[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"apnea-neonatal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:apnea-neonatal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100581383","manual-t-piece-versus-ventilator-positive-pressure-ventilation-during-resuscitation-of-extremely-premature-neonates-100581383",false,"NCT06849596","Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates","A Cluster Crossover Randomized Controlled Trial of Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates: The MVP Trial","MVP","Inclusion Criteria::\n\n* GA 25+0 to 28+6 weeks using the best available obstetrical estimate\n* Designated to receive full resuscitation, i.e., not pre-determined to receive only comfort care\n* Received PPV as determined by the resuscitation team during the first 10 minutes of birth\n\nExclusion Criteria:\n\n* Outborn birth status\n* Resuscitation performed in unforeseen circumstances outside typical delivery room (e.g., emergency department, antenatal ward)\n* Known major congenital or chromosomal anomaly\n* Established spontaneous respiration without receipt of PPV","ALL","25 Weeks","29 Weeks",{"count":21,"type":22},780,"ESTIMATED","INTERVENTIONAL",[25],"NA","Many extremely premature infants require immediate help with breathing after birth. Positive pressure ventilation (PPV) using a device called a T-piece resuscitator is a common method. PPV is needed to establish proper lung function, improve gas exchange, and encourage the infant to breathe spontaneously. However, T-piece resuscitators have limitations, like a lack of visual feedback and variable settings, which may result in reduced effectiveness of PPV. Improving PPV effectiveness may reduce the need for more invasive procedures, such as intubation, which pose an increased risk of complications and death for these fragile infants. A novel approach, that may overcome the above limitations and deliver PPV with precise settings through a nasal mask, is to use a ventilator to deliver PPV (V-PPV) using a respiratory mode called nasal intermittent positive pressure ventilation (NIPPV). While NIPPV is commonly used in neonatal intensive care units to support breathing in premature infants, the impact of V-PPV use during immediate post-birth stabilization needs to be studied. Preliminary data from our recent single-center study confirmed the feasibility of using V-PPV for resuscitation of extremely premature babies and indicated its potential superiority with a 28% decrease in the need for intubation compared to historical use of T-piece. This promising innovation may enhance outcomes for these vulnerable infants by refining the way we provide respiratory support in their critical first moments. The research objective is to compare the clinical outcomes of extremely premature infants receiving manual T-piece versus V-PPV during immediate post-birth stabilization. The primary aim is to evaluate the impact of V-PPV on major health complications or death. This study seeks to provide insights into improving the care and outcomes of these infants during a critical stage of transition from fetus to newborn.",[28,29],"Neonatal Resuscitation","Apnea Neonatal",[31,32,33,34,35,36,37],"Premature Infant","Preterm Neonates","Oxygen","Lung Injury","Respiration, Artificial","Resuscitation","Ventilator, Mechanical","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-11","ACTUAL",{"date":44,"type":42},"2025-12-01",{"date":46,"type":22},"2029-01-01",{"name":48,"class":49},"Michelle Baczynski","OTHER",10,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":58,"enrollmentInfo":59,"targetDuration":58,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100617924","the-role-of-electroencephalography-in-caffeine-discontinuation-timing-in-premature-infants-100617924","NCT07324941","The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants","The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants","Inclusion Criteria:\n\n1. Infants born before 28 weeks of gestation with a birth weight of 1250 grams or less, who received prophylactic caffeine therapy.\n2. Infants with a birth weight greater than 1250 grams and a gestational age below 32 weeks, who required invasive mechanical ventilation and were started on prophylactic caffeine therapy.\n3. Infants born at less than 37 weeks of gestation, admitted to the neonatal intensive care unit, and treated with caffeine for apnea of prematurity.\n4. Infants whose parents or legal guardians provided informed consent.\n\nExclusion Criteria:\n\n1. Infants who did not receive caffeine therapy,\n2. Infants for whom an EEG could not be performed,\n3. Infants with major congenital malformations such as neuromuscular disorders, central nervous system developmental abnormalities, thoracic malformations, or major cardiac anomalies,\n4. Infants who were transferred to another facility within one week before or after discontinuation of caffeine therapy.","1 Month",{"count":60,"type":22},100,"OBSERVATIONAL","The aim of this observational study is to investigate whether functional maturation assessment by electroencephalography in preterm infants can provide reliable data for the safe discontinuation of caffeine therapy without recurrence of apnea.\n\nIn preterm infants receiving caffeine therapy, an assessment of maturation will be performed by EEG at the time when discontinuation of caffeine treatment is planned.",[29,64],"Apnea of Prematurity","2026-04-27",{"date":67,"type":42},"2026-05-01",{"date":69,"type":42},"2026-01-02",{"date":71,"type":22},"2027-01-02",{"name":73,"class":49},"Uludag University",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":74},"100581572","application-to-predict-neonatal-apnea-with-bradycardia-100581572","NCT06852053","Application to Predict Neonatal Apnea With Bradycardia","Application to Predict Neonatal Apnea With Bradycardia (APNeA Study)","APNeA","Inclusion Criteria:\n\n* Documented episodes of apnea with bradycardia over the previous 24 hours.\n* Off ventilatory support\u002FNCPAP for \\> 48 hours prior to study entry\n* Gestational age \\\u003C 32 0\u002F7 weeks' gestation at birth\n* Parents\u002Flegal guardians have provided consent for enrollment\n\nExclusion Criteria:\n\n* a major malformation or a neuromuscular condition that affects respiration or causes apnea, or terminal illness or decision to withhold or limit support.","22 Weeks","32 Weeks",{"count":86,"type":22},25,[25],"This purpose of this study is to reduce or stop apneas and bradycardias in pre-term infants, before they occur using gentle stimulation.",[29,90],"Bradycardia Neonatal","NOT_YET_RECRUITING","2026-01-22",{"date":94,"type":42},"2026-01-23",{"date":96,"type":22},"2026-07-01",{"date":98,"type":22},"2027-12-31",{"name":100,"class":49},"University of Alabama at Birmingham"]