[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"appendicitis-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:appendicitis-acute":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,84,118,151,175,199,224,237,269,296],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100054028","the-impact-of-a-diagnostic-strategy-for-acute-appendicitis-in-children-with-acute-abdominal-pain-in-primary-care-100054028",false,"NCT06762275","The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care","Optimizing Management of Children Presenting With Acute Abdominal Pain in Primary Care: a Cluster Randomized Controlled Trial Evaluating the Impact of a Clinical Prediction Rule Including C-reactive Protein for Appendicitis","ISAAK","Inclusion criteria:\n\n\\- Children aged 4 to 18 years with acute abdominal pain (onset ≤ 7 days) who present at the GP.\n\nExclusion criteria:\n\n* A history of appendectomy\n* Current pregnancy\n* Traumatic cause of abdominal pain","ALL","4 Years","18 Years",{"count":21,"type":22},566,"ESTIMATED","INTERVENTIONAL",[25],"NA","BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g. constipation and gastroenteritis), resulting in missing 19% of children with AA at first presentation in primary care and 70% of non-AA cases among referrals.\n\nOBJECTIVE To evaluate the impact of the use of a diagnostic strategy for acute appendicitis (AA), which consists of a clinical prediction rule (cPR) including C-reactive protein point-of-care test (CRP POCT), on referral efficiency in children with acute abdominal pain in primary care, as compared to usual care.\n\nSTUDY DESIGN This is a cluster randomized controlled trial in primary care with a process evaluation. GPs in the intervention group will use an externally validated cPR based on symptoms and signs selectively followed by a CRP POCT in the medium risk group. GPs from general practices allocated to the control group will provide care and diagnosis as usual, i.e. following recommendations of the Dutch College of GPs guideline 'abdominal pain in children'.\n\nSTUDY POPULATION Children aged 4 to 18 years presenting to their general practitioner (GP) with acute abdominal pain.\n\nOUTCOME MEASURES Primary outcome: referral efficiency (proportion non-referrals in non-AA patients during 30 days follow-up).\n\nSecondary outcomes: safety (proportion of referrals in AA patients during the first consultation or planned reassessment), proportion of children with CRP-POCT, proportion of children with planned reassessment, child anxiety, parent or child satisfaction, quality of life, and costs.",[28,29],"Appendicitis Acute","Acute Abdomen in Children",[31,32,33,34,35],"General practitioner","Appendicitis","Clinical prediction rule","C-reactive protein","Children","RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2025-03-06",{"date":44,"type":22},"2029-03-01",{"name":46,"class":47},"University Medical Center Groningen","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":19,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100645133","effect-of-endotracheal-tube-cuff-pressure-management-on-postoperative-sore-throat-in-pediatric-laparoscopic-appendectomy-100645133","NCT07678086","Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy","The Effect of Intraoperative Endotracheal Tube Cuff Pressure on Postoperative Sore Throat in Pediatric Patients Undergoing Laparoscopic Appendectomy: A Prospective Randomized Controlled Trial.","Inclusion Criteria:\n\n* Pediatric patients aged 6-18 years\n* Patients with ASA physical status classification I-III\n* Patients scheduled for laparoscopic appendectomy\n* Voluntary written informed consent from the patient's legal guardian\u002Fparent after being informed in detail about the purpose and method of the study..\n\nExclusion Criteria:\n\n* Patients under 6 years of age\n* Patients with ASA IV or higher\n* Patients with preoperative sore throat\n* Patients who have not completed the preoperative fasting period\n* Patients who received intraoperative nasogastric tube\n* Patients who received intraoperative N₂O\n* Patients with complicated appendicitis diagnosis\n* Patients who underwent two or more intubation attempts\n* Patients with surgery duration longer than 2 hours\n* Patients with predicted or likely airway difficulties\n* Patients who underwent conversion from intraoperative laparoscopy to laparotomy\n* Presence of tracheal pathology\n* Congenital anomalies affecting the airway\n* Presence of known upper\u002Flower respiratory tract disease\n* Patients requiring planned postoperative mechanical ventilation\n* Patients in shock\n* Patients with decompensated heart failure or respiratory failure\n* Patient or legal representative's refusal to participate in the study\n* Patients with a history of smoking","6 Years",{"count":58,"type":22},60,[25],"Abstract Objective:\n\nThe aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed surgery for appendicitis). The goal is to see if maintaining the pressure in this cushion within a safe, specific range (15-18 mmHg) helps prevent or reduce sore throat, hoarseness, and discomfort, which are common postoperative complications in children.\n\nStudy Design:\n\nThis is a prospective, randomized, controlled study. Sixty children aged 6 to 18 years scheduled for laparoscopic appendectomy will be included. Participants will be randomly assigned to two equal groups: Group A (Control Group): Breathing tube cuff pressure is adjusted using the standard \"feeling\" (finger palpation) method common in routine practice. Group B (Intervention Group): Breathing tube cuff pressure is measured throughout the surgery using a medical pressure sensor (manometer) and maintained within a safe range (15-18 mmHg). Research Questions: Does actively monitoring airway pressure reduce the number of children experiencing postoperative sore throat? Does this method reduce the severity of sore throat, cough, hoarseness, or other respiratory discomfort compared to the standard method? What will happen?\n\nDuring surgery, respiratory and heart rate measurements will be recorded every 15 minutes for all participants. After surgery, researchers will visit participants (and their parents) at 2, 6, and 24 hours postoperatively to assess the presence of sore throat, discomfort, or hoarseness. No additional medications or invasive procedures will be used for this study; only how we manage airway pressure will be compared.",[28,62,63,64],"Postoperative Sore Throat, Cough, Hoarseness","Airway Complications","Respiratory Complications",[66,67,68,69,70,71,72],"Endotracheal tube cuff pressure","Post-anesthetic complications","Pressure transducer","Laparoscopic appendectomy","Pediatric anesthesia","Airway management","postoperative sore throat","NOT_YET_RECRUITING","2026-06-28",{"date":76,"type":40},"2026-07-01",{"date":78,"type":22},"2026-06-30",{"date":80,"type":22},"2026-08-25",{"name":82,"class":83},"Ankara Etlik City Hospital","OTHER_GOV",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":92,"maxAge":19,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100546492","early-detection-of-infection-using-the-fitbit-in-pediatric-surgical-patients-100546492","NCT06395636","Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients","Using the Fitbit for Early Detection of Infection and Reduction of Healthcare Utilization After Discharge in Pediatric Surgical Patients","i-DETECT","Inclusion Criteria:\n\n* children aged 3-18 years\n* must be post-surgical laparoscopic appendectomy for complicated appendicitis (Appendicitis is categorized as complicated if perforation, phlegmon, or abscess was present at surgery.)\n\nExclusion Criteria:\n\n* children who are non-ambulatory or have any pre-existing mobility limitations\n* children who have a doctor-ordered physical activity limit \\>48 hours post-surgery\n* children who have a comorbidity which will impact a patient's recovery\n* children and\u002For parents who do not speak English or Spanish (Translation services beyond Spanish will not be available at this time)","3 Years",{"count":94,"type":22},500,[25],"The purpose of this study is to analyze Fitbit data to predict infection after surgery for complicated appendicitis and the effect this prediction has on clinician decision making.",[98,32,28],"Appendectomy",[100,101,102,103,104,105,106,107],"consumer wearables","machine learning","ML","Fitbit","infection","detection","algorithm","prediction","2026-05-11",{"date":110,"type":40},"2026-05-13",{"date":112,"type":40},"2025-01-07",{"date":114,"type":22},"2027-06-30",{"name":116,"class":47},"Ann & Robert H Lurie Children's Hospital of Chicago",4,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":126,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":130,"phases":4,"briefSummary":131,"conditions":132,"keywords":137,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":48},"100637870","diagnosis-of-abdominal-pain-using-rna-levels-the-natural-study-100637870","NCT07579312","Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study","Neutrophil Activation Test Using RNA Levels to Assist in the Diagnosis of Abdominal Pain: The NATURAL Study","NATURAL","Inclusion Criteria:\n\nAge \\> 7 yr old Abdominal pain of likely non-traumatic origin Risk of intra-abdominal infection (see IAI signs) Ability to provide informed consent\u002Fassent Potential to order abdominal CT, ultrasound, endoscopy, or surgery for possible IAI\n\nExclusion Criteria:\n\nAny situation where delay could be detrimental Hemodynamically unstable (see age-adjusted criteria) Prisoner or other involuntary detainee Inability to provide informed consent\u002Fassent",true,"7 Years",{"count":129,"type":22},1000,"OBSERVATIONAL","The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.\n\nSummary of Research Study:\n\nHypothesis: A genomic-derived panel of 6 RNA biomarkers present in stabilized whole blood will provide diagnostic information about the presence of bacterial, biofilm, and viral infections in the abdomen. We hypothesize that biomarkers will be more than 90% sensitive with a high (\\>90%) negative predictive value for IAI.\n\nResearch Design: The project design is a prospective, pragmatic, observational study. The NATURAL Study will be sponsored by True Bearing Diagnostics, Inc., and performed at 5 or more academic medical centers. Patients with suspected intra-abdominal infections (IAIs), such as appendicitis, diverticulitis, acute cholecystitis, pancreatitis, peritonitis, pyelonephritis, and abscess are candidates for this study. This is a broad category of patients that are defined by the suspicion of an internal abdominal infection, usually involving some type of advanced imaging analysis, such as CT scan or ultrasound. All participants will be consented for this observational, minimal-risk study prior to venipuncture. Ultimately, The NATURAL Study will determine the positive agreement (\\~sensitivity) and negative agreement (\\~specificity) of the TruNAV RNA biomarkers in relation to the clinical diagnosis of the presence or absence of an IAI, based on CT scans and\u002For surgical confirmation, the current standard of care for diagnosis of IAI.\n\nObjective: To validate a novel RNA fingerprint in ED patients with suspected IAIs.\n\nThe NATURAL Study is designed to determine the accuracy of novel RNA biomarkers for diagnosis of IAI in patients suspected of having IAI. Subgroup analysis will analyse RNA biomarker for multiple types of actual and suspected IAIs (appendicitis, diverticulitis, acute cholecystitis, pancreatitis, peritonitis, pyelonephritis, and abscess.)\n\nSubjects: Approximately 1,000 ED patients presenting with abdominal pain that are candidates to receive CT or other confirmatory diagnostics will be enrolled.",[133,28,134,135,136],"Intra Abdominal Infections","Pyelonephritis","Diverticulitis","Epiploic Appendagitis",[133,138,32,134,135,139,140],"Biomarkers","Epiploic appendagitis","Gastroenteritis","2026-05-06",{"date":143,"type":40},"2026-05-12",{"date":145,"type":40},"2026-04-17",{"date":147,"type":22},"2027-09",{"name":149,"class":150},"True Bearing Diagnostics, Inc.","INDUSTRY",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":159,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":48},"100633075","out-patiente-management-for-gangrenous-acute-appendicitis-the-pendi-csi-ii-randomized-clinical-trial-100633075","NCT07521969","Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.","Safety, Efficacy, and Cost-effectiveness of Outpatient Surgery for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.","PENDI-CSI II","Inclusion Criteria:\n\n* Acute gangrenous appendicitis confirmed during surgery.\n* Patient who meets the criteria to be discharged on an outpatient basis\n* Signature of informed consent.\n* Older than 14 years of age\n\nExclusion Criteria:\n\n* \\- Uncomplicated appendectomy.\n* Intra-operative purulent or faecaloid peritonitis\n* Appendicular abscess or plastron diagnosed by imaging.\n* Paralytic ileus preventing oral tolerance.\n* Need for placement of abdominal drainage.\n* ASA IV and some selected ASA III.\n* Immunosuppression.\n* Patients with active neoplasia.\n* Pregnancy.\n* Doubts in the definitive diagnosis.\n* Suspicion of inflammatory bowel disease.\n* No family support.\n* Failure to sign the informed consent form.\n* Impossibility to comply with the follow-up.","14 Years",{"count":161,"type":22},122,[25],"PHASE II-III CLINICAL TRIAL TO EVALUATE THE SAFETY, EFFECTIVENESS AND EFFICIENCY OF DISCHARGE TO OUTPATIENT SURGERY IN PATIENTS WITH ACUTE GANGRENOUS APPENDICITIS UNDERGOING EMERGENCY SURGERY.",[28,165],"Gangrenous Appendicitis","2026-04-16",{"date":168,"type":40},"2026-04-21",{"date":170,"type":40},"2025-11-01",{"date":172,"type":22},"2027-11-01",{"name":174,"class":47},"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":126,"sex":17,"minAge":19,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":130,"phases":4,"briefSummary":185,"conditions":186,"keywords":187,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":48},"100629696","clinical-study-of-peg-bowel-preparation-in-appendectomy-patients-100629696","NCT07478029","Clinical Study of PEG Bowel Preparation in Appendectomy Patients","Impact of Polyethylene Glycol (PEG) Bowel Preparation on Intestinal Microbiota Composition and Diversity in Patients Undergoing Appendectomy","Inclusion Criteria:\n\n* Aged 18-75 years.\n* Scheduled to undergo colonoscopy.\n* Generally healthy without major organ diseases.\n\n  1. For appendectomy group: history of appendectomy or right hemicolectomy (including appendectomy).\n  2. For control group: no history of appendectomy or right hemicolectomy.\n\nExclusion Criteria:\n\n* Allergy or intolerance to PEG laxatives.\n* Pregnant or lactating women.\n* Mental disorders.\n* Use of antibiotics within 6 months prior to study enrollment.\n\n  1. Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency).\n  2. For control group only: presence of organic diseases.","75 Years",{"count":184,"type":22},10,"Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol (PEG2000 - 4000) is often used as laxative and lubricant in colonoscopy. However, the widespread use of PEG may cause long-term and irreversible damage to intestinal microorganisms and bring great hidden dangers to health. The appendix has long been regarded as a redundant organ in evolution. The incidence of appendicitis ranks first in surgical acute abdomen. Traditionally, once acute appendicitis is diagnosed, it is usually treated with appendectomy. However, recent studies have revealed that appendectomy may be associated with psychiatric diseases, colorectal cancer, cardiovascular diseases and other diseases. The appendix is not only an important organ of the immune system, but also undertakes the function of storing and protecting intestinal microbes.. . This change may affect the function of the central nervous system through the microbe gut brain axis, and then pose a potential threat to the health and behavior of the host, such as increasing the risk of diseases such as Parkinson's disease. Based on this, this clinical trial aims to investigate (1) the changes of intestinal flora in the appendectomy population before and after colonoscopy in the process of polyethylene glycol intestinal preparation; (2) the differences between the changes of intestinal flora before and after colonoscopy in the appendicectomy population and the normal population in the process of flora recovery.",[32,28],[188,189],"Bowel Preparation with Polyethylene Glycol (PEG) Laxatives","Gut microbiota","2026-03-13",{"date":192,"type":40},"2026-03-17",{"date":194,"type":40},"2024-02-23",{"date":196,"type":22},"2027-03-18",{"name":198,"class":47},"Huaping Xie",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":4},"100627965","first-appendectomy-using-revolve-surgical-robotic-arm-100627965","NCT07455487","First Appendectomy Using Revolve Surgical Robotic Arm","Inclusion Criteria:\n\n* Inpatients at Unity Health Toronto - St. Michael's Hospital scheduled for an elective appendectomy\n* Ages of 21-40 years old\n* Male and non-pregnant female patients (pregnancy test required)\n* No co-morbidities\n* Body Mass Index (BMI) between 18.5 and 25kg\u002Fm2\n* On no medications\n* Not taking any recreational drugs\n* Uncomplicated acute appendicitis (confirmed through abdominal ultrasound or abdominal computed tomography (CT) scan)\n* The pre-operative white blood cell count (WBC) must be between 4,500 - 15,000 cells per microliter.\n\nExclusion Criteria:\n\n* Any patient who does not have all the inclusion criteria described above.\n* Imaging of perforated appendix, free air, phlegmon, abscess, fluid collection, other any abdominal disease.\n* Any other abnormal laboratory test performed pre-operatively will cause the exclusion of the patient from the study.","21 Years","40 Years",{"count":208,"type":22},3,[25],"This study is testing a new surgical device called the Revolve Surgical System (RSS) during appendix removal surgery. The RSS is designed to help surgeons perform minimally invasive surgery with improved precision and stability while working at the patient's bedside, similar to standard laparoscopic surgery but with robotic assistance.\n\nThis will be the first time the device is used in patients. It will be evaluated in three adults with uncomplicated appendicitis who are already scheduled to have an appendectomy. The purpose of the study is to assess whether the device can be used safely and effectively and to better understand how it performs during surgery.",[28],[213,32,214],"Robotics","Laparoscopy","2026-03-02",{"date":217,"type":40},"2026-03-06",{"date":219,"type":22},"2026-04-01",{"date":221,"type":22},"2027-01-01",{"name":223,"class":47},"Unity Health Toronto",{"id":225,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":226,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":236,"locationsCount":48},"100574668",{"count":21,"type":22},[25],"BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g. constipation and gastroenteritis), resulting in missing 19% of children with AA at first presentation in primary care and 70% of non-AA cases among referrals.\n\nOBJECTIVE To evaluate the impact of the use of a diagnostic strategy for acute appendicitis (AA), which consists of a clinical prediction rule (cPR) including C-reactive protein point-of-care test (CRP POCT), on referral efficiency in children with acute abdominal pain in primary care, as compared to usual care.\n\nSTUDY DESIGN This is a cluster randomized controlled trial in primary care with a process evaluation. GPs in the intervention group will use an externally validated cPR based on symptoms and signs selectively followed by a CRP POCT in the medium risk group. GPs from general practices allocated to the control group will provide care and diagnosis as usual, i.e. following recommendations of the Dutch College of GPs guideline 'abdominal pain in children'.\n\nSTUDY POPULATION Children aged 4 to 18 years presenting to their general practitioner (GP) with acute abdominal pain.\n\nOUTCOME MEASURES Primary outcome: referral efficiency (proportion non-referrals in non-AA patients during 30 days follow-up).\n\nSecondary outcomes: safety (proportion of referrals in AA patients during the first consultation), proportion of children with CRP-POCT, proportion of children with planned reassessment, child anxiety, parent or child satisfaction, quality of life, and costs.",[28,29],[31,32,33,34,35],"2025-11-20",{"date":233,"type":40},"2025-11-26",{"date":42,"type":40},{"date":44,"type":22},{"name":46,"class":47},{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":130,"phases":4,"briefSummary":246,"conditions":247,"keywords":253,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":48},"100578786","prevention-of-postoperative-hernias-in-emergency-surgery-100578786","NCT06815822","Prevention of Postoperative Hernias in Emergency Surgery","PROPHECY","Inclusion criteria:\n\n* Patient age \\> 18 years.\n* Emergency or urgent surgery.\n* Specific surgical indications (acute appendicitis, acute cholecystitis, incarcerated hernia, gastrointestinal perforation, and obstruction).\n\nExclusion criteria:\n\n* Lack of patient consent.\n* Open abdomen technique applied.","100 Years",{"count":94,"type":22},"The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery. The main question it aims to answer is:\n\nWhat is the incidence of postoperative hernias in this group of patients?\n\nA brief telephone interview will be conducted with participants who will be included in this study one year after the surgery. If the presence of a postoperative hernia is suspected, the patient will be invited to a follow-up visit to the surgical clinic, where the diagnosis will be confirmed by imaging tests.",[248,28,249,250,251,252],"Incarcerated Hernia","Cholecystitis, Acute","Ileus","Perforated Gastro-duodenal Ulcers","Perforated Bowel",[254,255,256,257,258,259],"postoperative hernia","trocar site hernia","parastomal hernia","incisional hernia","outcomes","emergency surgery","2025-06-12",{"date":262,"type":40},"2025-06-15",{"date":264,"type":40},"2025-06-01",{"date":266,"type":22},"2026-12-31",{"name":268,"class":47},"Jan Kochanowski University",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":17,"minAge":276,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":283,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":48},"100506767","low-dose-contrast-media-for-low-kvp-abdomen-ct-100506767","NCT05878665","Low-dose Contrast Media for Low-kVp Abdomen CT","Optimizing Low-dose Contrast Media Protocol for Low-kVp Abdominopelvic CT in Suspected Acute Appendicitis","Inclusion criteria:\n\n* Patients in the emergency department with suspected acute appendicitis based on clinical examination\n* Patients scheduled for contrast-enhanced CT of the abdomen and pelvis for diagnosis of suspected acute appendicitis.\n\nExclusion criteria:\n\n* Patients who decline to participate\n* Contraindications to contrast-enhanced CT (eGFR \\\u003C 30 mL\u002Fmin\u002F173 m\\^2 or pregnant)\n* BMI \\>= 30.","19 Years","44 Years",{"count":279,"type":22},292,[25],"The purpose of this clinical study is to test the performance of low radiation dose abdominal CT combined with low dose contrast media for the diagnosis of acute appendicitis in young patients. The main questions to be answered are:\n\n1, Can low-dose contrast media paired with low-dose radiation CT of the abdomen provide acceptable diagnostic accuracy in acute appendicitis? 2. How much radiation dose can be saved by using low radiation dose abdominal CT in combination with low dose contrast media?",[28],[284,285,286],"acute appendicitis","acute abdomen","CT","2025-05-21",{"date":289,"type":40},"2025-05-28",{"date":291,"type":40},"2023-12-21",{"date":293,"type":22},"2025-12-31",{"name":295,"class":47},"Bohyun Kim",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":23,"phases":305,"briefSummary":306,"conditions":307,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":48},"100588950","enhanced-recovery-after-surgery-eras-for-complicated-appendicitis-100588950","NCT06948071","Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis","Enhanced Recovery Protocol for Acute, Complicated Appendicitis After Laparoscopic Appendectomy: An Exploratory Pilot Study","Inclusion Criteria:\n\n* Individuals between the ages of 18 and 65 years of age.\n* Patients undergoing a laparoscopic appendectomy.\n* Diagnosis of complicated appendicitis based on pre-operative imaging or intra-operative assessment. The definition of a complicated appendicitis will include: (a) perforated appendicitis, without generalized peritonitis; (b) gangrenous appendicitis, without generalized peritonitis; (c) suppurative appendicitis; (d) iatrogenic perforation of the appendix.\n* Meet criteria for discharge from the post-anesthesia care unit (PACU).\n* Ability to reliably follow up with the study procedures.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 65 years.\n* Pregnancy.\n* Homelessness.\n* Patients who present with generalized peritonitis.\n* Patients with comorbid conditions, including diabetes mellitus, immunosuppressed state for any reason, patients on chronic anticoagulation (excluding Aspirin 81 mg).\n* Patients who present with septic shock.\n* Patients who require conversion to an open appendectomy.\n* Patients who present with additional findings on imaging studies or intra-operatively, including ileus or small bowel obstruction.\n* Based on surgeon's clinical judgment for reasons that may not be outlined above.\n* Allergy or intolerance to study medication(s)",{"count":304,"type":22},20,[25],"The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days following a laparoscopic appendectomy for complicated appendicitis. Feasibility will be determined by high compliance and adherence of patients to the postoperative instructions, while safety will be assessed by the incidence of postoperative infectious complications and requirement for re-admission.",[28,308,309,310,311],"Appendicitis Perforated","Appendicitis With Perforation","Appendicitis Suppurative","Appendicitis Gangrenous","2025-04-22",{"date":314,"type":40},"2025-04-29",{"date":316,"type":22},"2025-04-21",{"date":318,"type":22},"2026-02-28",{"name":320,"class":47},"Cedars-Sinai Medical Center"]