[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aphasia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aphasia":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,52,0,25,[9,48,78,106,129,142,174,200,232,281,306,326,349,373,403,425,451,471,496,519,550,582,607,629,648],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":28,"conditions":29,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053932","phase-2-superiority-trial-of-aphasia-focused-rehabilitation-with-tdcs-stimulation-100053932",false,"NCT07688551","Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation","Transcranial Direct Current Stimulation to Treat Aphasia: A Superiority Study","STARS","Inclusion Criteria:\n\n* Be willing and able to give informed consent.\n* Be willing and able to comply with study requirements.\n* Be between 25 and 80 years of age.\n* Have used English as the primary language for \\> 15 years.\n* Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.\n* Be greater than 6 months post-stroke.\n* Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \\\u003C 9).\n* Correctly name 140 or fewer items on the PNT.\n\nExclusion Criteria:\n\n* History of brain surgery except for during the treatment of the acute stroke.\n* Seizures during the previous 12-months.\n* Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).\n* Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).\n* Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.\n* Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.\n* Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.\n* Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.","ALL","25 Years","80 Years",{"count":22,"type":23},130,"ESTIMATED","INTERVENTIONAL",[26,27],"PHASE2","PHASE3","The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.",[30,31],"Aphasia","Broca's Aphasia",[33,16,30,34],"tDCS","Stroke","RECRUITING","2026-07-10",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":23},"2026-07-31",{"date":43,"type":23},"2030-06",{"name":45,"class":46},"University of South Carolina","OTHER",3,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100053874","effects-of-semantic-context-on-criterion-learning-naming-treatment-in-aphasia-100053874","NCT07673198","Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia","Word Retrieval in Aphasia","Inclusion Criteria:\n\n* English as a native or primary language\n* Adults with stroke who are at least 6 months post-onset\n\nExclusion Criteria:\n\n* History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease\n* History of a learning disability that significantly impacted language development, such as developmental language disorder\n* Insufficient stamina to participate in the protocol","18 Years","89 Years",{"count":58,"type":23},12,[60],"NA","Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and\u002For comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.",[30],[64,65,66,67,68],"anomia","retrieval practice","word-finding problem","communication disorder","naming impairment","NOT_YET_RECRUITING",{"date":38,"type":39},{"date":72,"type":23},"2026-08",{"date":74,"type":23},"2028-08",{"name":76,"class":46},"Albert Einstein Healthcare Network",1,{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":18,"minAge":55,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":24,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":77},"100053795","language-processing-and-tms-100053795","NCT05425615","Language Processing and TMS","Probing Language Processes Using Transcranial Magnetic Stimulation","Inclusion Criteria:\n\n* Diagnosed with left hemisphere stroke\n* Consent date \\>= 1 month after stroke onset\n* Right-handed\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Non-decisional per decisionality questionnaire or other clinical assessment\n* Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)\n* A chronic medical condition that is not treated or is unstable\n* Presence of\n\n  1. cardiac stimulators or pacemakers or intracardiac lines\n  2. neurostimulators\n  3. medication infusion device\n  4. any other implants near the scalp (e.g., cochlear implants) or in the eye\n  5. metal in the body\n* Pregnancy\n* History of skull fractures, or skin diseases\n* History of ongoing or unmanaged seizures or a family history of epilepsy\n* Presence of factors that potentially decrease seizure thresholds\n* On pro-convulsant medications\n* Untreated Sleep deprivation or insomnia\n* Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)\n* History of dyslexia or other developmental learning disabilities",true,"85 Years",{"count":88,"type":23},135,[60],"This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.",[34,30,92],"Language",[94,95,30,96,97],"TMS","Transcranial Magnetic Stimulation","Semantic processing","Phonological processing","2026-07-09",{"date":38,"type":39},{"date":101,"type":39},"2024-06-05",{"date":103,"type":23},"2032-06",{"name":105,"class":46},"Medical College of Wisconsin",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":85,"sex":18,"minAge":55,"maxAge":86,"enrollmentInfo":113,"targetDuration":4,"studyType":24,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":77},"100053811","transcranial-alternating-current-stimulation-tacs-in-aphasia-100053811","NCT04375722","Transcranial Alternating Current Stimulation (tACS) in Aphasia","Exogenous Tuning of Neural Oscillations as a Mode of Treatment in Post-stroke Aphasia","Inclusion Criteria:\n\nHealthy Controls\n\n* 18 years of age or older\n* Fluent in English\n* No history of neurological or psychiatric disorders\n\nStroke Patients\n\n* Diagnosed with post-stroke aphasia by referring physician\u002Fneuropsychologist\n* Consent date \\>=1 months after stroke onset\n* Right-handed\n* Fluent in English\n* 18 years of age or older\n\nExclusion Criteria:\n\n* Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing\n* Presence of major untreated or unstable psychiatric disease\n* A chronic medical condition that is not treated or is unstable\n* The presence of cardiac stimulators or pacemakers\n* Any metal implants in the skull\n* Contraindications to MRI or tACS\n* History of seizures\n* History of dyslexia or other developmental learning disabilities",{"count":114,"type":23},50,[60],"This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.",[30,34],[119,120,121,122],"language","language impairment","transcranial alternating current stimulation","tACS",{"date":38,"type":39},{"date":125,"type":39},"2020-01-04",{"date":127,"type":23},"2030-12",{"name":105,"class":46},{"id":130,"slug":4,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":131,"targetDuration":4,"studyType":24,"phases":132,"briefSummary":61,"conditions":133,"keywords":134,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":141,"locationsCount":77},"100644757",{"count":58,"type":23},[60],[30],[64,65,66,67,68],"2026-06-23",{"date":137,"type":39},"2026-06-29",{"date":139,"type":23},"2026-07",{"date":74,"type":23},{"name":76,"class":46},{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":56,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":151,"briefSummary":152,"conditions":153,"keywords":163,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":77},"100595742","phase-2-comparing-traditional-semantic-feature-analysis-tsfa-and-semantic-feature-analysis--metacognitive-strategy-training-sfamst-100595742","NCT07036406","Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)","Comparing the Effectiveness of Traditional Semantic Feature Analysis (SFA) Versus SFA Plus Metacognitive Strategy Training (SFA+MST) for People With Acquired Aphasia","Inclusion Criteria:\n\n* Have aphasia due to a single acute event (e.g., left-hemisphere stroke, traumatic brain injury)\n* Be at least six-months post aphasia-onset,\n* Be a proficient English speaker,\n* Have normal or corrected to normal hearing (i.e., hearing aids) and vision (i.e., eyeglasses),\n* Have no history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems\n\nExclusion Criteria:\n\n* A history of neurodegenerative disease (e.g., dementia), severe motor speech disorder, significant mental illness, psychiatric disorder, drug\u002Falcohol abuse, or neurological condition that could influence their cognitive, language, and memory systems,\n* Children under the age of 18,\n* Adults over the age of 89,\n* Uncorrected hearing and vision.",{"count":150,"type":23},40,[26],"The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are:\n\n* What are the comparative outcomes in picture naming accuracy and strategy use during picture naming following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n* What are the comparative outcomes in percent of informative content and rate of informative content during spontaneous speech production following 2 months of traditional SFA versus SFA + MST in adults with acquired aphasia?\n\nResearchers will compare outcomes between these two treatments to see if SFA+MST yields larger effects in picture naming and spontaneous speech outcomes than traditional SFA.\n\nParticipants will complete:\n\n* 5-7 pre-treatment assessment sessions where they will be asked to name pictures, tell stories\u002Fdescribe pictures, answer questions, and complete questionnaires,\n* 3 treatment sessions of SFA \\*OR\\* SFA+MST per week for 8 weeks, for a total of 24 sessions,\n* 7 weekly probes (i.e., short, intermittent assessments throughout the treatment phase),\n* 3 post-treatment assessment sessions immediately after treatment ends, where they will complete the same assessment tasks as they did pre-treatment (e.g., naming pictures, telling stories, etc.),\n* 2 retention assessment sessions, one 30 days and the other 60 days following the final treatment session, where they will be asked to name pictures, tell stories\u002Fdescribe pictures, and describe what they learned during the study.",[30,154,155,156,157,158,159,160,161,162],"Aphasia Following Cerebral Infarction","Aphasia, Acquired","Aphasia, Rehabilitation","Aphasia, Anomic","Aphasia, Broca","Aphasia, Conduction","Aphasia, Expressive","Aphasia Non Fluent","Aphasia, Mixed",[30,164,34,165,92],"Anomia","Communication",{"date":167,"type":39},"2026-06-25",{"date":169,"type":39},"2025-07-28",{"date":171,"type":23},"2027-07",{"name":173,"class":46},"Teachers College, Columbia University",{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":86,"enrollmentInfo":181,"targetDuration":4,"studyType":24,"phases":183,"briefSummary":184,"conditions":185,"keywords":186,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":77},"100590534","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-subacute-aphasia-100590534","NCT06968663","Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia","Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia","Inclusion Criteria:\n\n* Left hemisphere stroke resulting in aphasia\n* The stroke must have occurred between 2 and 6 weeks prior to enrollment\n* Must be able to understand the nature of the study, and give informed consent\n* English proficiency\n* Right-handed\n\nExclusion Criteria:\n\n* History of serious and\u002For ongoing issues with substance abuse\n* Previous head trauma with loss of consciousness for more than 5 minutes\n* History of major psychiatric illness\n* Dementia, or other neurological conditions\n* Epilepsy, or seizure after the stroke event\n* Pacemaker\n* Diagnosis of tinnitus\n* Pregnancy",{"count":182,"type":23},63,[26],"The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with mCILT improve overall speech?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia.\n\nImportantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo MRI scans\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment\n* Complete follow-up assessments immediately and 4 months after treatment",[34,30,154],[187,188,95,189,190],"aphasia","stroke","Non-invasive brain stimulation","language therapy","2026-06-16",{"date":193,"type":39},"2026-06-18",{"date":195,"type":39},"2024-08-01",{"date":197,"type":23},"2029-07-31",{"name":199,"class":46},"University of Pennsylvania",{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":85,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":24,"phases":209,"briefSummary":211,"conditions":212,"keywords":218,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":230,"locationsCount":77},"100555412","early-phase-1-educational-support-group-program-for-bilingual-and-spanish-speaking-carepartners-and-people-with-progressive-aphasia-100555412","NCT06511752","Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia","Educational Support Group Program for Carepartners of Bilingual and Spanish-speaking Persons With Progressive Forms of Aphasia and for Persons With Progressive Forms of Aphasia","Inclusion Criteria:\n\nAll participants must:\n\n* speak Spanish and\u002For English (although participants may speak other languages in addition to Spanish and\u002For English)\n* identify as Hispanic and\u002For Latinx,\n* or their spouse\u002Ffamily member with PA identifies as Hispanic and\u002For Latinx\n* see and hear well enough to participate\n* have access to a computer or mobile device with video capability\n* have an internet connection\n\nAdditional inclusion criteria for PA\u002F language-led dementia support group participants:\n\n* Individuals with PA:\n* Has a diagnosis of PA, or language-led dementia, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Aware of language difficulties and willing to discuss them\n* Able to actively engage in group discussion and complete activities with minimal support\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nAdditional inclusion criteria for care partner support group plus implementation phase participants:\n\n* Individuals with PA:\n* Diagnosis of aphasia or dementia that is progressive in nature, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Have some ability to communicate and understand communication in order to participate in training sessions\n* Are functionally able to engage in training sessions (e.g., able to maintain some attention, minimal challenging behavior that would cause disruption)\n* Have a care partner who also consents to participating in the project\n* Care partners:\n* Self-identification as a caregiver of an individual with a diagnosis of PA or language-led dementia\n* Willing to discuss caregiving for individuals with PA\u002F language-led dementia\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nExclusion Criteria:\n\n• Beyond the inclusion criteria included above, no additional exclusion criteria apply",{"count":208,"type":23},120,[210],"EARLY_PHASE1","The current study aims to examine the benefits of an education\u002Fsupport group program for individuals with progressive aphasia (caused by various etiologies, diagnoses) and their carepartners. The current study utilizes pre-, post-treatment, and follow-up assessments to measure effects of a psychoeducational support group and an implementation\u002Fcommunication skills training phase on measures of psychosocial function, communicative effectiveness and speech\u002Flanguage function. Analysis of study-specific surveys and semi-structured interviews will provide qualitative data regarding outcomes. Before beginning the education and support group, focus groups will be run in order to set priorities for the themes to be included in the education program. Participants will join via tele-based means if preferred and these participants may reside in the United States, or internationally including Mexico and Spain.",[213,214,215,30,216,217],"Alzheimer Disease","Dementia","Primary Progressive Aphasia","Progressive Aphasia","Progressive Aphasia in Alzheimer's Disease",[219,220,221,222,223],"bilingual","Spanish","Castellano","multicultural","multilingual","2026-06-08",{"date":226,"type":39},"2026-06-10",{"date":228,"type":39},"2024-05-21",{"date":127,"type":23},{"name":231,"class":46},"University of Texas at Austin",{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":85,"sex":18,"minAge":239,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":24,"phases":242,"briefSummary":243,"conditions":244,"keywords":255,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":47},"100496255","cognitive-reserve-and-response-to-speech-language-intervention-in-bilingual-speakers-with-primary-progressive-aphasia-100496255","NCT05741853","Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia","Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)\n* Bilingual in Spanish and Catalan or bilingual in Spanish and English\n* Different proficiency levels across languages are expected, any prior experience in both languages is acceptable\n* Intervention study: Score of 15 or higher on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination\n\nExclusion Criteria:\n\n* Other central nervous system or medical diagnosis that can cause symptoms\n* Other psychiatric diagnosis that can cause symptoms\n* Significant, uncorrected visual or hearing impairment that would interfere with participation\n* Prominent initial non-speech-language impairments (cognitive, behavioral, motoric)\n* Intervention Study: Score of less than 15 on the Mini-Mental State Examination\n* Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination","40 Years",{"count":241,"type":23},60,[60],"Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA.\n\nThe overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how \"strong\" each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.",[215,214,245,213,246,247,248,249,250,251,252,253,30,254],"Dementia, Frontotemporal","Neurodegenerative Diseases","Frontotemporal Lobar Degeneration","Apraxia, Motor","Dysarthria","Communication Disorders","Language Disorders","Speech Disorders","Neurocognitive Disorders","Bilingual Aphasia",[256,257,258,215,259,260,261,262,263,264,265,266,267,268,269,270,220,221,271,272,273],"Dementia, ADRD","Bilingualism","Multilingualism","Bilingual Primary Progressive Aphasia","Cognitive Reserve","Language Decline","Bilingual Language Decline","Speech-Language Therapy","Bilingual Speech-Language Therapy","Spanish speakers","Spanish-Catalan Bilinguals","Spanish-English Bilinguals","Hispanic","Catalán","Catalan","Speech Therapy","Latino","Cognition",{"date":226,"type":39},{"date":276,"type":39},"2023-05-01",{"date":278,"type":23},"2027-11-30",{"name":280,"class":46},"Stephanie Grasso",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":24,"phases":291,"briefSummary":292,"conditions":293,"keywords":294,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":77},"100640815","recovery-from-post-stroke-aphasia-with-rtms-targeting-left-or-right-anterior-temporal-lobe-100640815","NCT07608588","Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe","Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes","ATLAS","Inclusion Criteria:\n\n* Right-handedness (assesed using the Edinburgh Handedness Inventory)\n* Native English speakers\n* Single left hemispheric stroke\n* Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician\n\nExclusion Criteria:\n\n* Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)\n* Major phonological impairments (defined as \\> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)\n* Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)\n* Contraindication to MRI\n* Stroke involving the left ATL\n* Severe depression or psychiatric history\n* Illiteracy\n* Known neurodegenerative disorders\n* Severe uncorrected visual or hearing impairments",{"count":290,"type":23},45,[60],"This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.",[34,30],[187,188,295,296,297],"rTMS","brain stimulation","speech and language therapy","2026-05-26",{"date":300,"type":39},"2026-05-29",{"date":302,"type":39},"2026-05-15",{"date":304,"type":23},"2027-07-30",{"name":45,"class":46},{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":85,"sex":18,"minAge":312,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":24,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":319,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":47},"100419528","neural-bases-of-vocal-sensorimotor-impairment-in-aphasia-100419528","NCT04742894","Neural Bases of Vocal Sensorimotor Impairment in Aphasia","Inclusion Criteria:\n\n* A total of 50 individuals with aphasia due to chronic left hemisphere stroke (\\> 6 months post-stroke) and 50 age- and gender-matched healthy control subjects will be recruited in this study. The general inclusion criteria for all subjects include: age range 21-75 years, right-handed, and native speaker of English. The aphasic subjects have previously undergone neuro-psychological speech\u002Flanguage testing and have been diagnosed with one type of aphasia (e.g., Broca's, Wernicke's, conduction or anomic). Subjects in the control group will meet the inclusion criteria with having normal voice, speech, language, and hearing function and no history of neurological and psychiatric disorder. We expect that a significant proportion of aphasic patients will show symptoms associated with Apraxia of Speech (AOS) or dysarthria; however, these patients will not be excluded unless their deficits will preclude them from performing the experimental tasks.\n\nExclusion Criteria:\n\n* Subjects with moderate to severe hearing, memory, and\u002For cognitive impairments will be excluded for both groups. In addition, subjects with history of peripheral laryngeal disorders (e.g., paresis or vocal fold paralysis) will be excluded. Subjects will undergo safety screening and will be excluded if there are any factors counter-indicative for EEG and\u002For MRI scanning.","21 Years","75 Years",{"count":315,"type":23},100,[60],"Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising health care costs. Traditional aphasia therapy focus on enhancing speech motor output; however, recent evidence suggests that the auditory feedback also plays a critical role in fluent speech. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech auditory feedback and identify their impaired function in patients with post-stroke aphasia. This study aims to examine the behavioral, neurophysiological (EEG), and neuroimaging (fMRI) biomarkers of speech impairment following stroke with focus on understanding the role of auditory feedback for speech production and control. We plan to test individuals with post-stroke aphasia and a matched neuroptypical control group during different speech production tasks under the altered auditory feedback paradigm. In addition, we aim to examine the effect of audio-visual feedback training on enhancing communication ability during speech. These biomarkers will be combined with existing lesion-symptom-mapping data in the aphasic group in order to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model for identifying the source of sensorimotor deficit and improve diagnosis and targeted treatment of speech disorders in aphasia.",[30],{"date":300,"type":39},{"date":321,"type":39},"2021-07-11",{"date":323,"type":23},"2027-02-28",{"name":325,"class":46},"The University of Texas at Dallas",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":334,"targetDuration":4,"studyType":24,"phases":335,"briefSummary":336,"conditions":337,"keywords":338,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":77},"100395729","targeted-tdcs-to-enhance-speech-language-treatment-outcome-in-persons-with-chronic-post-stroke-aphasia-100395729","NCT04432883","Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia","AphasiatDCS","Inclusion Criteria:\n\n1. aged 25-85\n2. must be greater than 6 months post-stroke\n3. must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production\n4. must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage\n5. must be stimulable for naming\n\nExclusion Criteria:\n\n1. comorbid neurological disease.\n2. damage to the anterior right hemisphere.\n3. significant mood disorder.\n4. substance\u002Falcohol dependence or abuse within the past year\n5. presence of any implanted electrical device or contraindications to tDCS or MRI\n6. recent medical instability (within 4 weeks)\n7. pregnancy",{"count":114,"type":23},[60],"62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis\u002Fphonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.",[34,30],[34,30,296,339,297],"communication problems","2026-05-20",{"date":342,"type":39},"2026-05-22",{"date":344,"type":39},"2022-10-18",{"date":346,"type":23},"2027-04-30",{"name":348,"class":46},"University of New Mexico",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":85,"sex":18,"minAge":356,"maxAge":4,"enrollmentInfo":357,"targetDuration":4,"studyType":24,"phases":359,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":58},"100636790","lexure-for-post-stroke-aphasia-100636790","NCT07570264","LEXURE for Post-Stroke Aphasia","A Prospective, Multicenter, Randomized, Evaluator-Blinded, Confirmatory Study to Evaluate the Efficacy and Safety of LEXURE for Improving Language Function in Patients With Post-Stroke Aphasia","Inclusion Criteria:\n\n1. Diagnosed with hemorrhagic or ischemic stroke\n2. At least 3 months have elapsed since stroke onset\n3. History of aphasia resulting from stroke\n4. Aphasia Quotient (AQ) score between 26 and 90 (inclusive) on the Korean version of the Western Aphasia Battery (K-WAB) or the Paradise Korean version of the Western Aphasia Battery-Revised (PK-WAB-R)\n5. Adults aged 19 years or older\n6. Native Korean speakers\n7. Able to use the investigational device or perform workbook-based training without difficulty\n8. Willing to participate voluntarily and provide written informed consent\n\nExclusion Criteria:\n\n1. Diagnosed with language impairment due to causes other than stroke (e.g., traumatic brain injury, brain tumor, or neurodegenerative disease)\n2. History of language impairment due to developmental disorders\n3. Currently receiving speech-language therapy or participating in another clinical trial related to language function\n4. Currently receiving medication for severe psychiatric disorders (e.g., bipolar disorder, major depressive disorder, schizophrenia, alcohol dependence, or substance abuse)\n5. Illiterate individuals\n6. Individuals deemed unsuitable for participation in this study by the investigator\n7. Severe cognitive impairment that would interfere with understanding or performing the study interventions","19 Years",{"count":358,"type":23},116,[60],"This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the other half will receive workbook-based language training as an active comparator.",[30],[187,188],"2026-05-12",{"date":365,"type":39},"2026-05-14",{"date":367,"type":39},"2026-04-16",{"date":369,"type":23},"2026-12-30",{"name":371,"class":372},"Nunaps Inc","INDUSTRY",{"id":374,"slug":375,"hasResults":12,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":379,"eligibilityCriteria":380,"healthyVolunteers":85,"sex":18,"minAge":55,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":24,"phases":384,"briefSummary":385,"conditions":386,"keywords":387,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":77},"100592251","effects-of-aphasia-identification-cards-on-service-workers-comprehension-of-people-with-aphasia-100592251","NCT06990997","Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia","Effects of Aphasia Identification Cards on Comprehension of Aphasic Language by Unfamiliar Communication Partners","PAUSE","Inclusion Criteria:\n\n* Adult age 18-59\n* Currently employed as a service worker\n* Understand spoken and written English well\n* High school diploma or equivalency\n* Normal vision or corrected vision with glasses or contact lenses\n\nExclusion Criteria:\n\n* Language disorder\n* Hearing impairment\n* Intellectual disability\n* History of acquired neurological disorder (e.g., stroke or moderate\u002Fsevere brain injury)","59 Years",{"count":383,"type":23},160,[60],"The goal of this clinical trial is to learn whether healthy volunteers are more successful at understanding people with aphasia if they have first viewed an aphasia identification (ID) card. The main questions this study aims to answer are:\n\n* Does viewing an aphasia ID card improve healthy volunteers' understanding of the language errors made by people with aphasia?\n* Does viewing an aphasia ID card improve healthy volunteers' understanding of people with aphasia who make long pauses in their speech?\n\nResearchers will compare aphasia ID cards to a control condition (no ID card) to see whether aphasia ID cards improve healthy volunteers' understanding.\n\nHealthy volunteers will visit the study site for a single session (about 2 hours long). During the session they will:\n\n* Complete brief tests of their vision, hearing and thinking\n* Listen to sentences produced by a speaker with aphasia while their eye movements are recorded\n* Complete a survey about the experience of listening to the speaker with aphasia",[30],[30,388,389,390,391,392,393],"Communication partner","Service worker","Language processing","Language comprehension","aphasia identification card","eye-tracking","2026-04-28",{"date":396,"type":39},"2026-04-29",{"date":398,"type":39},"2025-09-22",{"date":400,"type":23},"2026-08-01",{"name":402,"class":46},"University of Massachusetts, Amherst",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":413,"phases":4,"briefSummary":414,"conditions":415,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":4},"100634138","implementing-transcranial-direct-current-stimulation-in-a-rehabilitation-setting-100634138","NCT07535788","Implementing Transcranial Direct Current Stimulation in a Rehabilitation Setting","Implementing Transcranial Direct Current Stimulation (tDCS) in an Acute Rehabilitation Setting","tDCS implement","Inclusion Criteria:\n\n* ischemic or hemorrhagic stroke\n* aphasia\n\nExclusion Criteria:\n\n* not a patient at either inpatient and outpatient settings of Casa Colina Hospital and Centers for Healthcare",{"count":412,"type":23},30,"OBSERVATIONAL","This study looks at whether transcranial Direct Current Stimulation (tDCS) can be effectively implemented in inpatient and outpatient rehabilitation settings during routine speech therapy for people who recently had a stroke and now have aphasia (difficulty speaking or understanding language)",[30,34],"2026-04-15",{"date":418,"type":39},"2026-04-17",{"date":420,"type":23},"2026-05-04",{"date":422,"type":23},"2027-05-30",{"name":424,"class":46},"Casa Colina Hospital and Centers for Healthcare",{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":429,"acronym":430,"eligibilityCriteria":431,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":432,"enrollmentInfo":433,"targetDuration":4,"studyType":24,"phases":435,"briefSummary":436,"conditions":437,"keywords":438,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":450},"100579832","mirror-speech-entrainment-a-novel-technique-for-voice-personalized-speech-entrainment-for-nonfluent-aphasia-100579832","NCT06829420","Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia","MSE","Inclusion Criteria:\n\n* Adults between the ages of 18-70 years old\n* Dominant English-speaking\n* Aphasia due to left hemisphere stroke\n\nExclusion Criteria:\n\n* Individuals with aphasia due to other causes such as dementia, Alzheimer's disease and Parkinsonism\n* Non-dominant English adult speakers\n* Persons with significant difficulties with language comprehension\n* Persons with concomitant cognitive disability\n* Persons with uncorrected sensory deficits.","70 Years",{"count":434,"type":23},20,[60],"The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is:\n\n\\- What is the impact of personalized voice on speech entrainment in PWA compared to traditional speech entrainment?\n\nSpeech entrainment is a technique used by speech-language pathologists to improve the speech production of PWA. Traditionally, speech therapists act as the model for participants to speak along with to improve their speech production. This study proposes the use of one's own voice (digitally altered) to improve speech production.\n\nThe study uses a mobile health approach to administer speech entrainment treatment through a mobile app.\n\n* Smartphones with the mobile app pre-installed will be mailed to participants at no cost.\n* Participants will complete treatment in the comfort of their homes.\n* The experimental treatments involve: mirror speech entrainment (speaking along to one's own voice) and traditional speech entrainment (speaking along to someone else's voice).",[161,34,30],[30,439,440,441],"Nonfluent aphasia","Speech entrainment","Speech synchronization",{"date":443,"type":39},"2026-04-21",{"date":445,"type":39},"2025-05-01",{"date":447,"type":23},"2027-08-01",{"name":449,"class":46},"University of South Florida",2,{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":4,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":24,"phases":459,"briefSummary":460,"conditions":461,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":77},"100489463","phase-2-balancing-effortful-and-errorless-learning-in-naming-treatment-for-aphasia-100489463","NCT05653440","Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia","Integrating Complementary Learning Principles in Aphasia Rehabilitation Via Adaptive Modeling (Sub-study 1: Balancing Effortful and Errorless Learning Via Adaptive Naming Deadlines)","Inclusion Criteria:\n\n* Existing diagnosis of chronic (\\>6 months) aphasia subsequent to left hemisphere ischemic or hemorrhagic stroke.\n* Impaired performance on 2\u002F8 sections of the Comprehensive Aphasia Test.\n\nExclusion Criteria:\n\n* History of other acquired or progressive neurological disease.\n* Significant language comprehension impairments\n* Unmanaged drug \u002F alcohol dependence.\n* Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.",{"count":412,"type":23},[26],"Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life.\n\nThis study is one of two that are part of a larger grant. This record is for sub-study 1, which will adaptively balance effort and accuracy using speeded naming deadlines.",[30,34],"2026-04-07",{"date":464,"type":39},"2026-04-13",{"date":466,"type":39},"2023-11-27",{"date":468,"type":23},"2028-01-31",{"name":470,"class":46},"University of Pittsburgh",{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":475,"acronym":476,"eligibilityCriteria":477,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":478,"enrollmentInfo":479,"targetDuration":4,"studyType":413,"phases":4,"briefSummary":480,"conditions":481,"keywords":482,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":77},"100632814","development-and-validation-of-language-and-communication-assessment-scales-100632814","NCT07518576","Development and Validation of Language and Communication Assessment Scales","SCALE_COM","Inclusion Criteria:\n\nPatient admitted to the hospital for an intensive neurorehabilitation cycle or attending as an outpatient Diagnosis of language and communication disorders following a stroke in the right or left hemisphere Age \\> 18 years Ability to provide informed consent Native speaker of Italian (L1 Italian)\n\nExclusion Criteria:\n\n* Unstable clinical conditions that may interfere with participation in the study (e.g., active symptomatic infections, stupor, need for oxygen therapy)","90 Years",{"count":114,"type":23},"The aim of speech therapy for people with aphasia is to improve their ability to communicate in daily life. Traditional evaluations focus on linguistic tasks, but they do not fully address everyday communication skills, which are crucial for creating personalized treatment goals. The study suggests a multimodal approach to language assessment, stressing the importance of gestures in communication. It calls for the development of tools that evaluate communication in a wider context, including factors like motivation, attention, awareness, and alternative communication strategies. Additionally, there is a need for tools specifically designed to assess communicative gestures.",[251,30],[483,187,484,485,486],"language disorders","conversation","gestures","assessment","2026-04-02",{"date":489,"type":39},"2026-04-08",{"date":491,"type":39},"2022-05-09",{"date":493,"type":23},"2026-12-31",{"name":495,"class":46},"IRCCS San Camillo, Venezia, Italy",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":12,"sex":18,"minAge":312,"maxAge":20,"enrollmentInfo":504,"targetDuration":4,"studyType":24,"phases":505,"briefSummary":506,"conditions":507,"keywords":509,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":77},"100414869","telerehabilitation-for-aphasia-terra-100414869","NCT04682223","Telerehabilitation for Aphasia (TERRA)","Center for the Study of Aphasia Recovery (C-STAR): Telerehabilitation for Aphasia (TERRA)","TERRA","Inclusion Criteria:\n\n1. Participants must have sustained a left hemisphere ischemic or hemorrhagic stroke at least 12 months prior to enrollment.\n2. Participants must primarily speak English for at least the past 20 years.\n3. Participants must be capable of giving informed consent or indicating another to provide informed consent.\n4. Participants must be between 21-80 years of age.\n5. Participants must be magnetic resonance imaging (MRI) compatible (e.g., no metal implants, not claustrophobic) on a 3-Tesla (3T) scanner.\n\nExclusion Criteria:\n\n1. Participants must not have previous neurological disease affecting the brain (e.g. history of traumatic brain injury).\n2. Participants must not have severely limited speech production (severe unintelligibility) and\u002For auditory comprehension that interferes with adequate participation in the therapy provided (i.e., WAB-R Spontaneous Speech rating scale score of 0-1 or WAB-R Comprehension score of 0-1).\n3. Participants must not have a history of stroke to the right hemisphere of the brain.\n4. Participants must not have a bilateral, cerebellar or brainstem stroke.\n5. Participants must not have anything that makes them be 3T MRI incompatible\n6. Insufficient intelligible speech to provide accurate responses with discourse\u002Fnaming.",{"count":315,"type":23},[60],"Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) to the more traditional In-Clinic Therapy (I-CT).",[30,34,508],"Stroke Rehabilitation",[187,188,510,511],"telerehabilitation","speech-language therapy","2026-04-01",{"date":487,"type":39},{"date":515,"type":39},"2021-05-05",{"date":517,"type":23},"2027-03",{"name":45,"class":46},{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":525,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":20,"enrollmentInfo":527,"targetDuration":4,"studyType":24,"phases":528,"briefSummary":529,"conditions":530,"keywords":534,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":549},"100614570","aphasia-physical-exercise-study-randomized-trial-100614570","NCT07281313","Aphasia Physical EXercise Study: Randomized Trial","High-intensity Exercise in Stroke Recovery: Randomized Trial","APEX","Inclusion Criteria:\n\n* Aphasia following ischemic or hemorrhagic stroke\n* Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \\\u003C 93.8 at study intake)\n* At least 6 months from the last stroke\n* Proficient in English before the stroke\n* At least 8 years of education\n* Between the ages of 18 and 80\n* Independent with ambulation without a device (single-point cane accepted)\n* Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.\n\nExclusion Criteria:\n\n* Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse\n* Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing\n* Self-report uncontrolled cardiorespiratory and\u002For metabolic disorders incompatible with exercise",{"count":208,"type":23},[60],"The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is:\n\n• Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and\u002For psychosocial domains?\n\nParticipants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting.\n\nOutcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.",[155,30,531,532,154,533],"Aphasia, Fluent","Aphasia, Non-fluent","Aphasia Following Nontraumatic Intracerebral Hemorrhage",[187,535,536,537,538,539,188,119],"physical exercise","high intensity interval training","cognition","physical fitness","balance","2026-03-17",{"date":542,"type":39},"2026-03-19",{"date":544,"type":39},"2025-12-01",{"date":546,"type":23},"2030-03-01",{"name":548,"class":46},"University of California, Berkeley",4,{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":18,"minAge":557,"maxAge":20,"enrollmentInfo":558,"targetDuration":4,"studyType":24,"phases":559,"briefSummary":560,"conditions":561,"keywords":567,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":77},"100628315","chinese-specific-speech-imagery-coding-using-high-density-ecog-100628315","NCT07460037","Chinese-Specific Speech Imagery Coding Using High-Density ECoG","Investigation of Chinese-Specific Speech Imagery Encoding and Decoding Using High-Density Electrocorticography","Inclusion Criteria:\n\n* Age between 20 and 80 years.\n* Ability and willingness to provide informed consent and comply with study procedures.\n* No severe preoperative emotional or consciousness disorders that would preclude participation in experimental tasks.\n* For patients undergoing intraoperative temporary high-density ECoG coverage: Patients with cerebral eloquent-area gliomas or refractory epilepsy undergoing awake craniotomy as part of standard clinical management.\n* For patients undergoing intraoperative temporary high-density ECoG coverage: Lesions involving or adjacent to eloquent brain areas including language, motor, or memory-related regions.\n* For patients undergoing intraoperative temporary high-density ECoG coverage: Mild mass effect without severe intracranial hypertension.\n* For patients undergoing intraoperative temporary high-density ECoG coverage: Preoperative language function largely preserved, with naming, reading, and language comprehension ≥80% of normal performance.\n* For patients undergoing permanent high-density ECoG implantation: Severe speech or language dysfunction caused by stroke, brain tumors, amyotrophic lateral sclerosis (ALS), or locked-in syndrome.\n* For patients undergoing permanent high-density ECoG implantation: No substantial improvement after 3-6 months of adequate rehabilitation and disease duration \\>12 months.\n* For patients undergoing permanent high-density ECoG implantation: Structural integrity of speech imagery-related cortices (ventral central lobule, supramarginal gyrus, superior temporal gyrus, middle temporal gyrus, middle frontal gyrus, and inferior frontal gyrus).\n* For patients undergoing permanent high-density ECoG implantation: Diagnosis of severe dysarthria or severe motor aphasia, with spontaneous speech score \\\u003C5\u002F20 on the Aphasia Battery of Chinese (ABC) and auditory comprehension ≥80% of normal levels.\n\nExclusion Criteria:\n\n* Significant mass effect with severe intracranial hypertension precluding awake craniotomy or electrode implantation.\n* Severe neurological dysfunction that would prevent participation in study procedures (except for speech or language impairment in the permanent implantation cohort).\n* Contraindications to MRI scanning or awake craniotomy, including incompatible implanted medical devices, severe claustrophobia, or obstructive sleep apnea syndrome.\n* Severe psychiatric disorders or cognitive impairment preventing participation in treatment or follow-up assessments (Mini-Mental State Examination score \\\u003C24).\n* Severe systemic medical comorbidities.\n* Pregnancy or lactation.\n* Refusal or inability to provide informed consent.","20 Years",{"count":114,"type":23},[60],"The goal of this study is to investigate whether high-density electrocorticography (ECoG) signals recorded from the surface of the brain can be used to decode neural representations of Mandarin Chinese speech features, including lexical tone, without requiring overt speech movements. The study focuses on the development and evaluation of decoding algorithms based on neural activity recorded during clinically indicated neurosurgical procedures.\n\nThe main questions it aims to answer are:\n\nCan high-density ECoG signals be decoded to reconstruct neural representations of Mandarin Chinese speech features, particularly lexical tone?\n\nCan neural activity recorded during silent auditory speech imagery be decoded to reconstruct tone-specific speech representations without actual articulation?\n\nThe study includes two groups of adult patients with neurological conditions who require cortical electrode placement as part of clinically indicated care:\n\nA intraoperative high-density ECoG temporary coverage group, enrolling approximately 50 patients with functional-area glioma or drug-resistant epilepsy who undergo awake neurosurgery with temporary high-density ECoG coverage for clinical functional mapping.\n\nA permanent high-density ECoG implantation group, enrolling approximately 10 patients with severe speech or language impairment caused by neurological conditions such as stroke, brain tumors, amyotrophic lateral sclerosis (ALS), or locked-in syndrome, who receive permanent high-density cortical electrode implantation for long-term monitoring.\n\nParticipants will:\n\nComplete preoperative clinical assessments as part of standard medical care, including brain imaging, language function evaluation, and routine neurological assessments\n\nUndergo clinically indicated awake neurosurgical procedures during which high-density ECoG electrodes are placed on the cortical surface for clinical functional localization\n\nPerform language-related tasks, such as listening to speech, imagining speech, and limited spoken responses, while brain electrical activity is recorded for approximately 20-30 minutes during surgery, without altering standard surgical procedures\n\nFor participants in the permanent implantation group, participate in long-term follow-up visits approximately every 2 weeks or monthly for up to 12 months after surgery, including evaluation of signal quality and research-related analysis and optimization of decoding algorithms\n\nAll surgical procedures involving temporary or permanent electrode placement are performed for clinical indications and have been approved through institutional ethical and scientific review. Participation in this study does not alter standard clinical care for the temporary recording group and does not require additional clinical procedures beyond routine treatment.\n\nThis research aims to support the long-term development of silent brain-to-speech communication technologies for individuals with severe speech or motor impairments and to improve understanding of how frontal, parietal, and temporal brain regions represent imagined speech in tonal languages such as Mandarin Chinese.",[30,249,562,563,34,564,565,566],"ALS","Speech and Language Disorder","Brain Tumor Adult","Epilepsies","locked-in Syndrome",[568,569,570,571,572],"speech imagery","speech production","Chinese Mandarin","neural encoding","speech decoding","2026-03-09",{"date":575,"type":39},"2026-03-10",{"date":577,"type":23},"2026-03-15",{"date":579,"type":23},"2028-12-31",{"name":581,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":589,"targetDuration":4,"studyType":24,"phases":591,"briefSummary":592,"conditions":593,"keywords":595,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":598,"lastUpdatePostDateStruct":599,"startDateStruct":601,"completionDateStruct":603,"leadSponsor":605,"locationsCount":77},"100627940","effects-of-gesture-plus-verbal-treatment-gvt-in-cantonese-speakers-with-aphasia-100627940","NCT07455162","Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia","Contrasting Effects of Verbal Treatment and Gesture Plus Verbal Treatment for Word Retrieval in Cantonese Speakers With Aphasia","Inclusion Criteria:\n\n* Diagnosed with aphasia\n* Demonstrate Word finding Difficulty (WFD)\n* Able to repeat single words\n* Normal (or corrected) vision and hearing\n* Aphasia resulting from a unilateral left hemisphere stroke\n* Premorbidly fluent in spoken Cantonese\n* Without significant cognitive impairments\n* Chronic aphasia resulting from a unilateral left hemisphere stroke\n\nExclusion Criteria:\n\n* A history of other neurological disorders\n* With the above moderate to severe or severe motor speech impairment\n* With moderate to severe apraxia of speech\n* With very mild or very severe aphasia",{"count":590,"type":23},90,[60],"This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA).\n\nThe primary research question in this study is: \"For Cantonese-speaking people with aphasia, what are the relative effects of verbal treatment compared to gesture plus verbal treatment (GVT) on verbal and gesture naming at different levels?\"\n\nPeople with aphasia will be engaged in a repeated measures experimental design. Participants will be engaged in two phases of training. In the first phase, participants will be assigned to receive verbal-only treatment. To minimize and prevent the carry-over effects caused by the first intervention, a one-month washout period will be implemented before the start of the second phase. After a washout period, participants will switch to GVT in the second phase.",[30,594],"Gestures",[30,596,597],"Gesture","Rehabilitation","2026-03-08",{"date":600,"type":39},"2026-03-11",{"date":602,"type":39},"2025-04-01",{"date":604,"type":23},"2028-09",{"name":606,"class":46},"Hong Kong University",{"id":608,"slug":609,"hasResults":12,"nctId":610,"briefTitle":611,"officialTitle":612,"acronym":94,"eligibilityCriteria":613,"healthyVolunteers":12,"sex":18,"minAge":239,"maxAge":86,"enrollmentInfo":614,"targetDuration":4,"studyType":24,"phases":616,"briefSummary":617,"conditions":618,"keywords":619,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":77},"100580856","phase-2-transcranial-magnetic-stimulation--language-therapy-to-treat-mild-aphasia-100580856","NCT06842745","Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia","Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia","Inclusion Criteria:\n\n* Left Hemisphere stroke\n* Stroke occurred more than 6 months ago\n* Mild Aphasia (WAB AQ score \\> 85)\n* Proficient in English\n\nExclusion Criteria:\n\n* Ongoing substance or alcohol abuse\n* Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)\n* Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)\n* Pacemaker or cardiac defibrillator\n* Diagnosis of tinnitus\n* Epilepsy, or seizure in the past 6 months",{"count":615,"type":23},24,[26],"The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke.\n\nThe main questions this study aims to answer are:\n\n1. Can TMS combined with SLT improve conversational speech and comprehension?\n2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment?\n\nResearchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia.\n\nParticipants will:\n\n* Complete a screening and medical intake to determine eligibility\n* Undergo a MRI\n* Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment\n* Complete follow-up assessments 2 and 4 months after treatment",[30,34,154,155],[187,188,620,95],"non-invasive brain stimulation","2026-03-04",{"date":623,"type":39},"2026-03-05",{"date":625,"type":39},"2025-02-11",{"date":627,"type":23},"2026-08-31",{"name":199,"class":46},{"id":630,"slug":631,"hasResults":12,"nctId":632,"briefTitle":633,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":635,"targetDuration":4,"studyType":24,"phases":636,"briefSummary":637,"conditions":638,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":549},"100544395","effect-of-community-choir-singing-in-people-with-chronic-post-stroke-aphasia-100544395","NCT06368323","Effect of Community Choir Singing in People With Chronic Post-stroke Aphasia","Inclusion Criteria:\n\n* People with chronic aphasia following stroke\n* English or French as language of daily use\n* Last stroke must have occurred at least 6 months before the start of the first assessments in the study protocol.\n\nExclusion Criteria:\n\n* Regular music making in the past 6 months\n* Visual deficit that cannot be corrected and might impair testing\n* Hearing deficit that cannot be corrected and might impair testing\n* Presence of neurological\u002Fpsychiatric co-morbidity or substance abuse\n* No ability to produce vocal sound through singing\u002Fhumming\n* Legally considered unable to make decisions for oneself",{"count":114,"type":23},[60],"The goal of this randomized controled trial is to test the effects of assigning people with chronic post-stroke aphasia to 12 weekly choir sessions, compared to usual care.\n\nThe main question it aims to answer is:\n\nDoes the assignment to a choir singing program causes a beneficial effect on functional communication and language recovery as well as psychosocial outcomes compared to usual care in the rehabilitation of people with chronic post-stroke aphasia?\n\nParticipants will have:\n\n12 in-person choir-singing sessions (1 session\u002Fweek, 1,5 h\u002Fsession, total 18h) conducted by a choir master, and home singing training (3 x 30-minutes-sessions\u002Fweek, total 18h)",[30],"2026-02-12",{"date":641,"type":39},"2026-02-17",{"date":643,"type":39},"2024-04-22",{"date":645,"type":23},"2027-09-30",{"name":647,"class":46},"University of Ottawa",{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":4,"eligibilityCriteria":654,"healthyVolunteers":12,"sex":18,"minAge":356,"maxAge":4,"enrollmentInfo":655,"targetDuration":4,"studyType":24,"phases":656,"briefSummary":657,"conditions":658,"keywords":659,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":664,"lastUpdatePostDateStruct":665,"startDateStruct":667,"completionDateStruct":669,"leadSponsor":670,"locationsCount":47},"100623537","phase-2-exploratory-evaluation-of-the-digital-therapeutic-device-zenicom-for-subacute-stroke-aphasia-100623537","NCT07397923","Exploratory Evaluation of the Digital Therapeutic Device Zenicom for Subacute Stroke Aphasia","Evaluation of the Safety and Efficacy of the Digital Therapeutic Device Zenicom for Improving Aphasia in Patients With Subacute Stroke and Aphasia (AQ ≥25), a Multicenter, Single-blind, Prospective, Randomized Exploratory Clinical Trial","Inclusion Criteria:\n\n* Aged 19 years or older.\n* Confirmed by a specialist to have aphasia caused by a stroke lesion.\n* First-ever subacute stroke (within 3 months of onset) diagnosed via radiological examination (CT, MRI).\n* Diagnosed with aphasia based on the Speech Assessment (PK-WAB-R).\n* Whose native language is Korean.\n\nExclusion Criteria:\n\n* Have progressive or hemodynamically unstable stroke.\n* Having other neurological diseases suspected to affect language ability.\n* Co-morbid major psychiatric disorders requiring continuous medication (e.g., Major Depressive Disorder, Schizophrenia, Bipolar Disorder, Dementia).\n* Co-morbid major neurogenic diseases other than stroke.\n* Confirmed history of degenerative neuropathy.\n* Current or past substance or alcohol use disorder.\n* Visual impairment (Low vision severity: visual acuity of 0.1-0.3 or lower).\n* Intellectual disability.\n* Illiteracy (unable to read and consent).",{"count":434,"type":23},[26],"Clinical Trial Title A Multicenter, Single-Blind, Prospective, Randomized, Exploratory Clinical Trial to Evaluate the Safety and Efficacy of the Digital Therapeutic Device 'Zenicom' for Improving Aphasia in Patients with Subacute Stroke\n\nClinical Trial Objectives To evaluate the efficacy of the digital therapeutic device Zenicom.\n\nTo evaluate the safety of the digital therapeutic device Zenicom.\n\nClinical Trial Period 6 months from the date of clinical trial plan approval by the Ministry of Food and Drug Safety (MFDS).\n\nTarget Condition Patients with aphasia resulting from stroke lesions.\n\nTarget Sample Size Total of 20 subjects (10 in the experimental group and 10 in the control group).\n\nInvestigational Medical Device Zenicom\n\nClinical Trial Methodology\n\n1. Device Information\n\n   A) Experimental Device: Digital Speech Therapy Application\n\n   Group: Performs conventional speech therapy for 30 minutes daily + additional digital speech therapy program during the 2-week treatment period.\n\n   B) Control Device: Conventional Speech Therapy\n\n   Group: Performs only conventional speech therapy for 30 minutes daily during the 2-week treatment period.\n2. Treatment Duration:\n\n   Total 2 weeks (10 working days; total usage of 600 minutes or more).\n3. Visits:\n\nTotal of 3 visits including outpatient and therapy room visits.\n\nVisit 1 (T-1): Screening\n\nVisit 2 (T0): Baseline and Treatment initiation\n\nVisit 3 (T1): Post-treatment assessment\n\nInclusion and Exclusion Criteria\n\n1. Inclusion Criteria Patients who satisfy all of the following criteria:\n\n   Adults aged 19 years or older.\n\n   Patients confirmed by a specialist to have aphasia caused by a stroke lesion.\n\n   Patients with first-ever subacute stroke (within 3 months of onset) diagnosed via radiological examination (CT, MRI).\n\n   Patients diagnosed with aphasia based on the Speech Assessment (PK-WAB-R).\n\n   Patients whose native language is Korean.\n\n   Patients capable of voluntarily consenting to the study.\n2. Exclusion Criteria Patients meeting any of the following criteria will be excluded:\n\nProgressive or hemodynamically unstable stroke.\n\nPatients with other neurological diseases suspected to affect language ability.\n\nCo-morbid major psychiatric disorders requiring continuous medication (e.g., Major Depressive Disorder, Schizophrenia, Bipolar Disorder, Dementia).\n\nCo-morbid major neurogenic diseases other than stroke.\n\nConfirmed history of degenerative neuropathy.\n\nCurrent or past substance or alcohol use disorder.\n\nVisual impairment (Low vision severity: visual acuity of 0.1-0.3 or lower).\n\nIntellectual disability.\n\nIlliteracy (unable to read and consent).\n\nPatients deemed inappropriate for participation for other reasons.\n\nRefusal to participate in the study.\n\nSuspension and Dropout Criteria\n\n1. Suspension Criteria\n\n   If circumstances observed during the trial make it judged unreasonable to continue the study.\n\n   Occurrence of Serious Adverse Events (SAE).\n2. Dropout Criteria\n\nThe subject requests to stop participation or withdraws consent during the trial.\n\nThe investigator determines that the subject cannot continue the trial due to adverse events (e.g., headache, eye fatigue, nausea, dizziness, etc.).\n\nThe subject arbitrarily takes medication expected to affect the comparative evaluation of the investigational device during the trial.\n\nThe dosage of medication that may affect the comparative evaluation of the investigational device is changed during the trial.\n\nDiscovery of major protocol violations, such as violation of inclusion\u002Fexclusion criteria.\n\nThe subject fails to attend scheduled visits and cannot be contacted.\n\nThe subject fails to perform the digital speech therapy program for a total of 600 minutes or more.\n\nThe investigator determines that the trial should be stopped for other reasons.\n\nEndpoints (Outcome Measures)\n\n1. Primary Efficacy Endpoint\n\n   Change in PK-WAB-R scores between T0 and T1 between groups.\n2. Secondary Efficacy Endpoints\n\nChange in K-BNT scores between T0 and T1 between groups.\n\nChange in K-SAQOL-12 scores between T0 and T1 between groups.\n\nStatistical Analysis Methods To evaluate the change in PK-WAB-R between T0 and T1 between groups, an independent two-sample test will be used. Depending on the distribution of the change, a parametric method (Student's t-test) or a non-parametric method (Mann-Whitney U test) will be selected and applied.\n\nTo evaluate the changes in K-BNT and K-SAQOL-12 between T0 and T1 between groups, an independent two-sample test will be used. Depending on the distribution of the change, a parametric method (Student's t-test) or a non-parametric method (Mann-Whitney U test) will be selected and applied.",[30,34],[660,661,662,663],"digital therapeutics","aphasia treatment","subacute stroke","korean language","2026-02-07",{"date":666,"type":39},"2026-02-10",{"date":668,"type":39},"2025-12-10",{"date":627,"type":23},{"name":671,"class":46},"Seoul National University Bundang Hospital"]