[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"anxiety-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:anxiety-symptoms":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,42,79,108,138,167,209,265,292,320,351,382,409,439,460,488],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100540313","examining-the-health-effects-of-npower365-among-black-same-gender-loving-men-100540313",false,"NCT06315218","Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men","Inclusion Criteria:\n\n1. Identify as Black or African American, regardless of ethnicity\n2. Identify as male, regardless of sex assigned at birth\n3. Are living with HIV and prescribed a daily ART regimen\n4. Are age ≥ 18;\n5. Have sex with men\n6. Own an internet-connected device (e.g., smartphone, tablet)\n7. Reside in the Atlanta-area EHE jurisdictions.\n\nExclusion Criteria:\n\n1. Lack of English fluency\n2. Past participation in the pilot.","ALL","18 Years",{"count":18,"type":19},350,"ESTIMATED","INTERVENTIONAL",[22],"NA","This research study aims to test the effectiveness, reach, and maintenance over time of the NPOWER365 HIV care intervention for Black men who have sex with men (BMSM) living with HIV. NPOWER365 is a BMSM community-developed multicomponent intervention that aims to: 1) Support daily health promotion via HIV health education and health maintenance reminders; 2) Foster positive social connections among BMSM via online moderated forums, interpersonal chats, and community calendars; 3) Connect clients to BMSM-affirming healthcare, including HIV treatment and mental healthcare; 4) Provide resources for housing, transportation, and other economic empowerment.",[25,26,27,28,29],"Sexual and Gender Minorities","Social Stigma","Medication Adherence","Depressive Symptoms","Anxiety Symptoms","NOT_YET_RECRUITING","2026-06-08",{"date":33,"type":34},"2026-06-10","ACTUAL",{"date":36,"type":19},"2026-08",{"date":38,"type":19},"2028-04",{"name":40,"class":41},"Rutgers, The State University of New Jersey","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100625814","misapsy-childhood-maltreatment-food-insecurity-psychological-distress-and-professional-integration-among-socioeconomically-disadvantaged-young-adults-100625814","NCT07427524","MISAPSY: Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults","Psychosocial Intervention With Precarious Young People: a Comparative Longitudinal Study on Psychological Distress and Food Insecurity","PRESPA","Inclusion Criteria:\n\n* Be aged 18 to 25 years\n* Be supported by a Mission Locale in Paris as part of a social and\u002For professional integration program\n* Voluntarily participate in the study after receiving clear information and signing an informed consent form\n* Experiencing severe food insecurity (positive response to item 8 of the FIES)\n* Experiencing significant psychological distress, defined by: PHQ-9 score \\> 15; GAD-7 score \\> 10\n* Have been exposed to at least one adverse childhood experience, identified via the CTQ-SF (Childhood Trauma Questionnaire - Short Form).\n\nExclusion Criteria:\n\n* Being unable to provide informed consent due to impaired comprehension or communication skills\n* Currently receiving psychiatric care for an acute or chronic mental illness requiring regular specialized treatment\n* Experiencing a social or medical emergency incompatible with the study (e.g., unstable emergency housing, acute suicidal crisis, ongoing hospitalization)\n* Being incarcerated, under guardianship or curatorship without specific legal authorization to participate in research\n* Having previously participated in a similar study or currently being engaged in a structured psychological intervention protocol\n* Having insufficient command of the French language, preventing comprehension of instructions, questionnaires, or interviews.","25 Years",{"count":52,"type":19},70,[22],"The MISAPSY study (Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults) aims to model the complex interrelations between child maltreatment, trauma exposure, food insecurity, and psychological distress among precarious young adults enrolled in French youth employment and social integration services (Mission Locale).\n\nAdopting a methodology structured around three complementary components, this study consists of: (1) a cross-sectional survey to identify key associations ; (2) a qualitative study based on semi-structured interviews exploring psychologists' subjective experiences, and (3) a longitudinal comparative interventional study involving two different support programs to assess and compare the impact of these interventions on participants' food insecurity and psychological well-being.\n\nUsing a multi-phase design, MISAPSY seeks to move beyond linear risk-factor models by adopting a systemic and network-based approach to mental health and social vulnerability. The study integrates quantitative analyses, including network analyses, qualitative exploration of professional practices, and comparative longitudinal intervention to inform more holistic, equitable, and transferable models of care for vulnerable young adults.",[56,57,58,59,60,29],"Trauma and Stress-related Disorders","Food Insecurity","Child Maltreatment","Psychological Distress","Depression Symptoms",[57,62,63,64,65,66,67,68],"Mental health","young adults","trauma","adverse childhood experience","psychological distress","precarity","mixed-methods","2026-04-28",{"date":71,"type":34},"2026-05-05",{"date":73,"type":19},"2026-07-01",{"date":75,"type":19},"2027-06",{"name":77,"class":41},"University of Lorraine",6,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":20,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100484537","baduanjin-training-for-depression-and-anxiety-patients-100484537","NCT05589337","Baduanjin Training for Depression and Anxiety Patients","Effects of Baduanjin Breathing Training for Depression and Anxiety Patients: a Prospective Randomized Study","Inclusion Criteria:\n\n* Subject with depression or anxiety symptom diagnosed by ICD-10.\n* Depression 7≤HAMD-17≤29，anxiety 7≤HAMA-14≤29.\n* Subject has a clear mind and the ability to read, to talk and to communicate.\n* Subject agrees to participate in this study and sign to the informed consent.\n\nExclusion Criteria:\n\n* Subject with bipolar disorder, psychotic disorder, organic mental disorder and cognitive disorder.\n* Subject with alcohol abuse, substance dependence and suicidal behavior in past-year.\n* Subject has severe somatic disease.\n* Subject is pregnant or lactating women.","70 Years",{"count":88,"type":19},120,[22],"In recent years, the number of people with symptoms of depression or anxiety are on the rise. The aims of the prospective randomized study are: (1) to examine the effects of Baduanjin breathing training on reducing symptoms of depression or anxiety, and (2) to explore the correlates between improvements of depression or anxiety symptom and changes of lung functions.",[60,29],[93,94,95,96],"Baduanjin","Depression","Anxiety","Randomized controlled trial","RECRUITING","2026-04-23",{"date":100,"type":34},"2026-04-29",{"date":102,"type":34},"2021-07-01",{"date":104,"type":19},"2027-07-30",{"name":106,"class":41},"Shanghai University of Traditional Chinese Medicine",1,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":15,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":20,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":107},"100621127","touchminds-help-seeking-in-adolescents-with-anxiety-100621127","NCT07366580","TOUCHminds: Help-seeking in Adolescents With Anxiety","TOUCHMinds: An RCT on Help-seeking for Adolescent Anxiety","TOUCHminds","Inclusion Criteria:\n\nFor all experimental and control groups, the inclusion criteria are:\n\n* Aged between 15 and 17 years old at the time of screening;\n* Fluent in Portuguese;\n* Have access to a smartphone, tablet, or computer;\n* Have reliable internet access.\n\nClinical Groups Specific:\n\n* Must meet criteria for a primary diagnosis of at least one anxiety disorder, as assessed by the MINI-KID (Rijo et al., 2016).\n\nSubclinical Groups Specific:\n\n* Must not meet diagnostic criteria for any mental health disorder, as assessed by the MINI-KID (Rijo et al., 2016).\n\nExclusion Criteria:\n\nExclusion criteria for all experimental and all control groups are:\n\n* Psychotic symptoms or suicidal risk as assessed via the Mini-Kid (Rijo et al., 2016);\n* Being part of the special needs teaching system.\n* Currently receiving psychological counselling.",true,"15 Years","17 Years",{"count":120,"type":19},96,[22],"Adolescents frequently experience clinical and subclinical anxiety symptoms, yet many avoid seeking professional help. While universal interventions exist to promote help-seeking, targeted programs for adolescents with elevated anxiety symptoms remain scarce. Therefore, accessible and tailored strategies are needed to effectively promote help-seeking among this group.\n\nTOUCHminds is a web-based intervention designed to enhance help-seeking among adolescents with clinical or subclinical anxiety. The program consists of six self-guided modules featuring interactive activities (e.g., images, videos, simulation activities, and audio recordings), combined with three synchronous sessions led by a psychologist via videoconference. The intervention explicitly targets precursors of help-seeking, including mental health literacy, mental health stigma, self-compassion, readiness to change, and stage of change.\n\nThis research project comprises two studies. Study I, a feasibility study involving 10 adolescents aged 15 to 17, will assess recruitment procedures, dropout rates, usage patterns, therapist fidelity, acceptability, usability, satisfaction, and preliminary effects. Study II, a randomized controlled trial (RCT), intends to include 96 adolescents randomly assigned to four groups: clinical intervention, clinical control, subclinical intervention, and subclinical control. Clinical participants are those who meet diagnostic criteria for one or more anxiety disorders, whereas subclinical participants present high self-reported anxiety but no mental disorder diagnosis. Intervention effects will based on self-report assessments conducted at pre-intervention, post-intervention (9 weeks later), and at 3-month follow-up.\n\nThis research will provide evidence regarding the suitability and effectiveness of TOUCHminds in promoting help-seeking among adolescents experiencing different levels of anxiety symptoms. Findings will contribute to the field of empirically validated web-based interventions tailored specifically for adolescents.",[29,124],"Anxiety Disorders",[95,126,127,128],"Adolescents","Help-seeking","Web-based intervention","2026-01-16",{"date":131,"type":34},"2026-01-26",{"date":133,"type":19},"2026-09-15",{"date":135,"type":19},"2028-09-30",{"name":137,"class":41},"Aveiro University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":116,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":20,"phases":147,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":107},"100608999","developing-a-booster-session-for-problem-management-plus-in-the-bahamas-a-pilot-randomized-controlled-trial-100608999","NCT07208851","Developing a Booster Session for Problem Management Plus in the Bahamas: A Pilot Randomized Controlled Trial","Development, Feasibility, and Acceptability of a One-time Problem Management Plus (PM+) Booster Session in the Bahamas: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults of 18 years or above\n\n  * English-speaking\n  * A score of \\\u003C91 on Global Assessment of Functioning\n* Located in the Bahamas\n\nExclusion Criteria:\n\n* ● Imminent suicide risk (assessed at screening using Columbia Suicide-Severity Rating Scale, see document titled \" Screener updated 10-30- 24\")\n\n  * Severe mental disorder (e.g. psychotic disorders)\n  * Severe cognitive impairment (e.g. severe intellectual disability or dementia)",{"count":146,"type":19},50,[22],"Therapists at the Grand Bahama Resilience Center (GBRC) will be trained to deliver Problem Management Plus (PM+), a WHO intervention. Then, those therapists will deliver PM+ (5 one-on-one skills-based sessions) to a total of 50 adult clients experiencing mild to moderate mental health difficulties (excluding anyone with cognitive difficulties or psychosis). Participants will complete (de-identified) self-report survey assessments before PM+, after PM+, 3 months later, and 6 months later. After receiving 5 sessions of PM+, participants will be randomized to either receive a one-time booster session of PM+ (to be co-created by the PI and the GBRC providers) three months later or to a control group which will receive a phone call reminding them that they will receive their third assessment soon.",[60,29],[151,152,153,154,155,156,157],"PM+","Task-sharing interventions","Scalable mental health","Global mental health","Bahamian Mental Health","Hurricane","Climate Change","2026-01-02",{"date":160,"type":34},"2026-01-06",{"date":162,"type":34},"2024-10-16",{"date":164,"type":19},"2026-07-31",{"name":166,"class":41},"The New School",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":15,"minAge":117,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":20,"phases":178,"briefSummary":179,"conditions":180,"keywords":191,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":107},"100579744","culturally-adapted-i-cbt-for-farsidari-speaking-migrants-100579744","NCT06828276","Culturally Adapted i-CBT for Farsi\u002FDari Speaking Migrants","Culturally and Language-Adapted i-CBT for Common Mental Health Problems: A Randomized Controlled Study With Farsi\u002FDari-Speaking Migrants","i-CBT","Inclusion Criteria:\n\n* Between the ages of 15 and 29.\n* A score above the cut-off 1.75 on HSCL-25\n* Has a refugee or migrant background\n* Has a good and stable internet connection\n* Has access to a computer, tablet or smartphone\n* Is fluent in reading and writing Arabic\n* Has the ability to dedicate time to take part in the intervention for 6-10 weeks.\n\nExclusion Criteria:\n\n* Is suffering from a severe mental illness, such as psychosis or severe depression.\n* Is suffering from substance abuse\n* Is undergoing a psychological treatment\n* Has a high risk of suicide","29 Years",{"count":177,"type":19},128,[22],"The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues among Farsi\u002FDari-speaking youth migrants and refugees. Investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.",[28,29,181,182,183,184,185,186,187,188,189,190],"Grief","Psychological Trauma","Insomnia","Resilience","Stress","Psychological Well Being","Marital Relationship","Wellbeing","Common Mental Health Problems","Rumination",[192,193,194,195,196,197,198,184,199],"Refugee","Cognitive behavioral therapy","Psychological problems","Persian speaking","Psychological well-being","Youth","Mental problems","Asylum seeker","2025-12-05",{"date":202,"type":34},"2025-12-12",{"date":204,"type":34},"2025-03-25",{"date":206,"type":19},"2026-12-31",{"name":208,"class":41},"Karolinska Institutet",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":216,"enrollmentInfo":217,"targetDuration":4,"studyType":219,"phases":4,"briefSummary":220,"conditions":221,"keywords":241,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":264},"100609246","precision-subclassification-of-mental-health-in-diabetes-digital-twins-for-precision-mental-health-to-track-subgroups-100609246","NCT07212075","Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups","TwinPeaks","Inclusion Criteria:\n\n* 18 to 80 years of age\n* Diagnosis of type 1 diabetes or type 2 diabetes or other specific type of diabetes\n* Diabetes duration ≥ 1 year\n* Sufficient German language skills\n* Informed consent\n\nExclusion Criteria:\n\n* Inability to consent\n* Significant cognitive impairment (e.g. dementia)\n* Severe disorder or condition impacting the person's ability to participate in the study or likely to confound results (e.g. treated cancer, heart disease ≥ NYHA III, schizophrenia\u002Fpsychotic disorder)\n* Terminal illness\n* Being bedridden","80 Years",{"count":218,"type":19},1809,"OBSERVATIONAL","Mental conditions and disorders (e.g. distress, depressive, anxiety, and eating disorders) are more prevalent in people with diabetes (PWD) and associated with reduced quality of life and impaired glycaemic outcomes. Evidence supports a complex network between psychosocial factors and glycaemic control that can be highly variable between persons. It is assumed that subgroups exist that show different trajectories of glycaemia and mental health.\n\nBelonging to a particular subgroup may be linked with a higher risk of developing mental health problems compared to others. This suggests that it is possible to treat individuals in different subgroups in a manner that optimizes their treatment and can improve health outcomes. Accurate characterisation can inform more individualized care. This calls for a more personalised approach considering the idiosyncrasies of different subgroups.\n\nOver 3 years, the investigators have established the basis of a precision mental health approach for diabetes using n-of-1 analyses. By utilizing combined ecological momentary assessment (EMA: repeated daily sampling of psychosocial factors in everyday life) and continuous glucose monitoring (CGM), intensive longitudinal data per person could be collected. This enables the analysis of individual associations between glycaemic parameters and psychosocial variables and identification of individual sources of diabetes distress in each person.\n\nThe objective of the present study is to use of the n-of-1 approach to identify subgroups of PWD who share common characteristics in the associations between glucose and psychosocial variables. The identified subgroups shall be used to develop a digital twin for precision mental health in diabetes. The digital twin serves as representation of a real person, allowing to make simulations and predictions of the course of mental health and glycaemia. These predictions can inform diabetes care and lead to more precise, personalised treatment decisions.\n\nTo achieve this, a longitudinal panel including over 1,400 PWD who continuously complete EMA and questionnaire surveys and measure glucose levels using CGM was developed. Over 1000 clinical interviews to diagnose mental disorders have been conducted to identify major mental health conditions and map mental outcomes. To identify subgroups and develop the digital twin, the sampling will be expanded aiming at a total of 1,809 PWD. Incidence and remission of mental disorders will be determined via repeated interviews.\n\nThe complex networks between clinical, metabolic, and psychosocial data will be analysed using machine learning, leading to new insights with the potential to shape future guidelines. These results will be used by the digital twin to predict courses of glycaemic control and mental health, translating the individual evidence into direct treatment suggestions.",[222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,29,239,240],"Diabetes (DM)","Diabete Mellitus","Diabete Type 1","Diabete Type 2","Diabetes Distress","Diabetes Complications","Depression - Major Depressive Disorder","Depression Anxiety Disorder","Depression Bipolar","Depression Disorders","Anxiety Disorder (Panic Disorder or GAD)","Anxiety Disorder NOS","Eating Disorder Binge","Anorexia Nervosa","Bulimia Nervosa","Eating Disorder Not Otherwise Specified","Depressed Mood","Disordered Eating Behaviors","Fear of Hypoglycemia",[242,243,244,245,246,247,248,249,250,251,252,253,94,95,254,226,214],"Digital Twin","Precision Medicine","Precision Mental Health","Subclassification","Trajectories","Subtypes","Person-reported Outcomes (PRO)","Ecological Momentary Assessment (EMA)","Continuous Glucose Monitoring (CGM)","People with Diabetes (PWD)","Diabetes Mellitus","HbA1c","Eating disorder","2025-11-27",{"date":257,"type":34},"2025-12-04",{"date":259,"type":34},"2025-01-01",{"date":261,"type":19},"2027-12-31",{"name":263,"class":41},"Forschungsinstitut der Diabetes Akademie Mergentheim",3,{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":116,"sex":15,"minAge":271,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":20,"phases":275,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":4},"100611216","a-study-on-the-effectiveness-of-comprehensive-intervention-based-on-specialized-physical-education-courses-in-the-prevention-of-comorbidity-among-junior-middle-school-students-100611216","NCT07237698","A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students","Inclusion Criteria:\n\n* Individuals who voluntarily participate in this study and whose parents or guardians voluntarily sign the informed consent form.\n* Individuals capable of cooperating to complete measurements of all indicators throughout the entire intervention cycle.\n\nExclusion Criteria:\n\n* Individuals with eye conditions such as glaucoma, strabismus, or anisometropia.\n* Wearers of orthokeratology lenses.\n* Individuals who have undergone refractive surgery.\n* Individuals who have taken weight-loss medications or undergone weight-loss surgery.\n* Individuals with obesity caused by endocrine disorders or medication side effects.\n* Individuals with mental health disorders.\n* Individuals currently taking medications for mental health disorders.","11 Years","14 Years",{"count":274,"type":19},200,[22],"Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second, the overlapping occurrence of common conditions such as overweight\u002Fobesity, spinal deformities, and psychological anxiety.Traditional physical education classes, characterized by limited content and insufficient targeting, struggle to address these issues. Multimorbidity of common diseases in children and adolescents refers to the coexistence of two or more common diseases or chronic health problems in the same individual.\n\nTherefore, this study innovatively designed a specialized physical education curriculum integrating \"exercise + health education,\" aiming to fill the gap in comprehensive prevention and control of common adolescent health conditions through traditional physical interventions.\n\nThis study systematically investigated the effects of a specialized physical education intervention program on myopia prevention and control, as well as the simultaneous prevention of multiple common health conditions (overweight\u002Fobesity, abnormal blood pressure, insufficient cardiorespiratory fitness, abnormal spinal curvature, anxiety symptoms, and depression symptoms) among junior high school students in China. The program was designed and implemented for students at a Chinese secondary school, ultimately aiming to provide a replicable school-based physical education intervention model for adolescent health promotion. The study strictly adhered to a randomized controlled design, employing multidimensional evaluation, long-term follow-up, and rigorous quality control to ensure scientific validity and reliability of the findings.",[278,279,280,281,29,28,282],"Multimorbidity","Comorbidity","Common Diseases in Children and Adolescents","Myopia","Overweight , Obesity","2025-11-18",{"date":285,"type":34},"2025-11-20",{"date":287,"type":19},"2025-11-15",{"date":289,"type":19},"2026-09",{"name":291,"class":41},"Xiaoyan Wu",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":116,"sex":15,"minAge":300,"maxAge":272,"enrollmentInfo":301,"targetDuration":4,"studyType":20,"phases":303,"briefSummary":304,"conditions":305,"keywords":307,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":107},"100597239","video-feedback-intervention-to-promote-racial-ethnic-socialization-competency-vip-race-100597239","NCT07055906","Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE)","Developing and Testing a Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency in Latino\u002Fa\u002Fx Families","VIP-RACE","Inclusion Criteria:\n\n* Adolescent is 10-to-14 years old (inclusive)\n* Adolescent and parent are Latino\u002Fa\u002Fx\u002Fe or Hispanic\n* Parent and youth have the capacity to provide consent\u002Fassent\n* One parent is willing to participate\n* Families must be willing to be video or audio recorded for the parent-child interaction task\n* Youth and parent(s) must be willing to participate as dyads.\n* Primary language of parent and adolescent is English and\u002For Spanish\n\nExclusion Criteria:\n\n* Parent or adolescent has an intellectual disability, autism spectrum disorder, or other disorder that may limit ability to complete study (surveys and interviews require sustained attention, mental processing, and comprehension).\n* Adolescent is not 10-to-14 years old\n* Adolescent and\u002For parent are not Latino\u002Fa\u002Fx\u002Fe or Hispanic\n* Primary language of parent and\u002For adolescent is not English and\u002For Spanish\n* Youth and parent(s) are not willing to participate as dyads\n* Family participated in Phase 1 of the study","10 Years",{"count":302,"type":19},110,[22],"The aim of this study is to evaluate a novel cultural strengths parenting program - the Video-feedback Intervention to Promote Racial-Ethnic Socialization CompEtency (VIP-RACE) - which seeks to support Latine parents' motivation to engage in racial-ethnic socialization (RES) and strengthen their RES competency (improved skills and confidence, decreased stress). In the preliminary phases of this project, we iteratively refined the VIP-RACE program in partnership with advisory boards of youth, parents, and providers. The refined intervention will now be tested with five parents of 10-14-year-old Latine youth to identify gaps in the curriculum and obstacles to implementation that can be addressed prior to a larger pilot. The investigators will then conduct a proof-of-concept single-arm trial with Latine families to assess the feasibility, acceptability, and preliminary efficacy of VIP-RACE. The investigators hypothesize that VIP-RACE will be shown to be feasible and acceptable to families. The investigators also predict that bolstering parents' RES motivation and competency will result in increased frequency and quality of these conversations between parents and youth which, in turn, are expected to strengthen youth racial-ethnic identity and coping and have cascading effects on mental and behavioral health.",[28,29,306],"Conduct Problems",[308,309,310],"parenting program","Latino\u002Fa\u002Fx\u002Fé","racial-ethnic socialization","2025-07-03",{"date":313,"type":34},"2025-07-09",{"date":315,"type":34},"2025-05-12",{"date":317,"type":19},"2027-03-31",{"name":319,"class":41},"Penn State University",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":15,"minAge":117,"maxAge":16,"enrollmentInfo":328,"targetDuration":4,"studyType":20,"phases":330,"briefSummary":331,"conditions":332,"keywords":336,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":107},"100591042","trauma-focused-cognitive-behavioral-therapy-in-unaccompanied-refugee-minors-with-ptsd-in-greece-an-rct-100591042","NCT06975280","Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCT","Implementation, Cultural Adaptation, and Efficacy Evaluation of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for Unaccompanied Refugee Minors in Greece","TF-CBT","Inclusion Criteria:\n\n* Be unaccompanied upon arrival in Greece and aged between 15-18 years old.\n* Being diagnosed with PTSD based on DSM-5 criteria. Young refugees with post-traumatic stress symptoms (PTSS), as delineated by high or moderate trauma-related distress in the Child and Adolescent Trauma Screen (CATS), will also be eligible to participate in the study.\n* Reside in an accommodation center or SIL program for UAMs in Greece.\n* Have a stable living arrangement for at least 2-3 weeks prior to the intervention.\n* Not be expected to relocate within the 2-3 months following the start of the intervention.\n\nExclusion Criteria:\n\n* a diagnosed intellectual disability (IQ \\\u003C 70) or another developmental disorder\n* acute suicidality or life-threatening self-harm behavior\n* significant risk of harm to others\n* comorbidity with bipolar disorder or a psychotic disorder\n* substance abuse.",{"count":329,"type":19},60,[22],"This single-blinded, multicentered, randomized controlled trial aims to evaluate the effectiveness of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) compared to Treatment-as-Usual (TAU) in reducing post-traumatic stress symptoms among unaccompanied refugee minors (UAMs) residing in accommodation centers and Supported Independent Living (SIL) programs in Greece. Participants aged 15-18 will be randomly assigned to either a TF-CBT intervention group or a TAU control group. The intervention will be delivered by trained psychologists under supervision and culturally adapted to the Greek refugee context. Assessments will occur at baseline, post-intervention, and three months later, using standardized psychometric tools. Secondary outcomes include changes in comorbid psychiatric symptoms (depression, anxiety, somatic symptoms), emotional and behavioral difficulties, and quality of life. The study also investigates potential moderators of treatment response such as age, gender, trauma history, and psychiatric comorbidity.",[333,28,29,334,335],"Post-Traumatic Stress Disorder (PTSD)","Somatic Symptoms","Emotional and Behavioral Difficulties",[337,338,339,326,340,94,95,341],"Unaccompanied minors","Refugee adolescents","Trauma-Focused Cognitive Behavioral Therapy","PTSD","Child trauma","2025-05-08",{"date":344,"type":34},"2025-05-16",{"date":346,"type":34},"2023-04-13",{"date":348,"type":19},"2026-02",{"name":350,"class":41},"Theodora Anastasiou",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":11,"sex":15,"minAge":358,"maxAge":359,"enrollmentInfo":360,"targetDuration":361,"studyType":219,"phases":4,"briefSummary":362,"conditions":363,"keywords":367,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":107},"100587006","between-the-belly-and-the-brain-distorted-gut-brain-crosstalk-in-early-life-adversity-100587006","NCT06922773","Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity","BellyBrain","Inclusion Criteria:\n\n* Primary school-aged children (6 to 13 years of age) who have experienced at least one early-life traumatic event, based on the Childhood Trust Events Survey (CTES) questionnaire\n* The child and at least one of his\u002Fher parents (or guardian) speak Dutch sufficiently well to complete all of the questionnaires and the semi-structured child psychiatric interview (SCID-5-Junior)\n\nExclusion Criteria:\n\n* any chronic disorders or diseases known to affect the gut micobiome\n* inablity to complete questionnaires and\u002For semi-structured interview because of linguistic and\u002For cognitive barrier\n* congenital or acquired immunodeficiencies\n* use of medication(s) that affect gastrointestinal function (e.g., antibiotics) within the last 6 weeks, or laxatives within the last 4 weeks, or probiotic or prebiotic supplements within the last 4 weeks\n* current involvement in another clinical or food study","6 Years","13 Years",{"count":146,"type":19},"1 Month","The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are:\n\n* Do children who have experienced ELA have lower gut microbial diversity and\u002For an altered gut microbial composition?\n* Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and\u002For affective problems?",[364,365,29,28,366],"Early Life Adversity","Microbiome, Human","Posttraumatic Stress Symptoms",[368,369,370,371,372],"early life adversity","gut microbiome","anxiety symptoms","depressive symptoms","posttraumatic stress symptoms","2025-04-03",{"date":375,"type":34},"2025-04-10",{"date":377,"type":19},"2025-05",{"date":379,"type":19},"2026-06",{"name":381,"class":41},"Universitair Ziekenhuis Brussel",{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":116,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":20,"phases":392,"briefSummary":393,"conditions":394,"keywords":395,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":407,"locationsCount":107},"100573411","strengthening-health-and-insight-in-new-educators-100573411","NCT06745934","Strengthening Health and Insight in New Educators","Healthy Minds for Pre-Service Teachers","SHINE","Inclusion Criteria:\n\n* Students in Block 3 will be invited to participate in the study.\n\nExclusion Criteria:\n\n* Students who are not in Block 3 will be excluded. Participants experiencing suicidal ideations at baseline and deemed via the clinical risk assessment procedure to be at moderate or high risk of suicide will be excluded from the study after baseline, and prior to randomization.",{"count":391,"type":19},140,[22],"Teachers are at notable risk for depression and anxiety. The present study tests an app-based mindfulness intervention for teachers in their final year of training with the goal of preventing the deterioration of their mental health during the transition into the classroom. The project will strengthen the research environment at the University of Alabama and will involve undergraduate research assistants in each step of the research process.",[29,28],[396,397,398,399,400],"Healthy Minds Program","mindfulness-based intervention","app","pre-service teachers","mental health","2025-03-31",{"date":403,"type":34},"2025-04-02",{"date":405,"type":34},"2025-01-17",{"date":75,"type":19},{"name":408,"class":41},"University of Alabama, Tuscaloosa",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":116,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":20,"phases":418,"briefSummary":419,"conditions":420,"keywords":422,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":438},"100575519","the-impact-of-playing-tetris-on-migrants-mental-health-100575519","NCT06773338","The Impact of Playing Tetris on Migrants' Mental Health","Does Playing Tetris Prevent the Development of Post-Traumatic Stress Disorder or Related Anxiety and Depressive Symptoms During and After Migration?","Inclusion Criteria:\n\n* Arabic-speaking immigrants of any gender who have applied for asylum in Greece or in the Netherlands, regardless of the outcome of their asylum application and their current residency status (rejected asylum seekers, recognized refugees, undocumented migrants).\n\nExclusion Criteria:\n\n* Minors (under the age of 18).",{"count":417,"type":19},300,[22],"This study examines if playing Tetris prevents the development of Post-traumatic stress disorder or related anxiety and depressive symptoms. The investigators recruit 300 participants in total in Greece and in the Netherlands. The participants are immigrants who have applied for asylum at any point in the past. The participants are asked to answer three questionnaires (on Post-traumatic stress disorder, related anxiety and depressive symptoms, and post-migration living difficulties) on a recurring basis - once every 4 weeks, 12 times in total. Half of the participants (treatment group) are randomly selected to play Tetris after completing the questionnaires. Participants in the treatment group are instructed to play Tetris for at least 15 minutes while trying to remember bad things that recently happened to them. Tetris is administered at three instances and participants in the treatment group are encouraged to play Tetris in case of experiencing any traumatic events or having any intrusive memories during the course of the study.",[421,29,60],"Post-traumatic Stress Disorder (PTSD)",[423,340,95,94,424,425,426,427,428],"Post-traumatic stress disorder","Refugees","Asylum seekers","Migrants","Tetris","Longitudinal","2025-01-08",{"date":431,"type":34},"2025-01-14",{"date":433,"type":34},"2024-12-17",{"date":435,"type":19},"2025-12-07",{"name":437,"class":41},"Tilburg University",2,{"id":440,"slug":441,"hasResults":11,"nctId":442,"briefTitle":443,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":11,"sex":15,"minAge":445,"maxAge":16,"enrollmentInfo":446,"targetDuration":4,"studyType":20,"phases":447,"briefSummary":448,"conditions":449,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":107},"100543640","improving-sleep-to-prevent-depression--anxiety-in-adolescents-at-high-risk-100543640","NCT06358495","Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk","Inclusion Criteria:\n\n* Between the ages of 12 and 18.\n* Having at least one parent with a history of depressive or anxiety disorders but having no clinically significant history (per the Diagnostic and Statistical Manual of Mental Disorders 5) of internalizing disorders themselves.\n* Adolescents who score 10\u002F25 or greater on the Insomnia Severity Index, indicating subthreshold insomnia or greater.\n\nExclusion Criteria:\n\n* Experiencing symptoms of sleep disorders other than insomnia (i.e. restless legs syndrome \\[RLS\\], sleep-disordered breathing \\[SDB\\].\n* Having a history of untreated, serious psychiatric illness (i.e., bipolar disorder, schizophrenia).\n* Active suicidal ideation.\n* Currently taking prescribed medications for sleep problems.\n* Moderate to severe head injury.","12 Years",{"count":146,"type":19},[22],"Emerging evidence has shown that sleep interventions such as Cognitive Behavioral Therapy for Insomnia (CBT-I) improve depressive and anxiety symptoms in adults, even when the intervention is brief, such as four to six sessions. The overarching aim of the proposed research is to conduct a pilot trial to evaluate whether a brief intervention for insomnia adapted for improves sleep and subthreshold depressive and anxiety symptoms in adolescents at risk (i.e., with a parental history of depressive or anxiety disorders).",[183,450,28,29],"Sleep Disturbance","2024-12-03",{"date":453,"type":34},"2024-12-05",{"date":455,"type":34},"2024-11-01",{"date":457,"type":19},"2025-08-30",{"name":459,"class":41},"University of Calgary",{"id":461,"slug":462,"hasResults":11,"nctId":463,"briefTitle":464,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":116,"sex":467,"minAge":16,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":20,"phases":470,"briefSummary":471,"conditions":472,"keywords":473,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":107},"100562909","anxiety-is-one-of-the-most-frequent-disorders-during-the-perinatal-stage-which-is-associated-with-adverse-health-effects-for-women-and-their-babies-this-study-will-be-to-evaluate-the-effectiveness-of-a-telematic-cognitive-behavioral-preventive-intervention-to-manage-anxiety-during-pregnancy-100562909","NCT06609291","Anxiety is One of the Most Frequent Disorders During the Perinatal Stage Which is Associated with Adverse Health Effects for Women and Their Babies. This Study Will Be to Evaluate the Effectiveness of a Telematic Cognitive-behavioral Preventive Intervention to Manage Anxiety During Pregnancy.","Telematic Prenatal Psychological Intervention for Preventing Anxious Symptomatology","Inclusion Criteria:\n\n* Women over 18 years of age living in the Region of Galicia (Spain)\n* Pregnant with a gestational age ≤ 16\n* Understand and speak Spanish fluently\n* Informed consent to participate in the study\n* Accessibility to the internet and a digital device ( computer, tablet or smartphone)\n\nExclusion Criteria:\n\n* High-risk pregnancy or twins\n* Being pharmacological treatment for anxiety and\u002For depression\n* Not giving their consent","FEMALE",{"count":469,"type":19},130,[22],"Anxiety is one of the most frequent disorders during the perinatal stage which is associated with adverse health effects for women and their babies. In spite of this, preventive interventions during this stage are scarce. The National Institute for Health and Clinical Excellence recommends psychological interventions, such as cognitive behavioral therapy, as a first-line treatment for mild and moderate prenatal anxiety. Early detention of anxiety symptoms in the perinatal stage can help prevent the development of more serious mental health problems. However, there are barriers to accessing interventions during this period. A long-distance intervention carried out during the pregnancy can be an effective and accessible resource to help improve women's emotional state. The primary objective of the current study is to determine whether a preventive psychological intervention developed through videoconferencing is superior to the usual care during pregnancy (attendance at pregnancy follow-up consultations and information and answers to frequently asked questions provided by the midwife) to prevent anxious symptoms during pregnancy. The secondary objective is to examine whether this same intervention is more effective than usual care in preventing depressive symptoms during pregnancy, as well as anxious and depressive symptoms in the postpartum.\n\nA random clinical trial will be carried out among pregnant women in Spain. A recruitment of 130 participants is proposed with random assignment to one of two conditions (65 per group): (a) the experimental group will receive the cognitive-behavioral intervention via videoconference or (b) the control group will receive usual care pregnancy (attendance at pregnancy follow-up consultations and information and answers to frequently asked questions provided by the midwife).\n\nThe psychological intervention will take place via videoconference in seven weekly sessions, lasting one hour each, with groups of 6 - 8 pregnant women. A blinded assessment will be conducted through online self-administered testing at baseline, post-intervention, and at follow-up at one month, 3 and 6 months. A clinical interview will also be conducted to evaluate generalized anxiety disorder (GAD), at the same time times. Our primary hypothesis is that the intervention will decrease the frequency of women who present anxious symptomatology during pregnancy. The second objective is to analyze the effectiveness of this intervention to prevent depressive symptomatology during pregnancy, as well as postpartum anxious and depressive symptomatology.",[232,29],[474,475,476,477,478],"prevention","telematic","pregnancy","perinatal anxiety","perinatal depression","2024-09-23",{"date":481,"type":34},"2024-09-25",{"date":483,"type":19},"2024-12",{"date":485,"type":19},"2025-12",{"name":487,"class":41},"University of Santiago de Compostela",{"id":489,"slug":490,"hasResults":11,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":494,"eligibilityCriteria":495,"healthyVolunteers":11,"sex":15,"minAge":496,"maxAge":445,"enrollmentInfo":497,"targetDuration":4,"studyType":20,"phases":499,"briefSummary":500,"conditions":501,"keywords":502,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":513,"locationsCount":107},"100500766","testing-the-effectiveness-of-supportive-parents---coping-kids-100500766","NCT05800522","Testing the Effectiveness of Supportive Parents - Coping Kids","A Randomized Controlled Effectiveness Trial of a Transdiagnostic Parent Training Intervention to Prevent Childhood Mental Health Problems in Norwegian Frontline Services","SPARCK","Inclusion Criteria:\n\n* Children displaying elevated symptoms of internalizing or\u002Fand externalizing problems\n\nExclusion Criteria:\n\n* Child is referred to or receives ongoing help in the specialized mental health services for problems in the internalizing or externalizing domains\n* Child is diagnosed with psychosis, mental retardation or pervasive developmental disorder\n* Acute suicide risk\n* Documented or probable ongoing physical or sexual abuse\n* Child or caretakers receives other systematic interventions targeting internalizing or externalizing problems while enrolled in the study (prior to 6 month follow-up)","4 Years",{"count":498,"type":19},252,[22],"The aim of this clinical trial is to test the effectiveness of the parent training intervention Supportive Parents - Coping Kids (SPARCK) for prevention of childhood mental health problems. The main research questions are:\n\n• Is SPARCK effective in preventing and reducing negative outcomes and promoting positive outcomes for eligible children and parents compared with regular care practice?\n\nIn addition, investigators will conduct an implementation study to examine relations between implementation determinants and implementation and clinical outcomes in the SPARCK intervention condition\n\nParticipants in the effectiveness trial will be randomized to receive either the SPARCK intervention or active regular care practices provided by professionals in the Norwegian frontline services. Researchers will test the effectiveness of the SPARCK intervention at post treatment and six months follow-up.",[306,29,28],[503,504,505,506],"Transdiagnostic prevention","Childhood mental health problems","Parent training","Adaptive intervention","2023-03-23",{"date":509,"type":34},"2023-04-05",{"date":511,"type":34},"2023-02-15",{"date":75,"type":19},{"name":514,"class":41},"Norwegian Center for Child Behavioral Development"]