[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-depression":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,51,79,109,149,176,206,241,270,298,321,347,367,387,411,441,467,494,525,550,571,593,621,641,676],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100053787","prevention-of-burnout-in-spanish-healthcare-professionals-through-attachment-based-compassion-therapy-abct-100053787",false,"NCT07698379","Prevention of Burnout in Spanish Healthcare Professionals Through Attachment-Based Compassion Therapy (ABCT)","Mindfulness-based and Compassion-based Interventions in Anxious-Depressive Symptomatology in Mental Health Services: A Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Active healthcare professionals (physicians and nurses) of both sexes.\n2. Understanding of spoken and written Spanish.\n3. Availability of a computer and internet connection.\n4. Written informed consent.\n\nExclusion Criteria:\n\n* Previous psychological treatment within the last year, or current psychological treatment.\n\nPresence of a severe uncontrolled medical, infectious, or degenerative disease that may interfere with affective symptoms.\n\nPresence of a mental disorder related to substance dependence\u002Fabuse, or any other disease affecting the central nervous system.\n\nSuicide risk, defined as a score of ≥2 on item 9 of the PHQ-9. Scheduled surgical intervention during the course of the study.","ALL","18 Years","75 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","Burnout is a common problem among healthcare professionals and may affect their psychological well-being, quality of life, and professional functioning. This study will examine whether an intensive compassion-based intervention can help reduce burnout and improve well-being in healthcare professionals. Participants will be randomly assigned to either an Attachment-Based Compassion Therapy intervention or a relaxation intervention. Outcomes will be measured before the intervention, immediately after the intervention, and three months later.\n\nAttachment-Based Compassion groups will be composed of 80 participants each, and TAU group will be composed of 80 participants (total sample n = 160).\n\nBurnout Inventory-Human Services Survey - MBI-HSS. Burnout will be assessed using the Maslach Burnout Inventory-Human Services Survey. This questionnaire evaluates the three main dimensions of burnout: emotional exhaustion, depersonalization, and personal accomplishment.\n\nItems are rated on a Likert-type scale according to the frequency with which the participant experiences each symptom. Scores are calculated separately for each burnout dimension.\n\nIn this study, emotional exhaustion and depersonalization will be considered the primary outcome variables, while reduced personal accomplishment will be considered a secondary outcome variable",[28,29,30],"Burnout Syndrome","Anxiety Depression","Stress",[32,33,34,35,36,37],"burnout","anxiety","Mindfulness","Compassion","ABCT","healthcare personnel","RECRUITING","2026-07-07",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":22},"2026-07-10",{"date":46,"type":22},"2028-04-30",{"name":48,"class":49},"Hospital Miguel Servet","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":50},"100618466","efficacy-and-safety-of-probiotics-for-anxiety-depression-100618466","NCT07331987","Efficacy and Safety of Probiotics for Anxiety Depression","A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Clinical Efficacy and Safety of Probiotics in Participants With Anxiety Depression","Inclusion Criteria:\n\n* 1\\) Age: 18-60 years old; Gender: male or female.\n* 2\\) Meets the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) for a mild-to-moderate depressive or anxiety symptoms.\n* 3\\) Hamilton Depression Rating Scale (HAM-D-24) score ≥ 8 or Hamilton Anxiety Rating Scale (HAM-A-14) score ≥ 7 at screening.\n* 4\\) Has no used of anxiolytic or antidepressant medications (including traditional Chinese patent medicines), with the exception of Escitalopram Oxalate, within 2 weeks prior to the first dose.\n* 5\\) For participants of childbearing potential (male or female): Must agree to use least one medically approve form of contraception (e.g., intrautering device \\[IUD\\], oral contraceptives, or condoms) throughout the trial. For female participants of childbearing potential: Must have a negative urine pregnancy test at screening and must be non-lactating.\n* 6\\) The participant is willing and be able to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* 1\\) HAM-D-24 score ≥ 35 or HAM-A-14 score ≥ 29.\n* 2\\) Presence of significant suicidal ideation.\n* 3\\) History or current diagnosis of neuropsychiatric disorders such as schizophrenia or epilepsy.\n* 4\\) History of head trauma (with loss of consciousness for \\>10 minutes), other unstable major somatic diseases, or any somatic condition that could cause psychiatric symptoms.\n* 5\\) Suspected intellectual disability.\n* 6\\) History of alcohol or substance abuse prior to enrollment.\n* 7\\) Cranial magnetic resonance imaging (MRI) reveals organic lesions.\n* 8\\) Participants who are deemed unsuitable for the study by the investigator for any other reason.","60 Years",{"count":60,"type":22},60,[25],"This randomized, double-blind, placebo-controlled study will enroll 60 individuals with mild-to-moderate anxiety depression. Following a 3-month intervention and a 1-month follow-up period, the study aims to: 1) evaluate the efficacy of probiotics by comparing anxiety, depression, and sleep scores to baseline; and 2) investigate the safety and underlying mechanisms by analyzing changes in serum biomarkers, gut microbiota, and related metabolites.",[29],[65,66,67,68],"Depression","Anxiety","Mood","Probiotics","2026-06-25",{"date":71,"type":42},"2026-06-29",{"date":73,"type":42},"2026-06-15",{"date":75,"type":22},"2027-02-28",{"name":77,"class":78},"Moon (Guangzhou) Biotechnology Co., Ltd.","INDUSTRY",{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100641488","the-effect-of-using-weighted-blanket-on-anxiety-stress-depression-and-comfort-level-among-patients-with-cancer-undergoing-intravenous-anticancer-therapy-and-its-feasibility-of-use-by-nurses-compared-to-routine-care-100641488","NCT07653035","The Effect of Using Weighted Blanket on Anxiety, Stress, Depression and Comfort Level Among Patients With Cancer Undergoing Intravenous Anticancer Therapy and Its Feasibility of Use by Nurses Compared to Routine Care","The Effect of Using Weighted Blanket on Anxiety, Stress, Depression and Comfort Level Among Patients With Cancer Undergoing Intravenous Anticancer Therapy and Its Feasibility of Use by Nurses Compared to Routine Care; a Randomized Controlled Study (CALM-WB)","CALM-WB","Inclusion Criteria: for patients\n\n* Newly diagnosed cancer patients aged 18 years and older.\n* Receiving first-line intravenous anticancer therapy (chemotherapy or immunotherapy or a combination of both) in the daycare unit (adjuvant, neoadjuvant, or palliative).\n* Weighting at least 55 kg during obtaining the informed consent. (At least 54 kg before the intervention).\n* Able to complete study assessments.\n* Speaks Arabic or English.\n* Signs Informed consent.\n\nExclusion Criteria for patients:\n\n* Prior psychological treatment or psychotherapy (confirmed psychological diagnosis, history of psychotropic medications and previous psychotherapy).\n* Currently hospitalized in inpatient units.\n* Patients on daily anticancer infusions.\n* Positive fall risk assessment.\n* Open wounds and recent surgeries\u002F stoma.\n* Enrolled in any other device study or clinical trial during data collection.\n* History of:\n\n  * Diabetes mellitus\n  * Respiratory disorders,\n  * Claustrophobia (Miller et al 2003) Because of the possibility for altered sensory perception,\n  * Patients who had a diagnosis of peripheral neuropathy or fibromyalgia (Vinson et al. 2020)\n  * Cognitive impairment\n\nEligibility criteria for the nurse's population:\n\nDay Care Unit nurses will be recruited by convenient sampling and feedback will be sought per patient per visit. The reason to this is because the same nurses maybe caring for multiple patients using the WBs and each patient will provide a different experience for the nurses caring for those patients. Only nurses who agree to complete the study questionnaire will be included.",{"count":88,"type":22},152,[25],"Protocol Title: Protocol Title: The Effect of using Weighted Blanket on anxiety, stress, depression and comfort level among Patients with cancer undergoing intravenous (IV) anticancer therapy and its feasibility of use by nurses compared to routine care; a Randomized controlled study.\n\nStudy Tools: VAS-A, ESAS-R, DASS-21 and comfort level scale will be used to study the patients' population. A survey will be used to assess the feasibility of using the weighted blankets on patients receiving IV anticancer therapy.\n\nMethodology: Consented patients will be stratified per gender then randomized to either ARM1: The interventional arm, Weighted blanket, or ARM2: The control arm, Standard of care. (Regular blanket). The weighted blanket will be administered in the two cycles of IV anticancer therapy for the interventional arm, exploring the temporal trajectory of anxiety, depression, and psychological distress, and investigating the potential of a weighted blanket intervention to mitigate these symptoms. The tools will be administered according to the study protocol. Day Care Unit nurses will be assessed on how feasible they think the blankets are for patients. Expected Outcome: WB is expected to reduce the anxiety in patients undergoing IV anticancer therapy and reduce the nurses' burden when caring for those patients.",[92,29,30],"Solid Cancers",[94,95,33,96,97,98,99],"blankets","cancer","depression","comfort","intravenous infusion","non-pharmacological intervention","2026-06-14",{"date":102,"type":42},"2026-06-17",{"date":104,"type":42},"2025-12-25",{"date":106,"type":22},"2027-07",{"name":108,"class":49},"Sultan Qaboos Comprehensive Cancer Center",{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":131,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":148},"100603978","early-exercise-based-rehabilitation-in-patients-hospitalized-for-acute-pulmonary-embolism-100603978","NCT07143539","Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism","Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial","RehabPE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days\n3. Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission\n4. Written informed consent\n\nExclusion Criteria:\n\n1. Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)\n2. Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)\n3. Recently completed (i.e., \\\u003C6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication\n4. Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)\n5. Contraindication to anticoagulation\n6. Life expectancy \\\u003C1 year based on the treating physician's clinical judgement\n7. Known pregnancy\n8. Inability to speak German or French\n9. Participation in another study that prohibits concurrent participation in RehabPE\n10. Unable to provide informed consent (e.g., due to dementia)\n11. Unwilling to provide informed consent\n12. Prior enrollment in this study",{"count":118,"type":22},160,[25],"Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with anticoagulation (blood thinners). The randomized RehabPE trial investigates whether an early, structured rehabilitation program with physical training and patient education can prevent such long-term effects.\n\nThe study includes hospitalized patients with acute symptomatic PE who are at increased risk of impaired quality of life three months after diagnosis. After informed consent, patients are randomly assigned to one of two groups: one receives an early 6-8-week, center-based rehabilitation program; the other receives standard follow-up care without rehabilitation. The intervention group completes 16-18 outpatient sessions of endurance and strength training, along with two education sessions covering the condition, treatment, and symptom management.\n\nOver 180 days, changes in quality of life, physical exercise capacity, breathlessness, and psychological symptoms, and the time to return to work \u002F usual daily activities will be monitored and compared between groups.",[122,123,124,29,125,126,127,128,129,130],"Venous Thromboembolism (VTE)","Exercise Therapy","Quality of Life (QOL)","Humans","Exercise Tolerance","Rehabilitation Exercise","Dyspnea","Functional Status","Pulmonary Embolism (Diagnosis)",[132,133,134,135,136,33,96,137,138],"pulmonary embolism","deep vein thrombosis","excercise-based rehabilitation","post-PE syndrome","health-related quality of life","dyspnea","impact of early excercise-based rehabilitation","2026-06-11",{"date":141,"type":42},"2026-06-12",{"date":143,"type":42},"2025-12-17",{"date":145,"type":22},"2028-06",{"name":147,"class":49},"Insel Gruppe AG, University Hospital Bern",6,{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":175},"100489874","rxwell-to-decrease-post-operative-opioid-use-in-total-knee-or-hip-arthroplasty-100489874","NCT05658796","RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty","Telemedicine-delivered Digital Cognitive Behavioral Intervention to Decrease Post-operative Opioid Use Among Patients Undergoing Total Knee or Hip Arthroplasty","RxWell","Inclusion Criteria for the RXWell Study:\n\n* Adults \\>18 years\n* Scheduled for elective primary total knee arthroplasty (TKA) or hip replacement (THA) at the approved UPMC hospitals\n* Moderately high levels of mood disorder symptoms on validated PROMIS measures, defined as a T-score \\> or = to 60 on PROMIS Anxiety 4a short form and\u002For PROMIS Depression4a short form\n\nExclusion Criteria for the RXWell Study:\n\n* Patients undergoing non-elective surgery or secondary arthroplasty\n* Active delirium, neurocognitive impairment, or severe intellectual disability\n* No access to a smart device (phone or tablet)\n* Active alcoholism (defined as daily use of more than 1 liter of wine and \u002For 3 or more shots of hard liquor) or drug abuse (defined as daily use of illicit drugs)\n* Profound mood disorders requiring immediate intervention such as suicidal ideation, defined as a PROMIS Depression score of more than 70\n* A PROMIS Anxiety and\u002For Depression T-score \\>70, which corresponds to severe anxiety and depression.\n\n  * Patients needing immediate care will be referred to psychiatrists and primary team.","100 Years",{"count":159,"type":22},150,[25],"It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-operative outcomes, improving saving for the UPMC ISD by hastening the recovery and decreased resource utilization, and addition to the high-value care of UPMC with this holistic approach to patient perioperative care",[163,66,164,65,165,29],"Mood Disorders","Depressive Symptoms","Anxiety Disorders","2026-06-01",{"date":168,"type":42},"2026-06-03",{"date":170,"type":42},"2023-01-27",{"date":172,"type":22},"2026-12-30",{"name":174,"class":49},"University of Pittsburgh",3,{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":12,"sex":17,"minAge":183,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":23,"phases":187,"briefSummary":188,"conditions":189,"keywords":192,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":205},"100639687","group-based-act-for-psychological-distress-of-young-people-100639687","NCT07617467","Group-based ACT for Psychological Distress of Young People","ACT-YOUNG","Inclusion Criteria:\n\n* Score on DASS-21 depression scale ≤ 14\n\nExclusion Criteria:\n\n* Psychosis","16 Years","25 Years",{"count":186,"type":22},212,[25],"This clinical study investigates the effectiveness of two psychological treatment formats for young people aged 16-25 with symptoms of depression, anxiety, stress, or interpersonal difficulties. The study compares group-based Acceptance and Commitment Therapy (ACT) with treatment as usual (TAU), most frequent that would be individual psychotherapy, both of which are established treatment approaches.\n\nThe study uses a randomized controlled design (RCT), in which participants are randomly assigned to one of the two treatment conditions. This allows for a systematic comparison of treatment outcomes between ACT delivered in a group format and standard individual therapy.\n\nThe ACT group intervention consists of a structured program in which participants meet regularly over a defined treatment period. The treatment focuses on processes such as psychological flexibility, acceptance of internal experiences, and engagement in actions aligned with personal values.\n\nThe individual therapy condition consists of one-to-one sessions with a clinician, following standard therapeutic practice. Treatment content and duration are tailored to the participant's clinical presentation and therapeutic needs.\n\nOutcome measures include standardized assessments of mental health symptoms, functioning, and psychological processes. These assessments are conducted at baseline, during the treatment period, at post-treatment, and at follow-up time points. Data collected from these measures will be used to evaluate changes over time and differences between the two treatment conditions.\n\nThe primary aim of the study is to determine whether group-based ACT is as effective as, or more effective than, individual psychotherapy for young people receiving mental health services. The results are expected to contribute to improved knowledge about treatment options for this age group and inform future clinical practice.",[190,191,66,29],"Depression - Major Depressive Disorder","Depression Anxiety Disorder",[96,193,33,194,195],"Acceptance and Commitment Therapy","anxiety depression","adolescents","2026-05-22",{"date":166,"type":42},{"date":199,"type":42},"2026-03-09",{"date":201,"type":22},"2028-12-31",{"name":203,"class":204},"Sorlandet Hospital HF","OTHER_GOV",2,{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":214,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":218,"conditions":219,"keywords":224,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":50},"100603443","sos-for-caregiver-wellbeing-100603443","NCT07136584","SOS for Caregiver Wellbeing","SOS for Caregiver Wellbeing: Testing the Feasibility of a Screening, Outcomes and Support (SOS) Model for Parents and Caregivers of Children With Chronic Conditions","SOS","Inclusion Criteria:\n\n* must be a parent of a child \\\u003C18yo in an outpatient clinic at Royal Children's Hospital (in enrolled clinics either neuromuscular or diabetes)\n* able to complete a consent form in English without an interpreter\n\nExclusion Criteria:\n\n* need for an interpreter to complete informed consent",true,{"count":216,"type":22},100,[25],"Parents and caregivers of children who have a chronic condition carry a large care burden and are at higher risk of having mental health symptoms. This study aims to see if completion of a mental health questionnaire by parents \u002F caregivers at or before the child's paediatric appointment can help identify any symptoms of stress, anxiety or depression.\n\nFollowing the questionnaire, parents \u002F caregivers will be provided with the results of the questionnaire along with an information resource sheet. This will include information on anxiety, stress and depression, as well as different agencies they can contact to get support.\n\nParents \u002F caregivers will be followed up at 3 and 6 months to see if they have any changes to mental health and quality of life, and whether they accessed any support services. Participants who did not complete the 3-month survey will be asked at the 6-month clinic visit to provide responses on an iPad to up to 5 questions selected from the 3-month survey. A text message will be sent prior to the visit to inform them.\n\nThe primary aim for this trial is to see whether parents \u002F caregivers find this process acceptable, and whether it can work in a busy hospital clinic.",[220,221,29,30,222,223],"Mental Health","Depression and Burden in Caregivers","Caregiver Anxiety","Parent of Child With Chronic Life-threatening Illness",[225,226,227,228,229,33,96,230,231],"parent","caregiver","chronic illness","screening","mental health","stress","referral pathways","2026-05-07",{"date":234,"type":42},"2026-05-12",{"date":236,"type":42},"2025-10-22",{"date":238,"type":22},"2026-08",{"name":240,"class":49},"Murdoch Childrens Research Institute",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":250,"briefSummary":251,"conditions":252,"keywords":255,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":50},"100637117","calming-minds-study-100637117","NCT07577401","Calming Minds Study","Understanding the Mechanisms Driving the Reduction of Repetitive Negative Thought","Inclusion Criteria:\n\n* Aged 18+ years\n* Able to provide a valid Imperial Valley College email address\n* Access to a suitable smartphone\u002Fdevice (iPhone 8+ running iOS 16.4 or higher, or Android version 8 or higher)\n* Access to internet\n* Elevated repetitive negative thought (RNT) based on scores from Ruminative Response Scale Brood subscale (RSS-brood) and Penn State Worry Questionnaire (PSWQ)\n\nExclusion Criteria:\n\n* Concurrent psychotherapy\n* Self-reported current or past diagnosis or treatment for Psychosis\n* Self-reported current or past diagnosis or treatment for Bipolar disorder\n* Self-reported current or past diagnosis or currently receiving, or waiting to receive, treatment for substance abuse\u002Fdependence\n* Self-reported current diagnosis or currently receiving, or waiting to receive, treatment for alcohol abuse\u002Fdependence\n* Antidepressant\u002Fanxiolytic medication that has changed in dose or nature in last 6 weeks\n* Current severe PTSD defined as measured by the adapted International Trauma Questionnaire\n* Active suicidal thoughts or self-harm",{"count":249,"type":22},500,[25],"The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to:\n\n1. Figure out what actually causes repetitive negative thinking to decrease when people use cognitive-behavioral therapy (CBT).\n2. Find out which parts of RNT-focused CBT are the most important - the parts that truly make a difference in reducing RNT.\n\nThe main result we will look at is how much a person's repetitive negative thought patterns change from the start of the study to the end of treatment (16 weeks). We will measure this using the Perseverative Thinking Questionnaire at baseline and week 16.",[66,29,253,65,254],"Worry","Rumination - Thoughts",[256,257,65,253,66,220,258,259],"Imperial Valley College","Community College","STAND","Calming Minds","NOT_YET_RECRUITING","2026-05-03",{"date":263,"type":42},"2026-05-11",{"date":265,"type":22},"2026-06-08",{"date":267,"type":22},"2028-06-14",{"name":269,"class":49},"University of California, Los Angeles",{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":278,"targetDuration":280,"studyType":281,"phases":4,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":4},"100617607","quality-of-life-and-functional-outcomes-in-laryngeal-cancer-patients-100617607","NCT07320820","Quality of Life and Functional Outcomes in Laryngeal Cancer Patients","Assessment of Quality of Life, Patient Satisfaction, Swallowing Function, Voice Outcomes, Pain, and Anxiety-Depression at Baseline and at 3-, 6-, and 12-Month Follow-Up in Patients Diagnosed With Laryngeal Squamous Cell Carcinoma: A Prospective Questionnaire-Based Study","QoL in LSSC","Inclusion Criteria:\n\n* Age ≥ 18 years at the time of enrollment.\n* Histopathologically confirmed diagnosis of laryngeal squamous cell carcinoma.\n* Planned to undergo surgical treatment or radiotherapy\u002Fchemoradiotherapy as part of standard oncological care.\n* Willing and able to participate in the study and to provide written informed consent.\n* No history of psychiatric or neurological disorders that could impair comprehension, questionnaire completion, or study participation.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Presence of comorbid conditions that may independently affect swallowing or voice functions.\n* Patients who withdraw consent or request to discontinue participation during or after the treatment period.\n* History of psychiatric disorders or use of psychiatric medications that may interfere with study participation or completion of patient-reported outcome measures.",{"count":279,"type":22},120,"12 Months","OBSERVATIONAL","Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process.\n\nThe aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to:\n\nElucidate the course of functional recovery following treatment,\n\nIndividualize rehabilitation and follow-up strategies, and\n\nExamine the relationship between functional outcomes and oncological survival.",[284,124,285,286,287,288,29],"Laryngeal Carcinoma","Patient Satisfaction","Voice Quality","Swallowing Function","Pain Management","2026-04-21",{"date":291,"type":42},"2026-04-22",{"date":293,"type":22},"2026-04-02",{"date":295,"type":22},"2027-12-31",{"name":297,"class":49},"Saglik Bilimleri Universitesi",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":23,"phases":306,"briefSummary":308,"conditions":309,"keywords":310,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":319,"locationsCount":50},"100635404","phase-4-comparing-acupuncture-with-medication-to-reduce-anxiety-and-depression-in-china-100635404","NCT07552246","Comparing Acupuncture With Medication to Reduce Anxiety and Depression in China","Comparing Acupuncture With Medication to Reduce Anxiety and Depression in China: A Preference-based Trial Comparing Clinical Efficacy, Cost-effectiveness and Environmental Footprint","Inclusion Criteria:\n\n1. Chinese nationals 18 years old and above\n2. No mental health treatment in the past 6 months\n3. The patient diagnosis should meet one of the following ICD-10 diagnostic codes (or diagnosed as depressive state\u002Fanxiety state\u002Fanxious depression state):\n\n   1. Depressive disorder (F30-F39)\n   2. Fear anxiety disorder (F40)\n   3. Other anxiety disorders (F41)\n   4. Adjustment disorder (F43.2)\n   5. Organic\u002Fsecondary related disorders (F06)\n   6. F1x.4 Depressive disorder caused by psychoactive substances (x is a substance category, e.g., F10.4 alcohol, F11.4 opioids, etc.)\n   7. F1x.0 Anxiety disorder caused by psychoactive substances\n   8. F42.- Obsessive-compulsive disorder (often accompanied by significant anxiety)\n   9. F48.8 Neurasthenia (may be accompanied by symptoms of anxiety and depression)\n4. When using scale results (any of the following scales can be used, or other measurable scores\u002Fresults suggestive of depression\u002Fanxiety tendencies):\n\n   1. Depressive state\n\n      * Depression Self-Rating Scale (SDS) standard score ≥ 53 points, or suggesting depressive tendencies\n      * Hamilton Depression Rating Scale (HAMD-17) ≥7 points, suggesting the presence of depressive symptoms\n      * Patient Health Questionnaire-9 (PHQ-9) ≥ 5 points, suggesting the presence of depressive symptoms.\n   2. Anxiety state\n\n      * Anxiety Self-Rating Scale (SAS) standard score ≥ 50 points, or suggesting anxiety tendencies\n      * Hamilton Anxiety Scale (HAMA) ≥ 7 points, suggesting the presence of anxiety symptoms\n      * Generalized Anxiety Disorder Scale (GAD-7) ≥ 5 points, suggesting the presence of anxiety symptoms.\n\nExclusion criteria:\n\n1. Serious cardiovascular, cerebrovascular, liver, kidney and other serious life-threatening primary diseases\n2. Poorly controlled diabetes\n3. There is a risk of suicide\n4. Those with head trauma, loss of consciousness or severe mental disorders\n5. Drug, drug or alcohol abusers\n6. Received modified electrical convulsions (MECT\u002FECT), repetitive transcranial magnetic stimulation (r-TMS), vagus electrical stimulation (VNS), within half a year.\n7. Those who have received antidepressant or psychotic drugs within half a year;\n8. Those with severe skin injuries and skin diseases.\n9. Self-injury or even suicidal behavior occurs during the research process;\n10. Other diseases that suddenly become unsuitable for continued participation in the study during the study;\n11. Other conditions that the supervising physician deems unsuitable for continued participation in the study.",{"count":279,"type":22},[307],"PHASE4","The main objective of this study is to compare medication (usual care) with acupuncture (as a standalone comparator) to identify the most (cost)effective and environmentally sustainable intervention to reduce anxiety and mild to moderate depression in adults in China.",[29],[65,311,312,33],"Acupuncture","Antidepressants","2026-04-20",{"date":315,"type":42},"2026-04-27",{"date":317,"type":22},"2026-04-01",{"date":295,"type":22},{"name":320,"class":49},"Duke Kunshan University",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":327,"eligibilityCriteria":328,"healthyVolunteers":214,"sex":17,"minAge":329,"maxAge":184,"enrollmentInfo":330,"targetDuration":4,"studyType":23,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":345,"locationsCount":205},"100629301","ai-informed-peer-mentoring-behavioral-intervention-for-anxiety-and-depression-primary-prevention-in-youth-100629301","NCT07472894","AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH","PEER MENTORING FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN ADOLESCENTS AND YOUNG ADULTS","PeerMentorAnxD","Inclusion Criteria: Healthy individuals aged 12-25 yrs old -\n\nExclusion Criteria: Chronic mental health conditions, severe cognitive or communication deficits\n\n\\-","12 Years",{"count":331,"type":22},1680,[25],"The goal of this clinical trial will be to evaluate the efficacy of an AI-informed peer-mentoring program to improve stress management and social skills and reduce the risk of depressive and anxiety symptoms in healthy adolescents (12-18 years old) and young adults (18-25 years old). The main question it aims to answer is whether the peer-mentoring behavioral intervention will achieve the desired behavioral changes and reduce the emergence of anxiety and depression symptoms. Researchers will compare the AI-informed peer-mentoring behavioral intervention program with a standard peer-mentoring program and a standard health educational program. Some study participants will be trained to be peer mentors and subsequently they will be paired with slightly younger mentees and they will attend shared activities for an academic year",[29],[66,65,336,337,338],"Primary prevention","Peer-mentoring","Behavioral Intervention","2026-04-09",{"date":341,"type":42},"2026-04-14",{"date":343,"type":22},"2027-09-01",{"date":201,"type":22},{"name":346,"class":49},"University of Patras",{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":12,"sex":17,"minAge":353,"maxAge":157,"enrollmentInfo":354,"targetDuration":4,"studyType":281,"phases":4,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":50},"100592754","retrospective-analyses-of-the-greenbrook-database-evaluating-mental-health-treatments-100592754","NCT06997549","Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments","Inclusion Criteria:\n\n* Male or female reported in database and not an invalid entry\n* Age reported and not an invalid entry\n* Treatment date in 2011 or later.\n\nExclusion Criteria:\n\n• Incomplete information on treatment parameters","5 Years",{"count":355,"type":22},12000,"The study involves multiple retrospective analyses to understand the utilization of mental health treatments provided at Greenbrook and their effectiveness",[65,358,29],"OCD","2026-04-06",{"date":339,"type":42},{"date":362,"type":42},"2025-05-15",{"date":364,"type":22},"2035-12",{"name":366,"class":49},"Neuronetics",{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":353,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":281,"phases":4,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":382,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":386,"locationsCount":50},"100586589","retrospective-analyses-of-trakstar-database-100586589","NCT06917339","Retrospective Analyses of TrakStar Database","Retrospective Analyses Evaluating the Real-World Effectiveness of NeuroStar® TMS and the Factors Associated With Clinical Outcomes","Inclusion Criteria:\n\n* Male or female reported in database and not an invalid entry\n* Age reported and not an invalid entry\n* Treatment date of November 01, 2008 or later.\n\nExclusion Criteria:\n\n• Incomplete information on treatment parameters","120 Years",{"count":376,"type":22},156000,"In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.",[65,379,29],"Obsessive-Compulsive Disorder",[381],"TMS",{"date":339,"type":42},{"date":384,"type":42},"2025-02-25",{"date":364,"type":22},{"name":366,"class":49},{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":393,"eligibilityCriteria":394,"healthyVolunteers":12,"sex":17,"minAge":329,"maxAge":395,"enrollmentInfo":396,"targetDuration":4,"studyType":23,"phases":398,"briefSummary":399,"conditions":400,"keywords":4,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":50},"100625955","the-rewire-behaviour-study-100625955","NCT07429357","The REWIRE Behaviour Study","Research on Education With Individualized REwarding Behaviour (REWIRE): A Comparison of Two Youth Mental Health Programs","REWIRE","Inclusion Criteria:\n\n* Own a smartphone.\n* Use social media for \\>3 hours\u002Fday.\n* Are aged 12-17 years.\n* Are experiencing feelings of anxiety or depression.\n* Have a caregiver who is able and willing to participate in the study alongside them.\n* Have the ability to communicate in English.\n* Must sign and date the informed consent form, or provide assent and have a Substitute Decision Maker provide informed consent\n\nExclusion Criteria:\n\n* Own a smartphone.\n* Use their smartphone for \\>1 hour\u002Fday.\n* Are accompanying a youth participant enrolled in the study.\n* Have the ability to communicate in English.\n* Are willing to sign informed consent forms.","17 Years",{"count":397,"type":22},220,[25],"This two-phase, double-blind, balanced, parallel-group randomized controlled trial involves youth aged 12 to 17 years who experience symptoms of anxiety or depression and use social media for more than three hours per day.\n\nIn Phase 1, a small pilot group will participate in the REWIRE program to assess its feasibility, usability, and engagement before launching Phase 2. Results of the pilot will inform whether any modifications to the intervention are required and identify ways to increase adherence and reduce barriers.\n\nIn Phase 2, approximately 100 youth and their caregivers will be randomly assigned to one of two groups to evaluate the REWIRE program on anxiety and depression symptoms. One group will participate in the REWIRE program, which aims to reduce social media use to about half of usual levels while encouraging participation in positive offline activities such as spending time with friends, hobbies, physical activity, or time outdoors. The comparison group will receive psychoeducation about social media and health, but will not be asked to change their social media use. Both youth and caregivers will attend weekly group sessions over 12-weeks. Participants will also track their physical activity, complete questionnaires about mental health, daily activities, and social media use, and will provide daily smartphone usage screenshots. Youth will additionally take part in brain imaging scans and neurocognitive assessments before and after the program to explore how changes in social media use may be related to brain function. At the end of Phase 2, 20 participants will be randomly selected for interviews to explore their experiences with the intervention.\n\nAdditional secondary outcomes in Phase 2 include social phobia, social comparison, Fear of Missing Out (FOMO), loneliness, body esteem, disordered eating, social media disorder symptoms, cyberbullying, reinforcing efficacy of social media, impulsivity, suicidal ideations, well-being, executive functioning and cognition, while further assessing the feasibility.",[29,401],"Social Media","2026-02-20",{"date":404,"type":42},"2026-02-24",{"date":406,"type":22},"2026-03",{"date":408,"type":22},"2029-12",{"name":410,"class":49},"Gary Goldfield",{"id":412,"slug":413,"hasResults":12,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":424,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":50},"100623499","group-therapy-using-the-i-reconstruction-psychotherapy-method-to-reduce-anxiety-levels-100623499","NCT07397429","Group Therapy Using the \"I-Reconstruction\" Psychotherapy Method to Reduce Anxiety Levels","Group Therapy Using the I-Reconstruction Psychotherapy Method for Reducing Anxiety Levels: a Randomized Controlled Trial","Inclusion Criteria:\n\nAge between 18 and 55 years (inclusive).\n\nClinically significant level of anxiety according to the Beck Anxiety Inventory (BAI) ≥ 9 points.\n\nAnxiety subscale score on the Hospital Anxiety and Depression Scale (HADS-A) ≥ 11 points.\n\nSignificant level of preverbal trauma according to the \"Diagnostics of Preverbal Dysregulation\" (DPD, T. Pavlenko) questionnaire: total score ≥ 16.\n\nSpecific subscale scores in DPD: \"Desire\" ≥ 5, \"Satisfaction\" ≥ 5, and \"Possession\" (Obsession) ≥ 6 points.\n\nPresence of internal conflicts according to the \"Internal Conflict Test\" (ICT) ≥ 1 point on the skin tissue measurement scale.\n\nWillingness to comply with the study protocol and the online therapy format.\n\nExclusion Criteria:\n\nCurrent participation in any other psychotherapy during the study.\n\nUse of any psychotropic medications within the last 30 days (antidepressants, tranquilizers, neuroleptics, mood stabilizers).\n\nDiagnosed severe mental disorders (according to ICD-10\u002FDSM-5) requiring specialized psychiatric care or inpatient treatment.\n\nPresence of acute suicidal risk.\n\nSubstance abuse (alcoholism, drug addiction).\n\nFailure to meet any of the threshold values specified in the inclusion criteria.","55 Years",{"count":420,"type":22},36,[25],"Brief Summary of the Study The aim of this clinical trial is to find out if the group therapy method \"Self-Reconstruction\" helps to reduce anxiety in adults. The researchers want to see if the participants' emotional state becomes more stable after completing the course.\n\nThe main questions that this study aims to answer are:\n\nDo people's anxiety levels decrease after taking the course of \"I-Reconstruction\" classes?\n\nDo the positive effects of the classes persist 3, 6 and 12 months after they finish?\n\nDo the participants' quality of life and ability to enjoy life improve?\n\nThe researchers will compare a group of people who attend the therapy classes with a group of people who receive usual care to see if the new method is more effective.\n\nParticipants will:\n\nParticipate in 10 online group meetings once a week.\n\nDo simple breathing and movement exercises to calm the body and emotions.\n\nDiscuss your feelings and desires with a professional in a safe group.\n\nComplete questionnaires about your condition at the beginning, during, and after the study.",[66,29],[425,426,427,165,428,65,429,430,431],"Anxiety,","Group Therapy","Randomized Controlled Trial - RCT","Psychotherapeutic Intervention","I - Reconstruction","Internal Conflict Test","Preverbal trauma","2026-02-04",{"date":434,"type":42},"2026-02-09",{"date":436,"type":22},"2026-03-02",{"date":438,"type":22},"2027-06",{"name":440,"class":49},"International Association Psychosomatics And Health Therapy",{"id":442,"slug":443,"hasResults":12,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":214,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":448,"targetDuration":450,"studyType":281,"phases":4,"briefSummary":451,"conditions":452,"keywords":455,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":50},"100614074","prevalence-of-psychiatric-problems-among-patients-and-healthcare-providers-in-a-cardiology-department-a-cross-sectional-study-100614074","NCT07274865","Prevalence of Psychiatric Problems Among Patients and Healthcare Providers in a Cardiology Department: A Cross-Sectional Study","Prevalence of Psychiatric Problems Among Patients and Healthcare Providers in the Department of Cardiovascular Medicine","Inclusion Criteria:\n\nPatients\n\nAge ≥ 18 years. Diagnosed with a cardiovascular disease (e.g., ischemic heart disease, heart failure, valvular disease).\n\nAble to understand and complete self-administered questionnaires or participate in structured interviews.\n\nProvided informed written consent.\n\nHealthcare Providers\n\nPhysicians, residents, nurses, or allied staff working in the Department of Cardiovascular Medicine for ≥6 months.\n\nProvided informed written consent.\n\nExclusion Criteria:\n\nSevere cognitive impairment or communication difficulties that prevent questionnaire completion.\n\nRefusal to participate.",{"count":449,"type":22},380,"1 Day","The goal of this observational cross-sectional study is to determine the prevalence of psychiatric problems (depression, anxiety, stress, and burnout) among patients with cardiovascular diseases and healthcare providers working in the Department of Cardiovascular Medicine at Assiut University Heart Hospital.\n\nThe main questions it aims to answer are:\n\n* What is the prevalence of depression, anxiety, and stress among cardiovascular patients?\n* What is the prevalence of burnout, depression, and anxiety among healthcare providers in the same department?\n\nThe study will also explore potential sociodemographic, occupational, and clinical factors associated with these psychological outcomes.",[29,453,454],"Burnout","Sleep",[456,457],"psychiatric probldems in cardiologists","psychiatric problems in cardiovascular patients","2025-12-08",{"date":460,"type":42},"2025-12-10",{"date":462,"type":22},"2026-01",{"date":464,"type":22},"2028-03",{"name":466,"class":49},"Assiut University",{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":476,"briefSummary":477,"conditions":478,"keywords":481,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":492,"locationsCount":50},"100525560","psychiatric-outcomes-of-unruptured-intracranial-aneurysms-pouia-100525560","NCT06123325","Psychiatric Outcomes of Unruptured Intracranial Aneurysms (POUIA)","Impact of Observation Versus Treatment on The Psychiatric and Mental Outcomes of Patients With Unruptured Intracranial Aneurysms","POUIA","Inclusion Criteria:\n\n* Unruptured intracranial aneurysms (UIA)\n* mRS scores between 0-1\n* Observation Group: All patients with UIAs that are eligible for conservative management\n\n  1. Specific locations that are not good candidates for interventional treatment, such as cavernous internal carotid artery and very distally located aneurysms\n  2. Aneurysm size (largest dimension) is less than 4 mm\n* Treatment Group: All patients with UIAs that are decided to be treated either with endovascular or microsurgical treatments due to several reasons, such as aneurysm size above 4 mm, patient's decision\n\nExclusion Criteria:\n\n* Prior history of Subarachnoid Hemorrhage (SAH)\n* Prior history of intracranial aneurysm\n* Severe comorbidities that impact the mental health of the patients, such severe psychiatric disease, and chronic end stage diseases\n* Traumatic, mycotic, dissecting, or fusiform aneurysms\n* Patients with communication barriers (does not include foreign language), developmental disability, or psychiatric illness that prevent understanding of the questions required to complete assessments\n* Patients with any physical disabilities or handicaps",{"count":279,"type":22},[25],"The impact of cerebrovascular procedures on patients experiencing anxiety and depression is not well studied despite the high prevalence of these mental health disorders. Unruptured Intracranial aneurysms (UIAs) have a prevalence of approximately 3% and an annual risk of 1-2% in the general population. Despite the high risk of fatality following aneurysm rupture with a rate of 40-50%, the overall aneurysm growth and rupture risks are rare (less than 3% per aneurysm per year) and many patients can be observed with serial follow-up imaging over years. Nevertheless, due to the gravity of the bad consequences of aneurysm rupture, simply informing many patients of UIA diagnosis has been found to result in worse outcomes of health-related quality of life. This study aims to investigate the impact of awareness of untreated UIA on the patients' mental health utilizing the Hospital Anxiety and Depression Scale (HADS) tool.",[29,479,480],"Aneurysm Cerebral","Mental Health Wellness 1",[482,66,65,483,484],"Cerebral aneurysm","Endovascular","Clipping","2025-11-16",{"date":487,"type":42},"2025-11-19",{"date":489,"type":42},"2023-12-01",{"date":491,"type":22},"2027-09",{"name":493,"class":49},"Montefiore Medical Center",{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":500,"eligibilityCriteria":501,"healthyVolunteers":12,"sex":502,"minAge":18,"maxAge":4,"enrollmentInfo":503,"targetDuration":4,"studyType":23,"phases":505,"briefSummary":506,"conditions":507,"keywords":511,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":519,"completionDateStruct":521,"leadSponsor":523,"locationsCount":50},"100610112","latinas-integrating-fitness-and-therapy-100610112","NCT07223346","Latinas Integrating Fitness and Therapy","Latinas Integrating Fitness and Therapy (LIFT)","LIFT","Inclusion Criteria: 1) currently undergoing or within 6-months of completing primary cancer(s) (2) self-identify as Latina and female, (3) over the age of 18 years, (4) reside in Colorado, (4) have access to internet, and be (5) English or Spanish speaking.\n\nExclusion Criteria: (1) metastatic disease, (2) known contraindications for exercise (e.g. existing CVD or metabolic disease, use of an assistive-walking device, severe ataxia, etc.), (3) part of a vulnerable population (pregnant, homeless, in prison, have auditory impairment), and (4) currently participating in mental health counseling with a licensed professional and\u002For a structured exercise program.","FEMALE",{"count":504,"type":22},20,[25],"Investigators are studying how combining a stepped-care mental health counseling program with an evidence-based exercise program can help Latina cancer survivors feel better mentally and physically. The goal is to improve stress, emotions, and physical activity during and after cancer treatment. In addition, investigators will examine the feasibility and acceptability of the intervention among Latina cancer survivors.",[508,509,510,29],"Stepped Care Cognitive Behavioral Therapy","Exercise","Physical Activity",[512,513,514,509,515],"Latina cancer survivors","Mental health counseling","Stepped-care","Physical activity","2025-10-29",{"date":518,"type":42},"2025-10-31",{"date":520,"type":42},"2025-10-01",{"date":522,"type":22},"2027-05",{"name":524,"class":49},"Colorado State University",{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":17,"minAge":183,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":23,"phases":534,"briefSummary":535,"conditions":536,"keywords":537,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":544,"completionDateStruct":546,"leadSponsor":548,"locationsCount":205},"100604596","evaluating-the-big-five-intervention-in-norway-100604596","NCT07151573","Evaluating the Big Five Intervention in Norway","5 Gode Vaner - En Randomisert Kontrollert Studie","Inclusion Criteria:\n\n* PHQ or GAD cutoff 5 or above\n* Residing in Norway and have a Norwegian national identity number\n* 16 years or above\n\nExclusion Criteria:\n\n* Reporting 2 or higher on PHQ item 9 (suicidality concerns)\n* Do not comprehend Norwegian or English",{"count":533,"type":22},410,[25],"This randomized controlled trial will evaluate the Norwegian adaptation of the Big Five intervention (Things You Do; TYD) for individuals with self-reported anxiety and\u002For depressive symptoms. The study will compare the Big Five intervention with a Gratitude intervention and a waitlist control. A total of 410 participants will be recruited online and randomized to one of three groups. Intervention groups will receive a brief module and daily SMS reminders (Monday-Friday for four weeks) encouraging engagement in either the five daily actions or gratitude practices. The primary aim is to replicate findings from the Australian trial by comparing TYD to a waitlist control. A secondary aim is to examine whether TYD yields better outcomes than the active Gratitude control. This study will provide evidence on the effectiveness and cross-cultural applicability of a low-cost, scalable intervention for improving mental health. Data from the study will also be used to evaluate the psychometric properties of the Norwegian translation of the Things You Do-15 instrument (TYD-15).",[29],[66,538,539,540,541],"Internet interventions","Big Five","DIgital Mental Health Intervention","Preventive interventions","2025-09-26",{"date":520,"type":42},{"date":545,"type":42},"2025-09-10",{"date":547,"type":22},"2027-09-30",{"name":549,"class":49},"Haukeland University Hospital",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":17,"minAge":557,"maxAge":18,"enrollmentInfo":558,"targetDuration":4,"studyType":23,"phases":559,"briefSummary":560,"conditions":561,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":50},"100550032","a-metacognitive-group-therapy-of-depression-and-anxiety-in-youth-with-autism-100550032","NCT06441786","A Metacognitive Group Therapy of Depression and Anxiety in Youth With Autism","A Metacognitive Group Therapy of Depression and Anxiety in Youth With Autism: Feasibility, Acceptability and Effect in a Clinical Open Trial","Inclusion Criteria:\n\n* Age of 15 to 18 years\n* Seeking medical care PRIMA psychiatric clinic for children and youth in Stockholm\n* Diagnoses of anxiety disorder or depression as well as autism established in a clinical interview\n* Mastering the Swedish language enough to take part of the treatment\n* Willingness\u002Fability to participate after receiving information about what participation entails\n\nExclusion Criteria:\n\n* Assessed to meet one of the following diagnoses: Bipolar syndrome, alcohol use syndrome, substance use syndromes, psychotic symptoms and affective syndromes with psychotic symptoms and antisocial personality disorder.\n* Assessed to have a high suicide risk.\n* Assessed to have extensive self-harm behavior or moderate to high risk of such.\n* Participating in other psychological treatment or about to start such treatment during the time interval of the study.\n* Has not had stable medication in the last month or is planning a deposit\u002Fmedication adjustment during the time interval of the study.","15 Years",{"count":420,"type":22},[25],"The goal of this open clinical trial is to try out and evaluate a group metacognitive treatment protocol, for adolescents aged 15-18 years of age with anxiety and\u002For depression and an autism diagnosis.\n\nThe main questions it aims to answer are:\n\n1. How does the recruitment to the study work and what is the retention rate?\n2. What is the level of participant compliance?\n3. Is the treatment adherence satisfactory, are there any practical problems with treatment delivery?\n4. Are the outcome measures and assessment procedures feasible?\n5. Do the participants accept the treatment, are there any reports of adverse effects?\n6. What are the preliminary effects of the treatment regarding\n\n   1. Symptoms of anxiety and\u002For depression\n   2. Quality of life\n   3. Functional impairment\n   4. Subjective level of stress\n   5. Central metacognitive processes\n7. Are changes in metacognitive processes related to changes in anxiety and depression?\n\nThe participants will partake in metacognitive group treatment of 10 sessions following an initial screening.",[29],"2025-09-23",{"date":564,"type":42},"2025-09-29",{"date":566,"type":42},"2024-08-12",{"date":568,"type":22},"2026-08-29",{"name":570,"class":49},"Uppsala University",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":214,"sex":502,"minAge":18,"maxAge":578,"enrollmentInfo":579,"targetDuration":4,"studyType":23,"phases":581,"briefSummary":582,"conditions":583,"keywords":4,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":591,"locationsCount":50},"100607073","acupuncture-for-anxietydepression-in-patients-with-breast-cancer-100607073","NCT07183813","Acupuncture for Anxiety\u002FDepression in Patients With Breast Cancer","Effects of Acupuncture for Anxiety and\u002For Depression Among Patients With Breast Cancer","Inclusion Criteria:\n\n1. Female, aged 18 to 70 years old;\n2. Meeting the diagnostic criteria for breast cancer and at TMN I-III;\n3. Having completed specialized active treatment for at least one month;\n4. With an ECOG score of 0-2;\n5. Mild to moderate anxiety and\u002For depression;\n6. Voluntarily joining this study and signing the informed consent form.\n\nExclusion Criteria:\n\n1. Starting to take or change the regimen of anti-anxiety and\u002For -depression disorder medication within one month before enrolment;\n2. Received psychological intervention or physical therapy one month before enrolment or planning to use in the next 5 months;\n3. With diagnosis of anxiety and\u002For depression disorder prior to the diagnosis of breast cancer;\n4. Patients with suicidal tendencies, bipolar disorder and psychotic symptoms;\n5. Patients with severe anxiety and\u002For depression；\n6. Patients received acupuncture treatment within one month before enrolment;\n7. Participating in other clinical studies on the treatment of anxiety and\u002For depression;\n8. Combined with severe underlying diseases;\n9. Patients with severe skin ulcers;\n10. Pregnant or lactating patients;\n11. Poor compliance.","70 Years",{"count":580,"type":22},360,[25],"The aim of this study is to evaluate the effects and safety of acupuncture on anxiety and\u002For depression among patients with breast cancer.",[29,584,311],"Breast Cancer","2025-09-19",{"date":587,"type":42},"2025-09-24",{"date":589,"type":22},"2025-09-15",{"date":172,"type":22},{"name":592,"class":49},"Guang'anmen Hospital of China Academy of Chinese Medical Sciences",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":601,"enrollmentInfo":602,"targetDuration":4,"studyType":23,"phases":603,"briefSummary":605,"conditions":606,"keywords":609,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":50},"100483113","phase-2-neuroactive-steroid-to-treat-depressed-mood-a-trial-for-people-with-hiv-100483113","NCT05570812","Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV","In Vivo Targeting of Neuroactive Steroid and Immune Networks for Depression in People Living With HIV","SOOTHE","Inclusion Criteria:\n\n* 18-85 years\n* HIV-1 viral load \\\u003C200 copies\u002FmL on antiretroviral therapy (ART) at screening visit\n* Center for Epidemiological Studies - Depression (CES-D) score ≥ 20\n\nExclusion Criteria:\n\n* Contraindication to magnetic resonance imaging (MRI) or poor-quality baseline MRI preventing image analyses as determined by radiologist assessment\n* Recent severe infections including opportunistic infections, active bacterial, mycobacterial, fungal, or certain viral infections\n* Vulnerable populations (e.g., pregnant\u002Fnursing, severe cognitive or intellectual impairment, incarcerated)\n* Use of cobicistat or ritonavir\n* High risk for suicide (active suicidal ideation (SI) with plan\u002Fintent as assessed by using the Columbia Suicide Severity Rating (C-SSRS) or \\> 2 attempts in lifetime or any in the past 6 months) or expresses homicidal ideation necessitating clinical intervention or representing an imminent concern\n* Any severe (life-threatening or unstable) medical condition as determined by clinician assessment\n* Blood pressure, with the lowest reading taken after three repeat readings during screening visit, ≥ 160 mmHg systolic OR ≥ 95 mmHg diastolic or other life-threatening vital signs as determined by clinician assessment\n* Clinically significant abnormalities in physical examination or ECG that would interfere with study participation\n* Decompensated cirrhosis, active liver inflammation (alanine aminotransferase (ALT)\u002Faspartate aminotransferase (AST) ≥ 5 times the upper limit of normal) or unsuppressed viral hepatitis B or C infection\n* Severe renal disease (estimated glomerular filtration rate ≤ 30 mL\u002Fmin\u002F1.73m2)\n* Seizure disorder requiring antiepileptic treatment\n* History of allergic reaction or side effects with prior pregnenolone use\n* Currently using testosterone enanthate, testosterone cypionate, or estrogen containing preparations that significantly increase systemic estrogen levels, including but not limited to oral and transdermal forms of estrogen. All other forms of exogenous sex steroid hormones will be evaluated at the discretion of the PI and\u002For clinical delegates.\n* Currently using systemic immunosuppressive agents, including corticosteroids, chemotherapy, or specific immunomodulating agents, such as monoclonal antibodies and TNF-inhibitors\n* Excessive alcohol or other substances use that would interfere with classification of major depression disorder, study procedures and\u002For follow-up\n* Current diagnosis of bipolar disorder\n* Diagnosis of a psychotic disorder (current or lifetime)\n* Diagnosis of schizophrenia (current or lifetime)\n* \\\u003C70% adherence to study drug prior to randomization\n* Inability to swallow pills\u002Fcapsules\n* Not able to complete neuropsychological testing in English\n* Concurrent participation in another interventional trial, except for lifestyle and device studies (For vaccination studies, individuals in the observation period are not exclusionary. Other interventions will be evaluated at the discretion of the PI and\u002For clinical delegates.)","85 Years",{"count":279,"type":22},[604],"PHASE2","This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications. Brain imaging and behavioral assessments will be performed during the study.",[607,29,608],"Major Depressive Disorder","HIV",[608,65,610,611],"Neuroactive Steroid","Pregnenolone","2025-09-07",{"date":614,"type":42},"2025-09-12",{"date":616,"type":42},"2023-03-03",{"date":618,"type":22},"2028-01-31",{"name":620,"class":49},"Massachusetts General Hospital",{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":625,"acronym":4,"eligibilityCriteria":626,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":627,"enrollmentInfo":628,"targetDuration":4,"studyType":281,"phases":4,"briefSummary":629,"conditions":630,"keywords":4,"overallStatus":260,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":4},"100599103","research-on-the-psychological-status-of-patients-with-hiv-1-infection-100599103","NCT07080138","Research on the Psychological Status of Patients With HIV-1 Infection","Inclusion Criteria:\n\n1. Diagnosis: PLWH can be diagnosed if one of the following three items is met according to the Chinese AIDS Diagnosis and Treatment Guidelines (2021):\n\n   ① HIV antibody screening test positive and HIV supplementation test positive (antibody supplementation test positive or nucleic acid qualitative test positive or nucleic acid quantification\\>5000 copies\u002FmL);\n\n   ② Has a history of epidemiology or clinical manifestations related to AIDS, tested positive for HIV nucleic acid twice;\n\n   ③ HIV isolation test positive;\n2. Receive treatment at the hospital participating in the study; Age range: 18-80 years old, male or female not limited;\n3. Patients who are willing to participate in this clinical study and sign the informed consent form for this study.\n\nExclusion Criteria:\n\nIndividuals who meet any of the following criteria are not eligible to participate in this study:\n\n1. Pregnant or lactating women; Men and women who are preparing for natural conception or artificial assisted reproduction;\n2. Severe aphasia, physical disability, or any other non neuropsychological factors that may hinder the completion of the assessment;\n3. is currently involved in other research;\n4. Having a tendency towards violence may endanger the safety of others.","80 Years",{"count":249,"type":22},"The goal of this observational study is to investigate the neuropsychological states of People Living With HIV(PLWH), the prevalence of social and psychological stress adaptation overload and poor episodic memory in PLWH. The main questions it aims to observe are: to observe the prevalence of psychopathic states in PLWH with different viral loads and to compare the effects of different treatments on the prevalence of psychopathic states in PLWH. It is helpful to understand the mental health burden faced by PLWH in China, to improve clinicians' awareness of PLWH's mental and psychological state, and formulate targeted psychological support, treatment and nursing programs.",[631,29],"HIV-1-infection","2025-07-14",{"date":634,"type":42},"2025-07-23",{"date":636,"type":22},"2025-08-01",{"date":638,"type":22},"2026-12-31",{"name":640,"class":49},"Shanxi Bethune Hospital",{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":648,"enrollmentInfo":649,"targetDuration":4,"studyType":281,"phases":4,"briefSummary":651,"conditions":652,"keywords":659,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":667,"lastUpdatePostDateStruct":668,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":674,"locationsCount":50},"100481446","cbt-and-the-neural-circuits-of-anxiety-100481446","NCT05549102","CBT and the Neural Circuits of Anxiety","The Impact of CBT on Shock-Potentiated Neural Circuity","Inclusion Criteria:\n\n* Enrolled in IAPT Step 3 (high intensity service)\n* Score of or above 8 on the GAD-7 (indicating moderate anxiety on a standard scale of anxiety; Spitzer et al., 2006)\n* Willing and able to provide written consent\n\nExclusion Criteria:\n\n* Score above 22 on the GAD-7\n* Past\u002Fpresent psychotic disorder, bipolar disorder\u002Fmania or alcohol\u002Fsubstance use disorder (outside a comorbid psychiatric episode)\n* History of medical illness that may impair cognitive function (e.g. serious head injury, endocrine disorder)\n* Current psychotropic pharmacological intervention (e.g. SSRIs) or use within 3 months\n* MRI contraindications such as pacemaker, aneurysm clip, cochlear implant, neurostimulator, IUD, shrapnel, metal fragments in eye, weight of above 250lbs or claustrophobia\n* Females who are pregnant, planning pregnancy, or breastfeeding","64 Years",{"count":650,"type":22},174,"This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions. This study aims to provide a theoretical model of the neurobiological mechanisms of CBT's therapeutic effect, where there currently is none, and potentially allow for more targeted\u002Fspecific approaches to anxiety disorders following the identification of key CBT mechanisms. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.",[653,165,654,29,655,656,66,657,658],"Generalised Anxiety Disorder","CBT","Anxiety Disorders and Symptoms","Anxiety Generalized","Anxiety Disorder Generalized","Anxiety Disorder; Mixed With Depression (Mild)",[660,661,662,663,654,664,665,666],"GAD","generalised anxiety disorder","anxiety disorders","cognitive behavioural therapy","psychological therapy","neural circuitry","emotional processing","2025-06-25",{"date":669,"type":42},"2025-06-29",{"date":671,"type":42},"2020-02-02",{"date":673,"type":22},"2025-12-01",{"name":675,"class":49},"UCLH\u002FUCL Joint Research Office",{"id":677,"slug":678,"hasResults":12,"nctId":679,"briefTitle":680,"officialTitle":681,"acronym":4,"eligibilityCriteria":682,"healthyVolunteers":214,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":683,"targetDuration":4,"studyType":23,"phases":685,"briefSummary":686,"conditions":687,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":692,"lastUpdatePostDateStruct":693,"startDateStruct":695,"completionDateStruct":697,"leadSponsor":699,"locationsCount":50},"100562539","an-online-ecoaching-rct-intervention-for-carers-enhancing-wellbeing-and-resilience-through-self-help-strategies-100562539","NCT06604481","An Online Ecoaching RCT Intervention for Carers: Enhancing Wellbeing and Resilience Through Self-Help Strategies","Randomized Controlled Trial to Test the Efficacy of Online Ecoaching to Support Caregivers of Older Adults in Hong Kong: Enhancing Carers' Wellbeing and Resilience","Inclusion Criteria:\n\n* being an adult aged 18 or above with a family member aged 60 or above requiring caregiving, providing at least 6 hours of care per week\n* self-identifying as a family caregiver\n* living in Hong Kong\n* able to communicate with the interventionist\n* voluntary participation\n* reporting mild risk need in Carer Need Screening tool\n\nExclusion Criteria:\n\n* having diagnosed Alzheimer's or other dementia\n* experiencing acute health conditions that hinder caregiving support or intervention participation",{"count":684,"type":22},232,[25],"The goal of this three-armed, double-blind randomized controlled trial (RCT) is to compare the effectiveness of an online self-help eCoaching intervention designed for caregivers. The main questions it aims to answer are:\n\nWhat is the impact of the online self-help eCoaching intervention on the well-being, depressive symptoms, and self-efficacy of participants? Researchers will compare the results between the intervention groups and the control group to see if participants in the intervention groups have lower distress, burden and higher accuracy.",[688,689,690,29,691],"Caregiver Burden","Self Efficacy","Quality of Life","Resilience","2025-06-05",{"date":694,"type":42},"2025-06-10",{"date":696,"type":42},"2025-04-30",{"date":698,"type":22},"2026-09",{"name":700,"class":49},"The University of Hong Kong"]