[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arthroplasties-knee-replacement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arthroplasties-knee-replacement":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,78,106,130,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100633907","feasibility-of-good-boost-for-adults-awaiting-total-knee-replacement-100633907",false,"NCT07532785","Feasibility of Good Boost+ for Adults Awaiting Total Knee Replacement","Feasibility of a Community-Based Aquatic Exercise and Peer Support Intervention (Good Boost+) for Adults on Knee Replacement Waiting Lists: A Randomised Hybrid Type 1 Effectiveness-Implementation Feasibility Trial","Inclusion Criteria:\n\nAged 18 years or over. Registered on a wait list for primary total knee replacement with sufficient time to complete the 6 week intervention and follow up assessments prior to surgery.\n\nModerate self reported intensity knee joint pain within the previous month, defined as ≥4 but \\\u003C10 on the 11 point Numeric Pain Rating Scale (NPRS: 0 = no pain, 10 = worst pain imaginable).\n\nWilling and able to participate in a six week programme of weekly group water-based exercise at specified leisure centre swimming pools in Southwark and three times weekly land-based exercise training in a private setting.\n\nWilling to pay £4.30 for water-based exercise sessions 5 \\& 6. This fee is in line with the usual cost of over 60s group exercise classes at local leisure centres.\n\nAccess to a smart phone or tablet computer with internet access. Willing and able to accept either trial arm allocation. Willing and able to give informed consent.\n\nExclusion Criteria:\n\nIndividuals scheduled to have another major joint replacement (e.g. contralateral knee, hip or shoulder) within the study period.\n\nIndividuals on the waiting list for revision surgery of a previous knee replacement.\n\nIndividuals with active inflammatory arthritis (e.g., RA, PsA, lupus, axial SpA) that is clinically symptomatic or requires ongoing immunosuppressive therapy to control disease activity.\n\nIndividuals who self-report being advised by a healthcare professional not to exercise.\n\nIndividuals who have previously participated in water-based exercise sessions delivered via the Good Boost HUB application.\n\nParticipating or planning to participate in another interventional clinical study\u002Ftrial during the study period that in the opinion of the investigator could affect the outcomes of this study.\n\nIndividuals unable to understand written or spoken English or communicate sufficiently well in English to participate despite assistance from a family member or friend.\n\nIndividuals unable to comply with the protocol \u002F requirements of study participation.\n\nIndividuals with any other severe concomitant disease that, in the opinion of the investigator might interfere with trial procedures and\u002For assessments.","ALL","18 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomised controlled feasibility trial is to find out whether it is possible to run a larger study of the Good Boost+ community based rehabilitation programme for people waiting for a primary total knee replacement.\n\nThe study will look at how many people are willing to take part, whether they stay in the study, and whether they can follow the Good Boost+ programme as planned. It will also explore how acceptable the programme is to patients, NHS staff and leisure centre staff, and which outcome measures are most useful for a future full scale trial. The study will also look at what helps or hinders delivery of the programme in real world NHS and community settings.\n\nThe main questions it aims to answer are:\n\n* How many people waiting for knee replacement surgery are willing to take part in the study\n* Whether participants can continue with the Good Boost+ programme as planned over the study period\n* Which outcome measures best capture any potential benefits of the programme\n* How acceptable the programme is to patients, NHS and leisure centre staff\n* What helps or makes it difficult to deliver the programme in practice.\n\nParticipants will be randomly assigned to one of two groups.\n\n* Usual NHS care or\n* Usual NHS care plus the Good Boost+ programme\n\nParticipants in the Good Boost+ programme will take part in six weekly group water based exercise sessions held in local swimming pools, as well as land based exercise sessions that can be done individually or by joining a virtual group. The exercise sessions are delivered through Good Boost's digital technology, using small waterproof tablet computers at swimming pools, and smartphones or computers for land-based sessions. Physiotherapy staff will provide guidance throughout, and volunteers will offer refreshments after pool sessions to support social connection.\n\nAll participants, including those receiving usual NHS care only, will be asked to complete an exercise diary, rate their knee pain each week, and complete short questionnaires at 6 and 10 weeks after joining the study.",[26,27],"Osteoarthritis (Knee)","Arthroplasties, Knee Replacement",[29,30,31,32,33],"Total Knee Replacement","Prehabilitation","Feasibility","Randomised controlled trial","Implementation","NOT_YET_RECRUITING","2026-04-09",{"date":37,"type":38},"2026-04-16","ACTUAL",{"date":40,"type":20},"2026-06",{"date":42,"type":20},"2028-02",{"name":44,"class":45},"King's College Hospital NHS Trust","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100628708","multimodal-prehabilitation-of-frail-patients-undergoing-elective-knee-or-hip-replacement-100628708","NCT07465159","Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement","Multimodal Prehabilitation of Frail Patients 70 Years and Older Undergoing Elective Knee or Hip Replacement: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 70 years or older assigned to undergo hip\u002Fknee replacement at Landspítali University Hospital.\n* Inclusion will be offered to patients who have previously presented at the outpatient orthopedic department and been scheduled for an elective (with a waiting period ≥2 months before surgery) hip\u002Fknee replacement.\n* Patients who are willing to participate and sign informed consent and are willing to be randomized to the control or intervention arm.\n\nExclusion Criteria:\n\n* Patients who screen negative for all frailty tools will be excluded from the study.\n* Patients who are already in active physiotherapy, meeting with a physiotherapist \\>1 every month, will also be excluded.\n* In addition, those who do not undergo planned surgery, are undergoing redo hip\u002Fknee prosthesis replacement will be excluded","70 Years",{"count":56,"type":20},50,[23],"Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement. While prehabilitation has shown promise in enhancing outcomes, evidence from randomized controlled trials (RCTs) in frail orthopedic patients is limited.\n\nObjective: This study aims to evaluate the feasibility and preliminary data on the effectiveness of a multimodal prehabilitation program for frail patients undergoing elective hip or knee arthroplasty.\n\nMethods: A pilot RCT will be conducted at Landspítali-University Hospital. Patients ≥70 years scheduled for surgery with ≥2 months waiting time will be screened for frailty using PRISMA-7, the Clock Drawing Test, and Timed Up \\& Go. Patients screening positive for any of the three screening tools will be randomized to multimodal prehabilitation or standard of care. The intervention includes comprehensive geriatric assessment, medication review, tailored physiotherapy using the Otago Exercise Programme, and nutritional counseling if at risk of malnutrition. We will conduct an external pilot for feasibility measures (overall enrollment, recruitment, retention, adherence). Secondary outcomes include physical performance, postoperative complications, patient-reported health status (WOMAC scale) and quality of life (EQ-5D-5L ), length of primary hospital stay, discharge location, falls postoperatively, 180-day readmission and 180-day mortality.\n\nSignificance: This trial may aid in the design of larger RCT study and provide a signal of the role of multimodal prehabilitation on outcomes, including quality of life and health status among frail arthroplasty patients.",[60,30,27,61],"Frailty Syndrome","Arthroplasties, Hip Replacement",[63,64,30,65,66,67],"Frailty","Arthroplasty","Multimodal prehabilitation","Knee replacement","Hip replacement","RECRUITING","2026-04-01",{"date":71,"type":38},"2026-04-07",{"date":73,"type":38},"2026-03-20",{"date":75,"type":20},"2027-12-31",{"name":77,"class":45},"University of Iceland",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":46},"100587245","effect-of-micronized-creatine-monohydrate-on-muscle-mass-strength-and-performance-in-older-adults-submitted-to-total-knee-arthroplasty-100587245","NCT06925880","Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty","Efficacy of Supplementation With Micronized Creatine Monohydrate in the Recovery of Muscle Mass, Muscle Strength and Functional Capacity in Older Adults Operated on for Total Knee Arthroplasty: Randomized Clinical Trial","CREAR","Inclusion Criteria:\n\n* Persons 65 years of age or older who have been operated on for the first time for total knee arthroplasty,\n* who are undergoing an outpatient rehabilitation program according to standard clinical practice,\n* who sign the informed consent form.\n\nExclusion Criteria:\n\n* Chronic renal disease at stage G3b or higher or glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2.\n* Hepatic insufficiency, cirrhosis.\n* Neuromuscular and neurodegenerative diseases (amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myasthenia gravis, Parkinson's disease, etc.).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) (GOLD III-IV).\n* Moderate or severe chronic heart failure (NYHA 3-4).\n* Central sensitivity syndrome (fibromyalgia and chronic fatigue syndrome).\n* Moderate or severe cognitive impairment (GDS≥4).\n* Moderate-severe dependence for basic activities of daily living (preintervention Barthel index \\\u003C60 points).\n* Hemiparesis, amputation or malformation of any limb.\n* Consumption of creatine monohydrate supplements in the last 6 months.","65 Years",{"count":88,"type":20},262,[23],"Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g\u002Fday for 1 week and then continue with a maintenance dose of 5g\u002Fday for 11 weeks.\n\nMain outcome mesures included muscle mass, muscle strenght, sarcopenia, frailty, functional capacity and physical performance and will be assessed at baseline, 3 and 6 months follow-up.",[92,93,94,95,27,96],"Sarcopenia in Elderly","Frailty at Older Adults","Functional Capacity","Creatine Supplementation","Physical Performance","2026-03-25",{"date":99,"type":38},"2026-03-30",{"date":101,"type":38},"2025-06-10",{"date":103,"type":20},"2027-10-31",{"name":105,"class":45},"Consorci Sanitari del Maresme",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":113,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":21,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":46},"100617509","accelerated-rehabilitation-in-individuals-after-total-knee-arthroplasty-100617509","NCT07319546","Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty","Effectiveness of Accelerated Rehabilitation on Knee Joint Function and Quality of Life in Individuals With Total Knee Arthroplasty: A Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients diagnosed with end-stage knee OA necessitating primary unilateral TKA.\n\nExclusion Criteria:\n\n* History of joint infections, cancer, or inflammatory arthritis.\n* End-stage OA from rheumatoid or septic arthritis.\n* Individuals with neurological disorders such as Alzheimer's disease, - Parkinson's disease, stroke.\n* Individuals who are unable to follow a structured rehabilitation protocol.\n* Previous history of knee surgeries (other than arthroscopy).\n* Severe comorbidities that would hinder participation (e.g., advanced cardiovascular diseases).\n* Individuals who have severe osteoporosis.","50 Years","80 Years",{"count":116,"type":20},32,[23],"The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to conventional rehabilitation in Dali, Yunan, China. The study will include patients aged 50-80 years who are scheduled for primary unilateral TKA. Participants will be randomly assigned to either an accelerated rehabilitation group or conventional rehabilitation group. The primary outcomes will include knee joint function, assessed using the KOOS and quality of life measures using the SF-36 surveys. The study will follow participants for 6 months post-surgery to assess longer-term outcomes. This study will not include individuals undergoing revision TKA or those with severe comorbid conditions. The results will provide critical insights into the role of accelerated rehabilitation in improving post-operative recovery, functional outcomes, and overall quality of life for TKA patients.",[120,27],"Knee Osteoarthristis","2025-12-21",{"date":123,"type":38},"2026-01-06",{"date":125,"type":38},"2025-12-01",{"date":127,"type":20},"2027-06-30",{"name":129,"class":45},"Mahidol University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":137,"sex":16,"minAge":138,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":140,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":46},"100596807","phase-3-post-operative-urinary-retention-on-revision-knee-arthroplasty-the-role-of-intrathecal-morphine-100596807","NCT07050277","Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine","POURRKA","Inclusion Criteria:\n\n* Non pregnant patients undergoing unilateral non infected rTKA surgery;\n* Older than 21 years of age, with American Society of Anesthesiologists (ASA) physical status I-III;\n* With no alcohol or drug dependency history;\n* With sufficient understanding and co-operation about the usage of a perineural catheter for pain management; body mass index (BMI) under 45;\n* With no allergy to medications used in the study protocol (bupivacaine, lidocaine, ropivacaine, midazolam, propofol, ketamine, morphine, hydromorphone, fentanyl, acetaminophen, celecoxib, ondansetron, dexamethasone, tranexamic acid);\n* No current or recent use of opioids (within the last 2 weeks) in an average oral morphine equivalent (OME) of 20 mg\u002Fday or higher;\n* With no contra-indications for neuraxial anesthesia, IPACK block, ACB and adductor canal catheter insertion;\n* Who speak and understand the English language;\n* Who agrees to participate on this study through the signature of the consent form.\n\nExclusion Criteria:\n\n* Patients will be excluded of the study if they have a failed spinal anesthesia and needs for a conversion to general anesthesia;\n* If peripheral nerve blocks are not possible to be performed due to technical difficulties;\n* If during patient's care a deviation of the protocol occurs;\n* If CACB catheter has issues on its function, disconnects or exteriorizes within the first 48 hours of infusion;\n* Or if patient decides to withdraw from the study.",true,"21 Years",{"count":56,"type":20},[141],"PHASE3","Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs. The multimodal approach, including single shot or continuous nerve blocks with catheters and spinal or epidural morphine, is a stablished strategy. Although the administration of intrathecal morphine (IM) has been shown to significantly reduce pain scores, it is not free of adverse effects. Postoperative urinary retention (POUR) is possible and might increase the risk of periprosthetic infection. The purpose of this study is to compare patients undergoing rTKAS under spinal anesthesia with IM to patients undergoing the same procedure, under the same anesthetic technique, but with no IM, for POUR and postoperative pain related outcomes. All patients will have single shot and continuous adductor canal block (CACB) and single shot IPACK (interspace between the popliteal artery and the posterior knee capsule) block. The hypothesis is that postoperative pain control is comparable between the groups, with lower incidence of POUR in patients with no IM given.",[27,144,145,146],"Nerve Block","Urinary Retention Postoperative","Anesthesia, Spinal","2025-12-19",{"date":149,"type":38},"2025-12-29",{"date":151,"type":38},"2025-06-24",{"date":153,"type":20},"2027-08-01",{"name":155,"class":45},"University of Toronto",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":165,"briefSummary":166,"conditions":167,"keywords":170,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":186},"100575092","morbid-obesity-and-severe-knee-osteoarthritis---which-should-be-treated-first-100575092","NCT06767787","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?","Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? A Randomized Cross-over Study","Inclusion Criteria:\n\n* BMI \\> or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy\n\nExclusion Criteria:\n\n* a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class \\> 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.",{"count":164,"type":20},142,[23],"The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.\n\nParticipants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.",[168,27,169],"Osteoarthritis of Knee","Sleeve Gastrectomy",[171,172,173,174,175,176],"knee osteoarthritis","bariatric surgery","laparoscopic sleeve gastrectomy","knee replacement","knee arthroplasty","obesity","2025-01-28",{"date":179,"type":38},"2025-01-30",{"date":181,"type":20},"2025-02",{"date":183,"type":20},"2027-01",{"name":185,"class":45},"Memorial University of Newfoundland",2]