[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aortic-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aortic-disease":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100624885","cardiac-remodelling-following-endovascular-repair-of-the-aorta-100624885",false,"NCT07415447","Cardiac Remodelling Following Endovascular Repair of the Aorta","EVACaRe","Inclusion Criteria:\n\n\\- Patients over 18-year-old, with degenerative arch, descending thoracic or abdominal aortic aneurysms, penetrating aortic ulcers or intramural hematomas managed with total EVAR in elective setting.\n\nExclusion Criteria:\n\n* Heart failure with an ejection fraction \\\u003C35 vs 50% or New York Heart Association (NYHA) class III and IV.\n* LV wall motion abnormality.\n* Moderate to severe valve disease.\n* History of (or expected within the study period) cardiac\u002Faortic surgery.\n* Coronary artery disease.\n* Atrial fibrillation.\n* Congenital heart disease.\n* Connective tissue disorders.\n* Chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F173 m2).\n* Moderate to severe pulmonary disease as indicate either by post bronchodilator FEV1 (%predicted) \\\u003C50% or Modified Medical Research Council Dyspnoea Scale (mMRC) 3-4.\n* CMR contraindications (non-compatible pacemakers and metal implants, and claustrophobia).","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","OBSERVATIONAL","To assess the effects of endovascular aortic repair on cardiac morphology and function",[24,25],"Cardiac Failure","Aortic Disease",[27,28,29,30],"cardiac","failure","aortic","disease","RECRUITING","2026-02-12",{"date":34,"type":35},"2026-02-17","ACTUAL",{"date":37,"type":35},"2025-09-01",{"date":39,"type":20},"2027-09-01",{"name":41,"class":42},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":73},"100485626","phenotyping-heterogeneity-and-regionality-of-the-aorta-100485626","NCT05603520","Phenotyping Heterogeneity and Regionality of the Aorta","PHaRAo","1. apparently healthy volunteers\n\n   Inclusion Criteria:\n\n   • Healthy volunteers\n\n   Exclusion Criteria:\n   * \\\u003C 18 years\n   * Active Medication\n   * Cardiovascular Disease\n   * MRI not possible\n2. Patients with Aortic Stenosis\n\n   Inclusion Criteria:\n\n   • Patients suffering from 3rd drgree Aortic Stenosis\n\n   Exclusion Criteria:\n   * \\\u003C 18 years\n   * MRI not possible\n3. Patients with Aortic Aneurysms\n\nInclusion Criteria:\n\n• Patients suffering from Aortic Aneurysms\n\nExclusion Criteria:\n\n* \\\u003C 18 years\n* MRI not possible",true,{"count":52,"type":20},300,"The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen\u002Felastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated.\n\nWithin the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease",[55,25,56,57],"Large Artery Stiffness","Aortic Stenosis","Aortic Aneurysm",[59,60,61,62],"aortic disease","large artery stiffness","aortic stenosis","aortic aneurysm","2024-01-09",{"date":65,"type":35},"2024-01-10",{"date":67,"type":35},"2020-10-18",{"date":69,"type":20},"2027-06-30",{"name":71,"class":72},"Heinrich-Heine University, Duesseldorf","OTHER",1]