[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"antimicrobial\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:antimicrobial":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100610919","hydrogen-peroxide-and-ultraviolet-light-for-disinfecting-surfaces-in-intensive-care-units-100610919",false,"NCT07233837","Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units","Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units: A Randomized, Controlled, Cluster, Crossover Clinical Trial","Hylight","Inclusion Criteria:\n\n* All patients aged 18 years and older who will be admitted to the participating ICUs\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ICUs that use peroxide hydrogen or ultraviolet light for surface disinfection as part of their protocol","ALL","18 Years",{"count":20,"type":21},5000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Healthcare-associated infections (HAIs) remain a major problem in intensive care units (ICUs), driven by environmental contamination with multidrug-resistant organisms that persist despite routine manual cleaning. While hydrogen peroxide aerosolization and ultraviolet-C light devices have shown promise in reducing surface contamination, current evidence is inconsistent, mostly derived from single-center studies, and rarely linked to patient-centered outcomes.\n\nThe investigators will conduct this cluster-randomized, crossover trial in 12 Brazilian ICUs. Each ICU will sequentially implement three strategies: (1) usual surface disinfection; (2) usual surface disinfection followed by hydrogen peroxide aerosolization at 7.9% concentration, applied through a dedicated device inside a protective tent during terminal cleaning of patient beds; and (3) usual surface disinfection followed by automated ultraviolet-C irradiation, also applied under the same tent to shield adjacent occupied beds.\n\nThe primary outcome will be the antimicrobial utilization, measured as daily defined doses (DDD) of antimicrobials at the ICU level per 100 patient-days, with secondary outcomes including HAI incidence rate, environmental contamination with multidrug-resistant organisms, specific HAIs incidence rate (associated-ventilator pneumonia, central-line associated bloodstream infection, and catheter-associated urinary tract infection), and ICU length of stay costs.",[27,28,29,30,31],"Infection, Hospital","Antimicrobial","Pneumonia Associated With Mechanical Ventilation","Urinary Tract Infection(UTI)","Catheter Related Blood Stream Infections",[33,34,35,36,37,38,39,40],"Healthcare associated infections","Antimicrobial use","Intensive care units","pneumonia, ventilator-associated","Catheter-related infections","Urinary tract infections","Hydrogen Peroxide","Ultraviolet light","RECRUITING","2026-04-10",{"date":44,"type":45},"2026-04-15","ACTUAL",{"date":47,"type":45},"2026-01-05",{"date":49,"type":21},"2027-03-01",{"name":51,"class":52},"Hospital Israelita Albert Einstein","OTHER",12,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100406709","phase-2-anticariogenic-effect-of-moringa-oleifera-mouthwash-compared-to-chlorhexidine-mouthwash-100406709","NCT04575948","Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash","Antibacterial, Antiplaque and Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Systemically free as reported by the patients\n* Minimum of 20 teeth present in the dentition (excluding wisdom teeth);\n* Clinically healthy gingiva (on intact periodontium)\n* Dental biofilm-induced gingivitis (plaque induced gingivitis) according to the criteria set by the American Academy of Periodontology for classification of periodontal diseases and conditions in 2017\n* Moderate to high caries risk patients\n\nExclusion Criteria:\n\n* Patients with periodontitis or requiring other immediate dental treatments (within the current 6 months)\n* Subjects on antibiotics within last 6 months\n* Periodontal therapy for the past 6 months\n* Pregnant women and lactating mothers\n* Medically compromised patients\n* Subjects with tobacco consumption in any form\n* Subjects wearing partial dentures or having clinically unacceptable restorations or bridges\n* Subjects wearing orthodontic appliances\n* History of allergy to chemical or any herbal products","50 Years",{"count":63,"type":21},90,[65,66],"PHASE2","PHASE3","Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects.\n\nAim of the study:\n\nPart I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated.\n\nPart II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.",[69,28,70,71],"Plaque, Dental","Mouthwash","Cytotoxicity",[73,74,75,76,77,78,79],"Moringa Oleifera","antibacterial activity","mouthwash","chlorhexidine","antiplaque","herbal","translational research","NOT_YET_RECRUITING","2026-01-26",{"date":83,"type":45},"2026-01-27",{"date":85,"type":21},"2027-12",{"date":87,"type":21},"2028-12",{"name":89,"class":52},"Misr International University"]