[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aphasia-rehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aphasia-rehabilitation":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100595742","phase-2-comparing-traditional-semantic-feature-analysis-tsfa-and-semantic-feature-analysis--metacognitive-strategy-training-sfamst-100595742",false,"NCT07036406","Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)","Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia","Inclusion Criteria:\n\n* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)\n* Be at least six-months post aphasia-onset,\n* Be a proficient English speaker,\n* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),\n* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems\n\nExclusion Criteria:\n\n* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,\n* Children under the age of 18,\n* Adults over the age of 89,\n* Uncorrected hearing and vision.","ALL","18 Years","89 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are:\n\n* What are the comparative outcomes in picture naming accuracy and strategy use during picture naming following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n* What are the comparative outcomes in percent of informative content and rate of informative content during spontaneous speech production following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n\nResearchers will compare outcomes between these two treatments to see if SFA+MST yields larger effects in picture naming and spontaneous speech outcomes than traditional SFA.\n\nParticipants will complete:\n\n* 5-7 pre-treatment assessment sessions where they will be asked to name pictures, tell stories\u002Fdescribe pictures, answer questions, and complete questionnaires,\n* 3 treatment sessions of SFA \\*OR\\* SFA+MST per week for 8 weeks, for a total of 24 sessions,\n* 7 weekly probes (i.e., short, intermittent assessments throughout the treatment phase),\n* 3 post-treatment assessment sessions immediately after treatment ends, where they will complete the same assessment tasks as they did pre-treatment (e.g., naming pictures, telling stories, etc.),\n* 2 retention assessment sessions, one 30 days and the other 60 days following the final treatment session, where they will be asked to name pictures, tell stories\u002Fdescribe pictures, and describe what they learned during the study.",[27,28,29,30,31,32,33,34,35,36],"Aphasia","Aphasia Following Cerebral Infarction","Aphasia, Acquired","Aphasia, Rehabilitation","Aphasia, Anomic","Aphasia, Broca","Aphasia, Conduction","Aphasia, Expressive","Aphasia Non Fluent","Aphasia, Mixed",[27,38,39,40,41],"Anomia","Stroke","Communication","Language","RECRUITING","2026-06-23",{"date":45,"type":46},"2026-06-25","ACTUAL",{"date":48,"type":46},"2025-07-28",{"date":50,"type":21},"2027-07",{"name":52,"class":53},"Teachers College, Columbia University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":16,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":54},"100554027","acupuncture--neuromodulation-for-post-stroke-aphasia-100554027","NCT06493747","Acupuncture + Neuromodulation for Post-Stroke Aphasia","Efficacy and Mechanism Study of Acupuncture Combined With Neuromodulation Technology for Post-Stroke Aphasia Based on Multimodal Functional Magnetic Resonance Imaging","Inclusion Criteria:\n\n1. Diagnosed with aphasia following stroke according to both traditional Chinese and Western medical standards; first-time stroke in the left cerebral hemisphere (including cerebral infarction and cerebral hemorrhage), with unilateral lesion.\n2. Age between 25 and 75 years old, disease course of at least 1 month, no gender restrictions.\n3. Right-handed as tested by the Edinburgh Handness Inventory, with at least an elementary school education level.\n4. Retention of basic cognitive functions such as attention, memory, and visuospatial skills (Non-language-based Cognitive Assessment, NLCA score \\>70).\n5. Aphasia confirmed by initial assessment with the Western Aphasia Battery (WAB); an Aphasia Quotient (AQ) \\\u003C93.8 indicates aphasia.\n6. Possess a certain level of auditory comprehension and can tolerate research examinations lasting 0.5-1 hour.\n7. The subject and their legal guardian understand and consent to participate in this study and have jointly signed the informed consent form.\n\nExclusion Criteria:\n\n1. Moderate to severe dysarthria as assessed by the Frenchay Dysarthria Assessment.\n2. Severe speech apraxia or oral-facial apraxia.\n3. Significant anxiety or moderate to severe depressive symptoms as assessed by the Hamilton Anxiety and Depression Scales.\n4. Pre-stroke speech or language disorders.\n5. Severe systemic diseases such as cardiopulmonary diseases that cannot tolerate rehabilitation treatment or infectious diseases.\n6. Significant sleep disorders or mental disorders.\n7. Pregnant or lactating women.\n8. Contraindications for MRI examination (presence of metal foreign bodies or other implanted electronic devices in the body).",true,"25 Years","75 Years",{"count":66,"type":21},82,[68],"NA","The aim of this clinical trial is to assess the therapeutic efficacy of acupuncture combined with neuromodulation techniques for the treatment of post-stroke aphasia and to explore the brain mechanisms involved. The study seeks to answer two primary questions: the effectiveness of the integrated intervention of acupuncture and repetitive transcranial magnetic stimulation (rTMS) on post-stroke aphasia, and the mechanisms underlying language function impairment and recovery.\n\nThe research is divided into two parts:\n\nPart One:\n\nParticipants will be randomized into two groups:\n\nGroup A: Receives low-frequency rTMS followed by high-frequency rTMS. Group B: Receives high-frequency rTMS followed by low-frequency rTMS.\n\nPart Two:\n\nParticipants will be randomized into four groups:\n\nrTMS Experimental Group: Individualized targets and intervention methods based on integrated fMRI and behavioral data. The rTMS intervention involves continuous treatment for two weeks, 5 sessions per week, each lasting 10-25 minutes, at 80% of the active motor threshold (AMT).\n\nrTMS Control Group: Standard rTMS protocol guided by clinical recommendations, with continuous treatment for two weeks, 5 sessions per week, each 20 minutes, at 80% AMT.\n\nElectroacupuncture Group: Points include Speech Area 1 (Yan Yu Yi Qu 1), Speech Area 2 (Yan Yu Yi Qu 2), Fengchi (Fengchi, GB20), Tiantu (Tiantu, CV22), Tongli (Tongli, HT5), Lianquan (Lianquan, CV23), and Paralianquan (Pang Lianquan). After needle insertion and obtaining Qi, electrical stimulation is applied with a discontinuous wave at 2Hz, at a tolerable intensity for the patient, for 30 minutes each session.\n\nCombined rTMS and Electroacupuncture Group: Combines both intervention methods as described above.",[30],"2024-07-09",{"date":73,"type":46},"2024-07-10",{"date":75,"type":46},"2020-06-01",{"date":77,"type":21},"2025-01",{"name":79,"class":53},"Shanghai Yueyang Integrated Medicine Hospital","Aphasia Rehabilitation"]