[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arm-weakness-as-a-consequence-of-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arm-weakness-as-a-consequence-of-stroke":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,97,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100640783","ktmp-enhanced-motor-rehabilitation-for-chronic-stroke-recovery-kulminate-pilot-100640783",false,"NCT07631078","kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot","kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery","Inclusion criteria:\n\n1. Adults aged 18-80 years who have a history of an ischemic or hemorrhagic stroke ≥ 12 m prior to enrollment.\n2. Fugl-Meyer Assessment: Upper Extremity (FMA UE) score 20-50.\n3. Ability to communicate, understand, and give appropriate consent. Participants can follow two-step commands.\n4. Motor evoked potentials in a hand muscle when stimulating ipsilesional cortex with suprathreshold single-pulse TMS (MEP positive).\n\nExclusion criteria:\n\n1. Participants with moderate or severe cognitive impairment (MoCA \\\u003C 18).\n2. Participants with sensory deficits FMA-S \\\u003C 6\u002F12 (with proprioception \\\u003C 4\u002F8).\n3. Participants with severe apraxia (TULIA \\\u003C 5).\n4. Language impairment or behavioral disorder that interferes with their ability to adhere to the protocol or to provide informed consent.\n5. Individuals who have a serious uncontrolled medical condition, including but not limited to severe cardiovascular and cardiopulmonary disease.\n6. Pregnancy or plans to become pregnant during the study period.\n7. Botulinum toxin injections of the affected upper extremity within 3 months prior to onset of study.\n8. Severe spasticity of the affected upper limb (Modified Ashworth ≥ 4).\n9. Absolute contraindications related to non-invasive brain stimulation, including:\n\n9a) History of seizures in the last 12 months while taking anti-epilepsy medication 9b) Presence of any metal implants in the head (excluding the mouth), such as cortical stimulators and DBS, clips, coils, shunts, stents or skull plates, cochlear implants 9c) Permanent eye liner or head tattoos 9d) Implanted electronics such as pacemakers, defibrillators, intrathecal baclofen pumps or vagus nerve stimulator 9e) History of experiencing a serious adverse event during a previous transcranial magnetic stimulation (TMS) session","ALL","18 Years","80 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","kTMP, kilohertz transcutaneous magnetic perturbations, is a low intensity transcranial magnetic stimulation technique that will be used in this study to promote arm\u002Fhand rehabilitation in patients who have been disabled by stroke.",[27,28,29],"Stroke","Chronic Stroke Patients","Arm Weakness as a Consequence of Stroke",[31,32,33,34,35,36,37,27,38,39,40,41,42,43],"kTMP","Ischemic Stroke","Hemorrhagic Stroke","Cortical Excitability","Plasticity","kilohertz Transcranial Magnetic Perturbation","Cerebrovascular Disorders","Chronic Stroke","Transcranial Magnetic Stimulation","Non-Invasive Brain Stimulation","Brain Disorders","Central Nervous System Disorders","Cardiovascular Disorders","RECRUITING","2026-06-01",{"date":47,"type":48},"2026-06-05","ACTUAL",{"date":50,"type":21},"2026-07-01",{"date":52,"type":21},"2028-08",{"name":54,"class":55},"Magnetic Tides","INDUSTRY",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":68,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":56},"100574927","the-effect-of-non-invasive-brain-stimulation-rtms-on-hand-muscles-in-chronic-stroke-patients-100574927","NCT06765642","The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.","Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients","REALISE","Inclusion criteria:\n\n1. Age \\>=21 years old of any race or gender\n2. First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 3 months from stroke onset\n3. Unilateral arm weakness measured by FM-UM scale \\\u003C= 62 out of 66\n4. Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject\n\nExclusion criteria\n\n1. Bilateral strokes (infarcts and\u002For hematoma)\n2. Other co-existent neuromuscular disorders affecting upper extremity motor impairment.\n3. History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study.\n4. Uncontrolled hypertension despite medical treatment(s) at the time of randomization, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and randomized later).\n5. Presence of any MRI\u002FrTMS risk factors including but not limited to:\n\n   1. an electrically, magnetically, or mechanically activated metallic or nonmetallic implant including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system.\n   2. a non-fixed metallic part in any part of the body, including a previous metallic injury to the eye.\n   3. history of seizure disorder before stroke or seizure after stroke.\n   4. preexisting scalp lesion or bone defect or hemicraniectomy.\n6. Concurrent enrollment in another interventional stroke recovery study.\n7. Concerns that the subject cannot comply with study procedures and visits.\n8. Pregnant individuals","21 Years",{"count":67,"type":21},26,[24],"The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.",[27,71,29,72,73,39,74,28,75],"Stroke Patients","Brain Stimulation","Transcranial Magnetic Stimulation Repetitive","Motor Learning","Chronic Stroke Survivors",[77,78,79,80,81,82,83,84,85,86],"stroke","arm weakness","arm weakness as a consequence of stroke","stroke patients","transcranial magnetic stimulation","transcranial magnetic stimulation repetitive","motor learning","chronic stroke","chronic stroke patients","chronic stroke survivors","2026-05-19",{"date":89,"type":48},"2026-05-22",{"date":91,"type":48},"2025-06-09",{"date":93,"type":21},"2027-04-30",{"name":95,"class":96},"Duke University","OTHER",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":25,"conditions":108,"keywords":109,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":56},"100614284","ktmp-in-chronic-stroke-100614284","NCT07277595","kTMP in Chronic Stroke","KTMP: A Novel Method of Non-invasive Brain Stimulation to Enhance Motor Function in Chronic Stroke Patients.","KULMINATE","Inclusion Criteria:\n\n* Adults age 18-80 years old who have had a stroke resulting in hemiplegia\n* Ability to communicate, understand, and give appropriate consent\n* Other criteria may apply\n\nExclusion Criteria:\n\n* Significant cognitive impairment\n* inability to adhere to the study protocol or provide informed consent\n* pregnancy\n* additional criteria may apply",{"count":106,"type":21},100,[24],[27,28,29],[81],"NOT_YET_RECRUITING","2026-05-01",{"date":113,"type":48},"2026-05-06",{"date":50,"type":21},{"date":116,"type":21},"2030-08-01",{"name":118,"class":96},"University of California, San Francisco",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":65,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":56},"100609855","low-intensity-focused-ultrasound-stimulation-in-stroke-patients---parameter-optimization-100609855","NCT07220005","Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization","LIFUS-OPTIMIZE","Inclusion Criteria:\n\n* age \\>=21 years old of any gender or race\n* First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms\n* Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62\u002F64\n* Inducible rest motor threshold and testing motor threshold recorded from the affected abductor pollicis brevis muscle\n\nExclusion Criteria:\n\n* Bilateral strokes (infarcts and\u002For hematoma)\n* Other co-existent neuromuscular disorders affecting upper extremity motor impairment\n* History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study\n* History of confirmed dementia or taking dementia drugs\n* Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)\n* Presence of any MRI\u002FTMS\u002FLIFUS risk factors\n* Concurrent enrollment in another interventional stroke recovery study\n* Concerns that the subject cannot comply with study procedures and visits\n* Pregnant",{"count":127,"type":21},24,[24],"The goal of this research study is to optimize the parameter of Low-Intensity Focused Ultrasound Stimulation (LIFUS) that is most effective in changing cortical excitability and motor learning skills in patients who suffered a stroke. The researchers hope to answer two questions.\n\n* with increasing power, would LIFUS be more effective?\n* with the same power, what LIFUS timing is the best\n\nFor Aim 1, the study will compare 8, 4 W\u002Fcm\\^2 to a zero(sham) stimulation to see if higher power is the better.\n\nFor Aim 2, the study will compare 500 vs 1000 vs 2000 Hz \"timing\" to see which one is better.",[27,29,131,132,133],"Upper Extremity Hemiparesis","Upper Extremity Impairments","Upper Extremity Weakness",[72,135,136,137,74,138],"Transcranial Focused Ultrasound Stimulation","Low Intensity Focused Ultrasound Stimulation","Stroke Recovery","Corticospinal Excitability","2025-12-19",{"date":141,"type":48},"2025-12-23",{"date":143,"type":48},"2025-12-10",{"date":145,"type":21},"2026-06-30",{"name":95,"class":96}]