[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"arthroplasty-replacement-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:arthroplasty-replacement-knee":85},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,45,73,96,125,151,179,205,240,264,302,330,354,374],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100620338","a-prospective-single-arm-trial-to-determine-contamination-rates-when-using-an-antibacterial-incise-drape-during-orthopedic-surgery-100620338",false,"NCT07356323","A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery","Inclusion Criteria:\n\n* Subject is ≥ 22 years of age on the day of surgery.\n* Subject is scheduled to undergo a unilateral primary arthroplasty procedure on a hip or knee.\n* Subject is capable of providing informed consent.\n* Subject is willing and able to return for all visits.\n\nExclusion Criteria:\n\n* Subject is pregnant or lactating prior to surgery.\\*\n\n  \\*Women who have had surgical sterilization by a medically accepted method (e.g., tubal ligation, hysterectomy, or oophorectomy) or are post-menopausal, defined as not having menstruation for \\> 12 months will not be required to undergo pregnancy testing\n* Subject is scheduled to undergo a lower extremity bilateral arthroplasty procedure.\n* Subject had a previous open knee surgery on the study knee or is scheduled to undergo a revision knee arthroplasty.\n* Subject has had a previous surgery for revision femoral acetabular osteotomy or total hip arthroplasty on the study hip.\n* Subject is scheduled for lower extremity arthroplasty due to trauma.\n* Subject was previously diagnosed with septic arthritis or has a history of infection in the joint.\n* Subject has taken any antibiotics within 4 weeks before surgery.\n* Subject has an allergy or sensitivity to components of the device (e.g., chlorhexidine gluconate or acrylate-based adhesive).\n* Subject is currently enrolled in another trial.","ALL","22 Years",{"count":18,"type":19},179,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this clinical study is to generate data on the intended use of a chlorhexidine gluconate (CHG)-impregnated antimicrobial incise drape. The study includes subjects undergoing primary hip or knee arthroplasty procedures.\n\nThe study evaluates the intraoperative performance and safety of the incise drape during surgery, including assessment of contamination and operative characteristics.\n\nParticipants will have a CHG-impregnated antimicrobial incise drape applied during their surgical procedure. During surgery, samples will be collected from the operative site to assess potential bacterial contamination.",[25,26],"Arthroplasty Replacement, Knee","Arthroplasty Total Hip Replacement",[28,29,30,31],"Chlorohexidine Gluconate","Incise drape","CHG","Ioban","RECRUITING","2026-06-29",{"date":35,"type":36},"2026-07-01","ACTUAL",{"date":38,"type":36},"2026-02-19",{"date":40,"type":19},"2026-10",{"name":42,"class":43},"Solventum US LLC","INDUSTRY",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":15,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":20,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100645289","migration-rate-for-continuous-adductor-canal-block-catheters-after-primary-total-knee-arthroplasty-surgery-a-comparison-between-two-insertion-techniques-100645289","NCT07681622","Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between Two Insertion Techniques","Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between the Interfascial Plane Between SArtorious Muscle and FEmoral Artery (ISAFE) and the Out Of Plane Parallel to Saphenous Nerve (OOPS) Techniques: The ISAFE x OOPS Trial","ISAFExOOPS","Inclusion Criteria:\n\n* Non-pregnant patients older than 18 years of age;\n* Patients undergoing unilateral primary total knee arthroplasty in an inpatient regime;\n* American Society of Anesthesiologist (ASA) physical status Class I - IV patients;\n* With sufficient understanding and co-operation about usage of a perineural catheter for pain management;\n* With body mass index (BMI) under 45;\n* With no history of strong opioid use of more than 30 mg of oral morphine equivalent (OME)\u002Fday during the 2 weeks preceding the surgery;\n* No alcohol or drug use disorder history;\n* With no contra-indication for the performance of ACB and IPACK block;\n* With no contra-indication for spinal anesthesia;\n* With no contra-indication for CACB catheter insertion (local site infection, systemic infection, anatomical abnormality);\n* With no contra-indication for the medications to be used accordingly with the study protocol (ropivacaine, lidocaine, mepivacaine, midazolam, fentanyl, propofol, cefazolin, tranexamic acid, dexamethasone, ondansetron, celecoxib, acetaminophen, hydromorphone);\n* Speak and understand the English language;\n* Agree to participate on this study through the signature of the consent form.\n\nExclusion Criteria:\n\n* They have a failed spinal anesthesia and needs for a conversion to general anesthesia;\n* The peripheral nerve blocks are not possible to be performed due to technical difficulties;\n* A deviation of the protocol occurs (not follow the standardized postoperative analgesia orders; need an emergency re-operation of the same knee, in less than 24 hours, due to a surgical complication; have an important perioperative complication, leading to abnormal level of conscience);\n* CACB catheter has issues on its function and needs to be removed before the migration assessment\n* Patient decides to withdraw from the study.",true,"21 Years",{"count":56,"type":19},48,[22],"Continuous adductor canal block (CACB) is becoming increasingly popular for providing postoperative analgesia following knee arthroplasties. These continuous blocks are provided through inserted nerve catheters and effectively extend the duration of analgesia, thereby reducing opioid consumption. This, in turn, helps minimize opioid-related side effects, promotes early ambulation, and supports earlier discharge. However, catheter migration remains a significant concern, as the catheter tip can become displaced from the adductor canal due to movements associated with ambulation or physiotherapy. In this study, the investigators compare the migration rates of two different techniques for CACB catheters insertion: the Interfascial plane between SArtorious muscle and FEmoral artery (ISAFE) and the Out Of Plane parallel to Saphenous nerve (OOPS) techniques. Pain scores and opioid consumption on postoperative day 1 (POD1) will also be assessed as secondary outcomes. The hypothesis is that both techniques will result in similar migration rates of CACB catheter.",[25,60],"Anesthesia Conduction","NOT_YET_RECRUITING","2026-06-25",{"date":64,"type":36},"2026-07-02",{"date":66,"type":19},"2026-06",{"date":68,"type":19},"2027-06",{"name":70,"class":71},"University of Toronto","OTHER",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":53,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":72},"100431346","sleep-patterns-after-total-joint-replacement-surgery-100431346","NCT04896892","Sleep Patterns After Total Joint Replacement Surgery","Inclusion Criteria:\n\n* Patient is to undergo ambulatory total hip arthroplasty or total hip knee arthroplasty.\n* Patient is 18 years or older.\n\nExclusion Criteria:\n\n* Patient is unable to give consent\n* Non-English speaking patients\n* Patients with pre-existing sleep disorders or neurological disorders, including dementia.\n* Patients taking hypnotic drugs or other medication that is known to affect sleep.","18 Years",{"count":81,"type":19},60,"OBSERVATIONAL","The purpose of this study is to determine sleep patterns and sleep quality following total joint arthroplasty, in order to understand when patients should expect to return to baseline or improved sleep following total joint arthroplasty. Patients prospectively enrolled in this study are to undergo total knee arthroplasty (TKA) or total hip arthroplasty (THA). Patients will receive the SleepScore Max device and smart device app to track their sleep patterns starting one week prior to surgery and until six months after surgery. The SleepScore Max device tracks duration of sleep, time to fall asleep, number of nightly awakenings, rapid eye movement sleep, light sleep, deep sleep, and room temperature and light levels. Through the associated application, patients will also record caffeine and alcohol consumption and exercise. In addition to sleep tracking, patients will fill out Pittsburgh Sleep Quality Index (PSQI), PROMIS, Hip Disability and Osteoarthritis Outcome Score (HOOS), and Knee Injury and Osteoarthritis Outcome Score (KOOS) surveys at specified visits. Secondarily, Visual Analog Pain (VAP) scores and opioid consumption measure in milligram morphine equivalents (MME) will be measured during hospital stay and at subsequent post-operative clinic visits. The clinical goal of this study is to better under sleep patterns in patients undergoing TKA and THA and hopefully provide this patient population improved sleep recommendations and interventions.",[85,86],"Arthroplasty, Replacement, Knee","Arthroplasty, Replacement, Hip","2026-04-29",{"date":89,"type":36},"2026-05-05",{"date":91,"type":19},"2026-06-01",{"date":93,"type":19},"2028-03-01",{"name":95,"class":71},"Henry Ford Health System",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":20,"phases":106,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":72},"100620651","bifes-vs-ipack-in-postoperative-knee-arthroplasty-analgesia-100620651","NCT07360392","BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia","Comparison of Postoperative Analgesic Effects of Two Different Anesthesia Techniques in Knee Arthroplasty: Nerve Blocks Named BiFeS and iPACK","Inclusion Criteria:\n\n* Scheduled for unilateral total knee arthroplasty\n* Classified as ASA physical status I-III\n\nExclusion Criteria:\n\n* Scheduled for revision arthroplasty or bilateral surgery\n* Allergy to local anesthetics or contraindication to regional blocks\n* Neurological disorders, peripheral neuropathy, or conditions affecting lower extremity muscle strength\n* Coagulopathy or receiving anticoagulant therapy\n* History of severe liver, kidney, or heart failure\n* Chronic opioid use or history of substance abuse\n* Patients experiencing intraoperative complications (e.g., excessive bleeding)\n* Cases in which adequate sensory blockade is not achieved after the block","80 Years",{"count":105,"type":19},88,[22],"The Biceps Femoris Short Head (BiFeS) block is a new fascial plane block technique targeting the sensory innervation of the posterolateral capsule of the knee while preserving motor function. The aim of this study is to evaluate the postoperative analgesic efficacy of the BiFeS block combined with the adductor canal block (ACB) in patients undergoing total knee arthroplasty, compared to ACB + iPACK block. The study is planned as a prospective, randomized, double-blind, parallel two-group trial. Patients will be randomized in a 1:1 ratio to receive ACB + iPACK (Group A) or ACB + BiFeS (Group B). Postoperative pain scores (VAS), opioid consumption, early mobilization, and quality of recovery (QoR-15) outcomes will be compared.",[85,109,110],"Pain, Postoperative","Anesthesia, Regional",[112,113,114,115,116],"Pain Management","Knee Arthroplasty","BiFes","iPACK","Nerve Block","2026-04-20",{"date":119,"type":36},"2026-04-22",{"date":117,"type":36},{"date":122,"type":19},"2027-06-01",{"name":124,"class":71},"Amasya University",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":4},"100632307","effect-of-rebound-pain-on-chronic-postsurgical-pain-after-total-knee-arthroplasty-100632307","NCT07511985","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older\n* ASA physical status I to III\n* Scheduled for unilateral elective total knee arthroplasty\n* Planned to undergo spinal anesthesia\n* Planned to receive a peripheral nerve block as part of routine multimodal analgesia\n* Able to provide informed consent and complete study assessments\n\nExclusion Criteria:\n\n* Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer)\n* Significant neuropathy or radiculopathy\n* Bilateral or two-stage total knee arthroplasty during the same hospitalization\n* Contralateral total knee arthroplasty within the previous 6 months\n* Severe cognitive impairment or major psychiatric disorder\n* Chronic analgesic dependence",{"count":133,"type":19},220,"This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty. Adult patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia will be included. No additional intervention, drug administration, or biological sampling will be performed beyond standard clinical care.\n\nRebound pain will be assessed during the early postoperative period using pain diaries, numeric rating scale pain scores, and analgesic consumption records. Chronic postsurgical pain and related outcomes will be evaluated at postoperative 3 and 6 months using validated instruments assessing pain severity, neuropathic pain features, psychological status, functional outcomes, and health-related quality of life. The primary outcome is the presence of chronic postsurgical pain at 3 months after surgery. Secondary outcomes include chronic pain at 6 months, pain intensity, neuropathic pain characteristics, opioid consumption, rescue analgesic requirements, sleep disturbance, and quality-of-life measures. The study also aims to explore demographic and clinical factors associated with rebound pain and chronic postsurgical pain.",[136,137,85],"Acute Pain, Postoperative","Chronic Pain",[139,140,141],"rebound pain","chronic postsurgical pain","total knee arthroplasty","2026-04-05",{"date":144,"type":36},"2026-04-09",{"date":146,"type":19},"2026-04-07",{"date":148,"type":19},"2026-12-12",{"name":150,"class":71},"Konya City Hospital",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":20,"phases":160,"briefSummary":161,"conditions":162,"keywords":167,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":72},"100538631","real-component-vs-all-cement-articulating-spacers-for-periprosthetic-knee-infection-100538631","NCT06293352","Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection","Durable, Real-component Antibiotic Spacers vs All-cement Articulating Spacers for the Treatment of Periprosthetic Knee Infection","Inclusion Criteria:\n\n* Patients diagnosed with a chronic periprosthetic joint infection after a primary total knee arthroplasty with plan for explant and placement of an antibiotic spacer\n* PJI defined according to Musculoskeletal Infection Society (MSIS) 2018 Consensus Criteria\n\nExclusion Criteria:\n\n* Patients who are unable to consent\n* Infection at site of revision TKA\n* Soft tissue envelope compromise\n* Allergies to study materials (cement, vancomycin, tobramycin)\n* Incompetent extensor mechanism\n* Extensive bone loss\n\nRandomization-specific exclusion criteria\n\n* Extensive soft tissue defect\n* Extensor mechanism compromise",{"count":159,"type":19},153,[22],"In the US, if an infection in an artificial knee joint doesn't heal with antibiotics alone, the standard treatment is a two-stage revision of the artificial knee. In the first stage, the surgeon will remove the artificial knee and clean out the area around the knee. They will then place an antibiotic spacer. An antibiotic spacer is a type of artificial joint that will release antibiotics into the knee space continuously over time. The spacer allows only very basic function of the knee. The patient may need to use crutches or a walker while the antibiotic spacer is in place. After surgery to place the antibiotic spacer, the surgeon may prescribe a course of antibiotics as well. Because the antibiotic spacer is not as durable as a regular artificial joint, after the infection is gone, another surgery is required to take the spacer out and put a new artificial knee joint in.\n\nThere is another way for artificial joint infections to be treated. This is a one-stage revision. In this treatment, the surgeon will remove the artificial knee and clean out the area around the knee. Then the surgeon will place a new artificial knee in using a special kind of cement that contains antibiotics. The cement will release antibiotics into the knee space continuously over time (the surgeon may prescribe a course of antibiotics as well). The new artificial joint with antibiotic cement will function almost the same as the original artificial knee. This means that while the infection is healing the patient will be able to do most of the regular daily activities. However, the antibiotic cement is not as durable as what is normally used to implant an artificial knee. The artificial knee with the antibiotic cement may need to be replaced with a regular artificial knee. When replacement will need to be done is dependent on patient weight, bone strength and activity level, among other things. When it is time to replace the antibiotic cement artificial knee, the patient will have another surgery where the surgeon will take the antibiotic cement artificial knee and put a new artificial knee joint in.\n\nInvestigators know that both the one- and two-stage revision work equally well to heal the infection, but investigators don't know which patients prefer or which provides better function after many years. This study will randomly assign patients to receive either a one-stage or two-stage revision and then follow them for 5 years to ask them about pain, function, and satisfaction.",[163,164,165,166,85],"Prosthetic-joint Infection","Knee Infection","Arthroplasty Complications","Joint Infection",[168,169],"randomized trial","patient-reported outcomes","2026-03-20",{"date":172,"type":36},"2026-03-24",{"date":174,"type":36},"2024-08-08",{"date":176,"type":19},"2026-12",{"name":178,"class":71},"Northwestern University",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":20,"phases":188,"briefSummary":189,"conditions":190,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":203,"locationsCount":72},"100484806","a-study-of-the-effect-of-a-nurse-navigator-program-on-high-risk-patients-100484806","NCT05592847","A Study of the Effect of a Nurse Navigator Program on High Risk Patients","The Effect of a Nurse Navigator Program on Readmission Rates for Patients With Elevated BMI, COPD, CHF, Dialysis Use, and H\u002Fo Alcohol Abuse","Inclusion Criteria:\n\n\\- Require total or partial hip or knee replacement and have one or more of the following diagnosis: Heart Failure (HF); Chronic obstructive pulmonary disease (COPD); Dialysis; Alcohol Abuse; Low BMI.\n\nExclusion Criteria:\n\n\\- Decrease cognitive capacity to consent to the study.",{"count":187,"type":19},300,[22],"The purpose of this study is to examine if educational intervention in high risk patients can lead to decreased hospital readmissions when compared to patients who are not in the intervention program. Additionally, to determine patient satisfaction with the educational program.",[191,85,86,192,193,194,195,196],"Patient Readmission","Heart Failure","Pulmonary Disease, Chronic Obstructive","Renal Insufficiency","Body Mass Index","Alcoholism","2026-03-17",{"date":199,"type":36},"2026-03-19",{"date":201,"type":19},"2027-01",{"date":68,"type":19},{"name":204,"class":71},"Mayo Clinic",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":20,"phases":214,"briefSummary":215,"conditions":216,"keywords":217,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":72},"100619490","development-and-measurement-of-the-effects-of-a-digital-education-solution-for-patients-undergoing-total-hip-or-knee-arthroplasty-100619490","NCT07345299","Development and Measurement of the Effects of a Digital Education Solution for Patients Undergoing Total Hip or Knee Arthroplasty","CHUVeduc@home","Inclusion Criteria:\n\n* male and female patients admitted to the CHUV musculoskeletal department during the study period\n* primary total hip replacement or primary total knee replacement\n* a Risk Assessment and Prediction Tool (RAPT) score \\>6\n\nExclusion Criteria:\n\n* a RAPT score \\\u003C6,\n* knee\u002Fhip arthroplasty revision surgery\n* inability to give informed consent or answer questionnaires knowledgeably due to language or cognitive impairment as reported in the medical record",{"count":213,"type":19},160,[22],"This study aims to evaluate the effectiveness of a digital patient education solution, CHUVeduc@home, in improving preoperative preparation for patients undergoing total hip or knee arthroplasty. In Switzerland, many patients receive joint replacements each year to relieve osteoarthritis-related pain. With shorter hospital stays, adequate preparation before surgery has become increasingly important.\n\nA total of 160 patients will be randomized into two groups:\n\nIntervention group: access to CHUVeduc@home before surgery. Control group: standard preoperative preparation (group information session and consultation).\n\nAll participants will complete questionnaires through the application. No additional visits are required. The intervention lasts approximately 12 weeks.\n\nThe primary goal is to determine whether digital education increases patient knowledge, confidence, and satisfaction, and facilitates recovery and return home after surgery. Participation is voluntary and can be withdrawn at any time.",[25,86],[218,219,220,221,222,223,224,225,226,227,228,229,230],"knee","hip","replacement","arthroplasty","patient education","digital solution","preoperative care","perioperative care","interdisciplinary intervention","physiotherapy","nursing","health literacy","digital literacy","2026-01-09",{"date":233,"type":36},"2026-01-15",{"date":235,"type":19},"2026-02-15",{"date":237,"type":19},"2027-02-28",{"name":239,"class":71},"Haute Ecole de Santé Vaud",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":247,"enrollmentInfo":248,"targetDuration":4,"studyType":20,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":72},"100618911","comparing-different-doses-of-corticosteroids-in-local-infiltration-analgesia-lia-for-total-knee-arthroplasty-100618911","NCT07337772","Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Prospective Randomized Controlled Trial Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Inclusion Criteria:\n\n1. Male or female participants aged 18 years or older;\n2. Undergoing primary unilateral total knee arthroplasty (TKA)for unilateral knee osteoarthritis(OA)at ourhospital;\n3. Preoperative American Society of Anesthesiologists(ASA)physical status classification of 1-3;\n4. Ability to provide informed consent and sign a written informed consent form.\n\nExclusion Criteria:\n\n1. Previous surgery on the operative knee or a history of infection in the operative knee;\n2. Non-osteoarthritis conditions (including rheumatoid arthritis, traumatic arthritis, septic arthritis, and hemophilic arthritis);\n3. Severe osteoarthritis (including flexion contracture \\>30° or varus\u002Fvalgus deformity \\>30°);\n4. Allergy to the relevant study drugs;\n5. Presence of neuromuscular dysfunction in the ipsilateral limb;\n6. Dependence on anesthetic drugs (defined as weekly use of opioids exceeding 100 mg morphine equivalents or local anesthetics for preoperative pain control for more than 3 months);\n7. Poor systemic condition, including but not limited to: glycated hemoglobin (HbA1c) level \\>12%; blood pressure \\>170\u002F110 mmHg (1 mmHg = 0.133 kPa); history of myocardial infarction, stroke, transient ischemic attack, acute congestive heart failure, or any acute coronary event within 6 months; dialysis or renal transplantation; pregnancy or lactation.","100 Years",{"count":249,"type":19},120,[22],"This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.",[253,85,254],"Adrenal Cortex Hormones","Anesthesia, Local","2026-01-04",{"date":257,"type":36},"2026-01-13",{"date":259,"type":19},"2026-02-01",{"date":261,"type":19},"2028-11-01",{"name":263,"class":71},"First Affiliated Hospital of Fujian Medical University",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":20,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":72},"100597448","nurse-led-telehealth-vs-in-person-follow-up-after-total-knee-replacement-100597448","NCT07058623","Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement","A Randomized Controlled Trial of Nurse-Led Telehealth Versus In-Person Consultations in Detecting Complications and Improving Recovery After Total Knee Replacement","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Undergoing their first total knee replacement surgery\n* Within 4 weeks after surgery\n* Medically stable for discharge and suitable for home-based follow-up care\n* Have access to a smartphone and internet (for telehealth participants)\n* Able to communicate effectively in Cantonese\n* Provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Undergoing bilateral or revision total knee replacement surgery\n* Require immediate or intensive medical attention post-surgery (e.g., severe infection, hospitalization over 7 days)\n* Have severe systemic disease (ASA physical status classification III or higher)\n* Lack the technical ability or resources to participate in telehealth consultations\n* Unable to communicate effectively in Cantonese\n* Undergoing surgeries other than first-time total knee replacement",{"count":272,"type":19},98,[22],"Brief Summary\n\nThe goal of this clinical trial is to learn if nurse-led telehealth consultations can help detect complications and support recovery after total knee replacement surgery. The study will compare telehealth nursing consultations to traditional in-person nursing visits.\n\nThe main questions it aims to answer are:\n\n* Can nurse-led telehealth detect post-surgery complications as well as or better than in-person consultations?\n* Does telehealth nursing support better or equivalent recovery outcomes and patient satisfaction compared to in-person care?\n\nParticipants will:\n\n* Be adults who had their first total knee replacement surgery.\n* Receive follow-up care either through telehealth consultations using the HA Go mobile app or through traditional face-to-face nurse visits in the outpatient clinic.\n* Attend scheduled consultations and provide information about their recovery and any complications they experience.\n* Complete surveys about their satisfaction with the care they receive.\n\nThis study will help determine if telehealth nursing consultations can provide safe, effective, and convenient follow-up care for patients after knee replacement surgery, potentially improving access and reducing travel burdens.",[85,276],"Osteoarthritis, Knee",[278,279,280,281,282,283,284,285,286,287,288,289,290,291],"Total knee replacement","Knee arthroplasty","Postoperative care","Nurse-led telehealth","Telemedicine nursing consultation","Telehealth follow-up","Orthopedic nursing","Surgical complication detection","Recovery after knee surgery","Patient satisfaction","Outpatient follow-up care","Digital health interventions","HA Go mobile application","Remote patient monitoring","2025-12-30",{"date":294,"type":36},"2026-01-05",{"date":296,"type":36},"2025-09-10",{"date":298,"type":19},"2026-06-30",{"name":300,"class":301},"Hospital Authority, Hong Kong","OTHER_GOV",{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":310,"enrollmentInfo":311,"targetDuration":4,"studyType":20,"phases":313,"briefSummary":314,"conditions":315,"keywords":317,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":72},"100607047","return-to-sports-after-knee-arthroplasty-100607047","NCT07183475","Return to Sports After Knee Arthroplasty","Amendment to the Study \"Prospective, Multicenter Investigation of Clinical Rehabilitation and Everyday Recovery Following Knee Joint Endoprosthetic Replacement\" With Additional Return-to-sports-testing at One Participating Center","RTS","Inclusion Criteria:\n\n* The study includes all patients with a history of unicondylar or bicondylar knee joint replacement and engagement in sports activity.\n* All participating patients have provided their informed consent following comprehensive information and explanation.\n* All participating patients have signed the informed consent form for study participation as well as the data protection declaration after receiving detailed information and clarification.\n\nExclusion Criteria:\n\n* Patients who are unable to understand the patient information and study design (e.g., due to language barriers) or whose compliance is deemed insufficient by the study team\n* No knee joint endoprosthesis implanted\n* No engagement in athletic activity","85 Years",{"count":312,"type":19},50,[22],"The ability to return to sports after joint arthroplasty is increasingly becoming an important factor for patients in terms of their perceived quality of life. In sports orthopaedics, standardized functional tests have already been established - particularly for anterior cruciate ligament injuries - to assess athletic performance and prevent re-injury. These tests allow a stepwise evaluation of a subject's physical readiness for sports.\n\nIn the field of arthroplasty, and despite increasing sports activity among patients with joint arthroplasty such structured assessment is still lacking. As a result, patients with arthroplasty typically resume sports activities based solely on individual recommendations from the surgeon or treating therapist. However, an objective evaluation of sports capability is currently not available.\n\nTherefore the amendment intends to expand the current testing protocol of the already registered and ongoing study (Protocol ID: UBonn\\_TKA\\_FollowUp) to include additional standardized, evidence-based return-to-sprort-tests.",[316,25],"Knee Osteoarthristis",[318,319,320],"return to sports","knee oteoarthritis","knee arthroplasty","2025-09-16",{"date":323,"type":36},"2025-09-19",{"date":325,"type":36},"2025-07-15",{"date":327,"type":19},"2027-07-31",{"name":329,"class":71},"Technical University of Munich",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":337,"enrollmentInfo":338,"targetDuration":4,"studyType":20,"phases":340,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":72},"100593553","phase-2-phase-iia-trial-of-oral-sss17-for-post-arthroplasty-anemia-100593553","NCT07007936","Phase IIa Trial of Oral SSS17 for Post-Arthroplasty Anemia","A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial to Evaluate the Efficacy and Safety of Oral SSS17 Capsules in the Treatment of Anemia Following Total Hip or Knee Arthroplasty","Inclusion Criteria:\n\n1. Signed informed consent obtained\n\n   \\-\n2. Age 18-70 years (inclusive)\n\n   \\-\n3. Candidates for hip\u002Fknee arthroplasty\n\n   \\-\n4. No DVT on pre-op venous ultrasound\n\n   \\-\n5. Screening Hb 80-110 g\u002FL (no transfusion indication) - 6. Commitment to effective contraception\n\nExclusion Criteria:\n\n1. Hypersensitivity to the investigational product or any of its components\n2. Any other condition causing chronic anemia\n3. Coagulopathy or unstable anticoagulant dosing during screening\n4. Any of the following laboratory abnormalities at screening:\n\n   1. Serum albumin \\\u003C35 g\u002FL\n   2. ALT or AST \\>3×ULN\n5. Active infections or carrier status including:\n\n   * Known HIV infection\n   * Active syphilis\n   * Active HBV infection (HBsAg-positive with HBV DNA \\>10³ copies\u002FmL)\n   * Active HCV infection (anti-HCV positive with detectable HCV RNA)\n6. Acute joint injury with active trauma or infection at screening\n7. Cognitive impairment or psychiatric disorders,current or history of epilepsy\n8. Treatment with ESAs (erythropoiesis-stimulating agents) or HIF inhibitors within 30 days prior to dosing\n9. History of severe thromboembolic events or hematopoietic disorders\n10. Malignancy history\n11. Severe cardiovascular diseases including:\n\n    * Unstable coronary artery disease\n    * Heart failure (NYHA Class III\u002FIV)\n    * Myocardial infarction\u002Fstroke 12 .Poorly controlled hypertension\n\n13\\. Alcohol abuse 14.Pregnancy or lactation 15.Participation in other drug trials within 3 months prior to enrollment 16.Any other condition deemed by the Investigator to compromise subject safety or trial validity","70 Years",{"count":339,"type":19},90,[341],"PHASE2","To assess the safety, tolerability, efficacy, and pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) characteristics of orally administered SSS17 capsules in patients with postoperative anemia following elective total hip or knee arthroplasty.",[344,86,85],"Postoperative Anemia","2025-06-06",{"date":347,"type":36},"2025-06-11",{"date":349,"type":19},"2025-07",{"date":351,"type":19},"2026-04",{"name":353,"class":43},"Shenyang Sunshine Pharmaceutical Co., LTD.",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":363,"conditions":364,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":72},"100515481","wearable-sensors-for-monitoring-recovery-after-total-knee-arthroplasty-100515481","NCT05992064","Wearable Sensors for Monitoring Recovery After Total Knee Arthroplasty","Investigating the Potential of Wearable Sensors for Monitoring the Postoperative Recovery of Total Knee Arthroplasty Patients: A Protocol for Prospective Longitudinal Observational Study","Inclusion Criteria:\n\n* Patients diagnosed with knee OA and scheduled to undergo unilateral TKA at Aalborg University Hospital, Farsø.\n\nExclusion Criteria:\n\n* Daily pain (numeric rating scale (NRS) ≥ 4) or severe OA in the contralateral knee (KL-IV)\n* Daily pain (NRS ≥ 4) or severe OA in the spine and other lower limb joints\n* BMI \\> 35 kg\u002Fm2\n* Recent surgery in the spine or lower limbs (\\\u003C 6 months)\n* Neurological movement disorders\n* Inflammatory arthritis\n* Patients who are not smartphone users\n* Frail patients with clinical frailty scale (CFS)10 ≥ 5\n* Residents of nursing homes\n* Patients dependent to walking aids for ambulation\n* Patients with dementia or memory problems\n* Patients with skin sensitivity or issues at the location of the plasters.",{"count":362,"type":19},30,"The goal of this observational study is to investigate the potential of wearable sensors for monitoring the postoperative recovery of patients after TKA.\n\nThe main question the study aims to answer is:\n\n• whether alterations in gait characteristics and the changes in PA levels measured by wearable PA trackers can accurately reflect a patient's postoperative recovery status and provide clinically relevant information to aid their management.\n\nParticipants will wear PA trackers during the perioperative period of TKA (2 weeks before until 3 months after, and then agin for 2 weeks one year after the surgery) and we will analyze their gait and PA and correlate them with their recovery after surgery.",[85],"2025-04-08",{"date":367,"type":36},"2025-04-10",{"date":369,"type":36},"2024-03-12",{"date":371,"type":19},"2026-10-01",{"name":373,"class":71},"Aalborg University Hospital",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":15,"minAge":79,"maxAge":4,"enrollmentInfo":381,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":383,"conditions":384,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":44},"100430397","multigen-plus-h-study-and-amf-tt-cones-100430397","NCT04884542","Multigen Plus H Study and AMF TT Cones","A Prospective, Post-marketing Study Evaluating Clinical and Radiographic Early Outcomes of Revision Total Knee Arthroplasty With Multigen Plus H Alone or Involving AMF TT Cones.","Inclusion Criteria:\n\n* Male or female\n* Age ≥ 18 years old\n* Given written informed consent approved by the reference Ethics Committee (EC)\n* Subjects in whom a decision has already been made to perform a Total Knee Arthroplasty with the Multigen Plus H system as per Indication For Use. The decision to implant a Multigen Plus H system, alone or involving the AMF TT cones, must be taken prior to, and independently from, the decision to enrol the subject. This decision should be made in accordance with routine clinical practice at the study site concerned.\n* Subject is able to comply with the protocol\n\nExclusion Criteria:\n\n* Age \\< 18 years old\n* Subjects with any Multigen Plus system contraindication for use, or any AMF TT cones contraindication for use when used in combination with the Multigen Plus H, as reported in the current Instruction For Use.\n* Any clinically significant pathology based on the medical history or any medical intervention that the Investigator feels may affect the study evaluation\n* Female subjects who are pregnant, nursing, or planning a pregnancy\n* Previous knee replacement on the contralateral side within the last year and whose outcome is achieving an KSS \\< 70 points.",{"count":382,"type":19},43,"The aim of this study is to assess the clinical, patient-reported, and radiographic outcomes of a revision Total Knee Arthroplasty with Multigen Plus H and AMF TT Cones.",[85],"2025-03-05",{"date":387,"type":36},"2025-03-10",{"date":389,"type":36},"2022-01-19",{"date":391,"type":19},"2027-06-30",{"name":393,"class":43},"Limacorporate S.p.a"]