[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"apnea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:apnea":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,77,99,125,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100377163","upper-airways-pressure-drop-analyses-after-mandibular-advancement-and-maxillary-expansion-100377163",false,"NCT04190953","Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion","Skeletal, Dental and Upper Airway Changes in Skeletal Class II Division 1 Patients With the Constricted Maxilla (8-14 Years Old) Treated With Twin Block and Hyrax, Evaluated Through Pressure Drop Experimental Analysis.","Inclusion Criteria:\n\n* children between the ages 8-14 years old (8-12 years old girls and 9-14 years old boys), presenting skeletal class II division 1 malocclusion with maxillary constriction\n\nExclusion Criteria:\n\n* syndromic patients, previous ortho history, non-compliance, severe oral health issues (cavities, poor oral hygiene)",true,"ALL","8 Years","14 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least. But what if orthodontic treatment could help those patients to breathe better, with less effort? This research proposal aims to find out if the increase in the upper airway volume seen in some research results can be related to a decrease in respiratory effort and an improvement in the breathing capacity of those patients. In other words, if a tube shape is changed or if a tube is enlarged, would the airflow passing inside the tube change in velocity? Or would there be more air? Therefore, investigating the pressure\u002Fairflow, volume\u002Flumen relation and its possible changes after mandibular repositioning and maxillary expansion in children will lead to a better understanding of how orthodontics could potentially affect the upper airway. Previous studies have reported a link between mandibular advancement appliances and maxillary appliances to an increase in the upper airway volume. However, more studies are needed to evaluate the relationship between the changes in the upper airway volume and actual airflow and respiratory capability. The airway volume measurement is important to, preliminary, state if there is an increase in the upper airway after orthodontic treatment.\n\nHowever a change in shape, even with the same volume, can affect the pressure and airflow. In this sense, the pressure drop analysis will allow an answer to those questions",[28,29,30,31],"Apnea","Airway Obstruction, Nasal","Mandible Small","Maxillary Hypoplasia","RECRUITING","2026-03-16",{"date":35,"type":36},"2026-03-18","ACTUAL",{"date":38,"type":36},"2020-02-18",{"date":40,"type":22},"2027-03-01",{"name":42,"class":43},"University of Alberta","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100541633","hypoglossal-nerve-stimulation-therapy-in-patients-with-obstructive-sleep-apnea-belgian-registry-100541633","NCT06332404","Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry","Hypoglossal Nerve Stimulation (HNS) Therapy in Patients With Obstructive Sleep Apnea (OSA): Belgian Registry","B-HNS","Inclusion Criteria:\n\nAny patient implanted with or receiving the Inspire HNS system and who is able to give informed consent is eligible to participate in the registry. A patient is eligible for HNS implantation if he\u002Fshe meets the following criteria:\n\n* At least 18 years old at the time of implantation\n* The patient suffers from moderate to severe OSA (15 events\u002Fh ≤ AHI ≤ 65 events\u002Fh)\n* The patient has failed, not tolerated or has a contraindication for continuous positive airway pressure (CPAP) and\u002For mandibular advancement device (MAD) therapy\n* Absence of complete concentric collapse of the level of the soft palate during Drug-Induced Sleep Endoscopy (DISE)\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\>32 kg\u002Fm².\n* Combined mixed and central AHI is more than 25% of the total AHI\n* Patients with complete concentric collapse at the level of the soft palate or any other anatomical deviation that could impede the proper functioning of HNS\n* Patients with severely impaired neurological control over the upper airway\n* Pregnancy\n* Surgery performed on the soft palate in the past three months before implantation.","18 Years","99 Years",{"count":56,"type":22},225,"5 Years","OBSERVATIONAL","Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options. Recently, the request for reimbursement of the Inspire system in Belgium was approved.\n\nThe aim is to create a multi-center registry of OSA patients that are treated with HNS (Inspire system) within routine clinical care in Belgium.",[61,62,28],"Obstructive Sleep Apnea","Sleep Apnea",[64,65,66],"hypoglossal nerve stimulation","registry","routine clinical care","2025-09-12",{"date":69,"type":36},"2025-09-15",{"date":71,"type":36},"2024-04-18",{"date":73,"type":22},"2034-04",{"name":75,"class":43},"University Hospital, Antwerp",2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":85,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":44},"100559117","non-inferiority-analysis-of-two-titration-methods-for-hypoglossal-nerve-stimulation-therapy-100559117","NCT06559956","Non-inferiority Analysis of Two Titration Methods for Hypoglossal Nerve Stimulation Therapy","Non-inferiority Analysis of Daytime Versus Overnight Polysomnography for Hypoglossal Nerve Stimulation Titration in Obstructive Sleep Apnea","DOT-PSG","Inclusion Criteria:\n\n* Patients diagnosed with OSA and implanted with HNS therapy (Inspire system)\n* Cohort 1: Patients that previously underwent an overnight titration PSG as part of their routine clinical care at the Antwerp University Hospital\n* Cohort 2: Patients that recently underwent or will be undergoing a daytime titration PSG at the Antwerp University Hospital\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Not able to understand the language of the questionnaires",{"count":86,"type":22},110,"Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.\n\nApproximately 3 months after activation of HNS therapy, a fine-tuning sleep study is performed. To date, the standard of care involves an in-laboratory overnight titration PSG, which assesses the device settings and, if necessary, the stimulation strength will be adjusted based on observed respiratory events and\u002For snoring. Considering the growing patient population, the performance of these overnight titrations can become logistically challenging and labor-intensive. Recently, the feasibility of using a daytime PSG as an alternative to a conventional overnight PSG for titration of HNS therapy was demonstrated.\n\nThe aim of this study is to further investigate this technique by performing a non-inferiority analysis of daytime versus overnight PSG for titration of HNS therapy in patients with OSA.",[61,62,28],[64,90],"titration polysomnography","2025-09-08",{"date":93,"type":36},"2025-09-10",{"date":95,"type":36},"2024-08-27",{"date":97,"type":22},"2028-07",{"name":75,"class":43},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":106,"enrollmentInfo":107,"targetDuration":109,"studyType":58,"phases":4,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":44},"100602158","the-role-of-oxygen-reserve-index-ori-in-apneic-ventilation-100602158","NCT07119866","The Role of Oxygen Reserve Index (ORi) in Apneic Ventilation","The Role of Oxygen Reserve Index (ORi) Monitoring in Optimizing Apneic Ventilation for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* 18-60 years\n* ASA 1-2\n* Mallampati score \\\u003C2\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n\nExclusion Criteria:\n\n* \\\u003C18 and \\>60 years\n* ASA 3-4\n* Initial ORI value below 0.24","60 Years",{"count":108,"type":22},60,"1 Day","Background: The Oxygen Reserve Index (ORI) is a non-invasive parameter utilizing multi-wavelength pulse co-oximetry. ORI can provide early warnings of deteriorating oxygenation before changes are reflected in SpO₂ levels. This study aimed to investigate the feasibility of non-ventilated intubation in patients undergoing cholecystectomy as a means to achieve safe intubation without nasogastric tube placement, with reduced trauma and cost, and improved time efficiency.",[112,28,113,114],"Oxygen Reserve Index","Ventilation","Body Mass Index","NOT_YET_RECRUITING","2025-08-06",{"date":118,"type":36},"2025-08-13",{"date":120,"type":22},"2025-08-07",{"date":122,"type":22},"2025-08-30",{"name":124,"class":43},"Ankara City Hospital Bilkent",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":135,"briefSummary":136,"conditions":137,"keywords":138,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":44},"100566800","different-low-flow-rates-on-gas-exchange-in-children-during-apnea-100566800","NCT06659887","Different Low Flow Rates on Gas Exchange in Children During Apnea","Effect of Different Low Flow Rates on Gas Exchange in Anesthetized Children During Apnea A Single Blinded Randomized Study","Inclusion Criteria:\n\n* Children aged 1 to 6 years old weighting 10-20 kg.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Children will be scheduled for elective surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Parent refusal\n* Patient required nasal intubation\n* Children with a cardio-respiratory disease like asthma or recent upper respiratory infection.\n* Anemia.\n* Obstructive sleep apnea, sepsis.\n* Children prone to hypoxia or hypercarbia, and upper airway obstruction.\n* Children reported to have nasal obstruction .","1 Year","6 Years",{"count":108,"type":22},[25],"Effect of Low flow apneic oxygenation in pediatrics on rate of accumulation of transcutaneous carbon dioxide also, had been studied, compared to high flow rates. Furthermore, a recent study in apneic anesthetized adult discussed the rate of accumulation of carbon dioxide in arterial blood during 4 min of apnea but, no study in pediatrics discussed the effect of different low flow rates on rate of carbon dioxide accumulation during a period of apnea.\n\nAim of the study: the authors aim to study the effect of different flow rates of low flow oxygenation during 3 min of apnea in anesthetized children on the rate of accumulation of carbon dioxide",[28],[139,140,141],"Low flow rate","Children","Gas exchange","2024-11-18",{"date":144,"type":36},"2024-11-20",{"date":146,"type":36},"2024-10-01",{"date":148,"type":22},"2026-11-01",{"name":150,"class":43},"Yasser S Mostafa, MD",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":44},"100565157","effects-of-walking-apnea-at-high-lung-volume-on-hypoalgesia-100565157","NCT06638528","Effects of Walking Apnea At High Lung Volume on Hypoalgesia","Inclusion Criteria:\n\n* Asymptomatic subjects aged between 18 and 64 years.\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.\n\n  * History of epilepsy.\n  * Pregnant\n  * Pharmacological treatment.\n  * Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.","65 Years",{"count":108,"type":22},[25],"The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.",[162,163,164,28],"Pain","Hypoxemia","Hypercapnia","2024-10-09",{"date":167,"type":36},"2024-10-15",{"date":169,"type":22},"2024-11-01",{"date":171,"type":22},"2025-05-01",{"name":173,"class":43},"Universidad Rey Juan Carlos"]