[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:apical-periodontitis":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,50,71,96,131,159,191,223,254,285,311,344,370,390,408,437,467,490,513,536,556,585,606,636,667],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100611210","the-effect-of-different-intracanal-medicaments-on-periapical-lesion-healing-100611210",false,"NCT07237620","The Effect of Different Intracanal Medicaments on Periapical Lesion Healing","Comparison of Calcium Hydroxide and Diclofenac Sodium as Intracanal Medicaments on Periapical Healing: A Fractal Analysis Study","Inclusion Criteria:\n\nThe study is planned to include patients aged 18-60 years who are systemically healthy (ASA I-II), present with apical periodontitis after primary root canal treatment, and have single-rooted, root-filled mandibular teeth with a periapical index (PAI) score of ≥3.\n\nEndodontic treatment failure is to be evaluated based on clinical and radiographic examinations. The duration of the initial endodontic treatment is to be at least four years or longer and\u002For the teeth are to exhibit clinical symptoms and signs. Previous root canal fillings are to be assessed for obturation quality and classified as satisfactory if they meet the following criteria: no visible voids, good condensation, and termination within 1-2 mm of the radiographic apex. If one or more of these criteria are not fulfilled, the obturation is to be classified as poor quality.\n\nThe presence of post-treatment apical periodontitis, poor obturation quality, and\u002For persistent or newly developed symptoms (such as spontaneous pain, tenderness to palpation or percussion) and\u002For sinus tract formation are to be considered as indications for retreatment.\n\nExclusion Criteria:\n\nPatients with a history of psychiatric disorders, allergic reactions, or pregnancy, and those who have taken analgesics within seven days prior to treatment or antibiotics within the previous three months, are to be excluded from the study.\n\nTeeth presenting with a periodontal pocket depth greater than 4 mm, severe coronal destruction preventing rubber dam placement, vertical root fracture, internal or external resorption, ankylosis, overfilling, open apex, or that have undergone surgical or nonsurgical retreatment after primary therapy are to be excluded. Teeth with perforation or fractured instruments are also to be excluded.",true,"ALL","18 Years","60 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study is planned to evaluate the effects of two different intracanal medicaments-calcium hydroxide and diclofenac sodium-on periapical healing following endodontic retreatment. Fifty-four patients will be included and randomly assigned into two groups according to the type of medicament used. All procedures will be performed by a single experienced endodontist under standardized clinical conditions. Periapical lesion healing will be assessed radiographically at baseline and after 12 months using fractal analysis to quantitatively evaluate bone regeneration. The primary outcome will be the change in the fractal dimension values between the initial and follow-up radiographs.",[29,30],"Periapical Lesion Healing","Apical Periodontitis",[30,32,33,34,35,36],"intracanal medicaments","Diclofenac sodium","Calcium hydroxide","Fractal analysis","Endodontic retreatment","RECRUITING","2026-06-04",{"date":40,"type":41},"2026-06-08","ACTUAL",{"date":43,"type":41},"2025-09-15",{"date":45,"type":23},"2027-04-01",{"name":47,"class":48},"Mustafa Kemal University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":49},"100639238","phase-4-effect-of-two-different-irrigation-protocols-and-activation-techniques-on-postoperative-pain-in-single-visit-endodontic-retreatment-prospective-randomized-clinical-trial-100639238","NCT07599254","Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),\n\n  * Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,\n  * Teeth with previous root canal obturation 2-4 mm short of the apex,\n  * Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,\n  * Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,\n  * Teeth suitable for rubber dam isolation.\n\nExclusion Criteria:\n\n* o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,\n\n  * Teeth exhibiting periodontal attachment loss,\n  * Presence of vertical root fractures, external root resorption, or perforations,\n  * Teeth with retained broken instruments,\n  * Non-restorable teeth,\n  * Patients in the pregnancy and breastfeeding period.",{"count":57,"type":23},100,[59],"PHASE4","The relationship between different root canal irrigation techniques and pain after root canal treatment",[30],"2026-05-14",{"date":64,"type":41},"2026-05-20",{"date":66,"type":41},"2025-01-01",{"date":68,"type":23},"2026-07-15",{"name":70,"class":48},"TC Erciyes University",{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":24,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":49},"100473010","application-of-a-dental-dedicated-mri-in-the-diagnosis-of-temporomandibular-joint-disorders-tissue-alterations-related-to-third-molars-periapical-and-periodontal-inflammatory-diseases-and-implant-treatment-planning-100473010","NCT05439330","Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Treatment Planning","Application of a Dental-dedicated MRI in the Diagnosis of Temporomandibular Joint Disorders, Tissue Alterations Related to Third Molars, Periapical and Periodontal Inflammatory Diseases, and Implant Planning","Inclusion Criteria (one of the following):\n\n* referred for CBCT imaging of at least one tooth for endodontic reasons\n* referred for intra-oral and\u002For panoramic imaging covering at least one molar tooth for periodontal reasons\n* referred for CBCT imaging of the TMJ (bilaterally)\n* referred for panoramic imaging of the third molar (retained\u002Fsemi-retained, uni- or bilateral), prior to treatment planning\n* referred for CBCT imaging prior to implant treatment\n\nExclusion Criteria:\n\n* younger than 18 years\n* unable to give consent\n* pregnant\n* pronounced claustrophobia\n* pacemakers or implanted defibrillators\n* metal shrapnel injuries of the eyes or MRI incompatible metallic inclusions or implants large tatoos\n* non-removable piercings",{"count":79,"type":23},470,[26],"The aim of the present study is to show that the use of 0.55T MRI combined with a \"dental\" coil produces images of sufficient diagnostic value to assess areas of interest in dentistry, and to compare MR images to traditional, dental-oriented radiographic images for diagnostic purposes.",[83,30,84,85,86],"TMJ","Periodontal Inflammation","Retained Tooth","MRI","2026-04-28",{"date":89,"type":41},"2026-05-04",{"date":91,"type":41},"2022-09-01",{"date":93,"type":23},"2026-12-31",{"name":95,"class":48},"University of Aarhus",{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":18,"minAge":103,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":24,"phases":105,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":49},"100629015","efficacy-of-different-disinfection-technologies-in-molar-non-surgical-retreatment-100629015","NCT07469150","Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment","Efficacy of a Multisonic System vs. Conventional Therapy in the Disinfection of Molar Retreatment Cases: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Molars showing radiographic evidence of post-treatment apical periodontitis: a lesion that exceeds 3 mm in diameter on one or more roots.\n* Evidence from periapical and CBCT examination suggests that retreatment is a viable option, i.e., there are low risks of vertical root fracture, no major root canal obstruction, evidence of coronal leakage, and potential improvement on the previous treatment.\n* The initial root canal therapy was performed at least 2 years previously, or more than 1 year if the patient has signs and symptoms or symptomatic disease (pain, swelling, or sinus tracts).\n* Patients show no chronic systemic disease that may influence the outcome of care, such as uncontrolled diabetes, autoimmune disease, malignancy treated with chemotherapy or patients who are on immunosuppressive medications or require antibiotic prophylaxis before dental treatment.\n* Patients who are able to read and consent in English.\n\nExclusion Criteria:\n\n* Patients with a tooth requiring RCT retreatment that also presents with periodontal pocket(s) deeper than 5mm\n* Patients with a tooth requiring RCT retreatment that also presents with severe crown destruction that would prevent proper rubber dam isolation or an adequate restoration\n* Patients with a tooth requiring RCT retreatment that also presents with evidence of vertical root fracture, or cracks with probing defects \\> 5 mm\n* Patients with a tooth requiring RCT retreatment that is deemed unrestorable\n* Patients who received antibiotic therapy within the previous 3 months.\n* Patients under the age of 16 or those incapable of providing informed consent\n* Patients with a tooth requiring RCT retreatment that also presents with immature or open apices\n* Patients with a tooth requiring RCT retreatment that also presents with apices in the maxillary sinus or those teeth where the apical lesion has eroded the bone of the maxillary sinus floor\n* Patients with a tooth requiring RCT retreatment that also presents with apices that are less than 1 mm from the mandibular canal\n* Patients with a tooth requiring RCT retreatment that also presents with internal or external root resorption","16 Years",{"count":22,"type":23},[26],"Post-treatment apical periodontitis is commonly associated with persistent intracanal infection following root canal treatment. Effective disinfection of the complex root canal system during nonsurgical retreatment remains challenging due to anatomical complexities that may harbor microbial biofilms. Conventional retreatment protocols typically involve nickel-titanium rotary instrumentation combined with irrigation using sodium hypochlorite and activation techniques such as Passive Ultrasonic Irrigation (PUI).\n\nThe GentleWave System (GWS) is a minimally invasive irrigation technology designed to enhance tissue dissolution and microbial removal through multisonic energy, advanced fluid dynamics, and negative pressure. Although preliminary studies suggest promising results in root canal disinfection and patient outcomes, high-level clinical evidence comparing GWS with conventional retreatment techniques remains limited, particularly in molar teeth with post-treatment apical periodontitis.\n\nThis randomized clinical study aims to compare the disinfection efficacy of GWS with a conventional nickel-titanium rotary instrumentation protocol combined with PUI in nonsurgical retreatment of molars with post-treatment apical periodontitis. Intracanal bacterial load will be quantified using quantitative polymerase chain reaction (qPCR), and microbial composition will be analyzed using next-generation sequencing (NGS). Residual organic debris will be evaluated using the chairside diagnostic device Endocator and facultative bacterial culturing. Postoperative pain levels will also be recorded to assess short-term clinical outcomes.\n\nThe results of this study will provide clinical evidence regarding the comparative effectiveness, safety, and potential advantages of advanced irrigation technology for root canal disinfection in complex retreatment cases.",[30],[109,36,110,111,112,113,114,115,116,117,118,119,120],"Post-treatment apical periodontitis","Root canal disinfection","GentleWave System","Passive ultrasonic irrigation","Nickel-titanium rotary instrumentation","Sodium hypochlorite irrigation","Intracanal bacterial load","Root canal microbiome","Quantitative PCR","Next-generation sequencing","Endocator","Postoperative pain","NOT_YET_RECRUITING","2026-04-02",{"date":124,"type":41},"2026-04-08",{"date":126,"type":23},"2027-07",{"date":128,"type":23},"2030-12",{"name":130,"class":48},"University of Alabama at Birmingham",{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":24,"phases":140,"briefSummary":141,"conditions":142,"keywords":145,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":49},"100632839","phase-4-nanozymes-in-endodontics-100632839","NCT07518901","Nanozymes in Endodontics","Ferumoxytol Nanozymes for Biofilm Disruption: A Clinical Study","Inclusion Criteria:\n\n1. Patients willing to participate in the study.\n2. Patients are 18 years or above.\n3. Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II).\n4. Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and\n\n   1. responding to thermal sensitivity testing negatively (Difluordichlormethane at 50 °C, Endo-Ice,\n   2. Coltène\u002FWhaledent Inc., Cuyahoga Falls, Ohio) or a negative response to EPT testing.\n5. Tooth with adequate remaining tooth structure for proper isolation with rubber dam.\n6. No history of previous endodontic treatment on the tooth.\n7. Teeth with single roots or multirooted teeth.\n\nExclusion Criteria:\n\n1. Self-reported pregnancy.\n2. Patients requiring antibiotic premedication prior to dental treatment.\n3. Patients with multiple drug allergies.\n4. Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products.\n5. Patients who are scheduled for MRI for the head region within three months after Ferumoxytol nanoparticles application.\n6. Periodontal changes (pockets 3 mm, mobility Grade I, or gingival edema).\n7. Patients who cannot return for a subsequent appointment or follow-ups.\n8. Radiographic presence of resorptive processes.\n9. Cracked and fractured teeth.",{"count":139,"type":23},72,[59],"The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment. Building on prior protocols that demonstrated ferumoxytol nanozymes antimicrobial activity as a root canal irrigant, ferumoxytol solution will be applied topically, assessment of clinical and radiographical findings will determine its potential as a novel disinfection and its long-term outcome.",[30,143,144],"Endodontic Disease","Root Canal Infection",[146,147,148,149],"Nanozymes","Root canal irrigants","Nanotechnology","iron oxide nanoparticles","2026-04-01",{"date":152,"type":41},"2026-04-09",{"date":154,"type":23},"2026-06",{"date":156,"type":23},"2028-06",{"name":158,"class":48},"University of Pennsylvania",{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":17,"sex":166,"minAge":19,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":171,"conditions":172,"keywords":176,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":49},"100631759","biomarkers-in-apical-periodontitis-100631759","NCT07504861","Biomarkers in Apical Periodontitis","Effects of Different Irrigation Activation Techniques on Pro-inflammatory Cytokine and Proteolytic Enzyme Levels in Teeth With Chronic Apical Periodontitis","Inclusion Criteria:\n\n* Male patients aged 18-35 years.\n* Presence of chronic apical periodontitis in maxillary or mandibular incisors, canines, or single-rooted\u002Fsingle-channeled premolars.\n* History of root canal treatment performed at least 4 years ago.\n* Presence of a periapical lesion smaller than 1 cm.\n* Periapical Index (PAI) score of 3 or 4 according to Orstavik classification.\n\nExclusion Criteria:\n\n* Need for antibiotic prophylaxis\n* Diabetes\n* Hematological disorders\n* Use of antibiotics or anti-inflammatory drugs within the last month.\n* Excessive plaque and tartar\n* Gum redness or bleeding\n* Severe gingivitis\n* Widespread periodontitis\n* Periodontal pocket depths exceeding 3 mm.\n* Presence of sinus fistula (bleeding).\n* Presence of internal or external root resorption.\n* Pain on palpation of teeth\n* Swelling\n* Pregnancy during treatment.","MALE","35 Years",{"count":169,"type":23},66,"OBSERVATIONAL","Aim: To evaluate the effects of three different irrigation activation techniques-conventional syringe irrigation (CSI), ultrasonic irrigation (UI), and SWEEPS (Shock Wave Enhanced Emission Photoacoustic Streaming)-on the levels of proinflammatory cytokines (Tumor Necrosis Factor Alpha (TNF-α), interleukin-1beta (IL-1β)) and proteolytic enzymes matrix metalloproteinase-9 (MMP-9) in teeth with chronic apical periodontitis.\n\nMethodology: Sixty-six male patients (aged 18-35) with single-rooted teeth, previous root canal treatment (at least 4 years ago), and periapical lesions (\\\u003C1 cm, PAI score 3 or 4) were included. Sample size was determined by G\\*Power (Power=0.90, α=0.05). Following local anesthesia and rubber dam isolation, endodontic access was performed under a dental operating microscope. After removing old filling material and completing root canal preparation with Reciproc R25\u002FR50 files, patients were randomly assigned into three groups (n=22 each): (1) CSI (30G needle), (2) UI (EMS miniPiezon), and (3) SWEEPS (Er:YAG laser, 2940 nm). Periapical exudate samples were collected using sterile paper points (2 mm beyond the apex for 60s) at the first visit (pre-treatment) and the second visit (one week post-medication with calcium hydroxide). Samples were analyzed via ELISA for TNF-α, IL-1β, and MMP-9 levels.\n\nStatistical Analysis: Data were analyzed using IBM SPSS 20. Percent changes in biomarker levels were evaluated using the Kruskal-Wallis test for inter-group comparisons and the Wilcoxon test for intra-group (pre- vs. post-treatment) comparisons. Linear regression was used to identify effective factors (group, age, gender, tooth type). Significance was set at (p \\\u003C 0.05).\n\nKeywords: Apical periodontitis, SWEEPS, Ultrasonic activation, Cytokines, MMP-9, Endodontics.",[30,173,174,175],"Retreatment","Biomarkers","Cytokine",[177,178,179,180,181,182],"Apical periodontitis","SWEEPS","Ultrasonic activation","Cytokines","MMP-9","Endodontics","2026-03-26",{"date":150,"type":41},{"date":186,"type":23},"2026-03-30",{"date":188,"type":23},"2026-09-28",{"name":190,"class":48},"Kırıkkale University",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":200,"conditions":201,"keywords":204,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":49},"100615840","professional-practices-regarding-treatment-of-non-vital-primary-teeth-among-dental-surgeons-in-france-100615840","NCT07297836","Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","Description of Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","DTNV","Inclusion Criteria:\n\n* Being a dentist treating children\n\nExclusion Criteria:\n\n* Being a dentist treating children",{"count":57,"type":23},"When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates when performed correctly. Recommended by the American Academy of Pediatric Dentistry, this technique relies on rigorous disinfection and the use of materials adapted to natural exfoliation. Lesion sterilization tissue repair (LSTR), although more controversial due to the use of topical antibiotics, can also be considered in certain clinical situations. However, data on French practices in this area are very limited, hence the need to evaluate practitioners' treatment choices, their potential reservations, and the criteria guiding their decisions.",[202,203,30],"Pulpitis - Irreversible","Pulp Necrosis",[205,206,207,208,209,210,211,212,213,202,30],"Pulpectomy","Pulp necrosis","Primary teeth","Non-vital primary teeth","Irreversible pulpitis","Natural exfoliation","Lesion Sterilization","Tissue Repair","Topical antibiotics","2026-02-27",{"date":216,"type":41},"2026-03-03",{"date":218,"type":41},"2025-11-07",{"date":220,"type":23},"2026-11-07",{"name":222,"class":48},"University Hospital, Strasbourg, France",{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":49},"100627433","evaluation-of-revitalization-success-using-i-prf-in-non-surgical-root-canal-retreatment-100627433","NCT07448571","Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment","Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment: A Clinical Study","Inclusion Criteria:\n\n* Patients aged between 18 and 50 years.\n* Single-rooted maxillary anterior teeth with closed apices.\n* Presence of periapical lesion confirmed radiographically.\n* Previously treated root canal tooth requiring non-surgical retreatment.\n* Tooth has not previously undergone non-surgical root canal retreatment.\n* Tooth is considered restorable.\n* Patient is systemically healthy.\n* Patient is willing to participate and provides informed consent.\n\nExclusion Criteria:\n\n* Teeth without radiographic evidence of periapical lesion.\n* Teeth with developmental anomalies.\n* Patients with systemic diseases that may affect healing.\n* Pregnant patients.\n* Teeth presenting with internal or external root resorption.","50 Years",{"count":232,"type":23},140,[26],"The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment. The study includes adult patients who require non-surgical root canal retreatment due to persistent periapical lesions.\n\nThe main questions it aims to answer are:\n\nDoes regenerative endodontic treatment improve periapical healing compared with conventional non-surgical root canal retreatment? Does regenerative treatment increase long-term treatment success and tooth survival? Researchers will compare conventional non-surgical root canal retreatment with regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) to see if the regenerative approach results in better clinical and radiographic outcomes.\n\nParticipants will:\n\nBe randomly assigned to receive either conventional retreatment or regenerative endodontic treatment.\n\nUndergo clinical and radiographic evaluations over a two-year follow-up period. Be assessed for pain, sensitivity, pulp vitality, hard tissue formation, and periapical healing.",[30,236],"Periapical Diseases",[238,239,240,241,242,243,244],"apical periodontitis","root canal retreatment","regenerative endodontic treatment","Injectable Platelet-Rich Fibrin","Non-Surgical Endodontic Retreatment","Periapical Healing","Randomized Controlled Trial","2026-02-26",{"date":247,"type":41},"2026-03-04",{"date":249,"type":41},"2025-05-01",{"date":251,"type":23},"2027-12-01",{"name":253,"class":48},"Marmara University",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":24,"phases":265,"briefSummary":266,"conditions":267,"keywords":268,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":49},"100575746","phase-4-endodontic-microsurgery-100575746","NCT06776289","Endodontic Microsurgery","Endodontic Microsurgery With and Without Platelet-Rich Fibrin","EMS","Inclusion Criteria:\n\n* Maxillary or Mandibular Anterior teeth and premolars #4-13 and #20-29 with a history of failing RCT and a periapical radiolucency will be accepted\n\nExclusion Criteria:\n\n* Patients with vertical root fractures\n* Patients with non-restorable teeth\n* Patients with class 3 mobility\n* Pregnant\n* Smoker\n* Systematic disease contraindicating surgery","90 Years",{"count":264,"type":23},20,[59],"Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched. Whether it is able to reduce post-op pain or if it improves success rate in endodontic microsurgery is not well known. It is also not well known if it will be able to increase the rate of healing. This study will evaluate the success of endodontic microsurgery with and without PRF.",[30],[269,270,271,272,273,274,275],"endo","endodontic","microsurgery","apicoectomy","apico","prf","platelet rich fibrin","2026-01-14",{"date":278,"type":41},"2026-01-16",{"date":280,"type":23},"2026-03",{"date":282,"type":23},"2026-12-30",{"name":284,"class":48},"Mark Schachman",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":292,"enrollmentInfo":293,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":49},"100619981","antibacterial-activity-of-calcium-hydroxide-and-betamethasone-in-apical-periodontitis-100619981","NCT07351682","Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis","Antibacterial Efficacy of Calcium Hydroxide Used Alone or in Combination With Iodoform (Metapex) and Steroid (Betamethasone) in Patients With Apical Periodontitis","Inclusion Criteria:\n\n* \\- Adults aged 18 to 65 years.\n* Patients diagnosed with apical periodontitis requiring endodontic retreatment.\n* Presence of a single tooth with radiographic evidence of apical periodontitis.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Use of systemic antibiotics within the previous 3 months.\n* Presence of systemic diseases that may affect healing or immune response.\n* Pregnancy or lactation.\n* Known allergy or hypersensitivity to any of the intracanal medicaments used.\n* Teeth with acute abscess, severe periodontal disease, or root fractures.","65 Years",{"count":294,"type":23},45,"Apical periodontitis is a chronic inflammatory disease caused by bacterial infection of the root canal system. Although mechanical cleaning and shaping reduce most microorganisms, bacteria may persist in areas that are difficult to reach, making the use of intracanal medicaments between treatment sessions clinically important.\n\nCalcium hydroxide is one of the most commonly used intracanal medicaments because of its antibacterial properties. However, some resistant microorganisms, such as Enterococcus faecalis, may survive when calcium hydroxide is used alone. Therefore, combining calcium hydroxide with other agents, such as iodoform or corticosteroids, may improve its antibacterial effectiveness.\n\nThe purpose of this study is to compare the antibacterial activity of calcium hydroxide used alone or in combination with iodoform (Metapex) or betamethasone in patients with apical periodontitis. Bacterial load in root canals will be evaluated using droplet digital PCR (ddPCR), a highly sensitive molecular method that allows absolute quantification of bacteria. The results of this study are expected to provide evidence to support optimal intracanal medicament selection in endodontic retreatment cases.",[30],[298,299,300,301,173],"Betamethasone","Calcium Hydroxide","Enterococcus faecalis","Droplet Digital PCR","2026-01-10",{"date":304,"type":41},"2026-01-20",{"date":306,"type":23},"2026-03-01",{"date":308,"type":23},"2027-03-01",{"name":310,"class":48},"Duygu Degirmencioglu",{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":17,"sex":18,"minAge":318,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":24,"phases":322,"briefSummary":324,"conditions":325,"keywords":327,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":340,"leadSponsor":342,"locationsCount":4},"100615235","phase-3-comparative-evaluation-of-clinical-and-radiographic-treatment-outcomes-of-garlic-gel-and-calcium-hydroxide-as-an-intracanal-medicament-in-nonsurgical-root-canal-treatment-of-permanent-teeth-100615235","NCT07289971","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients with the physical status of ASA I and ASA II according to ASA classification.\n* Patients aged from 15-45 years.\n* Mature permanent single-rooted teeth with closed apices.\n* Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).\n* Patients having radiographic evidence of periapical radiolucency of endodontic origin.\n* Patients who have not taken antibiotics for the past 14 days.\n* Cooperative patients who show good compliance.\n\nExclusion Criteria:\n\n* Patients with physical status of ASA III, IV, and V according to ASA classification.\n* Teeth with a calcified pulp chamber in periapical radiography.\n* Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.\n* Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.\n* Presence of internal and external resorption of the root as viewed on the periapical radiograph.\n* Presence of vertical root fracture and perforation as viewed on the periapical radiograph","15 Years","45 Years",{"count":321,"type":23},96,[323],"PHASE3","Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.",[30,326],"Periapical Radiolucency",[328,329,34,330,331,332,333,334,335],"Intracanal Medicament","Allium Sativum","Root canal treatment","Periapical Index","Resolution of Periapical Radiolucency","Visual Analogue Scale","Palpation","Percussion","2026-01-01",{"date":338,"type":41},"2026-01-06",{"date":304,"type":23},{"date":341,"type":23},"2026-05",{"name":343,"class":48},"University of Health Sciences Lahore",{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":12,"sex":18,"minAge":351,"maxAge":4,"enrollmentInfo":352,"targetDuration":354,"studyType":170,"phases":4,"briefSummary":355,"conditions":356,"keywords":359,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":365,"leadSponsor":367,"locationsCount":4},"100611720","the-present-study-aims-to-follow-up-on-all-root-canal-treatments-performed-during-the-year-2023-within-the-public-dental-services-of-the-counties-of-jnkping-kalmar-and-stergtland-sweden-the-study-is-entirely-observational-in-nature-100611720","NCT07244250","The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature.","Result of Root Canal Treatment in General Dentistry","Inclusion Criteria:\n\n• All patients who have received and completed a root canal treatment in the Public Dental Service in the counties of Jönköping, Kalmar and Östergötland in 2023.\n\nExclusion Criteria:\n\n• All patients who decline participation","20 Years",{"count":353,"type":23},1500,"8 Years","Each year, nearly 200,000 teeth undergo root canal treatment in Sweden, most of them within general dental care. However, studies that evaluate the outcomes of root canal treatments have almost exclusively been conducted at specialist or university clinics, where treatment conditions differ from everyday practice in general dentistry. Moreover, the design of such studies often limits the ability to generalize their findings to routine clinical settings.\n\nThese earlier studies suggest that root canal treatment is a predictable procedure-about 80-90% of treated teeth become free from infection, 90% of patients experience no pain, and approximately 90% of root-filled teeth remain in the mouth six years after treatment. Still, the results from these studies cannot easily be applied to general dental care. This has been confirmed by large-scale epidemiological studies using X-rays to assess the technical quality of performed root fillings and to detect signs of disease. These studies have shown that many root fillings exhibit technical shortcomings, and a significant proportion of root-treated teeth have persistent infections.\n\nThe current study aims to increase understanding of the factors that may explain why the results of root canal treatment in general dental practice appear to differ from those in specialist care. Based on epidemiological data, it is estimated that about 35% of teeth treated with root canal therapy in general dental practice still show signs of disease after treatment. What happens to these patients is largely unknown. Evidence suggests that teeth with persistent apical periodontitis rarely cause discomfort, and the condition often goes unnoticed.\n\nIn the first part of the study, only patients who have already received treatment will be invited to participate, making this a retrospective study. Because it takes several years to evaluate the outcome of a root canal treatment, all patients aged 20 years and older who had a tooth root-filled in 2023 within the Public Dental Services of Jönköping, Kalmar, or Östergötland counties will be offered a free clinical and radiological examination-thus a three-year follow-up. The examination is entirely painless.\n\nIn the second part of the study, patients with a root-filled tooth showing persistent disease will be offered a five-year follow-up (2026-2031). They will be grouped according to whether they choose to have further treatment or leave the condition untreated. This second phase will therefore constitute a prospective follow-up.",[357,30,358],"Endodontic Treatment","Quality",[330,177,360],"Root filling","2025-12-15",{"date":363,"type":41},"2025-12-16",{"date":306,"type":23},{"date":366,"type":23},"2027-12-31",{"name":368,"class":369},"Region Jönköping County","OTHER_GOV",{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":292,"enrollmentInfo":377,"targetDuration":4,"studyType":24,"phases":379,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":49},"100606767","to-evaluate-periapical-healing-post-full-pulpotomy-in-teeth-with-and-without-apical-periodontitis-100606767","NCT07179835","To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis","To Evaluate Periapical Healing Post Full Pulpotomy in Permanent Mandibular Teeth With and Without Apical Periodontitis","Inclusion Criteria:\n\n1. The patient should be ≥18 years of age.\n2. Restorable mature permanent 1st and 2nd Mandibular molars with extremely deep caries (≥2\u002F3 dentine involvement)\n3. Tooth should give positive response to pulp sensibility testing.\n4. Radiographic finding of periapical index (PAI) score \\>\u002F=3 (for test group) , score \\\u003C\u002F= 2 (for control group)\n\nExclusion criteria\n\n1. Teeth with immature roots.\n2. No pulp exposure after caries excavation.\n3. Bleeding could not be controlled in 10 minutes.\n4. Signs of pulpal necrosis, sinus tract, swelling, insufficient bleeding after pulp exposure.\n5. History of analgesic intake in previous 1 week, or antibiotic intake in 1 month.\n6. Internal\u002Fexternal resorption.\n7. Contributory medical history (alcoholism, smokers, diabetic, hypertension, drug dependency, Heart or valve disease, hepatitis, herpes, immunodeficiency (HIV), infectious diseases, kidney or liver, migraine)",{"count":378,"type":23},128,[26],"This clinical study aims to evaluate the periapical and clinical healing outcomes of full pulpotomy using MTA in mandibular permanent molars diagnosed with symptomatic irreversible pulpitis. Patients will be stratified based on the presence or absence of apical periodontitis. Clinical and radiographic assessments will be conducted at baseline, 6 months, and 12 months to compare healing outcomes between groups. The study seeks to determine the effectiveness of full pulpotomy as a less invasive alternative to root canal treatment, even in teeth with apical pathosis.",[30],{"date":383,"type":41},"2025-09-18",{"date":385,"type":23},"2025-10-15",{"date":387,"type":23},"2027-10-01",{"name":389,"class":48},"Postgraduate Institute of Dental Sciences Rohtak",{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":398,"conditions":399,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":49},"100557974","evaluation-of-periapical-healing-following-endodontic-microsurgery-with-leukocyte-and-platelet-rich-fibrin-l-prf-100557974","NCT06545084","Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits.\n3. Male or Female age \\>18 years old.\n4. In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery.\n5. Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5)\n6. Intact coronal restorations with no evidence of leakage or caries under the restoration.\n\nExclusion Criteria:\n\n1. Minors.\n2. Suspected root fractures.\n3. ASA classification 3 or greater.\n4. Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5).\n5. Patients with history of Oral or IV Bisphosphonate use.\n6. Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.",{"count":397,"type":23},50,"The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.",[30],"2025-08-20",{"date":402,"type":41},"2025-08-27",{"date":404,"type":41},"2024-08-01",{"date":406,"type":23},"2026-06-30",{"name":158,"class":48},{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":230,"enrollmentInfo":415,"targetDuration":4,"studyType":24,"phases":417,"briefSummary":419,"conditions":420,"keywords":423,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":4},"100600710","early-phase-1-effect-of-bio-c-temp-versus-calcium-ydroxide-as-intracanal-dressings-on-postoperative-pain-intensity-and-periapical-mmp-9-level-in-patients-with-necrotic-pulp-100600710","NCT07101029","Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp","Effect of Bio-C Temp Versus Calcium Hydroxide as an Intracanal Dressing on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Age between 18-50 years old.\n2. Males and females.\n3. Healthy patients categorized as I or II according to The American Society of Anesthesiologists.\n\n   (ASA I or II), with no underlying allergies.\n4. Single-rooted mandibular premolar teeth, having single root canal:\n\n   * Diagnosed clinically with pulp necrosis.\n   * Absence of spontaneous pulpal pain.\n   * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\\*2 mm radiographically.\n5. Patients accepting to participate in the trial.\n6. Patients who can understand pain scale and can sign the informed consent\n\nExclusion Criteria:\n\n1. Medically compromised patients having significant systemic disorders (ASA III or IV).\n2. Pregnant females.\n3. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.\n4. Teeth with multiple canals. 9\n5. Teeth that show association with acute periapical abscess, swelling or fistulous tract.\n6. Teeth with vital pulp.\n7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.\n8. Immature teeth.\n9. Teeth with greater than grade I mobility or pocket depth greater than 4 mm.\n10. Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification.\n11. Patients with two or more adjacent teeth requiring endodontic treatment.\n12. Patients reporting bruxism, clenching or TMJ problems.\n13. Inability to perceive the given instructions.",{"count":416,"type":23},30,[418],"EARLY_PHASE1","To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on:\n\n* Intensity of postoperative pain\n* levels of MMP -9 in Periapical Fluids.",[421,30,299,174,422],"Intracanal Dressing","Inflammatory Mediators",[424,299,425,426,174,427],"Bio-C Temp","Intracanal medicament","Matrix Metalloproteinase 9","Post operative pain","2025-07-28",{"date":430,"type":41},"2025-08-03",{"date":432,"type":23},"2025-08",{"date":434,"type":23},"2026-07",{"name":436,"class":48},"Cairo University",{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":444,"enrollmentInfo":445,"targetDuration":4,"studyType":24,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":460,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":4},"100600708","a-comparative-evaluation-of-the-degree-of-pain-and-mmp-9-expression-following-instrumentation-of-necrotic-pulps-with-apical-periodontitis-in-one-or-two-visits-100600708","NCT07101003","A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits","A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 18-40 years.\n* Males\u002FFemales.\n* Straight single canaled permanent teeth:\n\n  * Non-Vital pulps.\n  * Negative response to cold pulp tester (ethyl chloride spray\\*).\n  * Absence of spontaneous pain.\n  * Chronic apical periodontitis with negative response to percussion\n  * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\\*2 mm radiographically. The Periapical Index (PAI) score by Ørstavik is 2 or 3 (Ørstavik et al., 1986 43)\n* Systemically healthy patients (ASA I or II)\n* No anti-inflammatory or antibiotic medications taken in the past month\n* Patients' acceptance to participate in the trial.\n* Patients who can understand pain scale and can sign the informed consent (Appendix I).\n* Patients' acceptance to participate in the trial.\n\nExclusion Criteria:\n\n* Medically compromised patients having significant systemic disorders. (ASA III or IV).\n* Teeth with swelling or fistulous tract.\n* Teeth with acute or chronic periapical abscess.\n* Mobility Grade II or III.\n* Previous root canal therapy.\n* Non-restorable teeth.\n* Immature teeth.\n* Pregnant females.","40 Years",{"count":446,"type":23},28,[26],"This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.",[30,450,451],"Necrotic Pulps","Single Rooted Teeth",[453,454,455,456,457,458,459],"necrotic pulps","root canal system","Enterococcus faecalis (E. faecalis)","Microbioogy","pain","bacterial reduction","Matrix metalloproteinases (MMPs)",{"date":430,"type":41},{"date":462,"type":23},"2025-08-01",{"date":464,"type":23},"2025-08-04",{"name":466,"class":48},"Marwa Hisham Mohamed Salah Eldin",{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":4,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":474,"enrollmentInfo":475,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":477,"conditions":478,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":488,"locationsCount":49},"100580916","bite-force-measurements-100580916","NCT06843525","Bite Force Measurements","Exploring a Neuropathic Basis for Acute Pulpal Pain- a Clinical Pilot","Inclusion Criteria:\n\n* Individuals who present for\n* a lower 1st or 2nd molar filling in an otherwise healthy tooth, i.e., does not have large decay that has already infected the nerve of the tooth, or there is increased mobility due to gum disease or a root canal treatment on a lower molar tooth and there is no history of injury to the tooth, or\n* a lower molar root canal treatment, and\n* are 18 years or older\n* capable of providing informed consent, are eligible to participate in the study, as long as they satisfy the criteria below.\n* The opposing tooth is present, symptom-free and has adequate tooth structure that allows it to make contact with the tooth it bites against, and\n* are English-speaking\n\nExclusion Criteria:\n\n* Any patient, even if satisfying the criteria above, may not take part if any of the below is true:\n* Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual\u002Fcognitive disability are not enrolled in the study.\n* Take prescription pain medications for long-standing health conditions\n* Addiction\u002F substance dependence\n* Swelling that extends beyond the tooth in question\n* Are already taking an antibiotic to treat an infection\u002Fswelling\n* Missing complementary molar on the same or opposite side of the mouth\n* Missing more than 2 teeth in a quadrant (other than 3rd molars)\n* Any other molar in the pair either on the side of the tooth of interest or the molar pair on the other side is painful to biting pressure or upon 'tapping' the tooth with the handle of the mouth mirror\n* The patient has taken a pain medication within the last 6 hours","89 Years",{"count":476,"type":23},112,"ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids. Addressing the need for non-opioid pain alternatives is crucial. Emerging evidence suggests that dental pain from pulpal and periodontal conditions (affecting the tooth's nerve and surrounding tissues) involves neuropathic mechanisms, such as mechanical allodynia (MA) and central sensitization (CS). These mechanisms can amplify pain perception, causing typically non-painful actions, like chewing, to become painful and resulting in hypersensitivity extending beyond the affected tooth. Reliably identifying these mechanisms with quantitative measures can support improved pain assessment and targeted non-opioid treatment. This minimally invasive prospective cohort study will use the FDA-approved Innobyte® device, a precise bite-force measurement tool, to evaluate periodontal health and to quantify mechanical pain thresholds in patients requiring endodontic treatment (root canal therapy).",[479,30,480],"Irreversible Pulpitis","Pulpal Necrosis","2025-07-22",{"date":483,"type":41},"2025-07-24",{"date":485,"type":41},"2025-05-16",{"date":487,"type":23},"2026-11-01",{"name":489,"class":48},"Rutgers, The State University of New Jersey",{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":496,"eligibilityCriteria":497,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":498,"targetDuration":4,"studyType":24,"phases":500,"briefSummary":501,"conditions":502,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":49},"100596635","chitosan-irrigation-in-premolar-root-canal-therapy-randomized-trial-100596635","NCT07048028","Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)","Evaluation of the Antibacterial Efficacy of Chitosan as an Irrigation Solution: A Randomized Controlled Clinical Trial","CHITO-PRE RCT","Inclusion Criteria:\n\n* Patients who agreed to participate in the study\n* Systemically healthy patient\n* Mandibular premolar teeth\n* Teeth that respond negatively to thermal tests and EPT\n* Patients who have not used antibiotics for at least 2 weeks\n\nExclusion Criteria:\n\n* Teeth with previous primary root-canal treatment\n* Pregnant patients\n* Severely curved roots (\\>25° curvature)\n* Canals with instrument separation during preparation\n* Calcified (obliterated) canals",{"count":499,"type":23},90,[26],"The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment. The main questions it will answer are:\n\nHow much does a chitosan solution used alone lower the number of bacteria inside the root canal? Do the combinations sodium hypochlorite + chitosan or sodium hypochlorite + EDTA lower bacteria even more than chitosan alone? Researchers will compare the three irrigation methods to see which one achieves the greatest bacterial reduction.\n\nWhat participants will do\n\nBe randomly assigned to one of three groups:\n\nGroup 1: Chitosan only Group 2: Sodium hypochlorite followed by chitosan Group 3: Sodium hypochlorite followed by EDTA\n\nAttend two clinic visits:\n\nVisit 1:\n\nReceive standard root-canal treatment under local anesthesia. Provide tiny paper-point samples from inside the canal before and after the assigned rinse (painless; takes seconds).\n\nVisit 2 (about 1 week later):\n\nReturn for a check-up and final filling of the tooth. Record any pain or discomfort for the first three days after treatment in a simple diary (or by phone).\n\nAbout 90 adults will take part. All procedures are routine in dental care, and there is no cost to participate. Participants may withdraw at any time and can ask the study dentist any questions throughout the trial.",[30,503,144],"Dental Pulp Necrosis","2025-07-01",{"date":506,"type":41},"2025-07-04",{"date":508,"type":41},"2025-05-05",{"date":510,"type":23},"2025-12-12",{"name":512,"class":48},"ESRA DAĞCI",{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":18,"minAge":520,"maxAge":319,"enrollmentInfo":521,"targetDuration":4,"studyType":24,"phases":523,"briefSummary":525,"conditions":526,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":532,"leadSponsor":534,"locationsCount":49},"100579243","phase-2-to-measure-post-operative-pain-severity-by-using-two-different-intra-canal-medicaments-calcium-hydroxide-and-triple-antibiotic-paste-in-teeth-with-single-roots-and-periapical-disease-called-apical-periodontitis-100579243","NCT06821763","To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis","Effect of Calcium Hydroxide on Post Operative Pain Severity in Single Rooted Teeth with Symptomatic Apical Periodontitis","Inclusion Criteria:\n\n* Patients of both genders having age 12-45 years\n* Newly diagnosed cases fulfilling the criteria of INTERNATIONAL ASSOCIATES FOR THE STUDY OF PAIN definition of pain.\n* A Single rooted teeth (Anterior or Posterior)\n* Teeth with symptomatic apical periodontitis\n* Teeth with necrotic pulp that gave a negative response to vitality testing.\n\nExclusion Criteria:\n\n* Patients who have allergies, sensitivity or unable to take medications, periodontal disease, acute endodontic or periodontal abscess, requiring prophylactic antibiotics, systemic diseases like hypertension, diabetes, liver dysfunction renal failure and mental disabilities were excluded.\n* Pregnant ladies or patients on nursing were also excluded from the sample.\n* Teeth with anatomical difficulties such as open apices.\n* Teeth with severe dilacerations, calcified canals, occlusal interferences, chronic periodontitis, internal\u002Fexternal root resorption.\n* Patients with serious medical illness, systemic disorders, immunocompromised diseases such as AIDS or HBV.","12 Years",{"count":522,"type":23},180,[524,323],"PHASE2","* The aim of this study is to compare post operative pain effectiveness between two most commonly available intra canal medicaments that are Triple Antibiotic Paste and Calcium Hydroxide during root canal treatment of single rooted teeth with symptomatic apical periodontitis.\n* Patients visiting OPD will be selected after fulfilment of inclusion criteria and randomly divided into two groups i.e group A patients receiving calcium hydroxide and group B with patients receiving Triple Antibiotic Paste as intra canal medicaments\n* Patient will be called at 48hrs 72hrs and 96hrs postoperatively.\n* Effectiveness of intra canal medicaments will be measured as no mild moderate severe on visual analogue scale(VAS).",[30,527],"Irreversible Pulpitis with Apical Periodontitis","2025-02-10",{"date":530,"type":41},"2025-02-12",{"date":249,"type":23},{"date":533,"type":23},"2025-11-01",{"name":535,"class":48},"Komal Ashraf Khan",{"id":537,"slug":538,"hasResults":12,"nctId":539,"briefTitle":540,"officialTitle":540,"acronym":4,"eligibilityCriteria":541,"healthyVolunteers":17,"sex":18,"minAge":542,"maxAge":318,"enrollmentInfo":543,"targetDuration":4,"studyType":24,"phases":544,"briefSummary":546,"conditions":547,"keywords":548,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":554,"leadSponsor":555,"locationsCount":49},"100574801","phase-1-the-effect-of-human-umbilical-cord-mesenchymal-stem-cells-and-exosomes-on-the-healing-of-postoperative-pain-and-periapical-lesions-in-the-treatment-of-apical-periodontitis-randomized-controlled-clinical-study-100574801","NCT06764004","The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study","Inclusion Criteria:\n\n1. Molar teeth with open apex\n2. Teeth with apical periodontitis\n3. Teeth for which prosthetic restoration is not planned\n4. Patients between the ages of 9-15 without any significant health problems\n5. Patients who are not accompanied by periodontal problems and whose oral hygiene is in good condition\n\nExclusion Criteria:\n\n1. Individuals with systemic diseases and allergic reactions\n2. Severely damaged teeth\n3. Previous root canal treatment has been performed on the tooth.\n4. Use of antibiotics, anti-inflammatory, and painkillers in the last two weeks\n5. Teeth with cracks and broken lines","9 Years",{"count":294,"type":23},[545,524],"PHASE1","The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic treatment of necrotic open apex molar teeth.\n\nRegenerative endodontic treatment aims to disinfect root canals and revascularize pulp tissue. Our goals in this study are; obtaining umbilical cord-derived MSCs, obtaining exosomes derived from umbilical cord MSCs, selecting patients with molar teeth with necrotic open apex and periapical lesion, initiation of regenerative endodontic treatment and disinfection of root canals, induction of bleeding in the periapical region and formation of a blood clot in the root canal in the 1st patient group, in the 2nd patient group, umbilical cord-derived MSCs were placed in the root canals without bleeding in the periapical region, in the 3rd patient group, placement of exosomes from umbilical cord-derived MSCs into the root canals without causing bleeding in the periapical region, it is the follow-up of patients at regular intervals for up to 1 year after treatment is completed.",[30],[549],"Regenerative endodontics, rejeneration, stem cell","2025-01-07",{"date":552,"type":41},"2025-01-08",{"date":66,"type":23},{"date":249,"type":23},{"name":70,"class":48},{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":563,"targetDuration":4,"studyType":24,"phases":565,"briefSummary":566,"conditions":567,"keywords":570,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":582,"locationsCount":584},"100408974","one-vs-two-visits-root-canal-treatments-in-infected-teeth-100408974","NCT04605445","One Vs Two Visits Root Canal Treatments in Infected Teeth","One Vs Two Visits Endodontics - a Prospective Randomized Multicenter Study in General Dental Practice","Inclusion Criteria:\n\n* Patient older than 17 years.\n* Permanent tooth excluding third molars.\n* Necrotic tooth with\u002Fwithout clinical and\u002For radiological signs of apical (juxta radicular) periodontitis (non-bleeding pulp in the canal orifice. In case of a multi rooted tooth, a non-bleeding pulp in at least one root canal orifice) where orthograde endodontic treatment is planned.\n\nExclusion Criteria:\n\n* Patients with severe general disease and\u002F or where endodontic treatment requires special consideration for health reasons (eg radiation-treated jaw bone in the area or increased susceptibility to infection).\n* Systemic involvement (fever).\n* Swelling (extra- and\u002For intra oral).\n* Previously root canal treated tooth (instrumented and\u002For rotfilled).\n* Confirmed or strong suspicion of transverse or longitudinal root fracture.\n* Trauma to the tooth (\\\u003C6 month).\n* Marginal bone loss \\>1\u002F3 of the root lenght.\n* Root resorption.\n* Non restorable tooth.\n* Endodontic treatment is not considered feasible because rubberdam cannot be used on the tooth.\n* Follow-up at the clinic of the treatment after\\> 1 year is considered not feasible.",{"count":564,"type":23},1000,[26],"The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment. Secondary aims are to compare the root filling quality and the frequency of complications for both treatment modalities.\n\nA pilot study will identify the shortcomings of the protocol, which will be revised accordingly.\n\nA multi-center study in several clinics from five counties throughout Sweden is planned. Consecutive eligible patients (see inclusion and exclusion criteria) with one tooth each will be included.\n\nThe study sample size calculation was based on a judgement that a minimal worthwhile effect of less than 10% was not clinically relevant. The presumption was that successful outcomes would be of 75% and 65% for the different treatment arms, respectively. Three hundred and fifty six patients per group are thus needed to detect that difference as statistical significant with a power of 80% and an alfa-error of 5%. To compensate for around 30% drop-outs a number of 1000 patients will be recruited.\n\nPatients will be randomly enrolled in two arms: one in which the endodontic treatment (root canal treatment) is performed in one visit, and in the other arm in two visits. The allocation sequences for one vs multiple visit endodontics will be computer generated followed by a dark colored envelope concealed allocation.\n\nThe patients will be contacted by telephone 5-7 days post-operatively, and a control visit at the clinic will be scheduled one month post-operatively to assess complications related to the treatment.\n\nA clinical control will be performed at the clinic one and four years after treatment. Intra-oral radiographs will be taken. The radiographs will be examined by two blinded and independent observers. A successful outcome is defined by clinical and radiographic normalcy.\n\nThe statistical methods selected to analyse the primary outcome will be the Chi square test of 2x2 tables, or Fisher´s exact test when proportions are small and the expected value \\\u003C5. The calculations will be two-tailed. Results will be considered statistically significant at p\\\u003C0.05.",[30,568,569,503],"Pain","Tooth Loss",[182,571,572,573,574],"General Dental Practice","Single Visit","Multiple Visits","Infection Barrier","2024-12-11",{"date":577,"type":41},"2024-12-16",{"date":579,"type":41},"2020-11-18",{"date":581,"type":23},"2031-12",{"name":583,"class":48},"Malmö University",7,{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":591,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":18,"minAge":593,"maxAge":292,"enrollmentInfo":594,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":595,"conditions":596,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":604,"locationsCount":49},"100569978","accuracy-of-poct-to-elisa-by-detecting-human-il-6-in-teeth-with-apical-periodontitis-100569978","NCT06701266","Accuracy of PoCT to ELISA by Detecting Human IL-6 in Teeth with Apical Periodontitis","Diagnostic Agreement of Human Interleukin-6 Chairside Point-of-Care Test (PoCT) to Enzyme-Linked Immunosorbent Assay (ELISA) in Teeth with Apical Periodontitis","PoCT ELISA","Inclusion Criteria:\n\n* Patient having single root tooth with AP that is negative to the pulp sensitivity test\n* Presence of periapical lesion\n\nExclusion Criteria:\n\n* Pregnancy","17 Years",{"count":416,"type":23},"To compare the diagnostic agreement of human IL-6 chairside PoCT to ELISA in apical periodontitis undergoing endodontic therapy which could be clinically helpful to monitor the healing of periapical tissues enabling the clinician to complete the endodontic procedure, leading to a better patient care.\n\nThis study will be conducted at the Conservative and Endodontics Department in Polyclinic B, Faculty of Dentistry, Manipal University College Malaysia (MUCM). It involves 30 selected patients who have single rooted tooth with apical periodontitis that undergo RCT. The collection of the exudate from the canal will be on pre and post-instrumentation. The exudated will collect twice in each instrumentation for PoCT and ELISA.",[30],"2024-11-20",{"date":599,"type":41},"2024-11-22",{"date":601,"type":23},"2024-12",{"date":603,"type":23},"2025-11",{"name":605,"class":48},"Manipal University College Malaysia",{"id":607,"slug":608,"hasResults":12,"nctId":609,"briefTitle":610,"officialTitle":611,"acronym":4,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":18,"minAge":613,"maxAge":354,"enrollmentInfo":614,"targetDuration":4,"studyType":24,"phases":616,"briefSummary":617,"conditions":618,"keywords":621,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":633,"leadSponsor":634,"locationsCount":4},"100564166","comparative-evaluation-of-antimicrobial-efficacy-clinical-and-radiographic-success-of-calcium-hydroxide-chlorhexidine-and-modified-triple-antibiotic-paste-in-different-combination-forms-as-intracanal-medicaments-against-enterococcus-faecalis-in-primary-teeth-100564166","NCT06625645","Comparative Evaluation of Antimicrobial Efficacy, Clinical and Radiographic Success of Calcium Hydroxide, Chlorhexidine, and Modified Triple Antibiotic Paste in Different Combination Forms As Intracanal Medicaments Against Enterococcus Faecalis in Primary Teeth","Comparative Evaluation of Antimicrobial Efficacy, Clinical and Radiographic Success of Calcium Hydroxide, Chlorhexidine, and Modified Triple Antibiotic Paste in Different Combination Forms As Intracanal Medicaments Against Enterococcus Faecalis in Primary Teeth: a Randomized Clinical Trial","Inclusion Criteria:\n\n• Primary molars necessitating pulpectomy diagnosed with deep dental caries with pulp necrosis, apical periodontitis and periapical pathosis or both.\n\n* Non-Vital pulps.\n* Negative response to hot or cold pulp tester (ethyl chloride spray ).\n* Decayed tooth with spontaneous unprovoked long dull aching pain showing signs of necrosis of the pulp\n\nExclusion Criteria:\n\n* Medically compromised and uncooperative children\n* Tooth indicated for extraction\n* Mobile teeth (Miller's Grade 2 or more)\n* teeth with more than two-thirds of root resorption\n* previous endodontic treatment","4 Years",{"count":615,"type":23},32,[26],"Comparing between different intracanal medications with different combination forms of Modified Triple Antibiotic Paste, Calcium Hydroxide and Chlorehexidine, regarding antimicrobial efficacy through bacterial reduction count of enterococcus Faecalis and regarding clinical and radiographic success in non vital primary teeth necessitating pulpectomy with follow up time 1 year.",[30,619,620],"Necrotic Primary Molars","Periapical Pathosis of Primary Molars",[622,30,623,624,625,626,627,628,458],"Necrotic Primary Teeth","Non Vital primary teeth","periapical pathosis of primary teeth","intracanal medication","triple antibiotic paste","enterococcus faecalis","Microbiology","2024-10-16",{"date":631,"type":41},"2024-10-17",{"date":66,"type":23},{"date":336,"type":23},{"name":635,"class":48},"Mahy Abdel Raouf Aly Kamar",{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":4,"eligibilityCriteria":642,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":24,"phases":645,"briefSummary":646,"conditions":647,"keywords":653,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":49},"100560208","effect-of-photobiomodulation-on-pain-and-healing-of-the-vertical-releasing-incision-after-endodontic-microsurgery-100560208","NCT06574152","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I or II.\n* At least one tooth will receive EMS.\n* Flap design that includes at least one VRI (triangular, rectangular, papilla base or submarginal rectangular).\n\nExclusion Criteria:\n\n* ASA III or IV.\n* Current heavy smokers (\\>10 cigarettes\u002Fday)\n* Uncontrolled diabetes (HbA1c ≥ 7%) or other uncontrolled systemic diseases that may comprise healing, such as vitamin C deficiency, neutrophil deficiencies, immunodeficiency syndromes, or leukemia.\n* Surgical access on the palatal surface.\n* Acute swelling or abscess present on the day of the surgery.\n* Any event or condition that would make continued participation in the study not in the best interest of the subject, as determined by the investigator.\n* Pregnancy.\n* Development of any medical condition that might affect the treatment and clinical outcomes, as determined by the investigator.\n* Initiation of any treatment or exposure that might affect therapy's healing, as determined by the investigator.",{"count":644,"type":23},40,[26],"The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of Dentistry Graduate Endodontic Clinic and to assess the soft tissue healing of the vertical releasing incision (VRI) after PBM",[30,648,143,649,650,651,652],"Endodontically Treated Teeth","Apical Cyst","Apical Granuloma","Periradicular Disease","Previous Endodontic Treatment",[654,655,272,656,657],"vertical incision","photobiomodulation","endodontic microsurgery","laser therapy","2024-08-27",{"date":660,"type":41},"2024-08-29",{"date":662,"type":41},"2024-08-20",{"date":664,"type":23},"2025-07-31",{"name":666,"class":48},"The University of Texas Health Science Center, Houston",{"id":668,"slug":669,"hasResults":12,"nctId":670,"briefTitle":671,"officialTitle":672,"acronym":4,"eligibilityCriteria":673,"healthyVolunteers":17,"sex":18,"minAge":674,"maxAge":19,"enrollmentInfo":675,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":676,"conditions":677,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":679,"lastUpdatePostDateStruct":680,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":686,"locationsCount":49},"100519431","revitalization-of-traumatized-immature-permanent-teeth-100519431","NCT06043453","Revitalization of Traumatized Immature Permanent Teeth","Revitalization of Immature Permanent Teeth With or Without Apical Periodontitis Post Trauma: a European Multicenter Cohort Study","Inclusion Criteria:\n\n* Provision of Informed Consent\n* Female and male patients\n* Age range: 6-18 years\n* \"Healthy\": ASA I and II\n* Permanent immature tooth (Cvek stage of root maturation ≤ 2) requiring revitalization\n* Etiological factor: (a)symptomatic apical periodontitis post dental trauma or irreversible pulpitis post dental trauma\n\nExclusion Criteria:\n\n* Unlikely to be able to comply with the study procedures, as judged by the investigator\n* Patients older than 18 years and younger than 6\n* Deciduous teeth\n* Cvek root maturation stage \\> 2: permanent immature tooth that can be treated by conventional root canal treatment or apexification\n* Known or suspected current malignancy\n* History of chemotherapy within 5 years prior to study\n* History of radiation in the head and neck region\n* History of other metabolic bone diseases\n* Bleeding disorders\n* Involvement in the planning and conduct of the study","6 Years",{"count":139,"type":23},"This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining\u002Fregaining pulp sensitivity and survival, than teeth with (a)symptomatic apical periodontitis.",[30,678],"Trauma","2024-06-28",{"date":681,"type":41},"2024-07-01",{"date":683,"type":41},"2023-10-01",{"date":685,"type":23},"2030-09-01",{"name":687,"class":48},"Universitaire Ziekenhuizen KU Leuven"]