[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arterial-occlusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arterial-occlusion":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100637132","phase-2-minocycline-after-successful-endovascular-thrombectomy-recanalization-in-posterior-circulation-arterial-occlusion-attraction-minop-100637132",false,"NCT07594301","Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)","Safety and Efficacy of Adjunctive Minocycline After Successful Endovascular Thrombectomy Recanalization for Acute Posterior Circulation Arterial Occlusion - A Multicenter, Prospective, Double-blind, Randomized Trial","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Pre-stroke mRS score of 0-1;\n3. Time from symptom onset to randomization ≤24 hours, including wake-up stroke or unwitnessed stroke. Symptom onset is defined as the last known well time;\n4. Baseline NIHSS score ≥6;;\n5. Posterior Circulation ASPECTS ≥6 on non-contrast CT or DWI;\n6. Clinical symptoms attributable to acute occlusion of the intracranial vertebral artery or basilar artery, confirmed by CTA, MRA, or DSA;\n7. Successful recanalization defined as mTICI 2b-3 after mechanical thrombectomy, with no evidence of secondary embolization in non-target vessels; or spontaneous improvement to mTICI 2b-3 on diagnostic angiography prior to thrombectomy with no planned intervention;\n8. Ability of the patient or legally authorized representative to provide written informed consent.\n\nExclusion Criteria:\n\n1. Acute intracranial hemorrhage on CT or MRI;\n2. Occlusion involving both anterior and posterior circulations on CTA, MRA, or DSA (except in patients with a prior history of anterior circulation occlusion);\n3. Complete bilateral thalamic infarction or bilateral brainstem infarction on CT or MRI;\n4. Cerebellar infarction with significant mass effect or compression of the fourth ventricle on CT or MRI;\n5. Vascular anatomy on CTA, MRA, or DSA that is severely tortuous, demonstrates significant anatomical variation, or shows severe stenosis or dissection precluding navigation of thrombectomy devices to the target vessel;\n6. History of pseudomembranous colitis or antibiotic-associated colitis;\n7. Known allergy to tetracycline antibiotics, any component of the investigational drug, radiocontrast agents, or nitinol materials;\n8. Known resistance to tetracycline antibiotics;\n9. Use of tetracycline antibiotics within 7 days prior to randomization;\n10. History of intracranial hemorrhage within the past 3 months, including intraparenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, subdural hematoma, or epidural hematoma;\n11. Intracranial tumors, vascular malformations, or other space-occupying intracranial lesions;\n12. History of intracranial or spinal surgery within the past 3 months;\n13. History of major surgery or significant trauma within the past 1 month;\n14. Receipt of any of the following treatments within the past 3 months: systemic retinoic acid or androgen\u002Fantiandrogen therapy (e.g., anabolic steroids, spironolactone);\n15. Platelet count \\\u003C100 × 10⁹\u002FL;\n16. Severe hepatic insufficiency, chronic hemodialysis, or severe renal insufficiency (defined as estimated glomerular filtration rate \\\u003C30 mL\u002Fmin or serum creatinine \\>265.2 μmol\u002FL \\[3.0 mg\u002FdL\\]);\n17. Women who are pregnant or lactating, or who have a positive pregnancy test prior to randomization;\n18. Life expectancy \\\u003C6 months (e.g., due to malignancy or severe cardiopulmonary disease);\n19. Participation in another interventional clinical trial that may affect outcome assessment;\n20. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation or poses significant risk (e.g., inability to understand or comply with study procedures or follow-up due to psychiatric, cognitive, or emotional disorders).","ALL","18 Years",{"count":19,"type":20},234,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE2","PHASE3","Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability worldwide. Among these, stroke caused by large vessel occlusion (LVO) are associated with particularly poor outcomes. Multiple randomized controlled trials have demonstrated that endovascular thrombectomy (EVT) significantly improves clinical outcomes in patients with acute LVO and is recommended as the standard of care by current guidelines. Posterior circulation strokes account for approximately 20% of all ischemic strokes and are generally associated with worse prognosis than anterior circulation strokes, especially in patients with basilar artery occlusion, who have a markedly increased risk of death or severe disability. Despite EVT treatment, more than three-quarters of these patients remain dead or functionally dependent at 90 days, indicating substantial room for improvement.\n\nSuccessful recanalization and restoration of effective cerebral perfusion are critical for achieving favorable outcomes. However, although recanalization rates exceed 80% with current thrombectomy techniques, fewer than 40 of patients achieve good functional outcomes at 90 days, suggesting a high incidence of futile recanalization. The underlying mechanisms may include no-reflow, reperfusion injury, and microcirculatory dysfunction, all of which are closely associated with post-recanalization neuroinflammation.\n\nMinocycline is a second-generation tetracycline with pleiotropic neuroprotective properties, including inhibition of microglial activation, reduction of inflammatory mediators, suppression of matrix metalloproteinases, attenuation of oxidative stress, and preservation of blood-brain barrier integrity. Preclinical and clinical studies suggest that minocycline may improve neurological outcomes in patients with AIS.\n\nThis study is a multicenter, prospective, double-blind, randomized controlled trial designed to evaluate the safety and efficacy of adjunctive minocycline in patients with acute posterior circulation arterial occlusion who achieve successful recanalization after EVT. The trial will assess whether early administration of minocycline improves functional outcomes and reduces the incidence of futile recanalization.",[27,28,29,30,31],"Acute Ischemic Stroke","Endovascular Thrombectomy","Minocycline","Posterior Circulation","Arterial Occlusion",[27,28,29,33],"Posterior Circulation Arterial Occlusion","RECRUITING","2026-05-19",{"date":37,"type":38},"2026-05-22","ACTUAL",{"date":35,"type":38},{"date":41,"type":20},"2028-12",{"name":43,"class":44},"Xiang Luo","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100523389","embolization-treatment-of-chronic-refractory-shoulder-tendinopathy-100523389","NCT06095050","Embolization Treatment of Chronic Refractory Shoulder Tendinopathy","Efficacy of Lipiodol Embolization for Chronic Tendinopathy of the Rotator Cuff","ELECTRC","Inclusion Criteria:\n\n1. Male, female, transgender female, transgender male, non-binary\n2. Moderate to severe shoulder pain (VAS \\> 40)\n3. Pain refractory to at least 6 months of physician-directed conservative therapy (analgesics or injections or PT), including a minimum of 6 weeks of PT\n4. Willing, able, and mentally competent to provide informed consent and to tolerate angiography and physical therapy\n\nExclusion Criteria:\n\n1. History of peripheral arterial disease or peripheral artery disease symptoms including claudication, diminished or absent upper\u002Flower extremity pulses, or known upper extremity arterial atherosclerosis or occlusion that would limit selective angiography\n2. Known history of anaphylaxis to iodinated contrast agents or gadolinium based contrast\n3. Acute kidney injury\n4. Allergy to poppy seeds or lipiodol\n5. Renal dysfunction as defined by serum creatinine \\>1.6 dl\u002Fmg or eGFR \\\u003C60 obtained within 30 days of procedure.\n6. Uncorrectable coagulopathy (platelet count \\\u003C 50,000, international normalized ratio \\>1.8 within 30 days of procedure\n7. Active systemic or local upper extremity infection\n8. Patient pregnant, intending to become pregnant during the study.\n9. Prior shoulder replacement surgery\n10. Prior rotator cuff repair surgery\n11. Previous history of complete full-thickness tear of the rotator cuff\n12. Presence of non-MRI compatible devices (e.g., non-compatible cardiac pacemaker).","21 Years","80 Years",{"count":57,"type":20},41,[59],"NA","This is a randomized controlled trial in which patients with moderate to severe shoulder pain (Visual Analog Scale (VAS) \\> 40), in the setting of rotator cuff tendinopathy refractory to conservative treatment, will be enrolled.\n\nThe primary aim of the study is to estimate the effect of transcatheter arterial embolization (TAE) with physical therapy (PT) vs PT alone on the change in shoulder pain at 12-month follow up. Scientific objectives also include an assessment of safety of the intervention, assessment of changes in Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity score, Shoulder Pain and Disability Index (SPADI) scores, MRI Tendinopathy Score between the TAE + PT and PT groups.",[62,63,64,65,66,31],"Shoulder Pain","Tendinopathy","Rotator Cuff Tendinitis","Rotator Cuff Tendinosis","Embolization",[68,69,70],"pain","shoulder pain","tendinopathy","2026-02-04",{"date":73,"type":38},"2026-02-06",{"date":75,"type":38},"2025-01-16",{"date":77,"type":20},"2028-04-21",{"name":79,"class":44},"Brigham and Women's Hospital"]