[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arfid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arfid":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,79,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100622580","sensory-feeding-and-parent-coaching-for-children-with-arfid-100622580",false,"NCT07385469","Sensory Feeding and Parent Coaching for Children With ARFID","Effects of the Sequential Oral Sensory Feeding Approach and Occupational Performance Coaching in Children With Avoidant\u002FRestrictive Food Intake Disorder (ARFID): A Randomized Controlled Trial","SOS OPC ARFID","Inclusion Criteria:\n\n* Inclusion Criteria (for the child):\n\n  * Having been diagnosed with ARFID according to the DSM-5 by a Child and Adolescent Mental Health and Diseases psychiatrist (Assoc. Prof. Dr. Hakan ÖĞÜTLÜ).\n  * Being between the ages of 3 and 8.\n  * Being medically stable for outpatient treatment.\n  * Having no conditions (visual, auditory, cognitive, or chewing) that would prevent participation in treatment.\n\nInclusion Criteria (for the mother):\n\n* Being the child's primary caregiver and living with the mother.\n* Having at least a primary school diploma and possessing Turkish reading and comprehension proficiency.\n* Agreeing to take an active role in the intervention process and participate in research evaluations.\n* Being a regular participant in the child's feeding process.\n* Not having another child with special needs.\n\nExclusion Criteria:\n\n* Exclusion Criteria (Child):\n\n  * History of comorbid neurological, genetic, psychiatric, or metabolic disease\n  * Child and family receiving other individual or family-based education and\u002For psychotherapy during the intervention\n  * Taking medication for comorbid disorders affecting appetite and\u002For weight\n  * Active psychiatric crisis (e.g., severe anxiety disorder, post-traumatic stress disorder)\n  * Significant family or environmental constraints that would prevent regular attendance\n\nExclusion Criteria (Mother):\n\n* Severe hearing, vision, or cognitive impairment\n* Child concurrent participation in another intervention program (dietician, psychotherapy, group education, etc.) related to feeding behaviors\n* Presence of a chronic health condition (e.g., neurological, psychiatric, orthopedic, oncological, etc.) that would prevent regular attendance at the intervention","ALL","3 Years","8 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to investigate the effects of the SOS approach alone, or the SOS approach plus the OPC intervention, on children's feeding problems and feeding behaviors, as well as parents' feeding attitudes and mealtime behaviors in children diagnosed with ARFID. This randomized, single-blind, controlled trial will be conducted with children aged 3-8 years who were diagnosed with ARFID by a Child and Adolescent Psychiatrist according to DSM-V criteria and referred to an occupational therapy department. Power analysis determined the sample size to be 45 children (15 per group). Participants will be assigned to three groups using computer-assisted block randomization: Group 1: Sequential Oral Sensory (SOS) Feeding Approach alone; Group 2: SOS approach plus Occupational Performance Coaching (OPC); and Group 3: Control group (standard follow-up without intervention). The study design will utilize the Consort checklist used for randomized controlled trials. Informed consent will be obtained from participants. Pre- and post-intervention assessments will be conducted on the child's feeding behaviors, food variety, and mealtime negative behaviors, as well as parental feeding attitudes, mealtime behaviors, and stress. The study concludes that feeding interventions implemented using the SOS approach will be effective in reducing food acceptance, food variety, and mealtime negative behaviors in children with ARFID. These effects are expected to be more pronounced and sustained when Occupational Performance Coaching (OPC) is added to the SOS approach. Furthermore, positive changes in parents' feeding attitudes and strengthened parent-child interactions at mealtime are anticipated. These results will contribute to the literature on the effectiveness of using sensory-based approaches and family-based counseling in combination in interventions for ARFID. They are also expected to provide an evidence-based roadmap for occupational therapists to develop holistic intervention programs when working with children with ARFID in clinical practice.",[28],"ARFID",[28,30,31,32,33],"Eating Disorder","Occupational Therapy","Sensory Feeding","Occupational Performance Coaching","NOT_YET_RECRUITING","2026-06-10",{"date":37,"type":38},"2026-06-12","ACTUAL",{"date":40,"type":22},"2026-07-15",{"date":42,"type":22},"2026-07-30",{"name":44,"class":45},"Hacettepe University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100629733","cognitive-evaluation-of-patients-with-eating-disorders-100629733","NCT07478510","Cognitive Evaluation of Patients With Eating Disorders","Neuro-cognitive Profiles of Patients With Nutritional and Eating Disorders","DNA_ARFID","Inclusion Criteria:\n\n* Diagnosis of a Feeding and Eating Disorder (ARFID, anorexia nervosa, or bulimia nervosa);\n* Patients of both sexes;\n* Age between 14 and 65 years;\n* Confirmed diagnosis of a Feeding and Eating Disorder;\n* Body Mass Index (BMI) \\\u003C 25;\n* Signed informed consent form for participation in the study.\n\nExclusion Criteria:\n\n* Diagnosis of Bipolar Disorder according to DSM-5-TR criteria;\n* Diagnosis of a Schizophrenia Spectrum Disorder according to DSM-5-TR criteria;\n* Intellectual disability according to DSM-5-TR criteria;\n* Presence of brain tumors;\n* History of seizure events;\n* Presence of other moderate to severe neurological disorders;\n* Lack of the patient's consent to voluntary participation in the study;\n* Lack of parental or legal guardian consent for participation of a minor in the study.",true,"14 Years","65 Years",{"count":59,"type":22},84,"OBSERVATIONAL","The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public health concern due to their significant impact on physical health, emotional well-being, and everyday functioning. Within this broader diagnostic category, particular attention is given to Avoidant\u002FRestrictive Food Intake Disorder (ARFID), a diagnosis introduced in the DSM-5 and still relatively underexplored compared to other feeding and eating disorders.\n\nDespite its clinical relevance, ARFID remains less well understood in terms of its underlying cognitive and psychological mechanisms. Individuals with ARFID often experience severe food avoidance or restriction that is not driven by weight or shape concerns, but rather by sensory sensitivities, fear of negative consequences of eating, or a lack of interest in food. For this reason, investigating ARFID can offer important insights into the diversity of mechanisms involved in feeding and eating disorders as a whole.\n\nThe study has two main objectives. The first objective is to examine the cognitive profile of individuals with ARFID, with a specific focus on autistic traits and cognitive flexibility, as previous research suggests potential overlaps between ARFID and neurodevelopmental conditions such as Autism Spectrum Disorders. Cognitive flexibility refers to the ability to adapt thoughts and behaviors in response to changing situations, and reduced flexibility may contribute to rigid eating patterns and food avoidance.\n\nThe second objective is to explore the role of body representation (how individuals perceive and mentally represent their own body) and inhibitory control (the ability to regulate or suppress automatic responses) in shaping the cognitive and behavioral features of ARFID and other feeding and eating disorders. These processes may help distinguish ARFID from other diagnoses and clarify shared and disorder-specific mechanisms across the FED spectrum.\n\nThe study involves adult participants of all genders, including individuals diagnosed with ARFID, anorexia nervosa, and bulimia nervosa, as well as healthy control participants without a history of feeding or eating disorders. This design allows meaningful comparisons between different diagnostic groups and with the general population.\n\nThe main questions the study aims to answer are:\n\nDo individuals with ARFID show a distinct cognitive profile, particularly in terms of autistic traits and cognitive flexibility, compared to individuals with other feeding and eating disorders and healthy controls?\n\nHow do body representation and inhibitory control contribute to differences in eating-related behaviors across feeding and eating disorders?\n\nAre there differences in brain activity associated with implicit, automatic attitudes toward food in individuals with feeding and eating disorders compared to healthy individuals?\n\nWhere comparison groups are included, researchers will compare participants with ARFID, anorexia nervosa, bulimia nervosa, and healthy controls to examine differences in cognitive functioning, psychological characteristics, and neural responses related to food processing.\n\nParticipants will be asked to take part in a series of non-invasive and well-established research activities, designed to be accessible and safe. These include:\n\nCompleting self-report questionnaires assessing autistic traits, body image perception, and general psychological well-being;\n\nPerforming computer-based tasks that assess cognitive flexibility and decision-making;\n\nCompleting behavioral tasks designed to measure inhibitory control and automatic associations with food-related stimuli;",[28,63,64,65,66,67],"Anorexia Nervosa","Bulimia Nervosa","Cognitive Flexibility","Implicit Association Test","Executive Functions","RECRUITING","2026-04-15",{"date":71,"type":38},"2026-04-16",{"date":73,"type":38},"2024-11-26",{"date":75,"type":22},"2028-03-31",{"name":77,"class":45},"Istituti Clinici Scientifici Maugeri SpA",3,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100626133","feeding-disorders-in-children-100626133","NCT07431671","Feeding Disorders in Children","Feeding Disorders in Pediatric Age: Effects of an Interdisciplinary Intervention","FEEDING","Inclusion Criteria:\n\n* Age between 2 and 7 years.\n* Diagnosis of a neurodevelopmental disorder according to DSM-5 criteria.\n* Presence of a feeding disorder.\n\nExclusion Criteria:\n\n* Presence of respiratory, cardiovascular, gastrointestinal, or neurological conditions preventing oral feeding.\n* Insufficient caregiver proficiency in the Italian language, such as to compromise completion of the questionnaires.\n* Children who are undergoing a different feeding intervention at the time of screening.","2 Years","7 Years",{"count":90,"type":22},24,[25],"Pediatric Feeding Disorders (PFDs) are conditions characterized by persistent difficulties in food intake, commonly manifesting as food selectivity, food refusal, and dysfunctional mealtime behaviors. Their prevalence in the general pediatric population ranges from 3% to 10%, with substantially higher rates reported among children with neurodevelopmental disorders. The impact of PFDs extends beyond growth and nutritional status, affecting cognitive and emotional development as well as the well-being of the entire family system. Although several treatment models have been proposed, scientific evidence supporting outpatient interventions remains limited and Italy-specific studies are lacking. Moreover, despite the availability of standardized assessment tools, feeding-related outcomes are not yet systematically addressed within outpatient clinical practice for children with neurodevelopmental disorders.\n\nThe present study aims to evaluate whether an interdisciplinary intervention protocol involving a psychologist, a speech and language therapist (SLP), and a Neuro and Psychomotor Therapist of Developmental Age (TNPEE) can improve food variety and reduce dysfunctional mealtime behaviors in this population. The study is designed as a pilot randomized controlled trial developed across five sequential phases: participant enrollment and screening using the Montreal Children's Hospital Feeding Scale (MCH-FS); baseline standardized assessment (T0) using the Pediatric Eating Assessment Tool (PediEAT) and the Short Sensory Profile (SSP); random allocation of participants to an experimental group or a control group; delivery of the interdisciplinary intervention exclusively to the experimental group; and a final standardized assessment conducted six weeks later (T1) to evaluate changes over time and between groups.\n\nThis pilot study primarily aims to assess feasibility and to estimate the variability of outcome measures; therefore, no formal sample size or power calculation was performed. The planned enrollment of 12 participants per group was determined based on feasibility considerations and in line with CONSORT recommendations for pilot trials. The proposed protocol seeks to address current gaps in the literature by systematically targeting feeding-related outcomes through an explicitly interdisciplinary approach that integrates psychological, speech and language, and neuropsychomotor perspectives in the management of PFD.",[94,95,28],"Neurodevelopmental Disorder (Diagnosis)","Feeding Disorder","2026-02-25",{"date":98,"type":38},"2026-02-27",{"date":100,"type":38},"2026-01-01",{"date":102,"type":22},"2026-02-28",{"name":104,"class":45},"IRCCS San Raffaele Roma",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":55,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":60,"phases":4,"briefSummary":115,"conditions":116,"keywords":158,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":46},"100424417","unhide-project-a-digital-health-platform-to-collect-lifestyle-data-for-brain-inflammation-research-100424417","NCT04806620","Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research","Unhide® Project Also Known as The Unhide® Solve Together Unified Platform","Participants may be either self-diagnosed, or diagnosed by a physician with the following conditions:\n\n* Infection-associated chronic conditions such as Long COVID, chronic Lyme, myalgic encephalomyelitis (ME\u002FCFS), and post-acute neuropsychiatric syndrome (PANS\u002FPANDAS).\n* Neuroimmune, developmental, autonomic, and neurological conditions like migraines, dysautonomia, POTS, multiple sclerosis, and autism spectrum disorder.\n* Autoimmune diseases such as Lupus, Sjogren's Disease, rheumatoid arthritis, myasthenia gravis, ankylosing spondylitis, and related autoimmune conditions.\n\nInflammatory gastrointestinal conditions such as Crohn's Disease, Celiac Disease, and ulcerative colitis.\n\n* Behavioral and mood disorders such as anxiety, depression, bipolar disorder, PTSD, eating disorders, OCD, and other related conditions.\n* \"Healthy\" people (without brain inflammation), including unaffected individuals, unaffected individuals in the same household, and unaffected individuals who are married to relatives and family members.\n* Have consistent internet access and a cell phone, tablet, or PC since this is an online or app-based platform that requires entering data and completing surveys.\n* Currently live in the United States\n* Be able to participate in English (stay tuned for updates about the Spanish language version)\n* Be willing to share symptom and health data through the platform",{"count":113,"type":22},10000,"10 Years","The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years and older will provide self-reported health data, biometrics, and symptom diaries through the MyDataHelps™ app (branded as unhide® for this study). The goal is to create comprehensive longitudinal profiles to facilitate research into disease subtypes, causes, diagnostics, and potential treatments, as well as to identify potential participants for future optional studies. \"Healthy\" individuals without brain inflammation are also eligible to participate.\n\nThe digital health research platform used in this study was originally developed and designed by Solve M.E and was called SolveTogether. The Brain Inflammation Collaborative (BIC) expanded upon Solve M.E.'s work to include related diagnoses, pediatric participants, enhance symptom tracking, and more. BIC and Solve M.E. combined Solve Together and unhide®, to create The unhide® Solve Together Unified Platform in 2025.",[117,118,119,120,121,122,123,124,125,126,127,128,129,63,64,28,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157],"Post-Acute COVID-19 Syndrome","ME\u002FCFS","Rheumatic Arthritis","Juvenile Rheumatoid Arthritis (JRA)","Psoriatic Arthritis (PsA)","Ankylosing Spondylitis (AS)","Autoimmune Encephalitis","Celiac Disease","Celiac Disease in Children","Chronic Lyme Disease","Post-treatment Lyme Disease Syndrome","Crohn's Disease","Dysautonomia","Avoidant \u002F Restrictive Food Intake Disorder","Ehlers Danlos Syndrome","Endometriosis","Fibromyalgia (FM)","Long COVID","Lupus","Migraines","Mast Cell Activation Syndrome","Multiple Sclerosis","Myalgic Encephalomyelitis (ME)","Myasthenia Gravis, Generalized","Myasthenia Gravis in Children","Narcolepsy","Obsessive Compulsive Disorder (OCD)","PANDAS","Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)","POTS - Postural Orthostatic Tachycardia Syndrome","General Anxiety Disorder, Social Anxiety Disorder","PTSD - Post Traumatic Stress Disorder","Psoriasis","Traumatic Brain Injury","Tourette's Syndrome","Inflammatory Bowel Disease (IBD)","Autoimmune Diseases","Neurological Diseases or Conditions","Psychiatric Disorder","Sjogren's Syndrome","Ulcerative Colitis and Crohn's Disease",[134,159,160,161,162,163,164,165,166,167,118,168,169,170,171,172,136,173,174,175,176,177,178,179,180],"Myalgic Encephalomyelitis","Chronic Fatigue Syndrome","Longitudinal Natural History Study","Observational","Neuroinflammatory Disease","Brain inflammation","Neuroinflammatory disorders","PANS\u002FPANDAS","Autoimmune encephalitis","Dysautonomia \u002F POTS","Multiple sclerosis","Autoimmune disease","Inflammatory bowel disease (Crohn's, ulcerative colitis)","Celiac disease","Mood disorders (anxiety, depression, bipolar, PTSD, OCD)","Mobile health app","Patient registry","Wearable devices","Fatigue","Post-exertional malaise","Brain Fog","Mental health","2026-01-20",{"date":183,"type":38},"2026-01-22",{"date":185,"type":38},"2023-07-05",{"date":187,"type":22},"2030-12-31",{"name":189,"class":45},"Brain Inflammation Collaborative"]