[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"appendectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:appendectomy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,84,119,146,181,209,235],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100572913","hospital-based-continuous-patient-monitoring-system-100572913",false,"NCT06739447","Hospital Based Continuous Patient Monitoring System","Implementing a Hospital-based Continuous Patient Monitoring System Using Consumer Wearable Devices in Ghana","Inclusion Criteria:\n\n* Pediatric patients presenting with traumatic injury\n* Pediatric patients postoperative status after an appendectomy\n\nExclusion Criteria:\n\n* Pediatric patients missing their upper limbs,\n* Pediatric patients who cannot wear a Fitbit on their wrist for known allergies to rubber or those with traumatic or medical conditions that prevent them from being able to comfortably wear a Fitbit on either hand","ALL","3 Years","18 Years",{"count":20,"type":21},250,"ESTIMATED","INTERVENTIONAL",[24],"NA","In Ghana, and many other low and middle income countries in Africa, manual vital signs monitoring is the prevalent mode of vital signs monitoring because continuous bedside monitors are non-functional. This lack of continuous vital signs monitoring may result in missed opportunities to catch physiologic deterioration.\n\nThe investigators propose to develop a dashboard that is based on the Garmin Venu 3, a consumer wearable device that reliably measures heart rate, SPO2, and respiratory rate, as an alternative to bedside monitors in hospitals in Ghana.",[27,28,29,30],"Trauma","Appendectomy","Pediatric ALL","Vital Signs Monitoring",[32,33,34,35],"Garmin Venu 3","pediatric appendectomy","trauma","vital sign monitoring","NOT_YET_RECRUITING","2026-06-30",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":21},"2026-09-01",{"date":44,"type":21},"2030-01-30",{"name":46,"class":47},"University of Alabama at Birmingham","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":18,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":83},"100639547","quality-of-life-and-pain-after-appendectomy-in-children-100639547","NCT07629362","Quality of Life and Pain After Appendectomy in Children","Chronic Postoperative Pain After Appendectomy: A Prospective Observational Study","CAPA-Peds","Inclusion Criteria:\n\nChildren between the ages of 8-18 years who underwent appendectomy, who had ASA physical status I-II\n\nExclusion Criteria:\n\nChildren who aged under 8 and over 18 years, who had American Society of Anesthesiologists (ASA) physical status III or higher, who had a history of previous surgery in the right lower abdominal quadrant, who had psychiatric disorders, who had preoperative chronic abdominal pain",true,"8 Years",{"count":59,"type":21},231,"3 Months","OBSERVATIONAL","Acute appendicitis is one of the most common emergency general surgical conditions worldwide and represents the leading cause of emergency abdominal surgery in children. In some cases, appendectomy may result in persistent or recurrent pain in the right iliac fossa, which may negatively affect quality of life, particularly in children. The primary aim of this study is to determine the prevalence of chronic pain at the third postoperative month in pediatric patients who underwent appendectomy. The age, sex, body mass index, and comorbidities of patients aged 8-18 years who underwent appendectomy will be recorded. Pain in children who met the inclusion criteria was assessed using the Numeric Rating Scale (NRS). To evaluate the effects of pain on quality of life, the child and parent versions of the Pediatric Quality of Life Inventory (PedsQL) were administered at the third postoperative month. In addition, the Functional Disability Inventory (FDI) was used at the third postoperative month to assess the impact of pain on the patient's functional status.",[64,65,66,28,67],"Chronic Pain, Postoperative","Quality of Life","Functional Ability","Numerical Rating Scale",[69,70,71,72],"chronic pain","appendectomy","FDI","PedsQL","2026-06-04",{"date":75,"type":40},"2026-06-05",{"date":77,"type":21},"2026-07-01",{"date":79,"type":21},"2027-02-25",{"name":81,"class":82},"Kocaeli City Hospital","OTHER_GOV",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100546492","early-detection-of-infection-using-the-fitbit-in-pediatric-surgical-patients-100546492","NCT06395636","Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients","Using the Fitbit for Early Detection of Infection and Reduction of Healthcare Utilization After Discharge in Pediatric Surgical Patients","i-DETECT","Inclusion Criteria:\n\n* children aged 3-18 years\n* must be post-surgical laparoscopic appendectomy for complicated appendicitis (Appendicitis is categorized as complicated if perforation, phlegmon, or abscess was present at surgery.)\n\nExclusion Criteria:\n\n* children who are non-ambulatory or have any pre-existing mobility limitations\n* children who have a doctor-ordered physical activity limit \\>48 hours post-surgery\n* children who have a comorbidity which will impact a patient's recovery\n* children and\u002For parents who do not speak English or Spanish (Translation services beyond Spanish will not be available at this time)",{"count":93,"type":21},500,[24],"The purpose of this study is to analyze Fitbit data to predict infection after surgery for complicated appendicitis and the effect this prediction has on clinician decision making.",[28,97,98],"Appendicitis","Appendicitis Acute",[100,101,102,103,104,105,106,107],"consumer wearables","machine learning","ML","Fitbit","infection","detection","algorithm","prediction","RECRUITING","2026-05-11",{"date":111,"type":40},"2026-05-13",{"date":113,"type":40},"2025-01-07",{"date":115,"type":21},"2027-06-30",{"name":117,"class":47},"Ann & Robert H Lurie Children's Hospital of Chicago",4,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":83},"100599777","the-effectiveness-of-dexmedetomidine-as-an-adjuvant-for-bupivacaine-caudal-block-in-pediatric-open-appendectomy-under-general-anesthesia-100599777","NCT07088900","The Effectiveness of Dexmedetomidine as an Adjuvant for Bupivacaine Caudal Block in Pediatric Open Appendectomy Under General Anesthesia","inclusion criteria:\n\n* ASA (American Society of Anesthesiologists) physical status I or II.\n* Legal guardian provides written informed consent. Exclusion Criteria\n* Refusal of participation by the legal guardian.\n* Known allergy or hypersensitivity to local anesthetics or dexmedetomidine.\n* Coagulation disorder or receiving anticoagulant therapy.\n* Active infection at or near the injection site.\n* Significant anatomical abnormalities of the lumbosacral spine.\n* Pre-existing neurological disorders, psychiatric disorders, or a history of convulsions.\n* Anticipated surgery time of more than 2.5 hours.\n* Patients with severe asthma or active wheezing.","2 Years","7 Years",{"count":128,"type":21},60,[24],"This study aims to evaluate if adding dexmedetomidine to bupivacaine in a caudal block can provide longer and better quality pain relief for children after open appendectomy surgery. The study will also assess the effect of this combination on the quality of recovery, including the incidence of emergence delirium, and its overall safety profile.",[28,132],"Pediatric",[134,135,136],"caudal","dexmedetomidine","open appendectomy","2026-04-30",{"date":139,"type":40},"2026-05-06",{"date":141,"type":40},"2025-08-01",{"date":143,"type":21},"2026-07-30",{"name":145,"class":47},"Ain Shams University",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":159,"conditions":160,"keywords":168,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":179,"locationsCount":83},"100592679","phase-2-exploring-the-impact-of-genetic-variations-on-the-clinical-efficacy-of-nalbuphine-in-postoperative-pain-management-100592679","NCT06996561","Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management","Nal","Inclusion Criteria:\n\n1. All adult men or women\n2. Age 18 to 70 years\n3. ASA criteria 1,2 and 3\n4. Abdomino-pelvic surgeries (open hernia repair, appendicectomy, open cholecystectomy, laparotomy, hysterectomy, cystectomy) lasting 2-4 hours\n\nExclusion Criteria:\n\n1. Surgical procedure duration lasting more than 4 hours\n2. Patients taking anti fungal fluconazole, anticoagulant (Warfarin or Clopidogrel) SNRI (Amitryptalline), Rifampicin or Buprenorphine,\n3. History of hypersensitivity or allergy to opioids,\n4. Pregnant or breastfeeding mothers,\n5. History of narcotic dependency, addiction, and withdrawal\n6. Patients experiencing any adverse side effects or complications during surgical procedure requiring intensive care admission\n7. Refusing to participate in the study\n8. Surgical procedures utilizing other modes of intraoperative analgesia e.g epidural analgesia or nerve blocks","70 Years",{"count":155,"type":21},263,[157,158],"PHASE2","PHASE3","The goal of this study is to identify the genes as well as their association with Nalbuphine. This will help the investigator to identify opioid vulnerability in Pakistani population in the postoperative patients and will contribute to overcoming the opioid crisis, resulting in better and safer outcomes.\n\nResearch question is:\n\nIs there any association between the underlying genetic variations and the analgesic efficacy of Nalbuphine in postoperative patients? The Research Objectives are\n\n1. To identify the underlying genes in postoperative patients having pain.\n2. To find an association between identified genes and nalbuphine clinical efficacy.\n\nProcedure: After the written informed consent adult men and women will be enrolled in the study. On the day of surgery in the preoperative area, a 5 ml blood sample will be drawn before surgery and will be sent to laboratory for analysis. After routine hemodynamic monitoring in the operative room, general anesthesia will be given including nalbuphine. Standard routine anesthesia monitoring will be done and maintained while monitoring heart rate, ECG, NIBP oxygen saturation, ETCO2 and temperature. Incremental analgesia will be provided whenever needed. After extubation and shifting to recovery room the 2nd sample of blood will be taken and will be sent for analysis. Pain score, nausea vomiting, sedation, requirement of analgesia will be assessed till 24 hours postoperatively.",[161,162,28,163,164,165,166,167],"Cholecystectomy","Hernia, Abdominal","Open Colorectal Surgery","Laparatomy","Postoperative Pain","Hysterectomy","Cystectomy",[169,170,171,172],"genetic variations","nalbuphine","opioids","polymorphism","2026-04-14",{"date":175,"type":40},"2026-04-15",{"date":177,"type":40},"2025-09-01",{"date":115,"type":21},{"name":180,"class":47},"Dr. Asma Abdus Salam",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":192,"conditions":193,"keywords":194,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":83},"100445039","re-assessment-of-appendicitis-evaluation-during-laparoscopic-appendectomy-peritoneal-irrigation-during-laparoscopic-appendectomy-does-the-grade-of-contamination-matter-100445039","NCT05075252","Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?","REsiDENT1 (Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy: Do we End a Non-standardized Treatment Approach and Habit?): Peritoneal Irrigation During Laparoscopic Appendectomy-Does the Grade of Contamination Matter? A Prospective Multicenter Resident-based Evaluation of a New Classification System","RESIDENT1","Inclusion Criteria:\n\n* Patients between 18 and 69 years old\n* Surgical laparoscopic approach for AA\n* Intra-operative and histological diagnosis of AA\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years old or \\> 69 years old\n* Previous appendectomy\n* Previous appendicitis treated conservatively\n* Open approach for surgery or intra-operative conversion\n* Co-existence of other intra-abdominal infections (IAI)\n* Patients with immunodeficiency\n* Patients treated with steroid, immunosuppressant, or CHT within previous 6 months","69 Years",{"count":191,"type":21},1067,"Type: prospective observational multicenter trial. Population of interest: adult patients undergoing laparoscopic appendectomy for acute appendicitis.\n\nHypothesis : laparoscopic lavage during laparoscopic appendectomy is a practice that should be used in selected patients according to the intraperitoneal grade of contamination and grade of appendicitis. Nonregulated use of laparoscopic lavage cannot be considered superior to suction only considering recent evidence. Few RCT available addressing this issue are available, but any with a high methodological quality.\n\nAim: The aim of this study is to investigate the impact of laparoscopic lavage during laparoscopic appendectomy on the postoperative incidence of intrabdominal abscesses, stratifying patients in different clusters according to a defined classification considering the intraperitoneal contamination and grade of appendicitis.",[97,28],[195,196,70,197,198,199],"laparoscopy","appendicitis","lavage","suction","abscess","2026-04-13",{"date":202,"type":40},"2026-04-16",{"date":204,"type":40},"2019-10-01",{"date":206,"type":21},"2027-09-30",{"name":208,"class":47},"Niguarda Hospital",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":16,"minAge":215,"maxAge":216,"enrollmentInfo":217,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":220,"conditions":221,"keywords":222,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":83},"100625962","phase-1-comparison-of-clinical-outcomes-of-intraperitoneal-bupivacaine-instillation-versus-placebo-as-preemptive-analgesia-in-patients-undergoing-open-appendectomy-100625962","NCT07429448","Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy","Inclusion Criteria:\n\n* Patients presenting to the emergency department undergoing open appendectomy.\n\nExclusion Criteria:\n\n* Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness\u002F fever) and USG findings (presence of abscess, fluid collection, or free air).\n* Uncontrolled medical disease (DM: BSL \\>200mg\u002Fdl, HTN: BP \\>140\u002F90)\n* History of chronic kidney or liver disease\u002F psychiatric illness\u002F Active peptic ulcer disease (as determined on history and medical records)\n* Alcoholics\n* History of chronic pain or patients on analgesic medications\n* Pregnant females\n* History of allergy to bupivacaine\u002F ketorolac as determined on history\n* Children, Adolescents and patients with mental illness.","20 Years","60 Years",{"count":128,"type":21},[219],"PHASE1","To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy",[28],[223,224,225],"Analgesia","Bupivacaine","Open Appendectomy","2026-02-17",{"date":228,"type":40},"2026-02-24",{"date":230,"type":40},"2025-12-16",{"date":232,"type":21},"2026-06-16",{"name":234,"class":82},"Sardar Umer Rehman",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":242,"targetDuration":244,"studyType":61,"phases":4,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":258},"100575570","a-global-prospective-cohort-study-on-outcomes-of-appendicectomy-for-appendicitis-100575570","NCT06774001","A Global Prospective Cohort Study on Outcomes of Appendicectomy for Appendicitis","AlliGatOr","Inclusion Criteria:\n\n* Age: There are no age restrictions, although, if appropriate participating hospitals can choose to only include children or only adults, based on an age cut-off of their choice.\n* Procedure: All patients undergoing appendicectomy for suspected or confirmed appendicitis by any surgical approach should be included. This includes patients who went theatre with suspect appendicitis even if the intraoperative or pathology results found a different diagnosis, so long as an appendicectomy was performed. It also includes patients who went to theatre for reasons other than suspected appendicitis but were found to have appendicitis intraoperatively and underwent appendicectomy. This includes interval appendicectomy and right hemicolectomy if performed for acute appendicitis.\n* Approach: Both open and minimally invasive (laparoscopic and robotic) interventions are eligible for inclusion. Laparoscopic and robotic converted to open cases are also eligible.\n\nExclusion Criteria:\n\n* Indication: Appendicectomy for any indication other than suspected or confirmed appendicitis should be excluded. For example, patients having appendicectomy for known appendiceal neoplasm.\n* Procedure: Patients having appendectomy as part of another surgical procedure should be excluded. For example, patients having removal of appendix as part of a colon cancer procedure are not eligible for inclusion.\n* Approach: Natural orifice surgery and endoscopic treatment for suspected appendicitis are excluded.\n* Previous appendicectomy: Patients having surgery for stump appendicitis are excluded.\n* Return to theatre: Patients should be entered into study only once. A patient returning to theatre after appendectomy should not be re-entered as a new patient.",{"count":243,"type":21},14000,"30 Days","This study aims to assess and improve the global management of appendicitis, the most common emergency surgery, by examining various aspects of emergency care systems worldwide. Appendicitis is a time-sensitive condition, and delays in diagnosis or treatment can lead to complications, affecting patient outcomes and increasing healthcare costs. The study uses appendicitis as a \"tracer condition\" to explore how different healthcare systems manage emergency care, focusing on factors like access, quality, and efficiency. By gathering data from hospitals worldwide, the study seeks to identify areas where emergency surgical care can be improved, particularly in low- and middle-income countries (LMICs).\n\nThe main goal is to identify gaps in emergency care systems, using a set of key performance measures (KPMs) that assess access to care, the quality of surgical treatment, and patient safety. These include factors like the time from symptom onset to first surgical assessment, the rate of appendectomy performed via minimally invasive (laparoscopic) surgery, and postoperative complications. The study aims to collect data on at least 14,000 patients from around 500 hospitals globally between February and May 2025. The data will be analyzed by hospital income group (from low to high) to understand how different resource levels impact outcomes and to help guide future policy and practice improvements.\n\nThe study also includes two sub-studies that focus on specific issues in surgical care. The Sustainability and Waste Management sub-study aims to explore how hospitals manage waste and sustainability practices in operating theatres. This sub-study is part of global efforts to reduce carbon emissions in healthcare settings. The Financing sub-study examines the financial burden of appendicectomy, particularly the out-of-pocket costs for patients in LMICs. It will explore how the costs of open vs. laparoscopic surgery differ and investigate the impact of these costs on patients.\n\nBy combining global data on clinical outcomes with information on hospital resources and patient finances, this study hopes to provide valuable insights into how to improve emergency surgical care across diverse settings, making recommendations that can lead to better access to safe, timely, and affordable treatment for appendicitis worldwide.",[97,28],[248,97,28],"Appendicectomy","2025-03-27",{"date":251,"type":40},"2025-04-02",{"date":253,"type":40},"2025-02-03",{"date":255,"type":21},"2025-12",{"name":257,"class":47},"University of Birmingham",7]