[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aspiration-pneumonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aspiration-pneumonia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,70,97,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100567273","gastric-pocus-for-airway-management-in-patients-using-glucagon-like-peptide-1-receptor-agonist-multicentric-100567273",false,"NCT06666049","Gastric POCUS for Airway Management in Patients Using Glucagon-like Peptide-1 Receptor Agonist (Multicentric)","POCUS","Inclusion Criteria:\n\nAdults patients ,ASA I-III, taking GLP-1 analog medications, undergoing scheduled surgery.\n\nExclusion Criteria:\n\n1. \\- History of esophagogastric pathology or previous abdominal surgery.\n2. \\- Hiatal hernia\u002Fgastroesophageal reflux disease.\n3. \\- Autonomic nervous system disorders.\n4. \\- Neurological or neuromuscular diseases.\n5. \\- Use of medications\u002Fdrugs that affect autonomic regulation and delay gastric emptying (opioids) or potentiate it (prokinetics).\n6. \\- Pregnancy.\n7. \\- Presence of arrhythmias.","ALL","18 Years","90 Years",{"count":20,"type":21},39,"ESTIMATED","OBSERVATIONAL","1\\. Introduction\n\nScheduled surgery requires patients to undergo a preoperative fasting period of at least 6 hours to reduce the risk of perioperative pulmonary aspiration. However, certain medications and conditions may delay gastric emptying, potentially increasing aspiration risk. These include diabetic gastroparesis and the use of glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of diabetes and obesity.\n\nGLP-1 receptor agonists are widely used due to their beneficial effects on glycemic control and weight reduction. However, one of their known effects is delayed gastric emptying, which may result in increased residual gastric content despite adherence to standard fasting guidelines. Recent reports have described cases of pulmonary aspiration during anesthesia in patients receiving GLP-1 receptor agonists, even after appropriate fasting.\n\nGiven the increasing use of these medications, there is a need for objective assessment tools to evaluate gastric content in the perioperative setting. Gastric ultrasonography has emerged as a non-invasive bedside technique that may help identify patients at increased risk of aspiration and guide airway management strategies.",[25],"Aspiration Pneumonia",[27,28],"Bronchopulmonary complications","Ultrasound","RECRUITING","2026-04-28",{"date":32,"type":33},"2026-05-05","ACTUAL",{"date":35,"type":33},"2024-10-21",{"date":37,"type":21},"2026-12-01",{"name":39,"class":40},"Clinica Universidad de Navarra, Universidad de Navarra","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":17,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100491093","gastric-assessment-of-pediatric-patients-undergoing-surgery-100491093","NCT05674643","Gastric Assessment of Pediatric Patients Undergoing Surgery","Inclusion Criteria:\n\n* Perioperative patients with ASA classification 1-2\n* Ages: 2 years- less than 18 years\n* Locations: Longwood and Waltham campuses of Boston Childrens Hospital\n\nExclusion Criteria:\n\n* History of gastrointestinal surgery\n* Gastrostomy\n* Known GI dysmotility (cohort 1 only)\n* Acetaminophen allergy (cohort 1 only)\n* Liver or renal dysfunction- pre-diagnosed or, if available, when serum biomarkers are 2 standard deviations above the highest value considered normal for age. (cohort 1 only)\n* Consumption of acetaminophen in the 4 hours prior (cohort 1 only)",true,"2 Years",{"count":51,"type":21},60,"The goal of this pilot prospective cohort study is to examine the reproducibility of gastric volume and emptying as measured by gastric ultrasound and its correlation to a gold-standard test for gastric emptying in the perioperative period in pediatric patients. The main questions it aims to answer are:\n\n* What is the reliability (inter-rater variability between expert and novice assessors, and intra-rater variability) of a) the gastric antral cross-sectional area (CSA) and b) gastric volume using the Perlas US qualitative grading assessment, measured by using an ultrasound device in pediatric patients undergoing general anesthesia for elective surgery?\n* What is the correlation between ultrasound assessment of gastric emptying by the antral-CSA and gastric emptying determined by the acetaminophen absorption test (AAT), the gold standard?\n\nThe study will include two cohorts. Cohort assignment will be based on age and anesthesia induction plan. Subjects \\>7yrs of age and expected to get an IV induction will be assigned to Cohort #1. Subjects \\\u003C7yrs of age and not expected to get an IV induction will be assigned to Cohort #2.\n\n* Cohort 1 will include abdominal ultrasound for gastric assessment AND the acetaminophen absorption test which includes administering enteral acetaminophen (tylenol) with 6 oz of water and drawing of blood samples through a peripheral intravenous line.\n* Cohort 2 will include subjects for whom a peripheral intravenous line placement is not part of routine pre-operative care. Procedures for Cohort 2 will include abdominal ultrasound only in the pre-op area (no tylenol). This cohort is included to examine the reliability of measurements across age groups.",[54,55,25,56],"Fasting","Delayed Gastric Emptying","Respiratory Aspiration of Gastric Content",[58,59],"gastric ultrasound","pre-operative fasting","2026-03-27",{"date":62,"type":33},"2026-04-02",{"date":64,"type":33},"2023-02-01",{"date":66,"type":21},"2028-12-31",{"name":68,"class":40},"Boston Children's Hospital",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":69},"100474242","phase-4-gastrointestinal-dysmotility-on-aspiration-risk-100474242","NCT05455359","Gastrointestinal Dysmotility on Aspiration Risk","The Impact of Upper Gastrointestinal Dysmotility on Aspiration-associated Symptoms","Inclusion Criteria:\n\n1. are 5-21 years of age;\n2. receive \\>90% of their calories by enteral tube (i.e., patients take no food or drink by mouth);\n3. are determined to be at high risk for aspiration pneumonia based on evidence of impaired airway protective mechanisms, documented by aspiration on video fluoroscopic swallow study;\n4. have static neurologic impairment, defined as functional and\u002For intellectual impairment that results from a chronic neurologic or related diagnosis (e.g., cerebral palsy) with no prospect of progression for at least one year;\n5. have chronic respiratory symptoms, defined as coughing, choking, or need for oral suctioning a minimum of three times per week during the prior four weeks.\n\n   \\-\n\nExclusion Criteria:\n\n1. have progressive neurologic impairment;\n2. have a history of prior intact Nissen fundoplication;\n3. are currently taking oral or inhaled antibiotics, including prophylactic antibiotics;\n4. are currently taking or have taken in the last four weeks acid suppression (H2 antagonist or PPI); or\n5. are fed by gastrojejunostomy rather than by gastrostomy. -","5 Years","21 Years",{"count":80,"type":21},120,"INTERVENTIONAL",[83],"PHASE4","The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.",[86,87,25,88],"Esophageal Motility Disorders","Gastric Motor Dysfunction","Gastro Esophageal Reflux","2025-12-23",{"date":91,"type":33},"2025-12-26",{"date":93,"type":33},"2025-02-13",{"date":95,"type":21},"2027-05-31",{"name":68,"class":40},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":104,"targetDuration":106,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":69},"100555399","fbs-asap-fibrobronchoscopy-in-aspiration-pneumonia-in-the-emergency-department-100555399","NCT06511583","FBS-ASaP: Fibrobronchoscopy in ASpiration Pneumonia in the Emergency Department","FBS-ASaP","Inclusion Criteria:\n\nAll adult patients who access the Emergency Department with a diagnosis of aspiration pneumonia and for whom the referring physician determines the need for aspiration of secretions or ingesta. Patients must have at least one of the following criteria\n\n* Radiological evidence of pneumonia (Chest X-ray\u002FCT scan\u002FChest ultrasound)\n* Clinical diagnosis of aspiration pneumonia\n* Presence of secretions in the upper airways\n* Respiratory distress in a dysphagic patient\n* Need for oxygen therapy or need to increase FiO2 in patients already on home oxygen therapy\n\nExclusion Criteria:\n\n* Lack of consent\n* Age \\< 18 years\n* Pregnancy\n* Hemorrhagic diathesis\n* Malignant cardiac arrhythmias (VT, AV block excluding first-degree AV block)\n* Severe airway obstruction",{"count":105,"type":21},100,"30 Days","Non-Profit Prospective Observational Pilot Study\n\nThe study will have an overall duration of 3 years, with patient enrollment starting after ethical committee approval.\n\nIn this study, all patients with a diagnosis of aspiration pneumonia who require aspiration of secretions or ingesta in the Emergency Department will be considered. A registry will be created with the patients\\' data, noting the type of procedure performed: laryngotracheal aspiration with a probe or with fibrobronchoscopy.\n\nThis observational registry pilot study aims to evaluate the utility and adverse events related to the use of aspiration via videobronchoscopy performed in the Emergency Department and to compare the clinical outcomes of patients undergoing bronchoscopy with those treated only with blind laryngotracheal aspiration using a probe.",[25,109],"Bronchoscopy",[111,109,112,113,114,115,116],"Aspiration pneumonia","toilette","interventional pulmunology","respiratory failure","pneumonia","bacterial pneumonia","2024-07-15",{"date":119,"type":33},"2024-07-22",{"date":121,"type":33},"2024-02-05",{"date":123,"type":21},"2027-03-05",{"name":125,"class":40},"Azienda Ospedaliero-Universitaria Careggi",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":81,"phases":136,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":69},"100479678","gastric-us-in-icu-patient-100479678","NCT05526105","Gastric US in ICU Patient","Gastric Ultrasound in Critically Ill Patients for Evaluation of Gastric Volume Residuals; A Comparison of NPO Protocols","Inclusion Criteria:\n\n* Patients age 18 or older, admitted to the ICU, requiring general anesthesia or sedation for a procedure with a pre-existing, cuffed endotracheal or tracheostomy tube. Most patients admitted to the ICU would be unable to consent.\n\nExclusion Criteria:\n\n* Known upper gastrointestinal anatomical problem that would prevent accurate estimation of gastric volume, gastric perforation, pregnancy beyond the first trimester.\n* Lack of a pre-existing, cuffed endotracheal or tracheostomy tube.","100 Years",{"count":135,"type":21},50,[137],"NA","This is a case series study using gastric ultrasound in critically ill patients to quantify gastric residual volumes to compare the efficacy of different NPO protocols.",[140,141,25],"Critical Illness","Surgery",[143,144,145,28,146,147,148,149,150,151,152,153,154],"NPO Protocols","Intensive Care Unit","Gastric Ultrasound","Surgical Intensive Care Unit","NPO","Nasogastric Tube","Orogastric Tube","Enteral Nutrition","Parenteral Nutrition","Gastric Residual Volume","Aspiration","Critical Illness Nutrition","2024-06-26",{"date":157,"type":33},"2024-06-27",{"date":159,"type":33},"2023-02-03",{"date":161,"type":21},"2025-02-03",{"name":163,"class":40},"Dartmouth-Hitchcock Medical Center"]