[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-acute":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,73,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644976","brief-postoperative-pain-management-intervention-meaning-making-amendment-100644976",false,"NCT07676500","Brief Postoperative Pain Management Intervention: Meaning Making Amendment","Brief Postoperative Pain Management Intervention for Knee and Hip Replacement Patients: Meaning Making Amendment","Inclusion Criteria:\n\n* Age ≥18,\n* Underwent joint arthroplasty of the knee or hip\n\nExclusion Criteria:\n\n* Inability to read English\n* Cognitive impairment preventing completion of study procedures","ALL","18 Years",{"count":19,"type":20},576,"ESTIMATED","INTERVENTIONAL",[23],"NA","This single-site, two-arm, parallel-group randomized controlled trial will enroll adults undergoing total knee or hip replacement surgery. Two days after surgery, participants will complete a brief guided mindful breathing practice delivered by text message and will then be randomized to receive either personalized meaning-making questions or implementation-focused questions. The trial will evaluate whether personalized meaning-making questions enhance the clinical effects of the mindfulness practice on acute pain, pain unpleasantness, anxiety, desire for pain medication.",[26,27],"Pain, Acute","Anxiety Acute","NOT_YET_RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-30","ACTUAL",{"date":34,"type":20},"2026-07-01",{"date":36,"type":20},"2027-09-30",{"name":38,"class":39},"University of Utah","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":56,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":40},"100641417","virtual-reality-to-reduce-anxiety-agitation-and-delirium-in-critically-ill-patients-100641417","NCT07649876","Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients","Inclusion Criteria:\n\n1. Aged ≥ 18 years old admitted to the Surgical Intensive Care Unit (SICU) at Penn State Health Milton S. Hershey Medical Center.\n2. No significant uncorrectable visual or auditory impairments\n3. Estimated ICU length of stay \\> 48h\n4. At the time of each VR session, able to keep eyes open for at least 30 seconds, follow simple commands and able to indicate discomfort or request to stop.\n5. English speaking\n\nExclusion Criteria:\n\n1. Significant hemodynamic instability\n2. Known psychotic disorders associated with delusions (e.g. schizophrenia)\n3. Severe dementia (e.g. inability to communicate or follow simple commands)\n4. History of disequilibrium syndrome or vertigo\n5. Acute hyperactive delirium, requiring physical restraints",true,{"count":49,"type":20},30,[23],"This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients. The study evaluates whether brief, non-interactive VR sessions delivered using a commercially available standalone head-mounted display with calming, nature-based content can be delivered safely and effectively within routine SICU workflow. Exploratory objectives assess whether VR sessions are associated with changes in anxiety, agitation, delirium, pain, and sedative medication requirements. This research is not intended to evaluate the safety or effectiveness of the headset and\u002For the specific VR software used for the research",[53,54,55,27],"Delirium in the Intensive Care Unit","Sleep Quality in Adult ICU Patients","Agitation Associated With Critical Illness",[57,58,59,60,61,62],"Virtual reality","Intensive care unit","Pain","Agitation","Anxiety","Sleep Quality","RECRUITING","2026-06-17",{"date":66,"type":32},"2026-06-22",{"date":68,"type":32},"2026-06-02",{"date":70,"type":20},"2026-09",{"name":72,"class":39},"Milton S. Hershey Medical Center",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":84,"conditions":85,"keywords":94,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":40},"100630348","mindfulness-in-fracture-recovery-and-reduction-of-opioid-reliance-evaluating-the-feasibility-of-implementing-a-brief-mindfulness-based-intervention-to-manage-pain-and-anxiety-before-and-after-fracture-surgery-100630348","NCT07486505","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance: Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","Mindfulness in Fracture Recovery and Reduction of Opioid Reliance (MIRROR): Evaluating the Feasibility of Implementing a Brief, Mindfulness-based Intervention to Manage Pain and Anxiety Before and After Fracture Surgery","MIRROR","The inclusion criteria are:\n\n1. Adults 18 years of age or older; and\n2. Presenting to the hospital with an open or closed appendicular fracture requiring internal fixation. Patients with multiple fractures may be included.\n\nThe exclusion criteria are:\n\n1. Does not have the English-language skills required to participate in trial interventions (in the judgement of site research personnel);\n2. Cognitive impairment (including traumatic brain injury);\n3. Auditory or visual impairment that would inhibit ability to receive intervention;\n4. Current incarceration;\n5. Concomitant injury which, in the opinion of the attending surgeon, is likely to impair function for as long as or longer than the patient's extremity fracture;\n6. Previously completed a standardized mindfulness program (e.g., MBSR) or regularly (e.g., daily) practice mindfulness;\n7. Active psychosis;\n8. Active suicidality;\n9. Stress fracture;\n10. Fragility fracture;\n11. Currently enrolled in a study that does not permit co-enrolment in other trials;\n12. Not willing to participate in the intervention;\n13. No provision of informed consent; or\n14. Other reason as approved by the Data Coordinating Centre.",{"count":82,"type":20},50,[23],"Breaking a bone is not only physically painful but also emotionally overwhelming. Patients often experience intense pain, anxiety, and uncertainty as they are rushed to hospital, undergo emergency treatment, and prepare for surgery. After surgery, many continue to struggle with pain and rely on opioid medications, which carry serious risks including addiction. In the context of our current opioid epidemic, it's critical that alternative treatment strategies are urgently evaluated.\n\nMindfulness is a practice that helps people focus on the present and has been shown to reduce stress and pain in other settings. In this trial, patients with broken arms or legs who need surgery at Hamilton General Hospital will be randomly assigned to one of two groups who will listen to a two-part, audio recording before and after surgery. Those in the interventional group will engage in a 7-minute audio-guided mindfulness exercise before surgery to help reduce anxiety, and another 7-minute audio-guided mindfulness exercise after surgery to help manage pain. Those in the control group will listen to a 7-minute educational audio recording before surgery and again after surgery.\n\nThe main goal is to see if this approach is practical-can enough patients be recruited, and will they complete the audio recordings? The study will also look at early signs of whether the intervention helps reduce pain, anxiety, and opioid use six weeks after surgery. If feasible, a larger study can be conducted to determine if these exercises can help patients manage pain and reduce their need for opioids after surgery.\n\nIf successful, this simple, low-cost approach could be widely used in hospitals to support recovery and reduce reliance on pain medications.",[86,87,88,89,90,27,91,92,93],"Orthopaedic Fractures","Orthopaedic Trauma Fractures and Non-unions","Orthopaedic Trauma","Orthopaedic Surgery","Orthopaedic Related Pain (Musculoskeletal Pain)","Anxiety After Surgery","Opioid Use","Opioid Use After Surgery",[95,96,97,98,99,100],"fractures","mindfulness","pain management","fracture surgery","opioid use","anxiety","2026-04-06",{"date":103,"type":32},"2026-04-07",{"date":105,"type":20},"2026-05-01",{"date":107,"type":20},"2026-10-30",{"name":109,"class":39},"McMaster University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":21,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":40},"100586276","virtual-reality-adjunct-for-procedural-pain-and-anxiety-management-in-burn-wound-care-100586276","NCT06913270","Virtual Reality Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care","Efficacy of Virtual Reality as an Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care: A Single-Center, Randomized Controlled Trial","VR-Burn","Inclusion Criteria:\n\nAdult burn patients (18-65 years) with confirmed partial-thickness burns. Scheduled for routine dressing changes. Able to provide informed consent. Baseline pain score of ≥4\u002F10 during a dressing change session.\n\nExclusion Criteria:\n\nPatients with cognitive impairment preventing comprehension of the intervention.\n\nHistory of severe motion sickness or visual impairments that preclude the use of VR devices.\n\nPatients with contraindications to standard analgesic care.","65 Years",{"count":120,"type":20},100,[23],"This randomized controlled trial is designed to evaluate the efficacy of immersive virtual reality (VR) as an adjunct to standard analgesia during dressing changes in adult burn patients. The study compares an intervention group receiving standard care combined with an immersive VR distraction (using a head-mounted display displaying an engaging virtual environment) versus a control group receiving standard care plus non-VR distraction (watching a nature video on a tablet). The primary outcomes include procedural pain intensity measured by the Visual Analog Scale (VAS) and anxiety levels measured by the State-Trait Anxiety Inventory (STAI). Secondary outcomes include patient satisfaction and physiological parameters (heart rate and blood pressure) recorded during the procedure. This trial addresses the critical gap of heterogeneity and small sample sizes noted in previous VR studies for burn care pain management (Dascal et al., 2017).",[124,125,126,27],"Burns","Burn Wound","Procedural Pain","2025-03-30",{"date":129,"type":32},"2025-04-06",{"date":131,"type":20},"2025-04-12",{"date":133,"type":20},"2026-05-25",{"name":135,"class":39},"Al Hayah University In Cairo"]