[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ascending-aortic-aneurysm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ascending-aortic-aneurysm":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100053531","a-study-of-lipid-metabolism-and-mitochondrial-function-in-myeloid-cells-and-total-aortic-tissue-in-patients-with-ascending-thoracic-aortic-aneurysm-ata-and-bicuspid-ba-or-tricuspid-ta-aortic-valves-100053531",false,"NCT07695545","A Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.","A Prospective, Single-center, Open-label Study of Lipid Metabolism and Mitochondrial Function in Myeloid Cells and Total Aortic Tissue in Patients With Ascending Thoracic Aortic Aneurysm (ATA) and Bicuspid (BA) or Tricuspid (TA) Aortic Valves.","PROMETA","Inclusion Criteria:\n\n* Individuals who have given their consent\n* Patients with an ascending aortic aneurysm for which surgical replacement is indicated\n* Age \\> 18 years\n* Scheduled surgery\n* Preoperative ultrasound confirmation of the heart valve architecture (bicuspid or tricuspid valve)\n\nExclusion Criteria:\n\n* A person subject to a legal protective measure (guardianship, conservatorship)\n* A person subject to a judicial safeguard measure - A pregnant woman, a woman in labor, or a breastfeeding woman\n* Adults who are legally incapacitated or unable to give consent\n* Emergency surgical procedures\n* Patients with uncontrolled inflammatory or autoimmune conditions\n* Patients with a history of recent acute infection (within the last 3 months or still undergoing treatment)\n* Patients with a condition requiring immunosuppressants - Patients with a confirmed or suspected genetic aneurysm (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.)\n* Patients with a history of cardiac surgery","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality. Their pathophysiology is based on complex mechanisms involving inflammatory and metabolic processes, as well as alterations in mitochondrial function. The presence of a bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) significantly influences the progression and severity of aneurysms. Bicuspid aortic valve (BAV) patients often develop aortic aneurysms earlier, as early as age 40-50, whereas tricuspid aortic valve (TAV) patients generally present with a degenerative condition that appears later (after age 50). The objective of this study is to compare the inflammatory, metabolic, and transcriptomic signatures of myeloid cells and total aortic tissue between BAV and TAV patients. These analyses will help identify specific molecular mechanisms, potential biomarkers, and therapeutic targets. To ensure pathophysiological homogeneity, patients with aneurysms of genetic origin (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) will be excluded.",[25],"Ascending Aortic Aneurysm","RECRUITING","2026-07-10",{"date":29,"type":30},"2026-07-13","ACTUAL",{"date":32,"type":30},"2026-06-28",{"date":34,"type":21},"2029-08",{"name":36,"class":37},"Centre Hospitalier Universitaire Dijon","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":38},"100622623","full-sternotomy-vs-mini-sternotomy-for-ascending-aortic-pathology-100622623","NCT07386028","Full Sternotomy vs Mini-sternotomy for Ascending Aortic Pathology","Full Sternotomy Versus J-shaped Mini-sternotomy for Chronic Ascending Aortic Pathology","Inclusion Criteria:\n\n* Signed informed consent.\n* Ascending aorta greater than 5 cm without involving the aortic arch\n\nExclusion Criteria:\n\n* Acute aortic dissection or urgent\u002Femergent cases.\n* Redo aortic surgery.\n* Aortic arch surgery.\n* Concomitant CABG or left ventricle restoration","80 Years",{"count":48,"type":21},200,"INTERVENTIONAL",[51],"NA","This study investigates outcomes after hemiarch repair in patients with chronic ascending aortic disease. The patients will be divided into two groups according to surgical approach: 100 patients will undergo hemiarch repair via full sternotomy (FS group) and 100 patients will receive hemiarch repair via J-shaped mini-sternotomy (MS group). Early and late outcomes will be recorded.",[25],[55,56,57,58],"ascending aortic aneurysm","aortic replacement","sternotomy","mini-sternotomy","2026-02-03",{"date":61,"type":30},"2026-02-05",{"date":63,"type":30},"2022-07-10",{"date":65,"type":21},"2027-12",{"name":67,"class":37},"Tomsk Cardiology Research Institute",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":49,"phases":77,"briefSummary":78,"conditions":79,"keywords":87,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":38},"100545096","influence-of-lung-ultrasonography-on-the-prognosis-and-postoperative-outcomes-in-cardiac-surgical-patients-100545096","NCT06377449","Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients","Influence of Ultrasound Examination of the Lungs on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients","Inclusion Criteria:\n\n* open heart surgery with cardiopulmonary bypass (CPB) between 15 December 2023 and 15 December 2024\n* signed informed consent for participation in the study\n\nExclusion Criteria:\n\n* reoperations on the open heart with CPB\n* surgical procedures on lungs and lung cancer in the anamnesis\n* chronic obstructive pulmonary disease, stage III\n* chronic kidney disease, stages 4 and 5\n* patients with low Risk Score profile by the Society of Thoracic Surgeons",{"count":76,"type":21},186,[51],"The goal of this interventional is to assess advantages of the ultrasound examination of the lungs in the early postoperative period in cardiac surgical patients after heart surgeries requiring cardiopulmonary bypass. Evaluation of pulmonary complications and outcomes during mid-term follow-up, as well as comparison of ultrasound examination and traditional roentgenologic methods (X-ray examination and CT of the chest) will be performed. The main question\\[s\\] it aims to answer are:\n\n* Is ultrasound examination of the lungs a more specific and sensitive method in identification of early postoperative pulmonary complications after on-pump cardiac surgical procedures, in comparison with traditional X-ray methods.\n* Does early identification of interstitial pulmonary edema (based on number of visualised B-lines in the early postoperative period), influences mid-term outcomes in this cohort of patients Participants will undergo ultrasound examination of the lungs on postoperative day 1, 3, 5 and 7 after heart surgery. Based on ultrasound findings and degree of interstitial pulmonary edema, medical (diuretics, anti-inflammatory, e.t.c) therapy will be modified.\n\nResearchers will compare this group of patients with control group, in which ultrasound examination will be performed in the same time frames, but no changes in medical management based on ultrasound findings will be made to see if timely administered medical therapy, based on ultrasound findings, can significantly improve symptoms, hospital lengths of stay and outcomes of this patients.",[80,81,82,83,84,85,86,25],"Ischemic Heart Disease","Aortic Stenosis, Severe","Aortic Insufficiency","Mitral Stenosis","Mitral Insufficiency","Mitral Stenosis With Insufficiency","Tricuspid Insufficiency",[88,89,90,91,92,93],"Ultrasound examination of the lungs","B-lines","Coronary artery bypass grafting","Heart valve surgery","Cardiopulmonary bypass","On-pump cardiac surgery","2024-12-04",{"date":96,"type":30},"2024-12-09",{"date":98,"type":30},"2024-05-15",{"date":100,"type":21},"2026-01-01",{"name":102,"class":37},"Saint Petersburg State University, Russia"]