[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"apnea-obstructive-sleep\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:apnea-obstructive-sleep":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100509301","osa-18-in-children-with-mild-obstructive-sleep-apnea-can-it-be-a-helpful-decision-making-tool-100509301",false,"NCT05911646","OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?","OSA-18","Inclusion Criteria:\n\n* Parent\u002Fcaregiver of child with an initial diagnosis mild obstructive sleep apnea defined as polysomnography AHI score between 1 and 5\n* Parent\u002Fcaregiver of child between 3 and 12 years of age\n* Parent\u002Fcaregiver of child who has been diagnosed with tonsillar hypertrophy grade 2 or higher\n\nExclusion Criteria:\n\n* Parent\u002Fcaregiver of child diagnosed with a syndromic or known neurologic condition and\u002For multiple (more than two) medical cardiac or respiratory medical conditions\n* Parent\u002Fcaregiver of child who has previously underwent tonsillectomy",true,"ALL","3 Years","12 Years",{"count":21,"type":22},130,"ESTIMATED","INTERVENTIONAL",[25],"NA","The concept is a novel research idea that incorporates the potential impact of patient quality of life (QOL) on decision-making for treatment of mild obstructive sleep apnea (OSA). Our hypothesis is that in children with mild OSA there is significant conflict with parental decision-making; in the absence of significant sleep apnea, there is limited research regarding comparative efficacy of various treatment options. The impact of a QOL questionnaire can be a significant deciding factor and may help guide management decisions in such situations.",[28,29],"Apnea, Obstructive Sleep","Obstructive Sleep Apnea",[31],"Mild Obstructive Sleep Apnea","RECRUITING","2026-05-26",{"date":35,"type":36},"2026-05-28","ACTUAL",{"date":38,"type":36},"2021-06-02",{"date":40,"type":22},"2027-05-31",{"name":42,"class":43},"Connecticut Children's Medical Center","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100538192","cpap-in-patients-with-severe-obesity-after-anesthesia-100538192","NCT06287632","CPAP in Patients With Severe Obesity After Anesthesia","Assessment of Cardiopulmonary Function in Response to Continuous Positive Airway Pressure in Patients With Severe Obesity After Anesthesia","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube\n2. Planned admission to the post-anesthesia care unit (PACU) after surgery\n3. BMI ≥ 40 kg\u002Fm2\n4. At the time of baseline measurements in the PACU, patients meet the following criteria:\n\n   * Receiving ≤ 6 liters of supplemental nasal cannula oxygen\n   * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1\n   * Oriented to person, place, and time\n\nExclusion Criteria:\n\n1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax\n2. Hemodynamic instability at the time of study assessment in the PACU defined as:\n\n   * systolic blood pressure \\\u003C90 mmHg or \\>180 mmHg\n   * mean blood pressure \\\u003C60 or \\>130 mmHg\n   * Any use of intravenous vasoactive agent\n   * heart rate \\\u003C 50 or \\> 120 beats per minute\n3. Respiratory insufficiency in PACU defined as:\n\n   * Respiratory rate \\> 30\n   * Oxygen saturation \\\u003C 92%\n   * Receiving \\> 6 liters of supplemental oxygen\n4. Known chronic lung disease requiring supplemental oxygen at home\n5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%)\n6. Contraindication for esophageal catheter placement:\n\n   * Known esophageal varices\n   * Known bacterial sinusitis\n   * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery\n   * Known coagulopathy: including history of thrombocytopenia defined as platelet count \\\u003C50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants)\n7. Contraindication for electrical impedance tomograph belt placement:\n\n   * Pacemaker and\u002For internal cardiac defibrillator\n   * Chest skin injury\n8. Concern for study inclusion by the perioperative nurse or anesthesia team","18 Years",{"count":54,"type":22},60,[25],"The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are:\n\n1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia?\n2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia?\n\nParticipants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes.\n\n* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure\n* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present).",[58,59,28,60,61],"Obesity, Abdominal","Anesthesia Morbidity","Atelectases, Postoperative Pulmonary","Ventilator Lung",[63,64,65,66,67,68],"clinical trial","crossover studies","continuous positive airway pressure","electrical impedance tomography","esophageal pressure monitoring","transthoracic echocardiography","NOT_YET_RECRUITING","2025-11-17",{"date":72,"type":36},"2025-11-18",{"date":74,"type":22},"2026-06",{"date":76,"type":22},"2027-06",{"name":78,"class":43},"Massachusetts General Hospital"]