[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-and-fear\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-and-fear":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,73,105,140,168,192],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100549596","evaluation-of-the-effectiveness-of-a-nursing-intervention-program-in-reducing-anxiety-in-users-who-perform-scheduled-sessions-in-the-hyperbaric-chamber-100549596",false,"NCT06436079","Evaluation of the Effectiveness of a Nursing Intervention Program in Reducing Anxiety in Users Who Perform Scheduled Sessions in the Hyperbaric Chamber","Inclusion Criteria:\n\n* Results in the Pfeiffer questionnaire\\\u003C2.\n* That they understand Spanish or Catalan\n\nExclusion Criteria:\n\n* That feel fear inside the hyperbaric chamber.","ALL","18 Years","100 Years",{"count":19,"type":20},42,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this experimental study is to determine if the application of a nursing educational intervention reduces the anxiety of patients who are going to undergo treatment in the hyperbaric chamber.\n\nThe researchers will compare the nursing educational intervention with the usual practice that is currently carried out in the unit for patients who are going to begin treatment in the hyperbaric chamber.\n\nParticipants will:\n\n* Receive explanatory information through a camera triptych when the treatment is indicated.\n* Come half an hour before the first session to receive a nursing educational intervention, with audiovisual support, on the operation of the camera.",[26,27],"Anxiety and Fear","Nurse's Role",[29,30,31],"Anxiety","Nursing intervention","Hyperbaric chamber","RECRUITING","2026-04-30",{"date":35,"type":36},"2026-05-06","ACTUAL",{"date":38,"type":36},"2024-01-06",{"date":40,"type":20},"2026-09-15",{"name":42,"class":43},"Universitat de Girona","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":15,"minAge":16,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100461034","early-phase-1-cannabidiol-effects-on-learning-and-anxiety-100461034","NCT05283382","Cannabidiol Effects on Learning and Anxiety","Inclusion Criteria:\n\n* 18-50 years of age\n\nExclusion Criteria:\n\n1. Difficulties seeing a computer screen\n2. Anyone currently taking CBD within the last 24 hours.\n3. Anyone using any cannabis product within the last 24 hours.\n4. Heart problems or heart disease\n5. A neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm\n6. Are currently pregnant or breast-feeding",true,"50 Years",{"count":54,"type":20},160,[56],"EARLY_PHASE1","To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut. All participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. The other face never is paired with a shock. After everybody learns this, half of the participants will receive 600 mg CBD Isolate Gel Capsules one time, and the other half will receive a placebo dose. Participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. It is hypothesized that participants that receive CBD will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.",[26],[60,61,62,63],"social anxiety","fear conditioning","cannabidiol","electrodermal response","2026-04-23",{"date":66,"type":36},"2026-04-29",{"date":68,"type":36},"2024-10-30",{"date":70,"type":20},"2027-02",{"name":72,"class":43},"University of Connecticut",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":15,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100569671","evaluation-of-the-efficacy-of-a-virtual-reality-when-placing-a-needle-on-an-implantable-venous-access-device-in-children-with-leukemia-100569671","NCT06697275","Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia","Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia: Randomized Multicenter Trial","LEAVE","Inclusion Criteria:\n\n* Children from 6 to 16 years old suffering from leukemia requiring needle insertion into an implantable port and having a life expectancy greater than or equal to 3 months\n* Subjects and their parents who have been informed of the study and having expressed their informed consent\n* Children without contraindications to the use of MEOPA® :\n* Patient requiring 100% oxygen ventilation\n* Intracranial hypertension\n* Any alteration in the state of consciousness preventing the patient\\'s cooperation\n* Children without contraindication to the use of the virtual reality mask:\n* Epilepsy\n* Psychiatric illness\n* Children and parents able to use the self-assessment scales proposed in the study\n* Enrolment in the Social Security system\n\nExclusion Criteria:\n\nChildren from 6 to 16:\n\n* Having a modification of pain\\'s integration (spina bifida for example)\n* Requiring contact isolation (conjunctivitis, contagious skin condition, etc.)\n* With a history of seizures","6 Years","16 Years",{"count":84,"type":20},120,[23],"Main objective:\n\nEvaluate the effectiveness of the repeated use of interactive or hypnotic virtual reality compared to standard treatment, on pain, during each needle placement on PAC for 3 months on children or adolescents (6 to 16 years old) with acute leukemia\n\nHypothesis:\n\nRepeated use over 3 months of hypnotic or interactive virtual reality provides more benefits in terms of :\n\n* pain management\n* anxiety of the child and his parents\n* satisfaction of the child's care, of his parents and of the caregivers compared to the standard method when inserting a needle into an implantable port in the pediatric oncology department or day hospital.",[88,89,90,26],"Virtual Reality","Children and Adolescents","Acute Leukemia",[92,93,94],"acute leukemia","virtual reality mask","children and adolescents from 6 to 16","2025-12-02",{"date":97,"type":36},"2025-12-04",{"date":99,"type":36},"2024-11-15",{"date":101,"type":20},"2027-10-01",{"name":103,"class":43},"University Hospital, Clermont-Ferrand",4,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":116,"conditions":117,"keywords":123,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":44},"100516407","phase-4-processes-and-circuitry-underlying-threat-sensitivity-as-a-treatment-target-for-co-morbid-anxiety-and-depression-100516407","NCT06004115","Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression","An individual must meet the following criteria to be considered eligible to participate in the study:\n\nInclusion Criteria:\n\nAll subjects:\n\n* Female or male sex assigned at birth;\n* Age 18-65;\n* Normal or corrected to normal vision\u002Fhearing, as protocol elements may not be valid otherwise;\n* Fluent English speaker, capable of providing written informed consent\n\nMDD and AD-MDD subjects:\n\n* Current major depressive episode assessed by clinician with guidance from the MINI;\n* Minimum score of 55 on PROMIS Depression scale\n\nAD and AD-MDD subjects:\n\n* Current anxiety disorder (generalized anxiety disorder, panic disorder, agoraphobia and social phobia) assessed by clinician with guidance from the MINI;\n* Minimum score of 55 on PROMIS Anxiety Scale\n\nExclusion Criteria:\n\nAll subjects:\n\n* Has uncontrolled, clinically significant neurologic (including seizure disorders): cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, endocrine disease, or psychiatric disorder, or other abnormality, which may impact the ability of the subject to participate or potentially confound the study results;\n* Reported body mass index (BMI) \\> 40;\n* History of moderate or severe traumatic brain injury, as assessed by a TBI questionnaire;\n* History of eating disorder or obsessive-compulsive disorder, schizophrenia, schizo-affective disorder, bipolar disorder or any sign of psychosis;\n* Current post-traumatic stress disorder (PTSD) diagnosis (although history of trauma is allowed);\n* Current use of medications with major effects on brain function or the fMRI hemodynamic response (e.g., methylphenidate, acetazolamide, excessive caffeine intake \\> 1000 mg\u002Fday) following an initial list compiled by LIBR but also assessed on a case-by-case basis. Individuals who are currently on medication (antidepressants such as SSRIs, TCAs, SNRIs, and Bupropion) and who have not undergone dose or medication changes over the past 6 weeks will be allowed to participate;\n* Current benzodiazepine or opiate use;\n* Moderate to severe current substance use disorder, defined as 5 or more symptoms of the criteria for Substance Use Disorder according to DSM 5;\n* Drug or alcohol intoxication (based on positive UTOX or breathalyzer test at screening or study session) or reported alcohol\u002Fdrug withdrawal, last cannabis use must be \\>48 hours prior to study session;\n* Has a risk of suicide according to the Investigator's clinical judgement or per Columbia-Suicide Severity Rating Scale (C-SSRS) or equivalent PhenX instrument, the subject scores \"yes\" on items 4 or 5 in the Suicidal Ideation section with referent to a 30-day period prior to Screening\u002FBaseline or the subject has had one or more suicidal attempts with reference to a 2-year period prior to Screening;\n* MRI contraindications;\n* Is pregnant or lactating or intending to become pregnant before, during, or within 12 weeks after participating in this study; or intending to donate ova during this time-period;\n* Any subject judged by the Investigator to be inappropriate for the study.\n\nMDD subjects:\n\n* Current (assessed by clinician with guidance from the MINI) anxiety disorder;\n* Score of \\> 60 on PROMIS Anxiety Scale\n\nAD subjects:\n\n* Current or past recurrent major depressive episodes assessed by clinician with guidance from the MINI;\n* Score of \\> 60 on PROMIS Depression scale","65 Years",{"count":113,"type":20},165,[115],"PHASE4","This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individuals will be recruited who will have a diagnosis of major depressive disorder (MDD) and at least one anxiety disorder (AD) (AD-MDD group), up to 65 participants will have a diagnosis of MDD and no diagnosis of an AD and up to 65 participants will have no diagnosis of MDD and a diagnosis of at least one AD will be enrolled to participate in an two session study to obtain 150 completers (50 per group). All participants will receive a single dose of Lorazepam and placebo (order randomized) taken orally. After the \\~2.5 hr screening session, participants will complete two identical \\~5 hr experimental sessions, each of which include a 30 min eyeblink startle session and a 1.5 hr functional magnetic resonance imaging (MRI) brain scan session. The total time involved in the study is approximately 10.5 hours.\n\nThe main questions the study seeks to answer are:\n\n* are people with comorbid depression and anxiety different than those with depression alone in terms of their eyeblink startle response to threat?\n* are people with comorbid depression and anxiety different than those with depression alone in terms of their brain activation in response to threat?\n* are people with comorbid depression and anxiety different than those with depression alone in terms of their responses to anxiety drugs?",[118,119,120,26,121,122],"Depression, Anxiety","Fear","Depression","Anxiety Disorders","Anxious Depression",[124,125,126,127,128,129,130],"depression","anxiety","fMRI","threat sensitivity","flight initiation distance","startle reflex","benzodiazepine","2025-10-30",{"date":133,"type":36},"2025-10-31",{"date":135,"type":36},"2023-11-08",{"date":137,"type":20},"2027-12-31",{"name":139,"class":43},"Laureate Institute for Brain Research, Inc.",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":15,"minAge":147,"maxAge":82,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100556966","effectiveness-of-a-digital-application-for-adolescents-with-mild-to-moderate-anxiety-100556966","NCT06531980","Effectiveness of a Digital Application for Adolescents With Mild to Moderate Anxiety","Effektiviteten av en Digital Mestringsapp for Ungdommer Med Mild Til Moderat Angst","Inclusion Criteria:\n\n* Ages 13-16\n* Resides in Bergen\n* Completed RCADS-25\n* Reports \"yes\" to both questions:\n* Do you have anxiety symptoms? Do you often feel stressed, scared, worried, or feel it in your body (e.g., stomach pain, heart palpitations, breathing problems, sweating, dizziness)?\n* Do anxiety symptoms prevent you from doing things you want or need to do (e.g., meeting new people, giving presentations at school, going to sleepovers, going to the shopping center)? Or do you spend so much time worrying that it affects your daily life? Can read Norwegian\n\nExclusion Criteria:\n\n* Currently receiving other psychological treatment\n* Immediate need for other psychological treatment, such as severe depression, suicide risk, OCD, psychosis\u002Fsubstance abuse issues, autism spectrum disorder\n* Anxiety is largely related to bullying\n* Extensive school absence of more than 50% in the last three months","13 Years",{"count":149,"type":20},128,[23],"The goal of this randomized controlled trial is to investigate the effectiveness of a new therapist-guided rule based intervention in Bergen Municipality, Child and Family help center.\n\nDo they have a decrease in anxiety symptoms following the intervention? Do they have an increase in functional level following the intervention?\n\nResearchers will compare the therapist-guided rule based intervention with treatment as usual for adolescents with mild to moderate anxiety.\n\nParticipants will use the intervention, which is based on CBT, for 8 weeks.",[29,26,153],"Adolescent - Emotional Problem",[155,156,157,158,125],"Digital Health","Digital interventions","Cognitive behavior therapy","adolescent","2025-08-22",{"date":161,"type":36},"2025-08-28",{"date":163,"type":36},"2025-01-16",{"date":165,"type":20},"2026-12-30",{"name":167,"class":43},"Haukeland University Hospital",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":15,"minAge":174,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":44},"100586586","virtual-reality-as-a-digital-premed-to-alleviate-pain-and-anxiety-preoperatively-in-patients-undergoing-spine-surgery-100586586","NCT06917300","Virtual Reality as a Digital Premed to Alleviate Pain and Anxiety Preoperatively in Patients Undergoing Spine Surgery","Inclusion Criteria:\n\n* Adult patients between 25-70 years old, undergoing an elective spinal surgery.\n* Patient's admission prior to surgery day (at least 1 day).\n* Expected hospital stay - 2 days.\n* Capable of providing informed consent and participate in the study follow-up questionnaire.\n* Patients speak Polish.\n\nExclusion Criteria:\n\n* Congestive heart failure, hypertension and anti-hypertensive medications\n* Adrenal insufficiency\n* Alcohol addiction (evaluated by CAGE\u002FAUDIT) and substance addiction (evaluated by DUDIT)\n* Cognitive impairment (evaluated by MMSE, MoCA)\n* Cerebrovascular diseases, ophthalmological diseases (strabismus, diplopia, retina degeneration, glaucoma), neurological conditions (epilepsy or seizure, dementia, vertigo, dizziness, motion sickness) - evaluated by: history taking, examination, vision test (Ishihara test), Simulator Sickness Questionnaire\n* Auditory impairment\n* Psychiatric illness (schizophrenia, bipolar disorder, psychotic depression) - (evaluated by MINI questionnaire)\n* Patients with neuropathic pain\n* Use of sedative drugs, anti-depressants, anxiolytics, and anti-epileptic drugs\n* Intracranial functional lesions (patients after TBI (Traumatic Brain Injury), cognitive or executive dysfunction)\n* Patient with high risk due to major and emergency operations\n* Claustrophobia\n* GCS \\\u003C 15","25 Years","70 Years",{"count":177,"type":20},150,[23],"The aim of this research study is to evaluate the impact of immersive VR exposure on preoperative anxiety and pain. Additionally, to assess whether VR intervention would significantly alleviate pain and anxiety levels of patients undergoing complex spinal surgeries. Investigators hypothesize that the application of pre-operative VR-based intervention will alleviate anxiety and pain both pre- and post-operatively when it is used as treatment to complement standard care compared to standard routine care alone, and that it may lead to better outcomes and higher satisfaction in patients.",[26,181,182],"Pain, Postoperative","Stress","2025-03-31",{"date":185,"type":36},"2025-04-08",{"date":187,"type":36},"2024-08-16",{"date":189,"type":20},"2026-09-30",{"name":191,"class":43},"Medical University of Lodz",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":51,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":200,"briefSummary":201,"conditions":202,"keywords":204,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100486485","art-as-healing-a-community-informed-art-based-programme-ciabp-for-reintegrating-ex-offenders-into-society-in-nigeria-100486485","NCT05614687","Art as Healing: A Community-informed Art-based Programme (CiAbP) for Reintegrating Ex-offenders Into Society in Nigeria","Inclusion Criteria:\n\n* Community members with previous experience of trauma\n* Aged 18+ years and are residents in areas including Lagos\u002FDelta states and its environs.\n* Able to give informed consent,\n* Speak the English language,\n* Able to partake in baseline, pre-, post- and three-month follow-up data collection.\n\nExclusion Criteria:\n\n* The exclusion criteria are those not meeting the study's inclusion criteria.",{"count":199,"type":20},60,[23],"The goal of this pilot experimental study is to test a community-informed art-based programme in improving community members trauma from crime and to aid the reintegration of ex-offenders into society.\n\nThe main question it aims to answer are:\n\n• What is the feasibility in terms of recruitment, retention, adherence to the intervention and communities\u002Fvictims' satisfaction with CiAbP to promote healing and improve the successful reintegration of ex-offenders into society?\n\nParticipants will be randomly allocated into two groups. The first group, the intervention group, will receive the Community-informed Art-based programme (CiAbP). The second group will receive government intervention involving media messages from the National Orientation Agency devoid of CiAbP. The CiAbP. sessions will cover relevant aspects of art, such as photo story, story telling, poetry, and drawing in tackling trauma and negative attitudes towards ex-offenders reintegration.\n\nResearchers will compare CiAbP group with the media orientation group to see if there are differences between a change in attitude towards ex-offenders' reintegration at base line, end of intervention and three months follow up.",[203,120,26],"Trauma",[203,26],"NOT_YET_RECRUITING","2022-11-19",{"date":208,"type":36},"2022-11-23",{"date":210,"type":20},"2023-09-01",{"date":212,"type":20},"2026-08-30",{"name":214,"class":43},"Teesside University"]