[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arthropathy-of-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arthropathy-of-knee":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,42,68,95,122,143,177],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100634790","evaluation-of-5-year-survival-and-clinical-outcomes-in-patients-undergoing-total-knee-arthroplasty-with-a-polyethylene-tibial-component-100634790",false,"NCT07544264","Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component","ALLPOLY-TKA","Inclusion Criteria:\n\n1. Male and female subjects aged ≥50 and ≤85 years who are candidates for primary cemented total knee arthroplasty based on physical examination and medical history, including a diagnosis of severe knee pain and disability due to at least one of the following conditions:\n\n   1. Primary or secondary osteoarthritis\n   2. Collagen disorders and\u002For avascular necrosis of the femoral condyle\n   3. Moderate valgus, varus, or flexion deformities (Hip-Knee-Ankle angle within ±15°).\n2. Patients who provide consent and are able to complete the scheduled study procedures and follow-up assessments.\n3. Patients who sign the informed consent approved by the Ethics Committee.\n\nExclusion Criteria:\n\n1. Patients under 50 years of age and over 85 years of age;\n2. Diagnosis of rheumatoid arthritis;\n3. Patients with a contralateral joint prosthesis on the same side;\n4. Coronal plane deformity with a Hip-Knee-Ankle (HKA) angle greater than 15 degrees in varus or valgus.","ALL","50 Years","85 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","Total knee arthroplasty (TKA) is one of the most successful procedures in orthopedic surgery for treating advanced knee osteoarthritis, providing pain relief, functional recovery, and improved quality of life. Advances in implant design and materials have further enhanced joint kinematics and patient satisfaction.\n\nAn aging population has increased the number of elderly patients with comorbidities, potentially affecting surgical outcomes and implant longevity. Polyethylene has long been used in knee prostheses; early all-polyethylene tibial components were abandoned due to high wear and failure rates, in favor of metal-backed designs, which became the gold standard.\n\nRecently, highly cross-linked ultra-high-molecular-weight polyethylene (UHMWPE) has renewed interest in all-polyethylene tibial components, although their use remains limited. These implants offer potential advantages, including elimination of locking mechanism failures, reduced backside wear, lower costs, and possibly better load distribution.\n\nEvidence from registries, systematic reviews, and meta-analyses shows that 15-year survival of all-polyethylene tibial components is comparable or even superior to metal-backed designs, with no significant differences in clinical-functional outcomes. Additionally, all-poly components are significantly less expensive.\n\nGiven these findings, increasing their use and evaluating outcomes in Italy is warranted. The aim of the present study is to assess implant survival of the Link Symphoknee prosthesis with an all-polyethylene tibial component, along with clinical-functional outcomes and post-discharge readmission rates in patients treated at the Rizzoli Orthopaedic Institute.",[27,28],"Prosthesis Survival","Arthropathy of Knee","RECRUITING","2026-06-22",{"date":32,"type":33},"2026-06-23","ACTUAL",{"date":35,"type":33},"2026-05-13",{"date":37,"type":21},"2032-10",{"name":39,"class":40},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":62,"leadSponsor":64,"locationsCount":67},"100642396","mako-more-registry-100642396","NCT07647354","Mako-MORE Registry","A Prospective, Multi-center, Post-market, Registry-based Evaluation of the Clinical Outcomes in Patients Receiving a Stryker Implant With Use of the Mako Robotic-Arm Assisted System (Mako-MORE)","Inclusion Criteria:\n\n* The subject is skeletally mature, and ≥ 18 years old.\n* The Subject has signed and dated an IRB\u002FEC approved, study specific Informed Patient Consent Form (ICF).\n* The subject is scheduled to undergo manual arthroplasty or Mako Robotic-Arm Assisted Arthroplasty according to IFU.\n* The subject is willing and able to comply with postoperative scheduled clinical evaluations.\n\nExclusion Criteria:\n\n* The subject is not able to express his\u002Fher consent as deemed by the investigator.\n* The subject is not able to fulfill a self-assessment questionnaire or follow-up visits as deemed by the investigator.\n* The subject is a prisoner.\n* Per surgeon discretion the subject is not a candidate for the study.\n* The subject is pregnant or breastfeeding.","18 Years",{"count":51,"type":21},950,"5 Years","OBSERVATIONAL","This is a prospective, post-market, multi-center, registry-based observational study designed to collect real-world clinical data on patients undergoing joint arthroplasty with Stryker implants, with or without the use of the Mako Robotic-Arm Assisted System. The registry will collect prospective data on patient characteristics, procedural details, patient-reported outcomes, radiographic assessments, and adverse events. Patients will be enrolled into procedure-specific cohorts and followed for up to five years postoperatively.",[28,56],"Arthropathy of Hip","NOT_YET_RECRUITING","2026-06-09",{"date":60,"type":33},"2026-06-15",{"date":60,"type":21},{"date":63,"type":21},"2037-03-15",{"name":65,"class":66},"Stryker Orthopaedics","INDUSTRY",5,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":16,"minAge":49,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100352525","total-knee-arthroplasty-fast-track-protocol-is-the-future-100352525","NCT03869996","Total Knee Arthroplasty: Fast Track Protocol is the Future?","Randomised Controlled Study Comparing Fast Track and Standard Care Protocol on the Functional Outcomes and Hospital Stay of Total Knee Arthroplasty","FastTrack-G","Inclusion Criteria:\n\n* patients affected by knee osteoarthritis, eligible for primary total knee arthroplasty\n* BMI \\\u003C 32\n* Time up ang go test \\\u003C\u002F= 12 seconds\n* American Society of Anesthesiologists physical status classification system (ASA) \\\u003C\u002F= 2\n* preoperative hemoglobin (HB) \\>13 g\u002Fdl\n* patients eligible for spinal anesthesia\n* presence of a care-giver\n\nExclusion Criteria:\n\n* psychiatric diseases\n* preoperative use of crutches\n* ASA \\> 3\n* preoperative HB \\\u003C 13 g\u002Fdl",true,"78 Years",{"count":79,"type":21},64,[24],"Fast-track total knee arthroplasty (TKA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery. The aim of this protocol is to compare the standard care and fast track total knee arthroplasties in terms of functional and subjective outcomes, hospital staying, number of transfusions and analgesic consumption.",[83,28],"Osteoarthritis, Knee",[85,86],"fast track care","total knee arthroplasty","2026-05-20",{"date":89,"type":33},"2026-05-22",{"date":91,"type":33},"2019-02-25",{"date":93,"type":21},"2026-11-01",{"name":39,"class":40},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":41},"100468594","pre-operative-inspiratory-muscle-strength-training-in-total-joint-surgery-100468594","NCT05381818","Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery","Preoperative Inspiratory Muscle Strength Training and Pulmonary Complications After Surgery","Inclusion Criteria:\n\n* 18 or older\n* History of current or previous tobacco use (including vaping containing nicotine products)\n* One or more risk factors for post operative pulmonary complications including history of current or previous tobacco use, a clinically diagnosed lung disease, shortness of breath with minimal exertion, FEV1 or FVC less than 80% than predicted or respiratory muscles strength below lower limit of normal for age and sex.\n* History of smoking related lung disease\n* Projected surgical time \\> 30 minutes\n* Ability to follow instructions to complete IMT exercises\n* Ability to communicate adverse effects such as pain or fatigue or the need for assistance\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists physical status classification of 4 or greater .\n* Recent history of acute pneumonia or lower respiratory infection in the previous two weeks requiring acute corticosteroid or antibiotic medication,\n* Preoperative dependence on continuous supplemental oxygen dependence.\n* Preoperative dependence on positive pressure breathing support while awake and upright (night time CPAP permitted),\n* Diagnosis of a neurologic condition (i.e. MS, ALS, Parkinson's, stroke),\n* Participating in a pulmonary rehabilitation program\n* Severe obstructive pulmonary disease (Classification of Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 or higher, indicating FEV1\\\u003C50% predicted.\n* Patients with an infectious disease requiring isolation (i.e. COVID-19).","100 Years",{"count":104,"type":21},36,[24],"The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery. It is known that breathing function decreases for a few days after surgery. in In this study, we want to see if exercising before surgery strengthens the breathing muscles and improves recovery after surgery.",[28,56,108,109],"Lower Extremity Fracture","Orthopedic Disorder",[111,112,113],"Inspiratory muscle training","Pulmonary complications","Total joint replacement",{"date":115,"type":33},"2026-05-15",{"date":117,"type":33},"2022-07-01",{"date":119,"type":21},"2026-12",{"name":121,"class":40},"University of Florida",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":102,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":41},"100433444","a-comparison-of-primary-tka-rehabilitation-using-a-smart-orthotic-versus-outpatient-physical-therapy-100433444","NCT04924205","A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy","A Prospective Comparison Of Primary Total Knee Arthroplasty Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy","Inclusion Criteria:\n\n* Ages 18-100\n* Indicated for primary total knee arthroplasty\n* Possess a smartphone with capabilities to use the FocusMotion app and FM2 Knee Brace\n* Home discharge post-operatively\n\nExclusion Criteria:\n\n* Prior ipsilateral knee surgery\n* Prior manipulation under anesthesia of either knee\n* BMI \\> 40",{"count":130,"type":21},80,[24],"This will be a prospective, randomized, noninferiority clinical trial comparing rehabilitation methods post-total knee arthroplasty (TKA). Population of interest is adult hip\u002Fknee clinic patients over age 18 who are indicated for unilateral primary total knee arthroplasty. All TKA patients are prescribed physical therapy (PT) for rehabilitation post-operatively. The investigators will compare this current treatment with a new, validated, wearable smart knee brace (FM2 Knee Brace) that can be used for rehabilitation post-TKA. Following enrollment in the study, the investigators will match and randomize participants into two cohorts (outpatient PT versus FM2 Knee Brace). Outpatient PT group will be prescribed routine six-week course of outpatient PT (no pool exercises, remainder at therapist's discretion) to start as soon as possible upon discharge. The FM2 Knee Brace group will complete device set up at pre-op visit and will be prescribed 3-4 exercises to complete at their discretion over six weeks. The investigators will collect measurements of knee flexion, extension, total arc of motion at pre-op visit and at 6-week, 3-month, and 1-year post-op visits. The investigators will also plan to record additional PROs, therapy compliance, and complication rates. The investigators will compare the two groups to test whether the new FM2 Knee Brace is noninferior to regular PT when recovering from TKA, and if the new technology could be an alternative to outpatient PT.",[28],"2026-03-21",{"date":136,"type":33},"2026-03-25",{"date":138,"type":33},"2021-09-01",{"date":140,"type":21},"2028-12",{"name":142,"class":40},"Nicolas Noiseux, MD, MS, FRCSC",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":41},"100461604","total-versus-robotic-assisted-unicompartmental-knee-replacement-100461604","NCT05290818","Total Versus Robotic Assisted Unicompartmental Knee Replacement","Total Versus Robotic Assisted Unicompartmental Knee Replacement (TRAKER) for Medial Compartment Osteoarthritis: Randomised Controlled Trial","TRAKER","Inclusion Criteria:\n\n* Listed for elective primary TKA for end stage medial compartment osteoarthritis\n* Intact anterior cruciate ligament\n* Full thickness and good quality lateral cartilage\n* Correctable intra-articular varus deformity and intact medial collateral ligament\n* American Society of Anesthesiologists (ASA) grades 1 and 2\n* Male or female, age 50 - 75 at the time of listing for surgery\n* Suitable candidate for a cruciate retaining TKA (Triathlon prosthesis) and a UKA\n\nExclusion Criteria:\n\n* Varus deformity of \\> 20 degrees\n* Fixed flexion of \\>10 degrees\n* Patient is unable to comply with the study protocol (incl. refusal for CT scan) or functional assessments\n* Female participants who are pregnant, lactating or planning pregnancy during the course of the study\n* Requires patella resurfacing or lateral compartment has significant OA\n* Inability to understand the patient information for the study, provide written informed consent or answer study questionnaires for cognitive or language reasons\n* Inflammatory disorder e.g. rheumatoid arthritis\n* Symptomatic foot, hip or spine pathology\n* Prior surgery (other than arthroscopy) or septic arthritis of the knee\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study,","75 Years",{"count":153,"type":21},159,[24],"The purpose of this research is to compare the functional outcomes of patients with end stage medial compartment OA of the knee undergoing a conventional mTKA to those undergoing rUKA and to assess the associated cost economics of such technology.",[157,158,28],"Osteo Arthritis Knee","Arthritis Knee",[160,161,162,163,164,165,166],"Arthroplasty","Robotic","Knee","Total","Partial","Outcome","MAKO","2026-02-04",{"date":169,"type":33},"2026-02-06",{"date":171,"type":33},"2024-08-26",{"date":173,"type":21},"2027-12-31",{"name":175,"class":176},"NHS Lothian","OTHER_GOV",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100610864","mri-role-in-knee-hemophilic-arthopathy-100610864","NCT07233122","MRI Role in Knee Hemophilic Arthopathy","MRI Vs Conventional Radiography in Assessing Knee Hemophilic Arthropathy : A Scoring Based Approach","Inclusion Criteria:\n\n* Adult patient ( more than 18 years old ) diagnosed as Haemophilia with history of bleeding in knee joint more than once\n\nExclusion Criteria:\n\n* \\*contraindications for MRI such as claustrophobia , metallic foriegn body carriers , cardiac pacemaker\n\n  * patient refused the exam\n  * Pregnant female patients",{"count":185,"type":21},95,"The aim of this study is to assess role of MRI in detecting synovial, cartilaginous , osseous abnormalities ، bleeding inside knee joint and to use a system for assessing HA as support for therapeutic regimes and for monitoring response to therapy .",[188,189,190,28],"MRI","Hemophilia","Arthropathy Hemophilic","2025-11-16",{"date":193,"type":33},"2025-11-18",{"date":195,"type":21},"2025-12-01",{"date":197,"type":21},"2027-12-01",{"name":199,"class":40},"Assiut University"]