[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"appendicitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:appendicitis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,53,84,108,133,153,174,198,222,246,269,297,327],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100546492","early-detection-of-infection-using-the-fitbit-in-pediatric-surgical-patients-100546492",false,"NCT06395636","Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients","Using the Fitbit for Early Detection of Infection and Reduction of Healthcare Utilization After Discharge in Pediatric Surgical Patients","i-DETECT","Inclusion Criteria:\n\n* children aged 3-18 years\n* must be post-surgical laparoscopic appendectomy for complicated appendicitis (Appendicitis is categorized as complicated if perforation, phlegmon, or abscess was present at surgery.)\n\nExclusion Criteria:\n\n* children who are non-ambulatory or have any pre-existing mobility limitations\n* children who have a doctor-ordered physical activity limit \\>48 hours post-surgery\n* children who have a comorbidity which will impact a patient's recovery\n* children and\u002For parents who do not speak English or Spanish (Translation services beyond Spanish will not be available at this time)","ALL","3 Years","18 Years",{"count":21,"type":22},500,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to analyze Fitbit data to predict infection after surgery for complicated appendicitis and the effect this prediction has on clinician decision making.",[28,29,30],"Appendectomy","Appendicitis","Appendicitis Acute",[32,33,34,35,36,37,38,39],"consumer wearables","machine learning","ML","Fitbit","infection","detection","algorithm","prediction","RECRUITING","2026-05-11",{"date":43,"type":44},"2026-05-13","ACTUAL",{"date":46,"type":44},"2025-01-07",{"date":48,"type":22},"2027-06-30",{"name":50,"class":51},"Ann & Robert H Lurie Children's Hospital of Chicago","OTHER",4,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100445039","re-assessment-of-appendicitis-evaluation-during-laparoscopic-appendectomy-peritoneal-irrigation-during-laparoscopic-appendectomy-does-the-grade-of-contamination-matter-100445039","NCT05075252","Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy, Peritoneal Irrigation During Laparoscopic Appendectomy Does the Grade of Contamination Matter?","REsiDENT1 (Re-assessment of Appendicitis Evaluation During Laparoscopic Appendectomy: Do we End a Non-standardized Treatment Approach and Habit?): Peritoneal Irrigation During Laparoscopic Appendectomy-Does the Grade of Contamination Matter? A Prospective Multicenter Resident-based Evaluation of a New Classification System","RESIDENT1","Inclusion Criteria:\n\n* Patients between 18 and 69 years old\n* Surgical laparoscopic approach for AA\n* Intra-operative and histological diagnosis of AA\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years old or \\> 69 years old\n* Previous appendectomy\n* Previous appendicitis treated conservatively\n* Open approach for surgery or intra-operative conversion\n* Co-existence of other intra-abdominal infections (IAI)\n* Patients with immunodeficiency\n* Patients treated with steroid, immunosuppressant, or CHT within previous 6 months","69 Years",{"count":63,"type":22},1067,"OBSERVATIONAL","Type: prospective observational multicenter trial. Population of interest: adult patients undergoing laparoscopic appendectomy for acute appendicitis.\n\nHypothesis : laparoscopic lavage during laparoscopic appendectomy is a practice that should be used in selected patients according to the intraperitoneal grade of contamination and grade of appendicitis. Nonregulated use of laparoscopic lavage cannot be considered superior to suction only considering recent evidence. Few RCT available addressing this issue are available, but any with a high methodological quality.\n\nAim: The aim of this study is to investigate the impact of laparoscopic lavage during laparoscopic appendectomy on the postoperative incidence of intrabdominal abscesses, stratifying patients in different clusters according to a defined classification considering the intraperitoneal contamination and grade of appendicitis.",[29,28],[68,69,70,71,72,73],"laparoscopy","appendicitis","appendectomy","lavage","suction","abscess","2026-04-13",{"date":76,"type":44},"2026-04-16",{"date":78,"type":44},"2019-10-01",{"date":80,"type":22},"2027-09-30",{"name":82,"class":51},"Niguarda Hospital",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100492377","same-day-ambulatory-appendectomy-samba-100492377","NCT05691348","Same Day Ambulatory Appendectomy (SAMBA)","SAMBA","Inclusion Criteria:\n\n* Patients aged 15-74 years\n* BMI ≤ 35 kg\u002Fm2\n* Uncomplicated acute appendicitis confirmed by imaging (ultrasound and\u002For CT and\u002For MRI)\n\n  * Temperature ≤ 38,1°C and \\> 35,5°C\n  * Appendix diameter \\> 6mm and ≤ 15mm\n  * Without effusion or with only localized peri-appendicular effusion\n  * Infiltration of peri-appendicular fat without abscess or plastron\n  * No sign of perforation\n  * Leukocytes ≤ 18,000G\u002FL AND\n  * CRP (C reactive protein) ≤ 60mg\u002FL\n* If pain, calmed by level 3 analgesic at maximum\n* Ambulatory criteria\n\n  * Availability of monitoring by a relative during the 12 hours after discharge from the hospital\n  * Residence located less than 20 minutes by car from a health center (hospital or clinic)\n  * Access to a telephone mobile or fixed in case of problems\n* Signature of the written informed consent form by the patient\n* If the patient is a minor, signature of the written informed consent form by both parents or their legal representative\n* Affiliation to a French health insurance scheme or equivalent\n\nExclusion Criteria:\n\n* Criteria that exclude ambulatory care such as an ASA score (Physical status score) \\> 2, severe or uncontrolled comorbidities, severe pulmonary disease including obstructive sleep apnea, anticoagulation or antiplatelet drug or contraindication to ambulatory surgery such as intubation difficulties\n* Presence of active cancer, a malignant hemopathy, drug addiction, coagulopathy, immunosuppressive treatment\n* Non-acute or interval appendectomy, i.e. after antibiotic treatment of a complicated appendicitis of the plastron or drainage of an appendicular abscess;\n* History of pelvic surgery\n* Vulnerable people: pregnant or breast-feeding women (patients will undergo a pregnancy test: plasmatic β-hCG (human chorionic gonadotropin) or urinary test), adult under guardianship or deprived of freedom. Pregnant women are considered to have a full stomach, with risk of inhalation at anesthetic induction and represent a contraindication to ambulatory surgery. In addition, the need to perform abdominal surgery on a pregnant woman requires obstetric monitoring that is difficult to reconcile with management in an outpatient surgery unit (need for obstetric ultrasound or monitoring).\n* Suspicion of a tumor of the appendix : Mucocele and pseudomyxoma, Carcinoid tumor, Adenocarcinoma of the appendix, Another type of tumor","15 Years","74 Years",{"count":94,"type":22},1400,[25],"The potential benefit of outpatient care for this common digestive emergency is considerable, both for the patients themselves and for the public health system:\n\n1. Optimization of the care pathway, reducing the length of stay in hospital (a major issue in the context of the COVID-19 (coronavirus disease) pandemic) liberating patient beds and staff, and reducing the risk of nosocomial exposure.\n2. Improved patient satisfaction compared to waiting for hours in the emergency department due to lack of hospital beds.\n3. Non-inferiority of care in an outpatient unit in terms of quality and safety in day hospitalization.\n4. Significant decrease in the overall cost of this pathology as a result of a reduction in the hospital stay.",[29],"2026-03-30",{"date":100,"type":44},"2026-03-31",{"date":102,"type":44},"2023-07-17",{"date":104,"type":22},"2028-01-17",{"name":106,"class":51},"Centre Hospitalier Universitaire de Nice",33,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":17,"minAge":19,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":83},"100629696","clinical-study-of-peg-bowel-preparation-in-appendectomy-patients-100629696","NCT07478029","Clinical Study of PEG Bowel Preparation in Appendectomy Patients","Impact of Polyethylene Glycol (PEG) Bowel Preparation on Intestinal Microbiota Composition and Diversity in Patients Undergoing Appendectomy","Inclusion Criteria:\n\n* Aged 18-75 years.\n* Scheduled to undergo colonoscopy.\n* Generally healthy without major organ diseases.\n\n  1. For appendectomy group: history of appendectomy or right hemicolectomy (including appendectomy).\n  2. For control group: no history of appendectomy or right hemicolectomy.\n\nExclusion Criteria:\n\n* Allergy or intolerance to PEG laxatives.\n* Pregnant or lactating women.\n* Mental disorders.\n* Use of antibiotics within 6 months prior to study enrollment.\n\n  1. Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency).\n  2. For control group only: presence of organic diseases.",true,"75 Years",{"count":118,"type":22},10,"Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol (PEG2000 - 4000) is often used as laxative and lubricant in colonoscopy. However, the widespread use of PEG may cause long-term and irreversible damage to intestinal microorganisms and bring great hidden dangers to health. The appendix has long been regarded as a redundant organ in evolution. The incidence of appendicitis ranks first in surgical acute abdomen. Traditionally, once acute appendicitis is diagnosed, it is usually treated with appendectomy. However, recent studies have revealed that appendectomy may be associated with psychiatric diseases, colorectal cancer, cardiovascular diseases and other diseases. The appendix is not only an important organ of the immune system, but also undertakes the function of storing and protecting intestinal microbes.. . This change may affect the function of the central nervous system through the microbe gut brain axis, and then pose a potential threat to the health and behavior of the host, such as increasing the risk of diseases such as Parkinson's disease. Based on this, this clinical trial aims to investigate (1) the changes of intestinal flora in the appendectomy population before and after colonoscopy in the process of polyethylene glycol intestinal preparation; (2) the differences between the changes of intestinal flora before and after colonoscopy in the appendicectomy population and the normal population in the process of flora recovery.",[29,30],[122,123],"Bowel Preparation with Polyethylene Glycol (PEG) Laxatives","Gut microbiota","2026-03-13",{"date":126,"type":44},"2026-03-17",{"date":128,"type":44},"2024-02-23",{"date":130,"type":22},"2027-03-18",{"name":132,"class":51},"Huaping Xie",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":83},"100375466","operative-versus-non-operative-management-for-appendicitis-with-abscess-or-phlegmon-100375466","NCT04168866","Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon","Inclusion Criteria:\n\n1\\. Complicated appendicitis with presumed perforation on (computer tomography) CT scan AND phlegmon or abscess greater than 2 centimeter (cm).\n\nExclusion Criteria:\n\n1. Antibiotic therapy greater than 24 hours prior to considering for enrollment.\n2. Attempted drainage before randomization\n3. Pregnancy\n4. Antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy.\n5. Previous major intra-abdominal surgery by laparotomy\n6. Hospitalization within 2 weeks of randomization\n7. Presence of septic shock on admission.\n8. Mechanical ventilation\n9. Acute renal failure requiring dialysis",{"count":140,"type":22},180,[25],"The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.",[29],"2025-08-22",{"date":146,"type":44},"2025-08-29",{"date":148,"type":44},"2020-03-11",{"date":150,"type":22},"2029-12-31",{"name":152,"class":51},"Yale University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":83},"100601807","results-of-laparoscopic-appendectomy-with-application-of-clips-versus-ligature-for-stump-closure-100601807","NCT07115303","Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure","Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure: A Comparative Study","Inclusion Criteria:\n\n* Any patient diagnosed with acute appendicitis of any age and of any sex presented to ER of the Department of General, Laparoscopic and Oncologic Surgery Department, Sohag University Hospital will be enrolled in this study.\n\nExclusion Criteria:\n\n* Patients with complicated appendicitis.\n* Patients with unstable cardiac or pulmonary condition.\n* Patients with suspicious crhon's disease or mass intraoperative.",{"count":161,"type":22},80,[25],"This a prospective study to compare between clipping and ligation of appendicular stump in laparoscopic appendectomies regarding ;technical feasibility , post operative complications as fecal fistula and economic consideration.",[29],"2025-08-04",{"date":167,"type":44},"2025-08-11",{"date":169,"type":44},"2025-07-14",{"date":171,"type":22},"2026-02-28",{"name":173,"class":51},"Sohag University",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":181,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":83},"100476756","pained-project-addressing-inequities-in-the-emergency-department-100476756","NCT05488080","PAINED: Project Addressing INequities in the Emergency Department","PAINED","Inclusion Criteria:\n\n* All Children's National Hospital Emergency Department clinicians\n* Patients 0-21 years with symptoms suggestive of appendicitis or long bone fracture\n\nExclusion Criteria:\n\n* Emergency Severity Index (ESI 1)","0 Years",{"count":183,"type":22},22032,[25],"Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes. Our overarching goal is to eradicate health care inequities through evidence-based interventions. The objectives of this proposal are to develop and test the impact of two interventions on overcoming clinician implicit bias and mitigating inequities in the management of pain among children seeking care in the emergency department for the treatment of appendicitis or long bone fractures.",[187,29,188,189],"Pain","Bias, Racial","Fractures, Bone",{"date":191,"type":44},"2025-07-17",{"date":193,"type":44},"2023-02-27",{"date":195,"type":22},"2026-08-23",{"name":197,"class":51},"Children's National Research Institute",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":23,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":212,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":4},"100588596","comparison-of-outcome-of-open-appendectomy-with-and-without-transversus-abdominis-plane-tap-block-100588596","NCT06943456","Comparison of Outcome of Open Appendectomy With and Without Transversus Abdominis Plane (TAP) Block","Comparison of Outcome of Open Appendectomy With and Without Transversus Abdominis Plane Block","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Both male and female patients.\n* Patients fit for general anesthesia.\n* Clinical findings of appendicitis.\n* Lower right quadrant or periumbilical pain radiating to the right lower quadrant, with nausea and\u002For vomiting.\n* Fever \\>38°C.\n* Tenderness with Alvarado score \\>7.\n\nExclusion Criteria:\n\n* Duration of symptoms \\>5 days.\n* Absence of clinical findings of appendicitis.\n* Palpable mass on physical examination suspected for appendiceal abscess.\n* History of cirrhosis or hematological disorders.\n* Allergic to or contraindicated for general anesthesia.\n* Pregnancy.\n* Patients who do not consent to participate.","65 Years",{"count":207,"type":22},136,[25],"This study is being conducted to compare two types of pain management techniques in patients undergoing open appendectomy (surgical removal of the appendix through a traditional incision).\n\nOne group of patients will receive a Transversus Abdominis Plane (TAP) block, a type of regional anesthesia given at the end of surgery to numb the abdominal area and reduce pain. The other group will undergo the same surgery without receiving the TAP block.\n\nThe purpose of this study is to find out whether adding the TAP block helps in:\n\nReducing postoperative pain\n\nShortening the hospital stay\n\nMinimizing complications like nausea, vomiting, and delayed mobility\n\nImproving patient satisfaction after surgery\n\nOpioid medications are commonly used for pain control after surgery, but they come with side effects such as nausea, vomiting, dizziness, and risk of dependency. TAP block offers a promising alternative that may reduce or eliminate the need for opioids by targeting specific nerves in the abdominal wall.\n\nThis will be a randomized controlled trial (considered the gold standard in medical research), meaning patients will be randomly assigned to one of the two groups to ensure fair comparison. The study will enroll 136 adult patients who are diagnosed with appendicitis and are scheduled for open appendectomy at Jinnah Hospital Lahore.\n\nBy conducting this study, the researchers aim to provide strong scientific evidence on whether TAP block should be routinely used in appendectomy patients to enhance recovery and comfort. If proven effective, this could influence hospital protocols and improve post-surgery care both locally and internationally.",[29,211],"Postoperative Pain","NOT_YET_RECRUITING","2025-04-24",{"date":215,"type":44},"2025-04-29",{"date":217,"type":22},"2025-05",{"date":219,"type":22},"2026-05",{"name":221,"class":51},"University of Health Sciences Lahore",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":229,"targetDuration":231,"studyType":64,"phases":4,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":245},"100575570","a-global-prospective-cohort-study-on-outcomes-of-appendicectomy-for-appendicitis-100575570","NCT06774001","A Global Prospective Cohort Study on Outcomes of Appendicectomy for Appendicitis","AlliGatOr","Inclusion Criteria:\n\n* Age: There are no age restrictions, although, if appropriate participating hospitals can choose to only include children or only adults, based on an age cut-off of their choice.\n* Procedure: All patients undergoing appendicectomy for suspected or confirmed appendicitis by any surgical approach should be included. This includes patients who went theatre with suspect appendicitis even if the intraoperative or pathology results found a different diagnosis, so long as an appendicectomy was performed. It also includes patients who went to theatre for reasons other than suspected appendicitis but were found to have appendicitis intraoperatively and underwent appendicectomy. This includes interval appendicectomy and right hemicolectomy if performed for acute appendicitis.\n* Approach: Both open and minimally invasive (laparoscopic and robotic) interventions are eligible for inclusion. Laparoscopic and robotic converted to open cases are also eligible.\n\nExclusion Criteria:\n\n* Indication: Appendicectomy for any indication other than suspected or confirmed appendicitis should be excluded. For example, patients having appendicectomy for known appendiceal neoplasm.\n* Procedure: Patients having appendectomy as part of another surgical procedure should be excluded. For example, patients having removal of appendix as part of a colon cancer procedure are not eligible for inclusion.\n* Approach: Natural orifice surgery and endoscopic treatment for suspected appendicitis are excluded.\n* Previous appendicectomy: Patients having surgery for stump appendicitis are excluded.\n* Return to theatre: Patients should be entered into study only once. A patient returning to theatre after appendectomy should not be re-entered as a new patient.",{"count":230,"type":22},14000,"30 Days","This study aims to assess and improve the global management of appendicitis, the most common emergency surgery, by examining various aspects of emergency care systems worldwide. Appendicitis is a time-sensitive condition, and delays in diagnosis or treatment can lead to complications, affecting patient outcomes and increasing healthcare costs. The study uses appendicitis as a \"tracer condition\" to explore how different healthcare systems manage emergency care, focusing on factors like access, quality, and efficiency. By gathering data from hospitals worldwide, the study seeks to identify areas where emergency surgical care can be improved, particularly in low- and middle-income countries (LMICs).\n\nThe main goal is to identify gaps in emergency care systems, using a set of key performance measures (KPMs) that assess access to care, the quality of surgical treatment, and patient safety. These include factors like the time from symptom onset to first surgical assessment, the rate of appendectomy performed via minimally invasive (laparoscopic) surgery, and postoperative complications. The study aims to collect data on at least 14,000 patients from around 500 hospitals globally between February and May 2025. The data will be analyzed by hospital income group (from low to high) to understand how different resource levels impact outcomes and to help guide future policy and practice improvements.\n\nThe study also includes two sub-studies that focus on specific issues in surgical care. The Sustainability and Waste Management sub-study aims to explore how hospitals manage waste and sustainability practices in operating theatres. This sub-study is part of global efforts to reduce carbon emissions in healthcare settings. The Financing sub-study examines the financial burden of appendicectomy, particularly the out-of-pocket costs for patients in LMICs. It will explore how the costs of open vs. laparoscopic surgery differ and investigate the impact of these costs on patients.\n\nBy combining global data on clinical outcomes with information on hospital resources and patient finances, this study hopes to provide valuable insights into how to improve emergency surgical care across diverse settings, making recommendations that can lead to better access to safe, timely, and affordable treatment for appendicitis worldwide.",[29,28],[235,29,28],"Appendicectomy","2025-03-27",{"date":238,"type":44},"2025-04-02",{"date":240,"type":44},"2025-02-03",{"date":242,"type":22},"2025-12",{"name":244,"class":51},"University of Birmingham",7,{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":23,"phases":256,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":268},"100522472","protocol-based-selective-imaging-versus-routine-computed-tomography-or-ultrasound-in-suspected-appendicitis-100522472","NCT06083064","Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis","Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis (PROSECCO)","PROSECCO","Inclusion Criteria:\n\n\\- Suspicion of appendicitis\n\nExclusion Criteria:\n\n* Time from symptom onset over 72 hours\n* Age \\\u003C18 years\n* Pregnancy, ruled out by serum or urine HCG measurement in 18- to 49-year-old women\n* CT-scan or ultrasound already done within the last 3 days (72 hours)\n* Clinical suspicion of other disease or other reason to perform imaging study\n* Recruited earlier to the same trial",{"count":255,"type":22},900,[25],"The goal of this clinical trial is to compare protocol based selective imaging to routine imaging in adult patients with suspected appendicitis. The main question\\[s\\] it aims to answer are:\n\n* Does protocol based selective imaging using clinical scoring affect clinical outcome?\n* Does protocol based selective observation combined with score based selective imaging affect clinical outcome?\n\nParticipants will be randomized into three groups:\n\n* Selective imaging based on Adult Appendicitis Score\n* Selective observation based on Appendicitis Severity Score combined with selective imaging based on Adult Appendicitis Score\n* Routine imaging using ultrasound and\u002For computed tomography\n\nResearchers will compare selective imaging groups separately with routine imaging to see if number of negative appendectomies or number of complicated appendicitis is not significantly increased.",[29],"2025-03-10",{"date":261,"type":44},"2025-03-12",{"date":263,"type":44},"2023-11-15",{"date":265,"type":22},"2028-12-31",{"name":267,"class":51},"Helsinki University Central Hospital",3,{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":17,"minAge":276,"maxAge":19,"enrollmentInfo":277,"targetDuration":4,"studyType":23,"phases":279,"briefSummary":280,"conditions":281,"keywords":283,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":83},"100529718","transumbilical-laparoscopic-appendectomy-100529718","NCT06177418","Transumbilical Laparoscopic Appendectomy","Glove Finger Method to Prevent Wound Infection in Children Undergoing Transumbilical Laparoscopic Appendectomy","Inclusion Criteria:\n\npatients undergo appendectomy between 5 and 18 years.\n\nExclusion Criteria:\n\nComorbidity previous surgery","5 Years",{"count":278,"type":22},100,[25],"Transumbilical laparoscopic appendectomy (TULA) is increasingly favored in the treatment of appendicitis within the realm of minimally invasive surgical approaches. This procedure offers advantages such as superior cosmetic outcomes and reduced postoperative pain. However, like all surgical interventions, it carries the inherent risk of surgical site infections (SSI), which pose significant challenges to patient health and healthcare systems by escalating treatment costs, prolonging recovery, and increasing morbidity rates. This study aims to evaluate the efficacy of the \"glove finger method\" in mitigating SSI risk in TULA.\n\nThe rationale for this study is predicated on the hypothesis that the glove finger method could serve as a simple and cost-effective measure offering potential protection against SSIs. When compared to traditional methods, this technique may not only reduce surgical duration but also diminish the risk of SSIs, thereby potentially decreasing hospital stay durations. Furthermore, enhancing the understanding of factors contributing to the development of SSIs and developing effective strategies for their prevention can elevate patient care quality and alleviate the burden on healthcare systems.",[29,282],"Surgical Site Infection",[284,285,69,286,287],"laparoscopic appendectomy","transumbilical laparoscopic appendectomy","children","surgical site infection","2024-08-19",{"date":290,"type":44},"2024-08-20",{"date":292,"type":44},"2023-12-25",{"date":294,"type":22},"2024-09-30",{"name":296,"class":51},"Necmi Kadıoğlu Hospital",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":17,"minAge":305,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":83},"100528438","phase-3-intravenous-ketorolac-vs-morphine-in-children-with-acute-abdominal-pain-100528438","NCT06160778","Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain","Intravenous Ketorolac Vs. Morphine In Children Presenting With Acute Abdominal Pain And\u002For Suspected Appendicitis: A Multi-centre Non-Inferiority Randomized Controlled Trial","KETOAPP","Inclusion Criteria:\n\n1. Age 6 to 17 years\n2. Abdominal pain ≤5 days duration\n3. Acute abdominal pain that is being investigated (suspected) by the clinical team for appendicitis\n4. Patient with IV cannula in situ or ordered\n5. Currently experiencing moderate to severe abdominal pain at rest or with movement: self-reported pain score ≥5 using the verbal Numerical Rating Scale\n\nExclusion Criteria:\n\n1. Previous enrollment in the trial\n2. NSAID use within 3 hours and\u002For opioid use within 1 to 2 hours (1 hour post-IV or intra-nasal fentanyl and 2 hours post IV morphine).\n3. Children who need immediate resuscitation, are hemodynamically unstable as deemed by the clinical team or have a Canadian Triage Assessment Score of 1\n4. Significant caregiver and\u002For child cognitive impairment precluding the ability to complete study questions.\n5. Chronic pain requiring daily analgesic use: confounding as response to analgesics maybe altered.\n6. History of severe undiagnosed gastrointestinal bleeding requiring medical intervention, peptic or duodenal ulcer disease or inflammatory bowel disease, coagulation disorders, prior cerebrovascular bleeding, known arterio-vascular malformations. History of minor gastrointestinal bleeding from conditions such as resolved fissures, polyps or allergic colitis will not exclude patients from participating.\n7. History of chronic and active interstitial kidney disease\n8. History of chronic and active hepatocellular disease: ketorolac is metabolized by the liver.\n9. Known or suspected pregnancy at the time of enrollment or breastfeeding females\n10. Known hypersensitivity to NSAIDs or opioids.\n11. Absence of a parent\u002Fguardian for children who are \\\u003C16 years of age if they are not a mature minor.\n12. Inability to obtain consent due to a language barrier and the absence of language translator in person or by a phone translation service available in the ED.","6 Years","17 Years",{"count":308,"type":22},495,[310],"PHASE3","Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly. Children often need pain medications given to them through a needle in their arm called an intravenous (IV). The most common IV pain medication is a type of opioid called morphine. We know that opioids work well to improve pain, but there are risks and side effects when taking them. There are non-opioid medications that doctors can give to patients, like ketorolac. Ketorolac helps decrease inflammation and pain and has fewer side effects when a patient takes it for a short period of time. Our past and present overuse of opioids, driven by an unproven assumption that opioids work best for pain, resulted in an Opioid Crisis and doctors are now looking for alternatives. To do this, we need to prove that there are other options to treat children's pain that are just as good as opioids, with less side effects.\n\nThe goal of our study is to discover if school aged children who arrive at the emergency department with belly pain, improve just as much with ketorolac as they do with morphine. To answer this question, we will need a very large number of patients in a study that includes several hospitals across Canada. With a flip of a coin, each participant will either get a single dose of morphine or a single dose of ketorolac. To make sure that our pain assessment is impartial, no one will know which medicine the child received except the pharmacist who prepared the medicine.",[313,314,315,29,316,317],"Acute Pain","Abdomen, Acute","Abdominal Pain","Emergencies","Child, Only","2024-06-21",{"date":320,"type":44},"2024-06-24",{"date":322,"type":44},"2024-05-27",{"date":324,"type":22},"2029-12",{"name":326,"class":51},"University of Calgary",{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":333,"eligibilityCriteria":334,"healthyVolunteers":115,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":335,"targetDuration":4,"studyType":23,"phases":337,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":212,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":4},"100411202","the-prevalence-of-appendiceal-tumours-in-periappendicular-abscess-100411202","NCT04634448","The Prevalence of Appendiceal Tumours in Periappendicular Abscess","The Prevalence of Appendiceal Tumours in Patients Presenting With a Periappendicular Abscess - A Nationwide Prospective Cohort Study","PeriAPPAC-T","Inclusion Criteria:\n\n* periappendiceal abscess proven by CT, Mri or US\n\nExclusion Criteria:\n\n* patient declines to participate, complicated appendicitis without periappendiceal abscess",{"count":336,"type":22},400,[25],"Complicated and uncomplicated appendicitis follow different epidemiological trends also suggesting different pathophysiology behind these two different forms of appendicitis. In 3-10% of patients complicated acute appendicitis is enclosed by formation of a circumscribed periappendicular abscess. The clinically established practice of antibiotic therapy and drainage, if necessary, has been shown safe and effective, allowing the acute inflammatory process to subside in more than 90% of cases without surgery. The need of subsequent interval appendectomy has been questioned with appendicitis recurrence risk varying between 5-26%.\n\nDuring trial enrollment in our randomized Peri-APPAC trial based on the interim analysis results with 17% appendiceal tumor rate in the study population, the trial was prematurely terminated based on ethical concerns. All the follow-up group patients were re-evaluated and surgery was offered and recommended to all follow-up group patients. After this assessment and additional appendectomies, two more tumors were diagnosed resulting in neoplasm rate of 20% in the whole study group all diagnosed in patients over 40 years and the neoplasm rate in patients over 40 years was 29%.\n\nBased on high appendiceal tumor rate in patients over 40 years, the appendiceal neoplasm rate needs to be further evaluated in prospective patient cohorts undergoing interval appendectomy as interval appendectomy is generally well tolerated and obliterates the risk of missing a possible tumor. In a recent systematic review of retrospective cohort studies with 13.244 acute appendicitis patients the overall appendiceal tumor rate was 1% after appendectomy, but in patients presenting with appendiceal inflammatory mass the neoplasm rate varied from 10% to 29%.\n\nThis nationwide prospective multicenter cohort study is designed to assess the prevalence of appendiceal tumors associated with a periappendicular abscess. All consecutive patients presenting with a periappendicular abscess are recommended to undergo interval appendectomy after initial conservative treatment with antibiotic therapy and drainage, if necessary. All patients older than 35 years will undergo laparoscopic interval appendectomy at 2 to 3 months and this is also recommended for the patients between 18 and 35 years of age. Asymptomatic patients under 35 years not willing to undergo interval appendectomy, will undergo a follow-up MRI at 1 year after the initial non-operative treatment.",[340,29,341,342,343,344,345],"Appendix Abscess","Appendix Mass","Appendix Cancer","Appendix Nec","Appendix Tumor","Appendix Diseases","2020-11-17",{"date":348,"type":44},"2020-11-18",{"date":350,"type":22},"2020-12-01",{"date":352,"type":22},"2035-12-31",{"name":354,"class":355},"Turku University Hospital","OTHER_GOV"]