[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arthritis-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arthritis-knee":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,42,69,99,134,156,179,204,243],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100609592","phase-4-zynrelef-versus-adductor-canal-block-100609592",false,"NCT07216586","Zynrelef Versus Adductor Canal Block","Comparing Opioid Consumption Following Total Knee Arthroplasty With The Perioperative Administration of Zynrelef Versus Adductor Canal Block","Inclusion Criteria:\n\n* Patients \\> 18 years of age\n* Patients undergoing primary, unilateral total knee arthroplasty\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Individuals under the age of 18\n* Pregnant women\n* Prisoners\n* Adults unable to consent\n* American Society of Anesthesiologists Physical Status score greater than 3\n* Patients taking any of the following medications before surgery:\n* Long-acting opioids within 3 days\n* Any opioids taken within 24 hours\n* Bupivacaine HCL within 5 days\n* Chronic opioid use or patients with known or suspected daily use of opioids for seven or more consecutive days within 6 months before their scheduled surgery\n* Illicit drug use determined by social history\n* Alcohol abuse determined by a CAGE Substance Abuse Screening Tool Score of at least two or greater\n* Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF\n* Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients",true,"ALL","18 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","To compare postoperative MME consumption 72 hours after TKA in patients receiving intraoperative periarticular HTX-011 (Zynrelef) instillation versus adductor canal block.",[27,28],"Knee Osteoarthritis","Arthritis Knee","NOT_YET_RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-12","ACTUAL",{"date":35,"type":21},"2027-01",{"date":37,"type":21},"2028-01",{"name":39,"class":40},"University of Miami","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100499804","developing-an-opioid-taper-intervention-before-total-joint-arthroplasty-100499804","NCT05788016","Developing an Opioid Taper Intervention Before Total Joint Arthroplasty","Developing and Testing an Opioid Taper Intervention Before Total Knee Arthroplasty: Phase 2 Intervention Development","Inclusion Criteria:\n\n* decided to pursue primary, unilateral total knee or hip arthroplasty with planned surgery date in 4-8 weeks\n* currently taking between 20 and 90 MME of oral opioids, and that dose has been stable for at least 3 months\n* have a reliable telephone number for contact\n* speaks English\n\nExclusion Criteria:\n\n* Taking opioid medications that include:\n\n  * Buprenorphine\n  * Methadone\n  * Long-acting formulations of opioid pain medications (e.g., extended-release oxycodone and extended-release morphine)\n  * Transdermal formations of opioid pain medications (e.g., fentanyl patches)",{"count":50,"type":21},45,[52],"NA","The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery. The main questions it aims to answer are:\n\n* Is the intervention feasible and acceptable to patients?\n* Does the intervention result in a decrease in opioid dose during the preoperative period?\n\nParticipants will meet with a clinical pharmacist, who will provide some basic education on pain and opioids, and will propose an opioid taper schedule. The pharmacist will then follow-up with the participant by phone each week until surgery to assess progress and adjust the taper as necessary.",[28,55,56],"Arthritis Hip","Chronic Pain",[58],"Opioids","RECRUITING","2026-05-27",{"date":62,"type":33},"2026-05-29",{"date":64,"type":33},"2024-01-10",{"date":66,"type":21},"2027-07-01",{"name":68,"class":40},"University of Alabama at Birmingham",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":41},"100609299","precision-of-pacient-specific-instrumented-open-wedge-high-tibial-osteotomy-vs-conventional-technicque-100609299","NCT07212777","Precision of Pacient-specific Instrumented Open Wedge High Tibial Osteotomy vs Conventional Technicque","Precisión de la osteotomía Tibial Proximal Con Instrumental Paciente-específico vs técnica Convencional","AMBE_OR","Inclusion Criteria:\n\n* Informed consent: able to sign informed consent\n* Clinical: predominantly medial pain\u002Flimitation refractory ≥3-6 months\n* Mobility: flexion ≥90º and flexion contracture ≤10º Stability: varus\u002Fvalgus and pivot-shift ≤ grade 1.\n* Radiology:\n\n  * Medial gonarthrosis Ahlbäck I-III with preserved lateral compartment.\n  * Patellofemoral Iwano 0-2 without disabling patellofemoral pain.\n  * Varus alignment: HKA 4-10°.\n  * Predominantly tibial deformity (decreased MPTA; LDFA close to normal) according to planning.\n* Anatomy\u002Ftechnical feasibility: proximal tibial morphology suitable for medial opening osteotomy and PSI guide placement.\n\nExclusion criteria:\n\n* Comorbidity\u002Fclinical situations:\n\n  * Inflammatory arthritis (e.g., RA, spondyloarthropathies), unresolved previous joint infection or osteomyelitis.\n  * Severe peripheral vasculopathy (ABI \\\u003C0.7), advanced peripheral neuropathy or Charcot foot.\n  * Poorly controlled diabetes (HbA1c \\>8.5%), advanced renal\u002Fhepatic failure (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²; Child-Pugh B\u002FC).\n  * Smoking \\>20 cigarettes\u002Fday without commitment to cessation; active IV drug use or uncontrolled alcoholism.\n  * BMI \\>35 kg\u002Fm².\n  * Disorder affecting gait (e.g., neurological disease).\n  * Inability to walk at a speed of at least 0.8m\u002Fs\n* Anatomy\u002Fradiology\n\n  * Multiplanar deformities not correctable with isolated medial opening tibial valgus osteotomy (e.g., dominant femoral deformity).\n  * Severe medial subchondral bone defect or extensive necrosis.\n  * Sequelae of proximal tibia fracture or previous ipsilateral HTO that prevent correction or guide use.\n* Treatments\u002Fmedication and logistics\n\n  * Anticoagulation\u002Fantiplatelet therapy that cannot be suspended or bridged.\n  * Systemic corticosteroids \\>10 mg\u002Fday or high-risk immunosuppressants without possibility of adjustment.\n  * Intra-articular infiltration (HA\u002FCS\u002FPRP) within the previous 60 days (respect defined wash-out).\n  * Pregnancy.\n  * Participation in another interfering trial.\n  * Inability to undergo CT (e.g., uncontrollable claustrophobia).\n  * Inability to complete ≥12 months of follow-up.","70 Years",{"count":79,"type":21},50,[52],"This study is a randomized clinical trial that will compare two surgical techniques for patients with knee osteoarthritis and varus deformity who are candidates for medial opening wedge high tibial osteotomy. The goal is to evaluate whether using patient-specific 3D-printed surgical guides improves the accuracy of the bone cut compared with the conventional technique performed with anatomical landmarks and fluoroscopy.\n\nA total of 50 adult patients will be randomly assigned to one of two groups: conventional osteotomy or osteotomy assisted by patient-specific instrumentation (PSI). The main outcome is the accuracy of the osteotomy cut, measured by comparing preoperative planning with the postoperative CT scan. Secondary outcomes include leg alignment, surgical time, radiation exposure, complications, and functional recovery assessed with validated questionnaires (KOOS, WOMAC, IKDC, EQ-5D) and gait analysis using depth cameras.\n\nPatients will be followed for up to 12 months after surgery to evaluate clinical and radiological outcomes.",[83,84],"Arthritis (Knee)","Varus Knee",[86,87,88,89],"patient-specific instrumentation","knee osteotomy","Prospective","Randomised Controlled Trial","2026-04-02",{"date":92,"type":33},"2026-04-03",{"date":94,"type":33},"2025-11-15",{"date":96,"type":21},"2028-10",{"name":98,"class":40},"University of Malaga",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":41},"100461604","total-versus-robotic-assisted-unicompartmental-knee-replacement-100461604","NCT05290818","Total Versus Robotic Assisted Unicompartmental Knee Replacement","Total Versus Robotic Assisted Unicompartmental Knee Replacement (TRAKER) for Medial Compartment Osteoarthritis: Randomised Controlled Trial","TRAKER","Inclusion Criteria:\n\n* Listed for elective primary TKA for end stage medial compartment osteoarthritis\n* Intact anterior cruciate ligament\n* Full thickness and good quality lateral cartilage\n* Correctable intra-articular varus deformity and intact medial collateral ligament\n* American Society of Anesthesiologists (ASA) grades 1 and 2\n* Male or female, age 50 - 75 at the time of listing for surgery\n* Suitable candidate for a cruciate retaining TKA (Triathlon prosthesis) and a UKA\n\nExclusion Criteria:\n\n* Varus deformity of \\> 20 degrees\n* Fixed flexion of \\>10 degrees\n* Patient is unable to comply with the study protocol (incl. refusal for CT scan) or functional assessments\n* Female participants who are pregnant, lactating or planning pregnancy during the course of the study\n* Requires patella resurfacing or lateral compartment has significant OA\n* Inability to understand the patient information for the study, provide written informed consent or answer study questionnaires for cognitive or language reasons\n* Inflammatory disorder e.g. rheumatoid arthritis\n* Symptomatic foot, hip or spine pathology\n* Prior surgery (other than arthroscopy) or septic arthritis of the knee\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study,","50 Years","75 Years",{"count":110,"type":21},159,[52],"The purpose of this research is to compare the functional outcomes of patients with end stage medial compartment OA of the knee undergoing a conventional mTKA to those undergoing rUKA and to assess the associated cost economics of such technology.",[114,28,115],"Osteo Arthritis Knee","Arthropathy of Knee",[117,118,119,120,121,122,123],"Arthroplasty","Robotic","Knee","Total","Partial","Outcome","MAKO","2026-02-04",{"date":126,"type":33},"2026-02-06",{"date":128,"type":33},"2024-08-26",{"date":130,"type":21},"2027-12-31",{"name":132,"class":133},"NHS Lothian","OTHER_GOV",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":144,"phases":4,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":41},"100579205","functional-recovery-after-total-knee-arthroplasty-100579205","NCT06821269","Functional Recovery After Total Knee Arthroplasty","Inclusion Criteria:\n\n* Candidate for TKA\n* Speak English \u002F understand study instructions--this is necessary to reliably complete the study questionnaires and understand study instructions which are not validated in other languages\n* Have medical clearance from PCP, PI, or co-Investigator to participate in the study\n* Willing to comply with all study procedures and be available for the duration of the study\n\nExclusion Criteria:\n\n* 2+ falls in the past year\n* Unable to ambulate 100 ft without assistive device or rest period\n* Acute illness\n* Have a history of cardiovascular disease or hypertension not controlled by medication\n* Severe visual impairment\n* Lower-extremity amputation\n* Neurological, muscular, systemic, or connective tissue disorder affecting the function of the lower extremities\n* Pregnant\n* Terminal illness\n* Plans to have another joint replacement during study period\n* Plans to relocate from immediate area during study period","40 Years","90 Years",{"count":143,"type":21},30,"OBSERVATIONAL","The goal of this observational study is to learn about patients' recoveries after receiving total knee arthroplasty (TKA). The main questions it aims to answer are:\n\nDoes robotic-assisted TKA have improved perceived recovery when compared to conventional TKA? Does robotic-assisted TKA lead to improved functional recovery when compared to conventional TKA?\n\nResearchers will compare if robotic-assisted versus conventional procedures lead to different recovery speeds.\n\nParticipants will answer questionnaires and undergo physical therapy testing before and at several timepoints after their procedure.",[28],"2025-12-04",{"date":149,"type":33},"2025-12-11",{"date":151,"type":33},"2023-09-01",{"date":153,"type":21},"2027-05-01",{"name":155,"class":40},"University of Pittsburgh",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":163,"enrollmentInfo":164,"targetDuration":166,"studyType":144,"phases":4,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":41},"100556211","evaluation-of-clinical-functional-and-radiographic-outcomes-in-patients-who-underwent-meniscal-allograft-transplantation-mat-at-10-years-100556211","NCT06522152","Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.","MAT 10 Y","Inclusion Criteria:\n\n* Patients aged between 18 and 65 at the time of surgery\n* Both male and female\n* Patients who underwent meniscal transplantation at the Rizzoli Orthopedic Institute at least 10 years ago\n\nExclusion Criteria:\n\n* Patients who do not give consent to be included in the study\n* Patients who are no longer reachable\n* Presence of infection or hematologic, rheumatic, or coagulation disorders at the time of evaluation","65 Years",{"count":165,"type":21},397,"10 Years","Menisci are crescent-shaped cartilage structures that are fundamentally important for the biomechanics and physiology of the knee joint. They play a primary role in load transmission, assist the ligaments in ensuring knee stability, and thus protect against the onset of knee osteoarthritis. Meniscal injuries are the most frequently encountered joint pathology and can cause pain, mechanical blocks, and recurrent effusions. The treatment of these injuries has progressively evolved from meniscectomy (removal of damaged meniscal tissue) to the use of meniscal sutures (where possible) to allow the preservation of the greatest amount of meniscus: numerous studies have shown a correlation between the amount of meniscus removed and the future onset of osteoarthritis (Hutchinson AJSM 2014, Harston KSSTA 2012).\n\nHowever, in some cases, especially in the presence of complex and\u002For chronic lesions, meniscectomy remains the only viable surgical solution even today. Over time, months or years later, a subgroup of patients experiences symptoms such as pain, joint swelling, and mechanical overload of the compartment subjected to meniscectomy, a condition known as \"post-meniscectomy syndrome.\" Some of these patients will subsequently develop knee osteoarthritis, requiring invasive interventions such as partial or total knee replacement.\n\nMeniscal allograft transplantation (MAT) represents a valid therapeutic option for post-meniscectomy syndrome. This procedure aims to restore joint functionality and stability through the transplantation of a meniscus from a cadaver donor. MAT has been widely adopted in clinical practice, showing success in reducing pain and improving joint functionality.\n\nCurrent studies suggest that meniscal transplantation can offer significant protection against osteoarthritis, but the duration of this preventive effect is not yet fully understood. Furthermore, there are no studies that can demonstrate the state of osteoarthritis with radiographic controls pre- and post-treatment at a follow-up of over 10 years.",[169,28],"Meniscus Disorder","2025-08-01",{"date":172,"type":33},"2025-08-06",{"date":174,"type":33},"2024-10-24",{"date":176,"type":21},"2030-07",{"name":178,"class":40},"Istituto Ortopedico Rizzoli",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":77,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":41},"100585803","phase-2-investigation-of-growth-hormone-and-platelet-rich-plasma-on-joint-health-100585803","NCT06907121","Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health","Investigation of Intra-Articular Growth Hormone and Platelet-Rich Plasma on Joint Health in Adults With Knee and Ankle Arthritis Resistant to Treatment","Inclusion Criteria:\n\n* Ankle\u002FKnee arthritis resistant to treatment in GP clinic setting.\n* Significant Ankle\u002FKnee cartilage injury can be shown on MRI scan or weight bearing X-Ray within 6 months of study application.\n* Able to give informed consent to participation in a clinical trial.\n* Able to commit to attending clinic for follow up.\n\nExclusion Criteria:\n\n* A known hypersensitivity to any of the components of the product.\n* Cancer diagnosis or suspicion.\n* Resected or active tumor.\n* Skeletally immature (\\\u003C18 years of age or no radiographic evidence of closure of epiphyses).\n* Pregnancy.\n* Active infection at the injection site.\n* Open soft tissue injury.\n* Metabolic disorders known to adversely affect the skeleton (e.g. renal osteodystrophy or hypercalcemia), other than primary osteoporosis or diabetes.\n* Over 70 years of age\n* Unstable joint or maligned joint \\> 5%\n* No cartilage detected in the joint (bone on bone in medical imaging)\n* Unable to give informed consent.\n* Unable to commit to attend clinic for follow up.",{"count":187,"type":21},60,[189,190],"PHASE2","PHASE3","This clinical study will evaluate the efficacy of intra-articular (IA) injection of growth hormone (HGH) and platelet-rich plasma (PRP) in adults with knee and ankle arthritis resistant to conventional treatment.\n\nThe study, sponsored by Integrant Pty Ltd and led by Prof. Gordon Slater, aims to determine whether IA HGH injections can enhance cartilage regeneration and joint healing.\n\nThe study will recruit 60 patients who will receive three IA injections of HGH and PRP spaced 7-16 days of each other.\n\nOutcomes will be assessed using AOFAS and AKS scoring systems at 3- and 6-months post-treatment.\n\nThe study hypothesizes that HGH will increase healing of arthritic or injured joints compared to standard treatment, potentially providing a non-surgical alternative for patients with treatment-resistant arthritis.",[193,28],"Arthritis Ankle","2025-03-26",{"date":196,"type":33},"2025-04-02",{"date":198,"type":21},"2025-06-01",{"date":200,"type":21},"2027-12-01",{"name":202,"class":203},"Integrant Pty Ltd","INDUSTRY",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":213,"briefSummary":214,"conditions":215,"keywords":224,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":4},"100570627","kinematic-alignment-in-total-knee-arthroplasty---a-double-blind-randomised-controlled-trial-between-robotic-and-caliper-based-techniques-100570627","NCT06709703","Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques","L'Alignement cinématique Dans Les prothèses de Totales de Genou : un Essai randomisé contrôlé à Double Insu Comparant la Robotique Aux Instruments Traditionnels","Inclusion Criteria:\n\n* Patient aged 18 or above\n* Patient being consented for a primary total knee arthroplasty (TKA)\n* The primary TKA is planned to be done with kinematic alignment\n* All pre-operative alignments are included\n\nExclusion Criteria:\n\n* Revision TKA (including revision of unicompartimental knee arthroplasty into total knee arthroplasty with primary components). TKA being done in the setting of previous femur or tibia fracture or osteotomy are however included.\n* No available adequate pre-operative imaging\n* Patient who does want to be randomized of the two groups\n* At the discretion of the surgeon, if the patient's pathology or particular anatomy precludes the use of kinematic alignment technique, robotic surgery, or traditional instrument TKA.",{"count":212,"type":21},200,[52],"Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery. To place the knee replacement in correct position, the kinematic alignment method, which tries to reproduce the patient normal anatomy, has shown promise in improving the satisfaction after knee replacement surgery. It is not known if using a robotic arm to assist in surgery is better than the traditional method when trying to recreate kinematic alignment.\n\nThe goal of this study is to learn if robotic assisted surgery is better than traditional method for knee replacement done using kinematic alignment. The main questions the study tries to answer are:\n\n1. Do the radiographs of kinematic knee replacement surgeries done with robotic assistance show better alignment than radiographs of kinematic knee replacements done with the traditional method?\n2. Does robotic assisted kinematic knee replacement give better function to patients than traditional knee replacement done with kinematic alignment?\n3. Does robotic assisted kinematic knee replacement decrease pain, improve knee movement and improve knee stability better than traditional knee replacement done with kinematic alignment?\n4. Are there more complications with robotic assisted kinematic knee replacement in comparison to traditional kinematic knee replacement?\n5. How long long does it take a surgeon to become good a performing a kinematic knee replacement using robotic assistance? Researchers will compare knee replacements done using a robotic to make the bone cuts, and compare it to the usual method using guides and manual instruments. All the knee replacements will be done using the kinematic alignment and with the same type of knee replacement prothesis.\n\nParticipants will:\n\n* Have a knee replacement done with the kinematic alignment technique by an experienced surgeon, with or without robotic assistance during the surgery.\n* Visit the clinic before surgery, six weeks after surgery, three months, six months, twelve months and twenty-four months after the surgery.\n* Fill questionnaire, have their knee examined and have radiographs of their knee done at each visit.",[216,83,217,218,219,220,221,222,223],"Arthritis","Osteoarthritis","Osteoarthritis Knee Pain","OA","OA Knee","OA Knee Pain","Osteoarthritis of Knee","Gonarthrosis; Primary",[225,226,227,228,229,230,231,232,233],"osteoarthritis","arthritis","knee osteoarthritis","knee OA","knee arthritis","total knee replacement","robotic","kinematic alignment","patient-specific surgery","2024-11-25",{"date":236,"type":33},"2024-11-29",{"date":238,"type":21},"2025-02",{"date":240,"type":21},"2028-09",{"name":242,"class":40},"Université de Sherbrooke",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":251,"briefSummary":252,"conditions":253,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100395681","phase-4-oral-dexamethasone-as-an-intervention-for-postoperative-pain-and-nausea-management-in-total-knee-arthroplasty-100395681","NCT04432259","Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty","Inclusion Criteria:\n\n* adult patients age 18 and older who will be undergoing joint replacement\n\nExclusion Criteria:\n\n* Patients with uncontrolled diabetes ( HbA1C, \\>7.5%), impaired hepatic function (Child class, \\>B), impaired renal failure (Glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m2), chronic narcotic use, alcohol and\u002For opioid dependence, patients with a known adverse reaction to corticosteroids, and patients unable to give informed consent.",{"count":250,"type":21},300,[24],"This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.",[28,254,255],"Postoperative Nausea","Postoperative Pain","2020-06-12",{"date":258,"type":33},"2020-06-16",{"date":260,"type":21},"2020-07",{"date":262,"type":21},"2022-12",{"name":264,"class":40},"Henry Ford Health System"]