[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arthropathy-of-hip\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arthropathy-of-hip":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,42,68,95,118,150,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100618151","peng-block-vs-peng-plus-periarticular-injection-vs-periarticular-injection-in-older-adults-100618151",false,"NCT07327892","PENG Block vs PENG Plus Periarticular Injection vs Periarticular Injection in Older Adults","Comparison of Pericapsular Nerve Group (PENG) Block, PENG Block Plus Periarticular Injection, and Periarticular Injection Alone for Postoperative Pain Management in Older Adults Undergoing Hip Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled for elective or emergency hip surgery (e.g., hip fracture fixation or hip arthroplasty)\n* ASA physical status I-III\n* Ability to communicate pain intensity using the NRS scale\n* Written informed consent obtained from the patient or legal representative\n\nExclusion Criteria:\n\n* Patient refusal or inability to provide informed consent\n* Allergy, intolerance, or contraindication to any study medication: ropivacaine\n* Pre-existing neurological deficit or neuropathy of the affected limb\n* Coagulopathy (INR \\>1.5, platelets \\\u003C100,000\u002FµL) or current therapeutic anticoagulation that contraindicates regional anesthesia\n* Infection at or near the injection site\n* Severe hepatic or renal impairment\n* History of chronic opioid use (daily opioids \\>30 days before surgery)\n* Cognitive impairment or delirium precluding reliable pain assessment\n* BMI \\> 40 kg\u002Fm² (if you want to exclude for technical difficulty)\n* Patients receiving another regional nerve block for hip surgery\n* Pregnancy or breastfeeding\n* Participation in another interventional clinical trial within 30 days","ALL","65 Years","100 Years",{"count":20,"type":21},108,"ESTIMATED","INTERVENTIONAL",[24],"NA","Pain after hip surgery is common in older adults and may limit early mobilization, increase the need for opioid medications, and contribute to complications such as delirium, nausea, or prolonged hospital stay. Effective postoperative pain management that preserves muscle strength and supports early rehabilitation is especially important in this population.\n\nSeveral analgesic strategies are currently used after hip surgery. Periarticular injection (PAI), administered by the surgeon during the procedure, is commonly used as part of standard care. The pericapsular nerve group (PENG) block is a newer ultrasound-guided regional anesthesia technique that targets the sensory nerves of the hip joint while sparing motor function. It may provide effective pain relief and facilitate early mobilization. However, it is unclear whether PENG block alone is superior to periarticular injection, and whether combining both techniques provides additional benefit.\n\nThe aim of this randomized controlled clinical study is to compare three postoperative analgesic strategies in older adults undergoing hip surgery: PENG block alone, PENG block combined with periarticular injection, and periarticular injection alone. Participants will be randomly assigned to one of three study groups.\n\nThe primary hypothesis is that regional anesthesia with a PENG block, either alone or combined with periarticular injection, will provide superior postoperative pain control compared with periarticular injection alone. A secondary hypothesis is that the combination of PENG block and periarticular injection will offer additional analgesic benefit compared with PENG block alone.\n\nOutcomes assessed in this study will include postoperative pain intensity, need for additional pain medications, time to first mobilization, and the occurrence of adverse events relevant to older adults, such as hypotension, excessive sedation, or postoperative delirium.\n\nThe results of this study may help determine the most effective and practical analgesic strategy for hip surgery in older adults and support evidence-based optimization of postoperative pain management.",[27,28],"Hip Osteoarthritis","Arthropathy of Hip","RECRUITING","2026-06-29",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":33},"2026-05-08",{"date":37,"type":21},"2027-02-28",{"name":39,"class":40},"Poznan University of Medical Sciences","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":62,"leadSponsor":64,"locationsCount":67},"100642396","mako-more-registry-100642396","NCT07647354","Mako-MORE Registry","A Prospective, Multi-center, Post-market, Registry-based Evaluation of the Clinical Outcomes in Patients Receiving a Stryker Implant With Use of the Mako Robotic-Arm Assisted System (Mako-MORE)","Inclusion Criteria:\n\n* The subject is skeletally mature, and ≥ 18 years old.\n* The Subject has signed and dated an IRB\u002FEC approved, study specific Informed Patient Consent Form (ICF).\n* The subject is scheduled to undergo manual arthroplasty or Mako Robotic-Arm Assisted Arthroplasty according to IFU.\n* The subject is willing and able to comply with postoperative scheduled clinical evaluations.\n\nExclusion Criteria:\n\n* The subject is not able to express his\u002Fher consent as deemed by the investigator.\n* The subject is not able to fulfill a self-assessment questionnaire or follow-up visits as deemed by the investigator.\n* The subject is a prisoner.\n* Per surgeon discretion the subject is not a candidate for the study.\n* The subject is pregnant or breastfeeding.","18 Years",{"count":51,"type":21},950,"5 Years","OBSERVATIONAL","This is a prospective, post-market, multi-center, registry-based observational study designed to collect real-world clinical data on patients undergoing joint arthroplasty with Stryker implants, with or without the use of the Mako Robotic-Arm Assisted System. The registry will collect prospective data on patient characteristics, procedural details, patient-reported outcomes, radiographic assessments, and adverse events. Patients will be enrolled into procedure-specific cohorts and followed for up to five years postoperatively.",[56,28],"Arthropathy of Knee","NOT_YET_RECRUITING","2026-06-09",{"date":60,"type":33},"2026-06-15",{"date":60,"type":21},{"date":63,"type":21},"2037-03-15",{"name":65,"class":66},"Stryker Orthopaedics","INDUSTRY",5,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":18,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":41},"100468594","pre-operative-inspiratory-muscle-strength-training-in-total-joint-surgery-100468594","NCT05381818","Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery","Preoperative Inspiratory Muscle Strength Training and Pulmonary Complications After Surgery","Inclusion Criteria:\n\n* 18 or older\n* History of current or previous tobacco use (including vaping containing nicotine products)\n* One or more risk factors for post operative pulmonary complications including history of current or previous tobacco use, a clinically diagnosed lung disease, shortness of breath with minimal exertion, FEV1 or FVC less than 80% than predicted or respiratory muscles strength below lower limit of normal for age and sex.\n* History of smoking related lung disease\n* Projected surgical time \\> 30 minutes\n* Ability to follow instructions to complete IMT exercises\n* Ability to communicate adverse effects such as pain or fatigue or the need for assistance\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists physical status classification of 4 or greater .\n* Recent history of acute pneumonia or lower respiratory infection in the previous two weeks requiring acute corticosteroid or antibiotic medication,\n* Preoperative dependence on continuous supplemental oxygen dependence.\n* Preoperative dependence on positive pressure breathing support while awake and upright (night time CPAP permitted),\n* Diagnosis of a neurologic condition (i.e. MS, ALS, Parkinson's, stroke),\n* Participating in a pulmonary rehabilitation program\n* Severe obstructive pulmonary disease (Classification of Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 or higher, indicating FEV1\\\u003C50% predicted.\n* Patients with an infectious disease requiring isolation (i.e. COVID-19).",{"count":76,"type":21},36,[24],"The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery. It is known that breathing function decreases for a few days after surgery. in In this study, we want to see if exercising before surgery strengthens the breathing muscles and improves recovery after surgery.",[56,28,80,81],"Lower Extremity Fracture","Orthopedic Disorder",[83,84,85],"Inspiratory muscle training","Pulmonary complications","Total joint replacement","2026-05-13",{"date":88,"type":33},"2026-05-15",{"date":90,"type":33},"2022-07-01",{"date":92,"type":21},"2026-12",{"name":94,"class":40},"University of Florida",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":103,"maxAge":18,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":41},"100637092","comparison-of-spinal-anesthesia-with-intrathecal-morphine-versus-peng-block-with-or-without-dexamethasone-in-hip-arthroplasty-100637092","NCT07584200","Comparison of Spinal Anesthesia With Intrathecal Morphine Versus PENG Block With or Without Dexamethasone in Hip Arthroplasty","Comparison of the Efficacy and Safety of Three Regional Anesthesia Strategies in Patients Undergoing Elective Total Hip Arthroplasty: A Prospective, Randomized, Multicenter Clinical Trial","THA","Inclusion Criteria:\n\n* Adults aged 60 to 100 years\n* Scheduled for elective total hip arthroplasty\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to ropivacaine, morphine, or dexamethasone\n* Coagulation disorders or ongoing anticoagulant therapy contraindicating spinal anesthesia or regional nerve blocks\n* Infection at the site of spinal or peripheral nerve block injection\n* Pre-existing neurological disorders affecting sensory or motor function\n* Severe hepatic or renal insufficiency\n* Chronic opioid use for more than 3 months prior to surgery\n* Refusal or inability to provide informed consent","60 Years",{"count":105,"type":21},90,[24],"The goal of this clinical trial is to learn which of three regional anesthesia approaches provides better pain relief and safety for older adults having planned hip replacement surgery. Researchers will study people aged 60 years and older who are scheduled for elective total hip arthroplasty.\n\nThe main questions this study aims to answer are:\n\nWhich anesthesia method provides better pain control after surgery? Which method reduces the need for opioid pain medicines? Are there differences in side effects and recovery between the approaches? Participants will be randomly assigned to one of three groups. All participants will receive spinal anesthesia. One group will receive spinal anesthesia with intrathecal morphine. The other two groups will receive spinal anesthesia combined with a nerve block called the pericapsular nerve group (PENG) block, with or without the addition of dexamethasone.\n\nParticipants will have their pain levels measured at regular times during the first two days after surgery. Researchers will also record opioid use, time to first pain medication, ability to move after surgery, length of hospital stay, and any side effects such as nausea or itching. Blood tests will be used to measure markers of inflammation.\n\nThe results of this study may help doctors choose safer and more effective pain control strategies for people undergoing hip replacement surgery.",[28,27],[110],"total hip arthroplasty","2026-05-06",{"date":86,"type":33},{"date":114,"type":21},"2026-06-01",{"date":116,"type":21},"2027-05-01",{"name":39,"class":40},{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":137,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":41},"100614824","pericapsular-nerve-group-peng-block-combined-with-lateral-femoral-cutaneous-nerve-lfcn-block-or-wound-infiltration-for-postoperative-analgesia-in-anterior-approach-total-hip-arthroplasty-a-randomized-controlled-trial-100614824","NCT07284615","Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration (WI) Combined With Pericapsular Nerve Group (PENG) Block for Analgesia in Elective Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial","Peng_lfcn\u002FWI","Inclusion Criteria:\n\n* Age \\> 18 years\n* Elective total hip arthroplasty\n* Spinal (subarachnoid) anesthesia\n* Written informed consent provided by the patient or by the legal guardian, if appointed\n\nExclusion Criteria:\n\n* INR \\> 1.5\n* aPTT \\> 1.5\n* Platelet count \\\u003C 75,000\u002Fmm³\n* Signs suggestive of infection at the puncture site\n* Absence of informed consent to the procedure\n* Documented or suspected allergy to local anesthetics",{"count":127,"type":21},102,[24],"This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach. Patients will be randomized to receive either a Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block, or a PENG block combined with wound infiltration (WI).\n\nThe primary outcome is postoperative pain intensity at rest, measured by Numerical Rating Scale (NRS) at 6 hours after surgery. Secondary outcomes include dynamic pain scores at 6, 24, and 48 hours, total opioid consumption, time to first rescue analgesia, quadriceps strength, hip flexion angle, length of stay, and adverse events.\n\nAll procedures are routinely used in clinical practice and carry minimal additional risk. Safety will be continuously monitored by the Principal Investigator and the study team according to an internal Safety Monitoring Plan.",[28,131,132,133,134,135,136],"Hip Arthropathy","Locoregional Anesthesia","Complication of Anesthesia","Regional Anesthesia Morbidity","Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge","Opioid Consumption",[138,139,140],"Postoperative muscle weakness","ERAS","Regional Block","2026-03-21",{"date":143,"type":33},"2026-03-25",{"date":145,"type":33},"2026-01-26",{"date":147,"type":21},"2026-11",{"name":149,"class":40},"Ospedale Edoardo Bassini",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":168,"locationsCount":41},"100618111","peng-block-with-dexmedetomidine-in-older-adults-100618111","NCT07327372","PENG Block With Dexmedetomidine in Older Adults","Effect of Perineural Dexmedetomidine as an Adjuvant to Pericapsular Nerve Group Block in Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled for elective or emergency hip surgery (e.g., hip fracture fixation or hip arthroplasty)\n* ASA physical status I-III\n* Ability to communicate pain intensity using the NRS scale\n* Written informed consent obtained from the patient or legal representative\n* Planned use of PENG block as part of multimodal perioperative analgesia\n\nExclusion Criteria:\n\n* Patient refusal or inability to provide informed consent\n* Allergy, intolerance, or contraindication to any study medication: ropivacaine, dexmedetomidine\n* Pre-existing neurological deficit or neuropathy of the affected limb\n* Coagulopathy (INR \\>1.5, platelets \\\u003C100,000\u002FµL) or current therapeutic anticoagulation that contraindicates regional anesthesia\n* Infection at or near the injection site\n* Severe hepatic or renal impairment\n* History of chronic opioid use (daily opioids \\>30 days before surgery)\n* Cognitive impairment or delirium precluding reliable pain assessment\n* BMI \\> 40 kg\u002Fm² (if you want to exclude for technical difficulty)\n* Patients receiving another regional nerve block for hip surgery\n* Pregnancy or breastfeeding\n* Participation in another interventional clinical trial within 30 days",{"count":158,"type":21},30,[24],"Pain after hip surgery is a common problem in older adults and may delay early mobilization, increase the need for opioid pain medications, and contribute to complications such as delirium, nausea, or prolonged hospital stay. Regional anesthesia techniques are increasingly used to improve pain control while reducing the use of systemic opioids.\n\nThe pericapsular nerve group (PENG) block is a modern ultrasound-guided regional anesthesia technique designed to provide effective pain relief after hip surgery while preserving muscle strength. It allows patients to begin mobilization earlier and may reduce the risk of postoperative complications, which is particularly important in older adults.\n\nRopivacaine is a commonly used local anesthetic for nerve blocks. Dexmedetomidine is a medication that, when added in small doses to local anesthetics, may prolong pain relief and improve the quality of nerve blocks without significantly increasing side effects. However, the benefits and safety of adding dexmedetomidine to the PENG block in older adults have not been sufficiently studied.\n\nThe aim of this randomized controlled clinical study is to compare the effectiveness and safety of two PENG block techniques in older adults undergoing hip surgery. Participants will be randomly assigned to one of two groups. One group will receive a PENG block with 20 mL of 0.2% ropivacaine. The second group will receive a PENG block with 20 mL of 0.2% ropivacaine combined with 25 micrograms of dexmedetomidine.\n\nThe study hypothesis is that the addition of dexmedetomidine to ropivacaine in the PENG block will provide longer-lasting and more effective postoperative pain relief compared with ropivacaine alone, without increasing adverse effects. Outcomes assessed in the study will include postoperative pain intensity, need for additional pain medications, time to first mobilization, and the occurrence of side effects such as low blood pressure, slow heart rate, excessive sedation, or delirium.\n\nThe results of this study may help optimize regional anesthesia techniques for hip surgery in older adults and contribute to safer, more effective postoperative pain management strategies.",[27,28],"2026-03-02",{"date":164,"type":33},"2026-03-04",{"date":166,"type":33},"2026-02-06",{"date":37,"type":21},{"name":39,"class":40},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":41},"100489122","post-marketing-surveillance-study-of-the-saphir-stem-in-primary-hip-surgery-100489122","NCT05649007","Post-marketing Surveillance Study of the Saphir Stem in Primary Hip Surgery","Inclusion Criteria:\n\n* patients\\>18 years\n* Candidate for primary total hip replacement with femoral stem and acetabular cup\n* if ostheoarthritis patients aged 18 to 85 years\n* if femoral neck fracture patients aged 18 to 90 years\n* patients with social security scheme\n* patients understands the condition of the study and is willing to partecipate for the duration of the clinical investigation\n* patients who gavee consent to partecipare in the clinical investigation\n\nExclusion Criteria:\n\n* \\\u003C18 years\n* if female, pregnant\n* patient who has already had primary hip surgery on the same side\n* local or disseminated neoplastic disease\n* inability to understand the study and agree to partecipate\n* patients cancelling partecipation before surgery\n* patients under guardianship or curatorship\n* patients without a social security scheme\n* patients refusing to partecipate",{"count":176,"type":21},630,"Post-market clinical follow up investigation on the use of saphir stem and FIN Cup or Dualis system in the treatment of pathologies requiring hip arthroplasty. The main object of the clinical investigation is the evaluation of long term survival rate of Saphir stem.",[28],"2022-12-12",{"date":181,"type":33},"2022-12-13",{"date":183,"type":33},"2022-09-30",{"date":185,"type":21},"2036-09-30",{"name":187,"class":66},"Gruppo Bioimpianti S.r.l."]