[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aphasia-following-cerebral-infarction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aphasia-following-cerebral-infarction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,55,83,113,142,176,200,231],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100595742","phase-2-comparing-traditional-semantic-feature-analysis-tsfa-and-semantic-feature-analysis--metacognitive-strategy-training-sfamst-100595742",false,"NCT07036406","Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)","Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia","Inclusion Criteria:\n\n* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)\n* Be at least six-months post aphasia-onset,\n* Be a proficient English speaker,\n* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),\n* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems\n\nExclusion Criteria:\n\n* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,\n* Children under the age of 18,\n* Adults over the age of 89,\n* Uncorrected hearing and vision.","ALL","18 Years","89 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are:\n\n* What are the comparative outcomes in picture naming accuracy and strategy use during picture naming following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n* What are the comparative outcomes in percent of informative content and rate of informative content during spontaneous speech production following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n\nResearchers will compare outcomes between these two treatments to see if SFA+MST yields larger effects in picture naming and spontaneous speech outcomes than traditional SFA.\n\nParticipants will complete:\n\n* 5-7 pre-treatment assessment sessions where they will be asked to name pictures, tell stories\u002Fdescribe pictures, answer questions, and complete questionnaires,\n* 3 treatment sessions of SFA \\*OR\\* SFA+MST per week for 8 weeks, for a total of 24 sessions,\n* 7 weekly probes (i.e., short, intermittent assessments throughout the treatment phase),\n* 3 post-treatment assessment sessions immediately after treatment ends, where they will complete the same assessment tasks as they did pre-treatment (e.g., naming pictures, telling stories, etc.),\n* 2 retention assessment sessions, one 30 days and the other 60 days following the final treatment session, where they will be asked to name pictures, tell stories\u002Fdescribe pictures, and describe what they learned during the study.",[27,28,29,30,31,32,33,34,35,36],"Aphasia","Aphasia Following Cerebral Infarction","Aphasia, Acquired","Aphasia, Rehabilitation","Aphasia, Anomic","Aphasia, Broca","Aphasia, Conduction","Aphasia, Expressive","Aphasia Non Fluent","Aphasia, Mixed",[27,38,39,40,41],"Anomia","Stroke","Communication","Language","RECRUITING","2026-06-23",{"date":45,"type":46},"2026-06-25","ACTUAL",{"date":48,"type":46},"2025-07-28",{"date":50,"type":21},"2027-07",{"name":52,"class":53},"Teachers College, Columbia University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":54},"100590534","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-subacute-aphasia-100590534","NCT06968663","Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia","Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia","Inclusion Criteria:\n\n* Left hemisphere stroke resulting in aphasia\n* The stroke must have occurred between 2 and 6 weeks prior to enrollment\n* Must be able to understand the nature of the study, and give informed consent\n* English proficiency\n* Right-handed\n\nExclusion Criteria:\n\n* History of serious and\u002For ongoing issues with substance abuse\n* Previous head trauma with loss of consciousness for more than 5 minutes\n* History of major psychiatric illness\n* Dementia, or other neurological conditions\n* Epilepsy, or seizure after the stroke event\n* Pacemaker\n* Diagnosis of tinnitus\n* Pregnancy","85 Years",{"count":64,"type":21},63,[24],"The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with mCILT improve overall speech?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia.\n\nImportantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo MRI scans\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment\n* Complete follow-up assessments immediately and 4 months after treatment",[39,27,28],[69,70,71,72,73],"aphasia","stroke","Transcranial Magnetic Stimulation","Non-invasive brain stimulation","language therapy","2026-06-16",{"date":76,"type":46},"2026-06-18",{"date":78,"type":46},"2024-08-01",{"date":80,"type":21},"2029-07-31",{"name":82,"class":53},"University of Pennsylvania",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":54},"100622671","intensive-comprehensive-aphasia-programme-for-people-with-post-stroke-aphasia-100622671","NCT07386652","Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia","Randomised Controlled Trial of an Intensive Comprehensive Aphasia Programme for People With Post-Stroke Aphasia","RCT of an ICAP","Inclusion Criteria:\n\n1. Adult (\\>18 years old) PWA caused by stroke\n2. More than 3 months post-stroke\n3. Can use English to communicate (even if not as their first language)\n4. Carers will be nominated (if available) by individual PWA\n\nExclusion Criteria:\n\n1. Severe speech apraxia (no meaningful spoken word output)\n2. Severe fatigue or other reasons they cannot commit to the timing and duration of the ICAP\n3. Ongoing debilitating psychiatric disorders (e.g. psychosis, but not low mood)\n4. Co-existing neurological disorders affecting engagement (e.g. dementia).",true,{"count":93,"type":21},334,[95],"NA","Research question Does participation in an Intensive Comprehensive Aphasia Programme produce a meaningful change in the communication of people with aphasia, their quality of life and that of their carers?\n\nBackground Aphasia is a persistent language disorder that severely impairs communicative abilities. Most commonly induced by a stroke, aphasia reduces quality of life more than any other condition. People with aphasia (PWA) and their carers feel abandoned by the NHS due to the limited treatment options available. Meanwhile, neuroscientific evidence suggests that PWA can make meaningful gains in communicative ability, mood, and quality of life if therapists are given enough time to work with them. Although studies indicate Intensive Comprehensive Aphasia Programmes (ICAPs) are effective ways to deliver such therapy, no randomised controlled trial (RCT) of an ICAP has yet been conducted. the investigators propose conducting the first ever ICAP RCT.\n\nAims and objectives Clinical: i) To test the efficacy of an ICAP in improving PWAs' language impairment, communicative ability, mood, and quality of life; ii) to measure the quantity and quality of therapy received in the community by the standard care group; iii) to assess the significance of age and time-since-stroke in PWA's responses to ICAP intervention.\n\nMechanistic: To test whether combining baseline behaviour and MRI brain scans can usefully predict individual patients' responses to the ICAP treatment.\n\nMethods The RCT will test the effect of an ICAP intervention by randomly assigning PWA and their carers to one of two groups receiving either ICAP or standard care at two participating sites. The investigators aim to deliver 100 hours of ICAP therapy over a 4-week schedule to adult PWA who are more than 3 months post-stroke. The investigators will compare the effects of the ICAP, comprising complex interventions with multiple interacting therapeutic components, with standard care, the quantity and quality of which will be recorded by research assistants. The primary outcome measure is a standardized scale for measuring quality of life for PWA (SAQOL-39g). The primary endpoint is 4 months post-randomisation. The investigators will also test for effects at 9 months.\n\nAnticipated impacts The trial could provide the evidence needed to transform how the NHS treats PWA and their carers. If the investigators demonstrate that participating in an ICAP leads to clinically meaningful and sustained improvements, the next stage in achieving wider NHS roll-out will be a multi-centre trial to investigate the cost- and clinical effectiveness of ICAPs across the UK.",[28],[99,100,101,102],"Intensive Comprehensive Aphasia Programme","ICAP","People With Aphasia","PWA","NOT_YET_RECRUITING","2026-04-08",{"date":106,"type":46},"2026-04-13",{"date":108,"type":21},"2026-09-01",{"date":110,"type":21},"2030-08-31",{"name":112,"class":53},"University College, London",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":54},"100631128","phase-3-effect-of-anodal-transcranial-direct-current-stimulation-on-naming-in-aphasic-patients-with-acute-ischemic-stroke-100631128","NCT07496645","EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE","Inclusion Criteria:\n\n* Aphasic patients with left middle cerebral artery territory Acute Ischemic Stroke\n* Patients between 18-65 years of age.\n* Within 5 days of onset of stroke.\n\nExclusion Criteria:\n\n* Patients with malignant Middle Cerebral Artery territory infarcts and previous clinical history of cerebral hemisphere stroke.\n* Patients with history of previous brain surgery or skull defect due to surgery e.g. craniectomy.\n* Patients with epilepsy.\n* Patients with history of significant head trauma in the last 1 month.\n* Patients with documented history of major depression prior to stroke.\n* Patients with alcohol\u002Fdrug abuse in the past 6 months.\n* Patients with prior significant cognitive impairment.\n* Pacemaker in situ, cochlear implant in situ.\n* Pregnancy.","65 Years",{"count":121,"type":21},28,[123],"PHASE3","The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other.\n\nIn aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging.\n\nImprovements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.",[126,127,28,29],"Acute Ischemic Cerebrovascular Disease","Post Stroke Aphasia",[129,130,126,131,28],"Transcranial Direct Current Stimulation","tDCS","Post stroke aphasia","2026-03-21",{"date":134,"type":46},"2026-03-27",{"date":136,"type":21},"2026-03-31",{"date":138,"type":21},"2026-09-30",{"name":140,"class":141},"Dr. Ram Manohar Lohia Hospital","OTHER_GOV",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":175},"100614570","aphasia-physical-exercise-study-randomized-trial-100614570","NCT07281313","Aphasia Physical EXercise Study: Randomized Trial","High-intensity Exercise in Stroke Recovery: Randomized Trial","APEX","Inclusion Criteria:\n\n* Aphasia following ischemic or hemorrhagic stroke\n* Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \\\u003C 93.8 at study intake)\n* At least 6 months from the last stroke\n* Proficient in English before the stroke\n* At least 8 years of education\n* Between the ages of 18 and 80\n* Independent with ambulation without a device (single-point cane accepted)\n* Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.\n\nExclusion Criteria:\n\n* Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse\n* Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing\n* Self-report uncontrolled cardiorespiratory and\u002For metabolic disorders incompatible with exercise","80 Years",{"count":152,"type":21},120,[95],"The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:\n\n• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and\u002For psychosocial domains?\n\nParticipants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.\n\nOutcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.",[29,27,156,157,28,158],"Aphasia, Fluent","Aphasia, Non-fluent","Aphasia Following Nontraumatic Intracerebral Hemorrhage",[69,160,161,162,163,164,70,165],"physical exercise","high intensity interval training","cognition","physical fitness","balance","language","2026-03-17",{"date":168,"type":46},"2026-03-19",{"date":170,"type":46},"2025-12-01",{"date":172,"type":21},"2030-03-01",{"name":174,"class":53},"University of California, Berkeley",4,{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":62,"enrollmentInfo":185,"targetDuration":4,"studyType":22,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":54},"100580856","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-mild-aphasia-100580856","NCT06842745","Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia","Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia","TMS","Inclusion Criteria:\n\n* Left Hemisphere stroke\n* Stroke occurred more than 6 months ago\n* Mild Aphasia (WAB AQ score \\> 85)\n* Proficient in English\n\nExclusion Criteria:\n\n* Ongoing substance or alcohol abuse\n* Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)\n* Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)\n* Pacemaker or cardiac defibrillator\n* Diagnosis of tinnitus\n* Epilepsy, or seizure in the past 6 months","40 Years",{"count":186,"type":21},24,[24],"The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with SLT improve conversational speech and comprehension?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo a MRI\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment\n* Complete follow-up assessments 2 and 4 months after treatment",[27,39,28,29],[69,70,191,71],"non-invasive brain stimulation","2026-03-04",{"date":194,"type":46},"2026-03-05",{"date":196,"type":46},"2025-02-11",{"date":198,"type":21},"2026-08-31",{"name":82,"class":53},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":230},"100604604","brain-stimulation-effects-on-post-stroke-fatigue-and-aphasia-100604604","NCT07151677","Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia","Pre-Frontal tDCS as a Novel Intervention to Reduce Effects of Post-Stroke Fatigue While Improving Language and Attention in Aphasia","Inclusion Criteria:\n\n1. 18 years or older.\n2. No diagnosis of neurological disorder (other than stroke).\n3. No diagnosis of psychiatric disorder, with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. No seizure within the past 6 months.\n5. Not pregnant.\n6. Does not currently have cardiac pacemaker\n7. In chronic phase of recovery, defined as at least 6 months post-stroke.\n8. Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study.\n9. No metal implants in the scalp or bone in the pre-frontal area of the head.\n10. No unhealed skull fractures.\n11. Onset of aphasia related to single, left hemisphere, ischemic stroke.\n12. Damaged brain tissue from stroke does not overlap with left hemisphere dorsolateral prefrontal cortex.\n13. Mild to moderate aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Self-report of post-stroke fatigue (as measured on SF-CAT)\n15. No significant challenges with vision or hearing (with use of corrective aids if needed; eyeglasses, hearing aids).\n16. Willing to allow audio-recording of study sessions.\n\nExclusion Criteria:\n\n1. Younger than 18 years old.\n2. Diagnosis or history of neurological disorder other than stroke.\n3. Diagnosis or history of psychiatric disorder with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. History of seizures within the past 6 months.\n5. Pregnant.\n6. Currently has cardiac pacemaker\n7. \\\u003C6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study)\n8. Currently undergoing speech and language therapy targeting auditory comprehension or attention.\n9. Metal implants in the scalp or bone in the pre-frontal area of the head.\n10. Currently has an unhealed skull fracture.\n11. Onset of aphasia related to etiology other than ischemic left hemisphere stroke.\n12. Damaged brain tissue significantly overlaps with left hemisphere dorsolateral prefrontal cortex.\n13. No aphasia or severe aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Does not report experience of post-stroke fatigue (as measured on SF-CAT)\n15. Significant challenges with vision and\u002For hearing (even with use of corrective aids).\n16. Unwilling to allow audio-recording of study sessions.",{"count":208,"type":21},60,[95],"The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and attention. The main question it aims to answer is:\n\n* Does transcranial direct current stimulation (tDCS) administered to the pre-frontal areas of the brain improve post-stroke fatigue and aphasia?\n* What kinds of participant characteristics are associated with better improvement of post-stroke fatigue and aphasia?\n\nResearchers will compare active electrical stimulation to sham stimulation to see if the active stimulation does a better job at reducing fatigue and language deficits after stroke. Participants will be asked to complete fatigue, language, and cognitive testing before and after receiving 10 sessions of tDCS plus speech and language therapy.",[28,212,213],"Stroke Ischemic","Fatigue Symptom",[69,215,216,130,217,218,73,219,220],"fatigue","post-stroke fatigue","brain stimulation","language treatment","speech therapy","speech-language therapy","2025-08-25",{"date":223,"type":46},"2025-09-03",{"date":225,"type":46},"2025-08-04",{"date":227,"type":21},"2029-11",{"name":229,"class":53},"Syracuse University",2,{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":244,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":54},"100592944","combined-aphasia-and-robot-assisted-arm-treatment-for-chronic-stroke-survivors-100592944","NCT07000019","Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors","CARAT","Inclusion Criteria:\n\n1. Male or female patients between 18-90 years of age.\n2. Right-handed prior to stroke\n3. English-speaking (monolingual)\n4. History of single left-hemisphere stroke at least 6 months prior to enrollment\n5. Presence of aphasia and naming deficits on Western Aphasia Battery (WAB-R)\n6. Comprehension score above 4 on WAB-R\n7. Unilateral upper limb paresis (Fugl-Meyer Upper Extremity score \\\u003C56)\n8. Documentation of signed Informed Consent by the study participant.\n\nExclusion Criteria:\n\n1. Diagnosis or history of speech impairment prior to stroke\n2. Severely limited speech output (score below 2 on spontaneous speech portion of WAB-R)\n3. Inability to perform screening tasks due to severe language and\u002For cognitive impairment\n4. Condition limiting passive movement in the range of motion required for robotic therapy (e.g. fixed contracture)\n5. Any medical or psychiatric condition that may impact participation or compliance with study procedures or activities in the opinion of the investigator","90 Years",{"count":121,"type":21},[95],"The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke. The mains questions it aims to answer are:\n\n* To determine the extent to which this combined treatment can improve language.\n* To determine the extent to which the combined treatment can improve arm movements.\n\nResearchers will compare the effects of this combined treatment with treatment that targets arm movements alone.",[39,28,243],"Hemiparesis After Stroke",[245],"stroke, aphasia, hemiparesis, robotic","2025-05-23",{"date":248,"type":46},"2025-05-31",{"date":250,"type":21},"2025-06",{"date":252,"type":21},"2027-11",{"name":254,"class":53},"New York Medical College"]