[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-postoperative":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100642205","anxiety-levels-in-living-liver-donors-100642205",false,"NCT07576920","Anxiety Levels in Living Liver Donors","Evaluation of Preoperative and Postoperative Anxiety in Living Liver Donors","Inclusion Criteria:\n\n* ASA 1-2 group patients aged 18-65 years who are liver transplant donors\n\nExclusion Criteria:\n\n* Patients with communication problems, those who are illiterate,\n* Patients do not have sufficient time for the tests,\n* Patients using sedatives, antidepressants, or antiepileptic drugs,\n* Patients with cerebrovascular or psychiatric diseases,\n* Patients with alcohol or substance addiction,\n* Patients who do not want or cannot undergo the second test",true,"ALL","18 Years","65 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates. In adult patients undergoing various surgical procedures, preoperative anxiety rates have been reported to range from 11% to 80%. Most studies show that postoperative anxiety levels are related to preoperative anxiety levels. In patients undergoing general anesthesia, anxiety levels increase a few days after surgery as issues related to recovery and pain become apparent. Patients with high postoperative anxiety levels have also been reported to have a higher rate of medical complications.",[26],"Anxiety Postoperative",[28,29],"Anxiety","Liver Transplantation","RECRUITING","2026-06-15",{"date":33,"type":34},"2026-06-16","ACTUAL",{"date":36,"type":34},"2026-05-04",{"date":38,"type":22},"2026-07-30",{"name":40,"class":41},"Inonu University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":42},"100432547","virtual-reality-and-olfactory-stimuli-multimodal-intervention-to-reduce-post-operative-pain-and-anxiety-in-patients-undergoing-cardiothoracic-surgery-100432547","NCT04912531","Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery","Using a Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery","Inclusion Criteria:\n\n* Be scheduled to undergo any one of the 5 major types of cardiothoracic surgical operations: coronary artery bypass grafting, aortic valve replacement, aortic valve repair, lung resection, and esophagectomy\n* Age \\> 18\n* No cognitive or psychiatric conditions prohibiting study consent or participation.\n\nExclusion Criteria:\n\n* Clinical signs of cardiogenic shock at time of surgery\n* Severe irreversible hypertension\n* Congenital heart disease\n* Chronic renal insufficiency defined by Cr ≥ 2.5 or chronic renal replacement therapy\n* Evidence of cirrhosis or hepatic synthetic failure\n* Patients with odor allergies or anosmia (lost their sense of smell)",{"count":51,"type":22},80,"INTERVENTIONAL",[54],"NA","Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benzodiazepines, which can have severe side effects and can be ineffective. Interventions combining virtual reality with olfactory stimuli are a promising alternative to opioids and benzodiazepines in the treatment of pain and anxiety around the time of surgery.\n\nThe aim of this study is to evaluate the feasibility of a virtual reality and olfactory stimuli multimodal intervention in patients undergoing cardiothoracic surgery. In addition, the investigators will evaluate the preliminary effects of the VR\u002FOS intervention on patient pain and anxiety before and after cardiothoracic surgery. Patients who meet study inclusion criteria and are undergoing cardiothoracic surgery may participate in this study. Patients have an equal being assigned to undergo the virtual reality and olfactory stimuli intervention or continue getting usual medical care with their doctor. If the patient is assigned to receive the virtual reality and olfactory stimuli intervention, the first therapy session will take place approximately two to four weeks before surgery. This will involve wearing a virtual reality headset and scented necklace for approximately 10 minutes. The second session will occur 90 minutes before the surgery. Additionally, for each day the patient recovers in the hospital after surgery, the patient will receive one session in the afternoon. During the patient's in-hospital recovery at night, they will receive lavender scented therapy.",[57,26,58],"Postoperative Pain","Opioid Use","2026-02-18",{"date":61,"type":34},"2026-02-20",{"date":63,"type":34},"2022-10-01",{"date":65,"type":22},"2028-06-30",{"name":67,"class":41},"Massachusetts General Hospital",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":52,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100612949","influence-of-a-psychological-intensive-support-program-for-lung-cancer-patients-on-post-operative-outcomes-100612949","NCT07260227","Influence of a PSychological Intensive Support Program for Lung Cancer Patients ON Post-operative Outcomes.","Influence of a PSychological Intensive Support Program for Lung Cancer Patients ON Post-operative Outcomes: a Prospective Clinical Trial (IPSILON Trial).","IPSILON","Inclusion Criteria:\n\n* age more than 18\n* candidate to thoracic resection for lung cancer with radical intent\n* consent to participate in the research study.\n\nExclusion Criteria:\n\n* synchronous cancer requiring chemo or radiotherapy\n* history of chronic pain, vulnerable patients (e.g., minors and\u002For incapacitated subjects)\n* patients with severe psychiatric conditions (psychosis and\u002For personality disorders).",{"count":77,"type":22},138,[54],"Anxiety is common among patients diagnosed with lung cancer, affecting 50-60% of cases, and over 30% report moderate to severe psychological distress. This distress includes symptoms such as depression, anxiety and social withdrawal. The waiting period before lung resection often heightens emotional tension due to fears about reduced respiratory function and postoperative dyspnea. Persistent anxiety may continue during follow-up because of the risk of recurrence and the potential need for adjuvant therapy. Previous studies have shown that high perioperative anxiety is associated with longer hospitalization, increased complications, particularly delirium and cardiac arrhythmias, and poorer adherence to treatment.\n\nThis study aims to assess whether a brief, intensive preoperative psychological intervention reduces anxiety levels in lung cancer patients, measured using the Hospital Anxiety and Depression Scale (HADS). Scores of 0-7 indicate normal levels, ≥ 8 probable anxiety or depression. Additional tools include the Visual Analogue Scale (VAS) for pain (0 = no pain, 10 = worst pain imaginable) and the Insomnia Severity Index (ISI) (0-7 no insomnia, 8-14 subthreshold, 15-21 moderate, 22-28 severe). At hospital discharge, patients were invited to complete a questionnaire about satisfaction. Measurement of psychological test will be collected at the first visit (T0), the day before surgery (T1) and 30 day after surgery (T3); VAS and ISI measurements were collected at T1, the day after surgery (T2) and 30 day after surgery (T3).\n\nPatients are divided into three groups: an intervention group receiving four weekly 45-minute psychological sessions, a pathological control group refusing support, and a healthy control group without anxiety. Primary outcomes are changes in HADS scores between T0 and T1; secondary outcomes include complications, pain, insomnia, length of stay, and patient satisfaction. The study is a twelve-month prospective controlled trial with an estimated 46 patients per group",[81,26,82],"NSCLC","Depression","NOT_YET_RECRUITING","2025-11-21",{"date":86,"type":34},"2025-12-03",{"date":88,"type":22},"2025-12-01",{"date":90,"type":22},"2027-04-30",{"name":92,"class":41},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]