[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-disorderanxiety-state\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-disorderanxiety-state":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100478070","predictive-and-impact-of-pain-after-6-months-of-radiotherapy-in-head-and-neck-cancer-100478070",false,"NCT05505188","Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer","Predictive and Impact of Pain at 6 Months in Patients Treated With Radiotherapy for Head and Neck Cancer","DIP-CAOS","Inclusion Criteria:\n\n* Patients with a first Head and neck cancer whose therapeutic sequence involves radiotherapy\n* Patient over 18 years of age\n* Having given written consent\n* patient not previously treated with radiotherapy\n* Life expectancy \\> 3 months\n* World Health Organization (WHO) score \\\u003C 3\n* Histologically proven Head and Neck cancer\n* Stable patient, with no signs of recurrence or other progressive neoplasia at the time of the examination\n* Patient treated with radiotherapy\n* Patient fluent in French\n\nExclusion Criteria:\n\n* Non-consenting patient\n* History of malignancy, other than treated and cured basal cell or cervical cancer\n* Patient who has had a salvage surgery other than lymph node removal\n* Patient with evidence of recurrence or other progressive neoplasia at the time of examination\n* Patient who has had previous mutilating surgery (causing sequelae of swallowing and eating)\n* Uncontrolled infectious pathology\n* Patient under 18 years of age\n* Patient who is not fluent in French\n* Patient with a psychiatric pathology that could disrupt the study or prevent the interpretation of the results.","ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","Head and neck cancers are a source of complications and after-effects related to the disease and treatment. These cancers and their treatment alter the quality of life of patients and generate pain with physical and psychological components. Chronic pain affects 36% of patients at 6 months and 30% after this period. These pains are responsible for the consumption of level II and III analgesics in 53% of these patients. At the same time, after the end of treatment, nearly a quarter of patients continued to smoke and half still consumed alcohol at least twice a week.\n\nThe hypothesis of this research is to investigate the correlation between pain and the continuation of addictions, the occurrence of depressive states, asthenia and the alteration of the patients' global quality of life.\n\nThe investigators propose a two-center prospective cohort study to evaluate this hypothesis at 6 months after radiotherapy treatment.\n\nThis study is planned to include 120 patients with a first head and neck cancer whit radiotherapy as part of their treatment sequence. The expected duration of inclusion is 18 months.\n\nThe identification of factors affecting survival, quality of life and patient compliance is essential to determine appropriate management, particularly by creating appropriate therapeutic education programs.",[27,28,29,30,31,32,33,34],"Neuropathic Pain","Anxiety Disorder\u002FAnxiety State","Pain, Chronic","Alcohol Use Disorder","Psychoactive Substance Use","Sleep","Symptoms and Signs","Addiction Nicotine",[36,37,38,39,40],"Head and neck cancer","pain","Quality of life","Addiction","Depression","RECRUITING","2025-07-22",{"date":44,"type":45},"2025-07-25","ACTUAL",{"date":47,"type":45},"2023-03-13",{"date":49,"type":21},"2026-09-01",{"name":51,"class":52},"University Hospital, Caen","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100590214","impact-of-psychological-stress-on-treatment-response-and-prognosis-in-lung-cancer-patients-100590214","NCT06964503","Impact of Psychological Stress on Treatment Response and Prognosis in Lung Cancer Patients","Inclusion Criteria (Advanced Stage Cohort):\n\nAge ≥ 18 years; Histologically confirmed diagnosis of lung cancer (including both non-small cell lung cancer \\[NSCLC\\] and small cell lung cancer \\[SCLC\\]); Unresectable, locally advanced, metastatic, or recurrent disease classified as stage IIIB-IV according to the 8th edition of the AJCC TNM staging system; Eastern Cooperative Oncology Group (ECOG) performance status of 0-1; No prior systemic treatment (e.g., chemotherapy, anti-angiogenic therapy, targeted therapy, or immunotherapy); At least one measurable lesion as defined by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1); Able to provide informed consent and voluntarily agree to participate in the study.\n\nExclusion Criteria:\n\nCombined with other malignant tumors in the past 3 years; Concurrent acute or chronic psychiatric disorders; Current receiving anti-depressive or anti-anxiety therapy; Previous treatment with other clinical drug trials; Patients with symptomatic brain metastasis; Can't cooperate with psychological scale assessment;\n\nInclusion Criteria (Early-Stage Surgical Cohort) Age ≥18 years; Pathologically diagnosed as non-small-cell lung cancer； Pathologically stage conformed as early stage of IA-IIIA Available for tumor tissue samples； Systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy ); Receiving radical surgery; Informed and agreed to participate in the study;\n\nExclusion Criteria:\n\nCombined with other malignant tumors in the past 3 years; Concurrent acute or chronic psychiatric disorders; Current receiving anti-depressive or anti-anxiety therapy; Previous treatment with other clinical drug trials; Can't cooperate with psychological scale assessment;\n\nInclusion Criteria (neoadjuvant therapy Cohort) Adults aged ≥18 years; Histologically confirmed diagnosis of non-small cell lung cancer \\[NSCLC\\]; Clinical stage IB-IIIB based on the 8th edition of the AJCC TNM staging system and deemed potentially resectable after neoadjuvant therapy; At least one measurable lesion can be evaluated according to the RECIST 1.1 standard; Planned to receive or currently receiving neoadjuvant systemic therapy (e.g., chemotherapy, targeted therapy, or immunotherapy) with curative intent; Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 prior to neoadjuvant treatment; No prior systemic treatment before the initiation of neoadjuvant therapy; Able to provide informed consent and voluntarily agree to participate in the study\n\nExclusion Criteria:\n\nCombined with other malignant tumors in the past 3 years; Concurrent acute or chronic psychiatric disorders; Current receiving anti-depressive or anti-anxiety therapy; Previous treatment with other clinical drug trials; Can't cooperate with psychological scale assessment;",{"count":61,"type":21},600,"OBSERVATIONAL","This study explores how psychological stress may influence the treatment response and long-term outcomes in patients with lung cancer. While advances in surgery, chemotherapy, immunotherapy, and targeted therapies have improved survival, emotional well-being remains an often-overlooked factor. We aim to investigate whether high levels of stress, anxiety, or depression at the time of diagnosis or during treatment are linked to poorer responses to therapy or shorter survival. By identifying these associations, the study hopes to highlight the importance of psychological care as part of comprehensive cancer treatment. The findings may inform future strategies to integrate mental health support into routine care for patients with both early-stage and advanced lung cancer.",[65,66,28],"Cancer of Lung","Depression Disorders","NOT_YET_RECRUITING","2025-05-01",{"date":70,"type":45},"2025-05-09",{"date":72,"type":21},"2025-05-30",{"date":74,"type":21},"2031-05-30",{"name":76,"class":52},"The First Affiliated Hospital of Guangzhou Medical University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":97,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":118},"100576742","co-occurence-of-mental-illness-and-problematic-alcohol-use-an-internet-based-cognitive-behavior-therapy-intervention-100576742","NCT06789250","Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention","CoMiT","Inclusion Criteria:\n\n* Age ≥18 years\n* AUDIT ≥ 6 points for women and ≥ 8 points for men\n* Symptoms of depression, anxiety disorder and\u002For stress-related illness\n* Adequate ability to speak, read and write Swedish\n* Having access to the internet and a smartphone, computer or other device.\n\nExclusion Criteria:\n\n* Ongoing psychological treatment.\n* Ongoing medication for AUD\n* Recent changes (within the past three months) in psychiatric medication or planned changes during the treatment period. New medication prescribed during the study shall be reported but will not lead to exclusion\n* Severe psychiatric disorders based on a Mini-International Neuropsychiatric Interview (MINI) interview and reported medical history\n* Severe medical conditions that may impede participation in the study\n* Severe cognitive impairment\n* Current suicidality\n* Severe alcohol addiction where specialized treatment is more appropriate\n* Risk for severe alcohol withdrawal symptoms with a need for medical treatment. Participation is possible after completing alcohol withdrawal treatment within the ordinary health-care system, accessible to the Swedish population.\n* Substance use disorder, other than alcohol or nicotine, within the past six months.",{"count":85,"type":21},240,[24],"The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression, anxiety, stress or disturbed sleep.\n\nThe main questions the study aims to answer are:\n\n* Does the ICBT program lower the self-rated suffering from mental illness?\n* Does the ICBT program lower the self-reported alcohol intake? Researchers will compare the ICBT program to the participants who are rancomized to a control grout that receives weekly attention from the research team, to see if the treatment works. In both groups, the participants will have the opportunity to ask for support from a therapist during the week days.\n\nParticipants are adults living in Sweden. They will:\n\n* Receive an ICBT program supported by a trained therapist. It consists of modules that the participants will work with on their computer for 10 weeks. Some modules will be compulsory and other optional for the participants.\n* Fill out forms to rate their mental illness and alcohol intake at the start and the end of the study as well as once every week during treatment.\n\nPrimary outcome measures are depression, anxiety and stress symptoms (measured with Depression Anxiety and Stress Scale 21 (DASS-21)) and alcohol intake measured with self-reported amounts. Other, secondary, outcome measures used will for example be about insomnia symptoms and disability assessment. Pre-treatment measurement, post-treatment measurement and 6-months and 12-months follow up is planned to be collected through an online survey.",[89,90,91,92,93,94,95,96,28],"Alcohol Drinking Related Problems","Alcohol Use Disorders","Depressive Disorders","Mental Illness","Mental Stress","Mental and Behavioral Disorders","Sleep Problems","Stress Disorders",[98,40,99,100,101,102,103,104,105,106,107],"Internet intervention","Anxiety","Individually tailored","Transdiagnostic","Internet-based cognitive behavioral therapy (ICBT)","Stress","Sleeping disorders","Mental illness","Harmful alcohol use","Alcohol addiction","2025-02-21",{"date":110,"type":45},"2025-02-24",{"date":112,"type":45},"2025-01-05",{"date":114,"type":21},"2026-05",{"name":116,"class":117},"Linkoeping University","OTHER_GOV",2]