[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"antibiotic-resistance-bacterial\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:antibiotic-resistance-bacterial":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100610516","biofilm-on-chest-drains-after-thoracic-surgery-clinical-impact-and-antibiotic-resistance-100610516",false,"NCT07228598","Biofilm on Chest Drains After Thoracic Surgery: Clinical Impact and Antibiotic Resistance","Biofilm Formation on Thoracic Drains: Clinical Significance and Association With Antibiotic Resistance","Inclusion Criteria:\n\n* Age 18 years and older\n* Undergoing elective thoracic surgery requiring chest drain placement\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Presence of active infection prior to surgery\n* Emergency thoracic surgery\n* Immunosuppressed patients (e.g., neutropenia, advanced malignancy, organ transplantation)\n* Patients receiving systemic antibiotic therapy at the time of drain removal\n* Drainage for empyema or pre-existing pleural infection\n* Presence of extrathoracic infection focus\n* Refusal or inability to provide informed consent","ALL","18 Years",{"count":19,"type":20},180,"ESTIMATED","30 Days","OBSERVATIONAL","This prospective observational study aims to investigate the frequency and clinical significance of biofilm formation on thoracic chest drains used after thoracic surgery. Biofilms are structured bacterial communities that adhere to surfaces and can promote infection and antibiotic resistance. In this study, small samples from the tips of chest drains will be collected under sterile conditions at the time of drain removal and analyzed in the microbiology laboratory.\n\nThe main objectives are to evaluate the relationship between the duration of chest drain placement and the presence of biofilm, and to identify the antibiotic resistance profiles of microorganisms isolated from these biofilms. Secondary outcomes include the association between biofilm formation, postoperative infections (such as empyema or wound infection), and the length of hospital stay.\n\nThis study will be conducted at Ondokuz Mayıs University Faculty of Medicine, Department of Thoracic Surgery, in collaboration with the Department of Microbiology. The findings are expected to contribute to better understanding of optimal drain management and infection prevention strategies after thoracic surgery.",[25,26,27,28],"Biofilms","Thoracic Surgery","Postoperative Infection","Antibiotic Resistance, Bacterial","RECRUITING","2025-11-16",{"date":32,"type":33},"2025-11-19","ACTUAL",{"date":35,"type":33},"2025-10-01",{"date":37,"type":20},"2026-07-01",{"name":39,"class":40},"Caner İşevi, MD","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":41},"100575884","sti-prophylaxis-and-emergence-of-antimicrobial-resistance-100575884","NCT06778083","STI Prophylaxis and Emergence of Antimicrobial Resistance","SPEAR","Inclusion Criteria:\n\n* Aged ≥ 18 years.\n* Identifies as a man (cis or trans).\n* Has sex with men.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Use of an antibiotic other than doxycycline in the 3 months prior to enrolment\n* Currently being treated for an STI with doxycycline\n* Use of doxycycline within the prior 3 months for an indication other than STI treatment or STI prevention.",true,"MALE",{"count":52,"type":20},108,"The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis.\n\nThe study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.",[55,56,28,57,58],"Sexually Transmitted Infection (STI) Prevention","Antibiotic Prophylaxis","Microbiome","Doxycycline",[60,61,58,62,63,64,57,65],"DoxyPEP","STI Prophylaxis","STI Prevention","Antimicrobial Resistance","Antibiotic Resistance","Men-who-have-sex-with-men","2025-03-26",{"date":68,"type":33},"2025-03-27",{"date":70,"type":33},"2025-02-10",{"date":72,"type":20},"2027-04-30",{"name":74,"class":40},"University College, London"]