent a promising and valuable area of research.\n\nObjective: This study aims to investigate the effects of a functional beverage enriched with anthocyanins and polyphenols -extracted from Sambucus nigra L. (black elderberry)- combined with a regular exercise program on muscle performance, muscle morphology, fatigue level, and gut microbiota composition in healthy individuals.\n\nMethod: This 12-week double-blind, randomized, placebo-controlled trial will include participants adhering to a berry-free diet. Participants will be randomly assigned to two groups: the intervention group will consume a functional elderberry beverage formulated with high-purity anthocyanins obtained via supercritical CO₂ extraction; the control group will receive a placebo beverage with matched taste and energy content but without active compounds. Both groups will engage in a structured combined exercise program (3 days\u002Fweek). Pre- and post-intervention assessments will include gut microbiota profiling (16S rRNA sequencing), short-chain fatty acid analysis, systemic biomarkers, muscle morphology (via ultrasound), exercise performance, and body composition. Mediator analyses will be used to explore the role of the gut-muscle axis in the observed effects.\n\nUnique value: This project represents one of the few human-based intervention studies systematically evaluating the interaction between functional beverages, exercise, and microbiota through the lens of muscle fiber-type-specific adaptations. Furthermore, by integrating mediator analyses and multi-level outcome measures, the study aims to elucidate the physiological relevance of the gut-muscle axis in a holistic manner. The development, standardization, and sensory evaluation of the elderberry-based beverage also contribute valuable insights to functional product innovation.",[65,29,66],"Exercise","Muscle Size",[29,65,68,69,70],"Functional food","Muscle strength","Microbiota","NOT_YET_RECRUITING","2025-06-27",{"date":74,"type":43},"2025-07-08",{"date":76,"type":22},"2025-11-01",{"date":78,"type":22},"2027-10-01",{"name":80,"class":50},"Burdur Mehmet Akif Ersoy University"]