[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ards-human\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ards-human":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,42,68,96,129,150,170,193,219,249,272,296,319],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100477083","personalized-mechanical-ventilation-guided-by-ultrasound-in-patients-with-acute-respiratory-distress-syndrome-100477083",false,"NCT05492344","Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Admitted to a participating ICU,\n* invasively ventilated and\n* fulfil the Berlin criteria for moderate or severe ARDS.\n\nExclusion Criteria:\n\n* Age under 18,\n* participation in other interventional studies with conflicting endpoints,\n* conditions in which LUS is not feasible or possible (e.g. subcutaneous emphysema, morbid obesity or wounds),\n* mechanical ventilation for longer than 7 consecutive days in the past 30 days,\n* history of ARDS in the previous month,\n* body-mass index higher than 40 kg\u002Fm²,\n* intracranial hypertension,\n* broncho-pleural fistula,\n* chronic respiratory diseases requiring long-term oxygen therapy or respiratory support,\n* pulmonary fibrosis with a vital capacity \\\u003C 50% (severe or very severe),\n* previously randomized in the PEGASUS study\n* ECMO\n* patients who receive invasive ventilation in home setting due to a neurological disease\n* pregnant patients\n* patients who are moribund or facing end of life and\n* no informed consent.","ALL","18 Years","100 Years",{"count":19,"type":20},538,"ESTIMATED","INTERVENTIONAL",[23],"NA","Rationale Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. The identification of ARDS phenotypes, based on focal or non-focal lung morphology, can be helpful to better target mechanical ventilation strategies of individual patients. Lung ultrasound (LUS) is a non-invasive tool that can accurately distinguish 'focal' from 'non-focal' lung morphology. The investigators hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients will lead to a reduction in 90-day mortality compared to conventional mechanical ventilation.",[26,27,28],"ARDS, Human","Lung Ultrasound","Mechanical Ventilation","RECRUITING","2026-05-22",{"date":32,"type":33},"2026-05-27","ACTUAL",{"date":35,"type":33},"2022-08-09",{"date":37,"type":20},"2027-11-01",{"name":39,"class":40},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",10,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100525267","transpulmonary-pressure---guided-mechanical-ventilation-in-morbidly-obese-ards-patients-a-feasibility-study-100525267","NCT06119516","Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.","TGV-MOA","Inclusion Criteria:\n\n* Adult patient (aged 18 years or older)\n* Class III morbid obesity (BMI \\> 40 kg\u002Fm2)\n* Moderate or severe ARDS criteria (according to the Berlin definition)\n* Less than 72 hours between fulfilling moderate or severe ARDS criteria and inclusion\n* Tracheal intubation and invasive mechanical ventilation\n* Informed consent (patient, next of kin), with possibility of an emergency procedure with deferred consent\n* Covid-19 and non-Covid-19 patients\n\nExclusion Criteria:\n\n* Contra-indication to nasogastric tube (uncontrolled coagulopathy, severe thrombocytopenia, nasal trauma, esophageal varices)\n* Order to limit life-sustaining therapy\n* ExtraCorporal Membrane Oxygenation (ECMO) in use\n* Invasive mechanical ventilation \\> 96 hours\n* Elevated intracranial pressure\n* Active air-leak: pneumothorax, pneumomediastinum\n* Pregnancy or breast feeding\n* Patient on state medical aid",{"count":50,"type":20},40,[23],"The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS). The intervention consists of personalized measurements and calculations of the different pressures inside the thorax. The main question to answer is:\n\n• Will the evaluated esophageal pressure-guided strategy lead to different mechanical ventilator settings than suggested by a strategy largely used in ARDS patients in France?\n\nA specific nasogastric probe permitting to measure esophageal pressure will monitor participants. Esophageal pressure will act as an indicator of the pleural pressure. Other respiratory signals displayed by the mechanical ventilators will also be acquired.\n\nFurther, ventilator settings will be adjusted to the evaluated esophageal pressure-guided strategy, with possible benefit of this personalized approach.",[26,54],"Obesity, Morbid",[26,56,28,57],"Obesity, morbid","Transpulmonary pressure","2026-04-20",{"date":60,"type":33},"2026-04-21",{"date":62,"type":33},"2024-04-04",{"date":64,"type":20},"2027-07-04",{"name":66,"class":40},"Assistance Publique - Hôpitaux de Paris",5,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":76,"targetDuration":78,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100550259","comparison-of-the-proteome-in-icu-patients-in-search-for-trali-biomarkers-a-case-control-study-using-both-retrospective-and-prospective-samples-100550259","NCT06444750","Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples","CURIE","Inclusion criteria\n\nPatients on the ICU:\n\n1. Without lung injury who received a red blood cell (RBC) or platelet transfusion (PLT).\n2. With indirect ARDS with and without a blood transfusion (RBC or PLT);\n3. With pneumonia, with and without a blood transfusion (RBC or PLT).\n\nExclusion criteria\n\n1. \"Objection to registration of data for scientific use\" as noted in the patient file.\n2. Patients in whom it is impossible to obtain blood samples.\n3. Patients with massive hemorrhage.\n4. Patients with ARDS due to multiple transfusions.",true,{"count":77,"type":20},210,"30 Days","OBSERVATIONAL","Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population. Due to preventive measures the incidence has decreased. However, the incidence of TRALI is 50-100 times higher in critically ill patients compared to the general hospital population. Since the absolute incidence of respiratory transfusion complications is low and TRALI is under-diagnosed and - reported, to this date is has not been possible to elucidate the exact pathophysiology of TRALI. Consequently, no biomarkers are yet known to detect TRALI. This study aims to identify TRALI biomarkers, gain insight in cellular pathways underlying TRALI development and the role of neutrophils and regulatory T cells, which could enhance transfusion safety.",[82,26],"Transfusion-Related Acute Lung Injury",[82,84,85,86],"Proteomics","Intensive Care Unit","Critical Ill patients","NOT_YET_RECRUITING","2025-08-27",{"date":90,"type":33},"2025-09-04",{"date":92,"type":20},"2025-12",{"date":94,"type":20},"2027-05",{"name":39,"class":40},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":105,"conditions":106,"keywords":113,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":128},"100598351","digital-early-warning-system-for-acute-lung-injury-in-liver-surgery-100598351","NCT07070362","Digital Early Warning System for Acute Lung Injury in Liver Surgery","The Construction of a Digital Intelligence Early Warning System for the Whole Process of Acute Lung Injury in Liver Surgery Based on Cardiopulmonary Interaction Characteristics","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Undergoing major liver surgery (including two-segment or more hepatectomy, liver transplantation, etc.)\n* Voluntary participation with signed informed consent",{"count":104,"type":20},4000,"This study focuses on developing an explainable machine learning model based on cardiopulmonary interaction characteristics to achieve early prediction of acute lung injury (ALI) in patients undergoing major liver surgery. The research will establish a digital early-warning system for ALI to provide support for clinical diagnosis and treatment decisions, thereby reducing the incidence and fatality rate of ALI.",[107,108,26,109,110,111,112],"Acute Lung Injury(ALI)","Liver Cirrhosis","MASLD","MASLD\u002FMASH (Metabolic Dysfunction-Associated Steatotic Liver Disease \u002F Metabolic Dysfunction-Associated Steatohepatitis)","NAFLD (Nonalcoholic Fatty Liver Disease)","Liver Cancer, Adult",[114,115,116,117,118],"Digital Intelligence","Acute Lung Injury","PPCs","Liver Surgery","Cardiopulmonary Interaction;","2025-07-08",{"date":121,"type":33},"2025-07-17",{"date":123,"type":33},"2024-11-01",{"date":125,"type":20},"2027-11-30",{"name":127,"class":40},"Beijing Tsinghua Chang Gung Hospital",1,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":75,"sex":15,"minAge":16,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":128},"100351684","alveolar-macrophage-programming-following-endotoxin-exposure-100351684","NCT03859050","Alveolar Macrophage Programming Following Endotoxin Exposure","Inclusion Criteria:\n\n1. Written, informed consent\n2. Age 18-50\n\nExclusion Criteria:\n\n1. Current or recent illness (past 2 weeks)\n2. Presence or prior history of cardiac, pulmonary or systemic disease\n3. Bleeding disorder, use of systemic anticoagulants or antiplatelet therapy\n4. American Society of Anesthesiology (ASA) class 2 or greater\n5. Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants)\n6. Use of any inhaled substance, including tobacco, marijuana, e-cigarrettes, cocaine, methamphetamines, or toxic vapors in the past 3 months or greater than 10 pack-year smoking history\n7. Alcohol use disorder or greater than 7 drinks\u002Fweek for women or greater than 14 drinks\u002Fweek for men in the past 3 months\n8. Allergy or prior adverse reaction to lidocaine, midazolam or fentanyl\n9. Abnormal spirometry or electrocardiogram at time of screening\n10. Pregnant (based on urine pregnancy test) or breast feeding","50 Years",{"count":137,"type":20},25,[23],"The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).",[26],"2025-05-02",{"date":143,"type":33},"2025-05-06",{"date":145,"type":33},"2019-03-18",{"date":147,"type":20},"2032-07",{"name":149,"class":40},"National Jewish Health",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":128},"100500361","pulmonary-immune-cell-microbiome-interactions-in-ards-100500361","NCT05795257","Pulmonary Immune Cell-microbiome Interactions in ARDS","Pulmonary Immune Cell-microbiome Interactions in Acute Respiratory Distress Syndrome: the ILLUMINA-1 Study","ILLUMINA-1","Inclusion Criteria:\n\n* Inclusion criteria - moderate-to-severe ARDS\n* Admitted to the ICU at Hvidovre Hospital\n* Intubated within the past 72 hours\n* Moderate-to-severe ARDS according to the Berlin definition19\n* Age ≥ 18 years\n\nInclusion criteria - none-to-mild ARDS\n\n* Admitted to the ICU at Hvidovre Hospital\n* Intubated within the past 72 hours\n* None-to-mild ARDS according to the Berlin definition19\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* ARDS caused by COVID-19\n* Absolute contraindications for bronchoscopy\n* Untreated malignant arrhythmia\n* Documented or suspected intracranial hypertension (intracranial pressure ≥ \\> 15 mmHg)\n* One-lung ventilation\n* Severe coagulopathy",{"count":50,"type":20},"The overall aim is to compare the composition and spatial heterogeneity of the following in critically ill intensive care unit (ICU) patients: i) immune cell populations and their activation patterns, ii) the surrounding cytokine-chemokine milieu, including trans-compartmental fluxes of these mediators between the lung and bloodstream, and iii) the lung microbiome.\n\nMain hypotheses:\n\n* The immune cell population in bronchoalveolar lavage fluid (BALF) from patients with ARDS is dominated by neutrocytes, while T cells are depleted, and show evidence of hyper-activation and exhaustion\n* T cell hyper-activation and exhaustion is specifically compartmentalised to the lungs, and much more pronounced in moderate-to-severe than none-to-mild ARDS\n* Cyto- and chemokines derived from pulmonary immune cells are higher in moderate-to-severe than none-to-mild ARDS with a greater release from lungs to the bloodstream, notably of IL-6 and IL-8.\n* The differences in T cell profile in BALF, notably the ratio between regulatory T cells and T helper 17 cells, will change with disease severity over time, and can be explained by the presence of tI-IFN antibodies and\u002For a low microbial diversity of the respiratory tract with low enrichment from the oral cavity.",[26],"2025-03-13",{"date":163,"type":33},"2025-03-17",{"date":165,"type":33},"2023-03-14",{"date":167,"type":20},"2028-11-30",{"name":169,"class":40},"Hvidovre University Hospital",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":128},"100504386","depth-of-sedation-and-its-impact-on-cerebrovascular-reactivity-in-acute-respiratory-distress-syndrome-a-pilot-analysis-100504386","NCT05847634","Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis","Inclusion Criteria:\n\n* Adult patient admitted to the ICU\n* ARDS confirmed according to the Berlin Definition\n* Invasive mechanical ventilation\n* Deep sedation and\u002For neuromuscular blockade required for ARDS treatment at the discretion of the treating medical team\n* Application of monitoring devices feasible\n\nExclusion Criteria:\n\n* More than 24 hours elapsed since ICU admission\n* Death is deemed imminent and inevitable during the next 24 hours\n* Known allergy to a textile component of the device\n* Consent declined from patient or authorized third party\n* The treating clinician believes that participation in the study would not be in the best interest of the patient",{"count":50,"type":20},"Investigation of the feasibility of monitoring processed transcutaneous electroencephalography (EEG), a method of interpreting brain activity, and near-infrared spectroscopy (NIRS), a method of determining levels of tissue oxygenation (StO2) in the brain, for patients with acute respiratory distress syndrome (ARDS) in the ICU.",[26],[180,181,85,182,183],"Near-Infrared Spectroscopy","Depth of Sedation","Electroencephalography","Acute Respiratory Distress Syndrome","2024-12-03",{"date":186,"type":33},"2024-12-06",{"date":188,"type":33},"2024-11-25",{"date":190,"type":20},"2026-01",{"name":192,"class":40},"University of Manitoba",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":21,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":128},"100560064","non-invasive-phrenic-nerve-stimulation-in-ards-patient-100560064","NCT06572280","Non-invasive Phrenic Nerve Stimulation in ARDS Patient","Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study","Inclusion Criteria:\n\n1. Adult ARDS patients undergoing controlled mechanical ventilation\n2. The duration of endotracheal intubation \\\u003C 48 hrs\n\nExclusion Criteria:\n\n1. Neurological condition affecting motor neuron or muscle (e.g. ALS)\n2. Paralysis of the phrenic nerve\n3. Proven or suspected spinal cord injury\n4. Conditions that limit diaphragm movement\n5. Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator)\n6. Patients with implanted medical pumps\n7. Pregnancy\n8. Patients with skin lesions, infections or strictures in throat\u002Fneck area\n9. Patients with metallic implants\n10. Refusal to sign informed consent",{"count":41,"type":20},[23],"Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.",[26,204,205],"Ventilator-Induced Lung Injury","Diaphragm Injury",[207,208,209],"ARDS","diaphragm injury","mechanical ventilation","2024-08-25",{"date":212,"type":33},"2024-08-27",{"date":214,"type":33},"2024-08-01",{"date":216,"type":20},"2025-01-30",{"name":218,"class":40},"Southeast University, China",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":229,"conditions":230,"keywords":234,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":248},"100555785","fulminant-severe-cap---an-observational-study-100555785","NCT06516601","Fulminant Severe CAP - an Observational Study","Fulminant Cases Among Severe Community-acquired Pneumonia - an Observational Retrospective Study","FULMISCAP","Inclusion Criteria: severe community acquired pneumonia according to ATS\u002FIDSA -\n\nExclusion Criteria: incomplete outcome data\n\n\\-",{"count":228,"type":20},1460,"Severe community-acquired pneumonia (CAP) represents a major cause of hospital mortality. Among severe CAP cases, some exhibit a rapidly progressive evolution, leading to severe ARDS\u002Facute respiratory failure and septic shock within hours to a few days. This type of pneumonia, known as \"fulminant pneumonia,\" is characterized by its rapid onset and deterioration, often necessitating immediate medical intervention. Despite its severity, the true incidence and optimal treatment for fulminant pneumonia are not well understood. This knowledge gap is due to the lack of attention towards pneumonia as a potential time-dependent illness and the separation of overlapping clinical topics: severe pneumonia, ARDS, and sepsis.\n\nIn clinical practice, pneumonia is the most frequent cause of both ARDS and sepsis. However, these conditions are often considered separately, combining ARDS and sepsis from various extra-pulmonary causes with those originating from pneumonia. The COVID-19 pandemic, with its vast number of severe CAP cases in a short period, has highlighted the existence of fulminant pneumonias, underscoring the need for further investigation. Recent randomized clinical trials (RCTs) and experiences from COVID-19 have suggested that early and prolonged corticosteroid administration can reduce mortality in patients with severe SARS-CoV-2 infection and severe CAP\u002FARDS of bacterial origin.\n\nThe aim of this observational study is to analyze the rate of fulminant pneumonia and assess the impact of early corticosteroid treatment in a multicentric population of hospitalized patients with severe pneumonia.",[231,232,26,233],"Community-acquired Pneumonia","Severe Pneumonia","Sepsis",[235,236,207,237,238],"fulminant pneumonia","community acquired pneumonia","sepsis","corticosteroids","2024-07-17",{"date":241,"type":33},"2024-07-24",{"date":243,"type":33},"2018-01-02",{"date":245,"type":20},"2024-10-01",{"name":247,"class":40},"University of Trieste",2,{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":259,"conditions":260,"keywords":264,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":271,"locationsCount":4},"100479665","echocardiographic-evaluation-of-rv-injury-in-the-icu-100479665","NCT05525936","Echocardiographic Evaluation of RV Injury in the ICU","Characterization and Definition of Right Ventricular Injury in Patients Admitted to Intensive Care: Prospective Observational Study","RECHOicu","Inclusion Criteria:\n\n* Patients admitted to intensive care unit\n* With a central venous catheter inserted in the superior vena cava territory or a pulmonary arterial catheter for their management,\n* Requiring invasive ventilation, and\u002For catecholamine infusion.\n\nExclusion Criteria:\n\n* Advanced chronic heart failure,\n* Planned or unplanned surgery including cardiac,\n* Advanced cancer,\n* Child C cirrhosis,\n* Contraindication to PLR and volume expansion,\n* Age \\\u003C 18 years,\n* Pregnancy.",{"count":258,"type":20},440,"The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome. An RV failure is expected to induce fluid-unresponsiveness and potentially worst outcome.\n\nThe main objective is to characterize different types of RV injury in critically ill patients by examining their association, including predictive performances, in hemodynamics parameters, ventilation parameters, and clinical outcomes\n\nThe study will be based on the realisation of an echocardiography within 48 hours following inclusion.",[261,262,26,263],"Right Heart Failure, Unspecified","Critical Illness","Septic Shock",[265],"echocardiography","2024-07-08",{"date":268,"type":33},"2024-07-10",{"date":214,"type":20},{"date":123,"type":20},{"name":66,"class":40},{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":282,"conditions":283,"keywords":284,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":128},"100553451","regional-assessment-of-the-risk-of-lung-injury-in-ventilated-patients-100553451","NCT06486259","Regional Assessment of the Risk of Lung Injury in Ventilated Patients","Regional Assessment of the Risk of Lung Injury in Ventilated Patients With Similar Lung Load","RLY","Inclusion Criteria: ARDS patients\n\n\\-\n\nExclusion Criteria:Patients with any of the following criteria were excluded:\n\n* History of emphysema, asthma, pneumothorax, or active bronchopulmonary fistula.\n* Severe instability at the time of the study defined by at least one of the following indicators: SaO2 ≤ 90%, shock requiring \\> 0.5 γ\u002Fkg\u002Fmin of noradrenaline, complex arrhythmia, myocardial ischemia, intracranial hypertension refractory despite first-line measures.\n* Esophageal pathology contraindicating esophageal balloon placement (esophageal varices, stenosis, trauma or esophageal surgery, tumor) and\u002For hematemesis.\n* Severe coagulopathy (platelet count \\\u003C20,000\u002Fmm3 or INR \\>4.\n* Inability to undergo computed tomography: morbid obesity (\\>170 kg) or abdominal circumference \\>200 cm.\n* Patients with do-not-resuscitate orders and pregnant women.\n* Participation in another research study in the last 30 days.","75 Years",{"count":41,"type":20},"Specific characteristics of the lung, such as its functional capacity, heterogeneity, and recruitment potential, can influence the development of ventilator-induced lung injury even under safe ventilation conditions. Objective: To evaluate the risk of ventilator-induced lung injury at the regional level in patients with acute respiratory distress syndrome ventilated with similar tidal volumes and inspiratory pressures.",[26],[207,285,286],"VILI","Mechanical ventilation","2024-06-26",{"date":289,"type":33},"2024-07-03",{"date":291,"type":33},"2023-12-01",{"date":293,"type":20},"2024-07-01",{"name":295,"class":40},"Hospital El Cruce",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":305,"conditions":306,"keywords":307,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":128},"100540796","extracorporeal-carbon-dioxide-removal-using-prismalung-in-reducing-ventilator-induced-lung-injury-100540796","NCT06321497","Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury","Measuring the Impact of Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury in Mechanically Ventilated Patients","Inclusion Criteria:\n\nAdult patients (18 years or older) with diagnosis of ARDS as per Berlin Definition21.\n\nDriving pressure (ΔP) \\> 14 and\u002For Plateau \\>\u002F= 25 (ΔP is calculated using as plateau pressure minus positive end-expiratory pressure)20 Respiratory rate \\> 20 breaths per minute pH \\\u003C 7.25 and PaCO2 \\>45\n\nExclusion Criteria:\n\nARDS lasting more than 72 hours at the time of inclusion High pressure (Plateau pressure \\>30 cm H2O) or high FiO2 (\\>0·8) ventilation for more than 168 h (7 days); Life threatening hemodynamic instability as defined by ongoing arrhythmias that is not responsive to treatment Contraindication to limited anticoagulation Treatment limitation including not for resuscitation and not for reintubation Patients with potentially irreversible respiratory failure caused by conditions such as pulmonary fibrosis.",{"count":304,"type":20},15,"Lung protective ventilation with low tidal volumes and low driving pressure are known to reduce mortality in mechanically ventilated patients with acute respiratory failure. This reduction in mortality is known be due to reduction of ventilator induced lung injury that occurs due to high tidal volumes and high driving pressure. When receiving such mechanical ventilation, some patients develop hypercapnia and associated hypercapnic acidosis. Such patients have an increased risk of mortality. While the exact reasons for such increase in mortality is not known, it is recommended to minimise hypercapnia and hypercapnic acidosis during lung protective ventilation. Minimally invasive extracorporeal carbon dioxide removal (ECCO2R) devices are shown to reduce hypercapnia and hypercapnic acidosis. There are several devices that are currently available in the current clinical practice. However, the effect of these devices on reduction in ventilator induced lung injury is not clearly demonstrated. This study aims to assess the use of an ECCO2R device called Prismalung in reducing ventilator induced lung injury. PrismaLung is currently used in our intensive care unit. This assessment is done by measuring interleukins in bronchoalveolar lavage fluid and blood interleukin levels as well as clinical assessment including the reduction of driving pressure.",[26],[308],"ECC2R, Carbon dioxide, ventilator induced lung injury","2024-03-13",{"date":311,"type":33},"2024-03-20",{"date":313,"type":33},"2024-02-05",{"date":315,"type":20},"2028-02-28",{"name":317,"class":318},"Peninsula Health","OTHER_GOV",{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":327,"enrollmentInfo":328,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":330,"conditions":331,"keywords":333,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":4},"100539311","renal-doppler-to-predict-acute-kidney-injury-aki-in-ards-patients-red-aki-study-100539311","NCT06302192","Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study)","RED-AKI: Renal Doppler in Acute Kidney Injury. Capability of Intrarenal Venous Flow Doppler (IRVF) to Predict Acute Kidney Injury (AKI) in Critically Ill Patients With Acute Respiratory Distress Syndrome (ARDS)","RED-AKI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Critically ill patients admitted to intensive care unit with a diagnosis of ARDS according to Berlino criteria\n* Beginning of IMV less than 48 hours or Clinical decision to begin IMV.\n* Life expectancy \\> 24 hours\n* Informed consent signed\n\nExclusion Criteria:\n\nNo patient will be excluded from the study because of gender, race, ethnicity, or sexual preference.\n\n* AKI prior to the onset of ARDS\n* Chronic respiratory failure due to chronic respiratory diseases\n* Chronic renal disease (CKD stage ≥ 2) and any ureteral obstruction. Definition of CKD patient is according to the latest guideline KDIGO\n* Chronic Heart Failure\n* Chronic liver disease\n* Major trauma in the past 3 months\n* Major surgery in the past 3 months\n* Smoking and Alcohol drinking\n* BMI ≥ 35\n* Patients needing of VV-ECMO and VA-ECMO\n* Beginning of positive pressure ventilation more than 48 hours (invasive or no invasive)\n* Life expectancy \\\u003C24 hours\n* Cardio Circulatory Arrest\n* Neoplasm in chemotherapy\u002Fradiotherapy\n* Do Not Resuscitate or Comfort Measures\n* Pregnancy at ICU admission\n* Refused Informed Consent by the patient or surrogate decision-maker","80 Years",{"count":329,"type":20},164,"This is a multicenter international observational prospective cohort study. The main questions it aims to answer are:\n\n* PRIMARY AIM: To describe the capability of IRVF demodulation at diagnosis of ARDS to predict development of AKI within 7 days from the ARDS onset\n* SECONDARY AIMS: A)Describe the capability of IRVF demodulation or pattern of IRVF (continuous, pulsatility, biphasic, monophasic) to predict development of AKI within 14 days from the ARDS onset. B) To describe the RD parameters and VexUS in the AKI and no AKI patients over time. C) Describe the impact of invasive mechanical ventilation (IMV) on the intrarenal venous congestion and VexUS., D) Evaluation of effect of CRRT on IRVF pattern, VexUS and parameters. E) Describe the feasibility of renal doppler to assess IRVF in critically ill respiratory patients. F) Evaluate the incidence of AKD and CKD Participants will Adult patients with diagnosis of ARDS admitted to intensive care unit and undergoing invasive mechanical ventilation",[332,26],"Acute Kidney Injury",[334],"Renal Doppler","2024-03-04",{"date":337,"type":33},"2024-03-08",{"date":339,"type":20},"2024-04-01",{"date":341,"type":20},"2026-06-30",{"name":343,"class":40},"Policlinico Hospital"]