[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aphasia-non-fluent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aphasia-non-fluent":125},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,83,110,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100595742","phase-2-comparing-traditional-semantic-feature-analysis-tsfa-and-semantic-feature-analysis--metacognitive-strategy-training-sfamst-100595742",false,"NCT07036406","Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)","Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia","Inclusion Criteria:\n\n* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)\n* Be at least six-months post aphasia-onset,\n* Be a proficient English speaker,\n* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),\n* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems\n\nExclusion Criteria:\n\n* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,\n* Children under the age of 18,\n* Adults over the age of 89,\n* Uncorrected hearing and vision.","ALL","18 Years","89 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are:\n\n* What are the comparative outcomes in picture naming accuracy and strategy use during picture naming following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n* What are the comparative outcomes in percent of informative content and rate of informative content during spontaneous speech production following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n\nResearchers will compare outcomes between these two treatments to see if SFA+MST yields larger effects in picture naming and spontaneous speech outcomes than traditional SFA.\n\nParticipants will complete:\n\n* 5-7 pre-treatment assessment sessions where they will be asked to name pictures, tell stories\u002Fdescribe pictures, answer questions, and complete questionnaires,\n* 3 treatment sessions of SFA \\*OR\\* SFA+MST per week for 8 weeks, for a total of 24 sessions,\n* 7 weekly probes (i.e., short, intermittent assessments throughout the treatment phase),\n* 3 post-treatment assessment sessions immediately after treatment ends, where they will complete the same assessment tasks as they did pre-treatment (e.g., naming pictures, telling stories, etc.),\n* 2 retention assessment sessions, one 30 days and the other 60 days following the final treatment session, where they will be asked to name pictures, tell stories\u002Fdescribe pictures, and describe what they learned during the study.",[27,28,29,30,31,32,33,34,35,36],"Aphasia","Aphasia Following Cerebral Infarction","Aphasia, Acquired","Aphasia, Rehabilitation","Aphasia, Anomic","Aphasia, Broca","Aphasia, Conduction","Aphasia, Expressive","Aphasia Non Fluent","Aphasia, Mixed",[27,38,39,40,41],"Anomia","Stroke","Communication","Language","RECRUITING","2026-06-23",{"date":45,"type":46},"2026-06-25","ACTUAL",{"date":48,"type":46},"2025-07-28",{"date":50,"type":21},"2027-07",{"name":52,"class":53},"Teachers College, Columbia University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100579832","mirror-speech-entrainment-a-novel-technique-for-voice-personalized-speech-entrainment-for-nonfluent-aphasia-100579832","NCT06829420","Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia","MSE","Inclusion Criteria:\n\n* Adults between the ages of 18-70 years old\n* Dominant English-speaking\n* Aphasia due to left hemisphere stroke\n\nExclusion Criteria:\n\n* Individuals with aphasia due to other causes such as dementia, Alzheimer's disease and Parkinsonism\n* Non-dominant English adult speakers\n* Persons with significant difficulties with language comprehension\n* Persons with concomitant cognitive disability\n* Persons with uncorrected sensory deficits.","70 Years",{"count":64,"type":21},20,[66],"NA","The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is:\n\n\\- What is the impact of personalized voice on speech entrainment in PWA compared to traditional speech entrainment?\n\nSpeech entrainment is a technique used by speech-language pathologists to improve the speech production of PWA. Traditionally, speech therapists act as the model for participants to speak along with to improve their speech production. This study proposes the use of one's own voice (digitally altered) to improve speech production.\n\nThe study uses a mobile health approach to administer speech entrainment treatment through a mobile app.\n\n* Smartphones with the mobile app pre-installed will be mailed to participants at no cost.\n* Participants will complete treatment in the comfort of their homes.\n* The experimental treatments involve: mirror speech entrainment (speaking along to one's own voice) and traditional speech entrainment (speaking along to someone else's voice).",[35,39,27],[27,70,71,72],"Nonfluent aphasia","Speech entrainment","Speech synchronization","2026-04-15",{"date":75,"type":46},"2026-04-21",{"date":77,"type":46},"2025-05-01",{"date":79,"type":21},"2027-08-01",{"name":81,"class":53},"University of South Florida",2,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":54},"100462590","effects-of-neuronavigated-theta-burst-stimulation-in-therapy-of-post-stroke-aphasia-100462590","NCT05303649","Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia","Inclusion Criteria:\n\n* First-ever left middle cerebral artery ischemic stroke (brain damage localization confirmed by magnetic resonance imaging, MRI)\n* 3 or more months from the onset of stroke\n* Non-fluent aphasia (confirmed in the BDAE test) with functional communication difficulties ranging from mild to significant (grades from 2 to 4 in ASRS), marked difficulties in naming, and relatively preserved everyday speech comprehension\n* Native Polish speaker\n* Right-handedness prior to stroke\n* Signing of the informed consent for the participation in the study.\n\nExclusion Criteria:\n\n* Psychiatric and\u002For neurological comorbidity (e. g. dementia, depressive disorder, alcohol dependence)\n* Diagnose of epilepsy or epileptic changes in EEG, also frequent losses of consciousness of unclear etiology which might suggest epileptic seizures\n* History of any neurosurgical procedure around the head area\n* 1.5 T MRI examination contraindications (metal elements in the body, e. g. implantable cardioverter-defibrillator, deep brain stimulation devices; claustrophobia)\n* Regular intake of medication that could affect cortical excitability (e. g. antiepileptic or antipsychotic drugs, antidepressants, benzodiazepines) or medication influencing neuroplastic processes (e. g. dopamine)\n* Significant cognitive impairment limiting patient's cooperation during assessment and behavioral aphasia therapy\n* Visual deficits significantly hindering the perception of therapeutic tasks presented visually on a computer's screen\n* New neurological episode (e. g. another brain stroke) or somatic illness (e. g. COVID-19) during the cycle of the therapy, requiring its interruption.","75 Years",{"count":91,"type":21},45,[66],"Aphasia is an impairment in the ability to express and\u002For understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manner by increasing the excitability of preserved language areas in the left hemisphere. In our study, we plan to administer the newest form of rTMS called Theta Burst Stimulation (TBS), which is safer than the conventional rTMS, even when used in the perilesional area. Computer-based neuronavigation system will be implemented to precisely localize stimulation targets, control administration of stimuli during rTMS sessions, and evaluate differences between participants regarding deviations from established stimulation points. 45 patients (all right-handed, polish native speakers, aged 18-75 years, diagnosed with non-fluent aphasia) will be enrolled in a randomized, double-blind, sham-controlled trial. Subjects will be randomly assigned to one of the three groups: 1) a group with excitatory intermittent TBS of the left hemisphere (iTBS group), 2) a group with inhibitory continuous TBS of the right hemisphere (cTBS group), 3) a group with sham TBS (sTBS group as a control group). Specific forms of stimulation will be carried out for three consecutive weeks (Monday to Friday; a total of 15 stimulation sessions). Immediately after each session of the stimulation, patients will undergo individual SLT. Assessment of language functioning will be carried out three times: before and after the therapy period, and 3 months after its completion. Results of the study will broaden knowledge about hemispherical mechanisms of language and speech recovery after stroke and provide insight into possibilities of their modulation for the purpose of post-stroke rehabilitation.",[95,35],"Stroke, Ischemic",[27,39,97,98,99,100],"Theta Burst Stimulation","Therapy","Rehabilitation","Noninvasive Transcranial Brain Stimulation","2026-03-26",{"date":103,"type":46},"2026-03-31",{"date":105,"type":46},"2022-09-02",{"date":107,"type":21},"2027-12",{"name":109,"class":53},"Institute of Psychiatry and Neurology, Warsaw",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":145},"100614570","aphasia-physical-exercise-study-randomized-trial-100614570","NCT07281313","Aphasia Physical EXercise Study: Randomized Trial","High-intensity Exercise in Stroke Recovery: Randomized Trial","APEX","Inclusion Criteria:\n\n* Aphasia following ischemic or hemorrhagic stroke\n* Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \\\u003C 93.8 at study intake)\n* At least 6 months from the last stroke\n* Proficient in English before the stroke\n* At least 8 years of education\n* Between the ages of 18 and 80\n* Independent with ambulation without a device (single-point cane accepted)\n* Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.\n\nExclusion Criteria:\n\n* Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse\n* Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing\n* Self-report uncontrolled cardiorespiratory and\u002For metabolic disorders incompatible with exercise","80 Years",{"count":120,"type":21},120,[66],"The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:\n\n• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and\u002For psychosocial domains?\n\nParticipants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.\n\nOutcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.",[29,27,124,125,28,126],"Aphasia, Fluent","Aphasia, Non-fluent","Aphasia Following Nontraumatic Intracerebral Hemorrhage",[128,129,130,131,132,133,134,135],"aphasia","physical exercise","high intensity interval training","cognition","physical fitness","balance","stroke","language","2026-03-17",{"date":138,"type":46},"2026-03-19",{"date":140,"type":46},"2025-12-01",{"date":142,"type":21},"2030-03-01",{"name":144,"class":53},"University of California, Berkeley",4,{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":89,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":54},"100395765","sensory-motor-integration-for-speech-rehabilitation-in-patients-with-post-stroke-aphasia-100395765","NCT04433351","Sensory-Motor Integration for Speech Rehabilitation in Patients with Post-stroke Aphasia","Evaluation of an Enriched Speech Rehabilitation Program Combining Speech Therapy and Sensory-motor Integration in Aphasic Patients","SEMO","Inclusion Criteria:\n\n* patients with non-fluent aphasia after lesion in the dominant hemisphere for language\n* native speakers of French\n* normal or corrected to normal vision\n* satisfying all criteria for the MRI examination\n\nExclusion Criteria:\n\n* patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","55 Years",{"count":156,"type":21},36,[66],"SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.",[35,39],[161,162,163,164,165,166],"post-stroke aphasia","non-fluent aphasia","speech rehabilitation","neuroimaging","neural reorganization","recovery","2025-03-18",{"date":169,"type":46},"2025-03-21",{"date":171,"type":46},"2022-05-05",{"date":173,"type":21},"2026-03",{"name":175,"class":53},"University Hospital, Grenoble"]